Results 111 to 120 of about 267,086 (349)

Chemerin Regulates Crosstalk Between Adipocytes and Vascular Cells Through Nox

, 2015
Adipocytes produce adipokines, including chemerin, a chemoattractant that mediates effects through its ChemR23 receptor. Chemerin has been linked to endothelial dysfunction and vascular injury in pathological conditions, such as obesity, diabetes ...
Ana Maria de Oliveira, Aikaterini Anagnostopoulou, Nubia Souza Lobato, Rhian M. Touyz, Aurelie Nguyen Dinh Cat, Karla Bianca Neves, Augusto C. Montezano, Rheure Alves Moreira Lopes, Francisco Jose Rios, Rita C. Tostes   +9 more
core   +1 more source

Self‐Assembling Hybrid Hydrogel Reprograms the Stromal Vascular Fraction to Treat Osteoarthritis

Advanced Science, EarlyView.
This study presents a bioinspired injectable hydrogel that enhances the therapeutic potential of stem cell‐rich stromal vascular fraction for treating osteoarthritis. By reprogramming cell behavior through epigenetic modulation, the hydrogel promotes cartilage regeneration and reduces joint damage in a rat model, offering a promising new approach for ...
Waifang Hou, Yongfeng Chen, Longyou Xiao, Wei Qi, Tianshu Du, Qiang Sun, Borui Xue, Qinghe Zhao, Pengfei Xie, Zi Ye, Fei Han, Lingli Guo, Yang Jiao, Ranran Zhang, Hong Jia, Xiao Huang, Jianwei Guo, Peng Wang, Huayi Wang, Yuanrui Wang, Wenjing Chen, Haining Wu, Liumin He, Dawei Zhang   +23 more
wiley   +1 more source

Regulació nutricional i endocrina de la lipòlisi i la lipoproteïna lipasa en la truita irisada ("Oncorhynchus mykiss") i l'orada ("Sparus aurata") [PDF]

, 2005
[cat] En aquest treball s'ha posat a punt el protocol per a l'obtenció d'adipòcits aïllats de truita irisada (Oncorhynchus mykiss) i d'orada (Sparus aurata).
Albalat Ribé, Amaya
core  

Polymer Matrix‐Based 3D Culture Significantly Enhances the Differentiation and Immunomodulatory Functions of Human Adipose‐Derived Stem Cells

Advanced Science, EarlyView.
The 3D culture of human adipose‐derived stem cells (hADSCs) on a crosslinked cyclosiloxane‐based poly‐Z matrix platform enables the formation of spheroid structures enriched with extracellular matrix (ECM). These ECM‐enriched hADSC spheroids cultured on poly‐Z exhibit enhanced differentiation potential, immunomodulatory capacity, and in vivo ...
Changjin Seo, Dohyeon Kim, Junhyuk Song, Sun‐Young Kim, Youngju Son, Afia Tasnim Rahman, Sangyong Jon   +6 more
wiley   +1 more source

Differentiation of human pre-adipocytes into adipocytes.

, 2013
Panel A shows human pre-adipocytes (long, thin and flatted cells without detectable fat organelles). Panel B shows that differentiated fat cells (adipocytes) are spherical with differences in fat organelle size.
Marcel de Vries (354275), Kees Meijer (354274), Han van der Want (354281), Bart-Jan Kroesen (64351), Martijn Dijkstra (354279), Desirée Weening (354278), Roelof Jan van der Leij (354280), Marcel Bruinenberg (354277), Niels Kloosterhuis (191336), Saad Al-Lahham (354276), Roel Vonk (354282), Farhad Rezaee (35414)   +11 more
core   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

MEOX1 Coordinates Autocrine‐Paracrine Programs via SPHK1/S1P to Promote Lymph Node Metastasis in Ovarian Cancer

Advanced Science, EarlyView.
In ovarian cancer, MEOX1 activates the SPHK1/S1P pathway to promote both tumor progression and tumor–stroma crosstalk. MEOX1‐dependent signaling drives CAF activation, enhances VEGF‐C expression, and stimulates lymphangiogenesis, ultimately facilitating lymph node metastasis.
Jiajia Li, Xiuling Zhi, Qianhan Lin, Yating Sun, Yihua Sun, Zulimire Abudousalamu, Mengyang Xue, Chang Zheng, Xiaotian Li, Liangqing Yao, Mo Chen   +10 more
wiley   +1 more source

Evidence of mature adipocyte proliferation regulated by proliferin

, 2010
Despite much research, whether mature adipocytes proliferate remains controversial. Here, we examined 5-bromo-2′-deoxyuridine (BrdU)-labelling of mature adipocytes.
Kazuo Kajita, Hiroyuki Morita, Yuzo Takahashi, Yoshihiro Uno, Tatsuo Ishizuka, Aki Minami, Takahide Ikeda, Hideyuki Okada, Kei Fujioka, Masahiro Yamauchi, Toshiko Kajita, Isao Nagano, Wu Zhiliang, Mitsuru Seishima, Ichiro Mori, Takayuki Hanamoto, Masao Takemura   +16 more
core  

Subcutaneous adipocytes.

, 2016
Representative H&E sections of mouse subcutaneous adipocytes at 40x magnification showing (a) small male adipocytes become greatly engorged with a high fat intake (b).
Peter K. M. Maitz (3342593), David G. Le Couteur (134171), Zhe Li (219258), Samantha M. Solon-Biet (3342596), Aisling C. McMahon (576520), Jonathan Hew (3342599), Kari Ruohonen (113782), J. William O. Ballard (3342590), David Raubenheimer (201534), Yiwei Wang (403386), Caroline Nicholls (3342587), Stephen J. Simpson (145769)   +11 more
core   +1 more source

Multi‐Omics Profiling Reveals Immunomodulatory and Pro‐Regenerative Effects of a Graphene Oxide–Collagen Scaffold in Massive Rotator Cuff Tears

Advanced Science, EarlyView.
A graphene oxide/collagen scaffold is developed for chronic massive rotator cuff tear repair. The scaffold improves compressive stability, supports reparative mesenchymal differentiation, and modulates the immune microenvironment. In chronic MRCT models, it reduces muscle degeneration, enhances tendon–bone regeneration, and improves functional recovery,
Renwen Wan, Yechuan Deng, Zixin Hu, Yanwei He, Xinting Feng, Jun Ma, Yisheng Chen, Zhijie Zhao, Jie Mei, Zhiheng Lin, Wei Luo, Zhengyuan Fang, Zhufeng Hu, Kunlun Feng, Xinrong Li, Dan Wu, Bowen Han, James Hoi po Hui, Xuanyong Liu, Chen Chen, Gang Chen, Shiyi Chen, Nirong Bao, Jiajun Qiu, Zhiwen Luo   +24 more
wiley   +1 more source