Results 111 to 120 of about 237,921 (307)

SPSB1 Promotes Subcutaneous Adipose Hyperplasia in Facial Port‐Wine Stains by Controlling HDAC1 Degradation and Stability Through Two Distinct Proteolytic Pathways

Advanced Science, EarlyView.
In PWS‐ASPCs, FOSL1 drives the expression of SPSB1. SPSB1, as part of the ESC complex, further binds to HDAC1 and promotes K29‐linked and K48‐linked polyubiquitination of HDAC1. These modifications facilitate the degradation of HDAC1 through the ALP and UPS pathways, respectively.
Hongrui Chen, Bin Sun, Yajing Qiu, Chen Hua, Xiaoxi Lin, Wei Gao   +5 more
wiley   +1 more source

Adipocytes Sequester and Metabolize the Chemotherapeutic Daunorubicin

Molecular Cancer Research, 2017
Obesity is associated with poorer outcome for many cancers. Previously, we observed that adipocytes protect acute lymphoblastic leukemia (ALL) cells from the anthracycline, daunorubicin.
Xia Sheng, J. Parmentier, Jonathan Tucci, Hua Pei, Omar Cortez-Toledo, C. Dieli-Conwright, M. Oberley, M. Neely, E. Orgel, S. Louie, S. Mittelman   +10 more
semanticscholar   +1 more source

A Second Pathogenic Protein, PolyGN2C‐iso2, Reveals a Dual‐Protein Pathology in Neuronal Intranuclear Inclusion Disease

Advanced Science, EarlyView.
This study reveals that NOTCH2NLC transcript variant 2 generates PolyGN2C‐iso2, an aggregating protein present within intranuclear inclusions of NIID patient tissues. A novel mouse model expressing PolyGN2C‐iso2 recapitulates white matter abnormalities and cognitive deficits, mechanistically linked to mitochondrial dysfunction. These findings support a
Kang Zhang, Wenhao Ma, Yi Zhou, Zhijie Wu, Pan Gao, Hongze Niu, Hongfei Tai, Tianyi Zhao, Zheyue Dong, Li Li, Yan Zhang, An Wang, Si Shen, Yueyang Li, Sifei Yu, Yan Peng, Wang Sheng, Xiaoyan Dong, Hua Pan, Kaibin Shi, Magdalena J. Koziol, Xiaobing Wu, Zaiqiang Zhang   +22 more
wiley   +1 more source

Erianin inhibits 3T3-L1 adipocyte differentiation through downregulation of CCAAT-enhancer binding protein-α and peroxisome proliferator-activated receptor-γ, lipogenic genes and impairment of mitochondrial respiration

Adipocyte
Erianin, a natural bibenzyl compound, has recently garnered attention owing to its diverse biological activities. In the present study, we investigated the effects of Erianin on adipocyte differentiation, lipid metabolism, and mitochondrial respiration ...
Hathaichanok Yimpreeda, Chayanee Laowittawat, Siraprapa Siritutsoontorn, Pinnara Rojvirat, Sarawut Kumphune, Sarawut Jitrapakdee   +5 more
doaj   +1 more source

Adipocytes and Obesity-Related Conditions Jointly Promote Breast Cancer Cell Growth and Motility: Associations With CAP1 for Prognosis

Frontiers in Endocrinology, 2018
The global increase in overweight and obesity rates represent pressing public health concerns associated with severe comorbidities, amongst a rising incidence and impaired outcome of breast cancer.
Ann H. Rosendahl, Malin Bergqvist, Barbara Lettiero, Siker Kimbung, Signe Borgquist, Signe Borgquist   +5 more
doaj   +1 more source

Is oxidative stress of adipocytes a cause or a consequence of the metabolic syndrome?

Journal of Clinical & Translational Endocrinology, 2018
Metabolic syndrome is accompanied by oxidative stress in animals and humans. The main source of ROS in experimental metabolic syndrome is NADPH oxidase and possibly adipocyte mitochondria.
L. Maslov, N. V. Naryzhnaya, A. Boshchenko, S. Popov, V. V. Ivanov, P. Oeltgen   +5 more
semanticscholar   +1 more source

Current Challenges of Transcription Compartmentalization Research

Advanced Science, EarlyView.
Transcription factors, coactivators, and RNA polymerase II assemble into transcription compartments ranging from small, defined complexes to liquid‐like condensates. This review unifies these seemingly competing descriptions along a single continuum and asks what these compartments have been shown to do, and what they have not, revealing that the most ...
Thomas Quail, Sina Wittmann
wiley   +1 more source

Palmitic acid differently modulates extracellular vesicles and cellular fatty acid composition of SGBS adipocytes without impairing their insulin signaling

Frontiers in Endocrinology
ScopeAdipocyte-derived extracellular vesicle (EV) lipid cargo reflects the obese metabolic state. Nevertheless, it is currently unknown whether the adipocyte-derived EV lipid profile is influenced by saturated fatty acid overload. This study investigated
Domenico Sergi, Sharon Angelini, Fabiola Castaldo, Marco Beccaria, Carlo Bellinghieri, Flavio Franchina, Alice Omenetto, Gabriella Stifani, Sefora Del Mastro, Stefania Merighi, Stefania Gessi, Ravin Jugdaohsingh, Carlo Cervellati, Martin Wabitsch, Luca Maria Neri, Guillaume Bidault, Antonio Vidal-Puig, Juana Maria Sanz, Angelina Passaro   +18 more
doaj   +1 more source

PDGFRα/PDGFRβ signaling balance modulates progenitor cell differentiation into white and beige adipocytes

Development, 2018
The relative abundance of thermogenic beige adipocytes and lipid-storing white adipocytes in adipose tissue underlie its metabolic activity. The roles of adipocyte progenitor cells, which express PDGFRα or PDGFRβ, in adipose tissue function have remained
Zhanguo Gao, Alexes C. Daquinag, Fei Su, Brad E Snyder, M. Kolonin   +4 more
semanticscholar   +1 more source

The IRE1‐XBP1s Axis Drives Inflammatory Osteolysis by Regulating a 5‐HT Dependent Endogenous Anti‐Autophagy Mechanism

Advanced Science, EarlyView.
A previously unrecognized IRE1‐XBP1s‐Slc6a4 signaling axis links endoplasmic reticulum stress to serotonin metabolism, autophagy, and inflammatory osteoclastogenesis. By promoting intracellular serotonin uptake and reducing endogenous 3‐methyladenine accumulation, this pathway accelerates inflammatory bone destruction and provides a promising ...
Pengchao Yang, Binxiang Zhu, Yuzhi He, Yang Tian, Honglei Kang, Shian Hu, Pengju Wang, Yong Xu, Zhuowei Lei, Peijun Qi, Hao Yang, Yang Lin, Yimin Dong, Feng Li, Hanfeng Guan   +14 more
wiley   +1 more source