Results 91 to 100 of about 267,086 (349)

The Pivotal Role of Adipocyte-Na K peptide in Reversing Systemic Inflammation in Obesity and COVID-19 in the Development of Heart Failure

Antioxidants, 2020
This review summarizes data from several laboratories that have demonstrated a role of the Na/K-ATPase, specifically its α1 subunit, in the generation of reactive oxygen species (ROS) via the negative regulator of Src.
Zi-jian Xie, Joel Novograd, Yaakov Itzkowitz, Ariel Sher, Yosef D. Buchen, Komal Sodhi, Nader G. Abraham, Joseph I. Shapiro   +7 more
doaj   +1 more source

Exosomes secreted by mesenchymal stromal/stem cell-derived adipocytes promote breast cancer cell growth via activation of Hippo signaling pathway

Stem cell research & therapeutics, 2019
Although adipocytes are the most abundant stromal cell component in breast cancer tissues, their interaction with breast cancer cells has been less investigated compared to cancer-associated fibroblasts or macrophages.
Shihua Wang, Xiaodong Su, Meiqian Xu, Xian Xiao, Xiaoxia Li, Hongling Li, A. Keating, R. Zhao   +7 more
semanticscholar   +1 more source

Oleate induces apoptosis in 3T3-L1 adipocytes [PDF]

, 2011
Oleic acid (C18:1) play an important role in proliferation of fat cells. In this study, the effect of oleate on cells viability in 3T3-L1 cells (fat cells) was investigated.
Rohana, Abu, Muhammad Roji, M. S., Fadzilah Adibah, A. M.   +2 more
core  

Short-chain fatty acid acetate stimulates adipogenesis and mitochondrial biogenesis via GPR43 in brown adipocytes [PDF]

, 2016
Short-chain fatty acids play crucial roles in a range of physiological functions. However, the effects of short-chain fatty acids on brown adipose tissue have not been fully investigated.
GK Dimitriadis (7772033), Kyrou, Ioannis, Tan, B.K, G Tripathi (7804103), J Hu (7741025), V Patel (7804106), Patel, V., Dimitriadis, G.K, Chen, J, Dimitriadis, Georgios K., Ramanjaneya, M., Ramanjaneya, M, Tripathi, G, Tan B.K., I Kyrou (7772027), Ramanjaneya, Manjunath, James, Sean G., Tripathi, G., S James (7748780), Patel, Vanlata H., James, Sean, J Chen (80904), Hu, Jiamiao, Hu, J, Kawan, M, Hu, J., Tan, Bee K., Kawan, Mohamed, M Kawan (7804109), James, S, Tripathi, Gyanendra, Kawan, M., Kyrou, I, James, S., Randeva, Harpal S., M Ramanjaneya (7804100), Kyrou, I., Chen, J., HS Randeva (7772048), Patel, V, BK Tan (7718081), Patel, Vanlata, Dimitriadis, G.K., Randeva, H.S., Randeva, H.S, Chen, Jing   +45 more
core   +1 more source

Weighing in on Adipocyte Precursors [PDF]

Cell Metabolism, 2014
Obesity, defined as an excessive increase in white adipose tissue (WAT), is a global health epidemic. In obesity, WAT expands by increased adipocyte size (hypertrophy) and number (hyperplasia). The location and cellular mechanisms of WAT expansion greatly affect the pathogenesis of obesity.
Berry, Ryan, Jeffery, Elise, Rodeheffer, Matthew S.   +2 more
openaire   +2 more sources

Extracellular Vesicles Modulation by an Adiponectin Receptor Agonist Provides Cardioprotection for Myocardial Ischemic Injury

Advanced Healthcare Materials, EarlyView.
This study demonstrates that ALY688, a drug mimicking the heart‐protective hormone adiponectin, reduces myocardial ischemia injury. ALY688 increases the production of extracellular vesicles, which carry protective cargo including adiponectin itself.
Jialing Tang, Wing Yan Chung, Serena M. Pulente, Yubin Lei, Khang Nguyen, Eddie Tam, Nadya M. Morrow, Ilka Lorenzen‐Schmidt, Fengxia Xiao, Augusto Zani, Dylan Burger, Hye Kyoung Sung, Erin E. Mulvihill, Gary Sweeney   +13 more
wiley   +1 more source

Hypoxia-driven metabolic reprogramming of adipocytes fuels cancer cell proliferation

Frontiers in Endocrinology, 2022
ObjectiveObesity increases the risk of certain cancers, especially tumours that reside close to adipose tissue (breast and ovarian metastasis in the omentum).
R. Aird, J. Wills, K. F. Roby, C. Bénézech, R. H. Stimson, M. Wabitsch, J. W. Pollard, A. Finch, Z. Michailidou   +8 more
doaj   +1 more source

Single cell analysis reveals immune cell–adipocyte crosstalk regulating the transcription of thermogenic adipocytes

bioRxiv, 2019
Immune cells are vital constituents of the adipose microenvironment that influence both local and systemic lipid metabolism. Mice lacking IL10 have enhanced thermogenesis, but the roles of specific cell types in the metabolic response to IL10 remain to ...
Prashant Rajbhandari, Douglas V. Arneson, Sydney K. Hart, I. Ahn, G. Diamante, Luis C. Santos, Nima Zaghari, An-Chieh Feng, Brandon J Thomas, L. Vergnes, Stephen D. Lee, A. Rajbhandari, K. Reue, S. Smale, Xia Yang, P. Tontonoz   +15 more
semanticscholar   +1 more source

Microengineered Gradient Hydrogels for Mechanobiology

Advanced Healthcare Materials, EarlyView.
Gradient hydrogels are used to mimic the mechanical heterogeneity in native tissues, offering powerful in vitro platforms to study cell‐material interactions in diverse pathophysiological contexts. Here, we present a comprehensive review of the design and experimental considerations for stiffness gradient hydrogels, discussing exemplary achievements ...
Shin Wei Chong, Deepu Ashok, Anna Waterhouse, Marcela M. M. Bilek, Daniele Vigolo   +4 more
wiley   +1 more source

CIRCADIAN RHYTHMICITY IN MURINE PRE-ADIPOCYTE AND ADIPOCYTE CELLS

Chronobiology International, 2009
Adipose tissue is central to metabolic homeostasis, signaling in part through the secretion of molecules termed adipokines. Circadian rhythms play an important role in adipose physiology, with plasma adipokine concentration and approximately 20 % of the murine adipose transcriptome undergoing 24 h variation. However, due to the heterogeneity of adipose
Otway, DT, Frost, G, Johnston, JD
openaire   +5 more sources