Results 101 to 110 of about 237,921 (307)

Characterization of the long pentraxin PTX3 as a TNFα-induced secreted protein of adipose cells

Journal of Lipid Research, 2003
Exposure of preadipocytes to long-chain fatty acids induces the expression of several markers of adipocyte differentiation. In an attempt to identify novel genes and proteins that are regulated by fatty acids in preadipocytes, we performed a substractive
Anissa Abderrahim-Ferkoune, Olivier Bezy, Chiara Chiellini, Margherita Maffei, Paul Grimaldi, Frédéric Bonino, Naïma Moustaid-Moussa, Fabio Pasqualini, Alberto Mantovani, Gérard Ailhaud, Ez-Zoubir Amri   +10 more
doaj   +1 more source

Bone marrow adipocytes facilitate fatty acid oxidation activating AMPK and a transcriptional network supporting survival of acute monocytic leukemia cells

Cancer Research, 2017
Leukemia cells in the bone marrow (BM) must meet the biochemical demands of increased cell proliferation and also survive by continually adapting to fluctuations in nutrient and oxygen availability.
Y. Tabe, Shinichi Yamamoto, Kaori Saitoh, K. Sekihara, Norikazu Monma, K. Ikeo, K. Mogushi, M. Shikami, V. Ruvolo, J. Ishizawa, N. Hail, S. Kazuno, Mamoru Igarashi, H. Matsushita, Y. Yamanaka, H. Arai, I. Nagaoka, T. Miida, Y. Hayashizaki, M. Konopleva, M. Andreeff   +20 more
semanticscholar   +1 more source

Longitudinal Single‐Axon‐Resolution Imaging of Peripheral Nerve Injury Response in Mice Using an Optical Window Implant

Advanced Science, EarlyView.
A minimally invasive optical window enables stable, long‐term imaging of peripheral nerves in vivo at single‐axon resolution. Dynamic processes of degeneration, regeneration, and cellular remodeling are visualized across multiple time scales within the same nerve region, providing a unique platform to study a variety of anatomical and molecular events ...
Igor D. Luzhansky, Emma Anisman, Ron Perez, Sophia Zhang, Morgan Hoffman, Daniel Hunter, Abigail Cherian, Jevon Bonner, Emilia Feria, Ahmed Ahmed, Muneeb Malik, Junwei Du, Leland C. Sudlow, David M. Brogan, Matthew D. Wood, Mikhail Y. Berezin   +15 more
wiley   +1 more source

Dermal white adipose tissue: a new component of the thermogenic response

Journal of Lipid Research, 2015
Recent literature suggests that the layer of adipocytes embedded in the skin below the dermis is far from being an inert spacer material. Instead, this layer of dermal white adipose tissue (dWAT) is a regulated lipid layer that comprises a crucial ...
Caroline M. Alexander, Ildiko Kasza, C-L. Eric Yen, Scott B. Reeder, Diego Hernando, Richard L. Gallo, Colin A.B. Jahoda, Valerie Horsley, Ormond A. MacDougald   +8 more
doaj   +1 more source

Multi‐Omics Profiling of High‐Grade Serous Ovarian Cancer Reveals an Inflammation‐Related Lipid Metabolism Subtype Associated With Platinum Resistance

Advanced Science, EarlyView.
Through integrated proteomic and metabolomic profiling, Zhao et al. identified three molecular subtypes of high‐grade serous ovarian cancer. The high‐risk subtype exhibits activated arachidonic acid metabolism and cyclooxygenase‐2 overexpression. This metabolic axis promotes M2‐like macrophage infiltration, which contributes to platinum resistance ...
Yuxi Zhao, Junyi Li, Bo Zheng, Wanshan Liu, Yaru Wang, Shufeng Wang, Ying Cui, Huiqin Guo, Hongxia Wang, Ting Xiao, Kun Qian, Jing Zuo   +11 more
wiley   +1 more source

Perilipin-2 deletion promotes carbohydrate-mediated browning of white adipose tissue at ambient temperature

Journal of Lipid Research, 2018
Mice lacking perilipin-2 (Plin2-null) are resistant to obesity, insulin resistance, and fatty liver induced by Western or high-fat diets. In the current study, we found that, compared with WT mice on Western diet, Plin2-null adipose tissue was more ...
Andrew E. Libby, Elise S. Bales, Jenifer Monks, David J. Orlicky, James L. McManaman   +4 more
doaj   +1 more source

HMGCR‐Driven Cholesterol Metabolism Promotes Osteoarthritis Progression by Accelerating Synovial Fibroblast Senescence

Advanced Science, EarlyView.
In the pathological context of osteoarthritis (OA), the phosphorylation of AKT1 at Ser473 enhances its binding to Lys140 of Insig1, which facilitates the formation of AKT1–Insig1 complex. Subsequently, the activation of AKT1 promotes the phosphorylation of Insig1 at Ser189, potentially enhancing the dissociation of Insig1 from sterol regulatory element‑
Xiaoqi Zhang, Siru Zhou, Xi Liu, Wei Xiang, Xiuqin Peng, Yu Tian, Song Li, Hailin Wang, Bo Liao, Shunzheng Fang, Runze Jin, Jinhui Wu, Chuanqing Bai, Wei Zhang, Bo Huang, Bingfei Li, Lifeng Chen, Lin Chen, Bin Zhang, Zhenhong Ni   +19 more
wiley   +1 more source

Xenotransplantation of human fetal adipose tissue: a model of in vivo adipose tissue expansion and adipogenesis

Journal of Lipid Research, 2014
Obesity during childhood and beyond may have its origins during fetal or early postnatal life. At present, there are no suitable in vivo experimental models to study factors that modulate or perturb human fetal white adipose tissue (WAT) expansion ...
Briana Garcia, Heather Francois-Vaughan, Omobola Onikoyi, Stefan Kostadinov, Monique E. De Paepe, Philip A. Gruppuso, Jennifer A. Sanders   +6 more
doaj   +1 more source

Periprostatic adipocytes act as a driving force for prostate cancer progression in obesity

Nature Communications, 2016
Obesity favours the occurrence of locally disseminated prostate cancer in the periprostatic adipose tissue (PPAT) surrounding the prostate gland. Here we show that adipocytes from PPAT support the directed migration of prostate cancer cells and that this
Victor Laurent, Adrien Guérard, C. Mazerolles, S. Le Gonidec, A. Toulet, Laurence Nieto, Falek Zaidi, B. Majed, D. Garandeau, Y. Socrier, M. Golzio, T. Cadoudal, Karima Chaoui, C. Dray, B. Monsarrat, O. Schiltz, Y. Wang, B. Couderc, P. Valet, B. Malavaud, C. Muller   +20 more
semanticscholar   +1 more source

QRICH1 Disrupts Endoplasmic Reticulum Homeostasis and Amplifies NF‐κB Signaling in Periodontal Ligament Stem Cells to Exacerbate Diabetic Periodontitis

Advanced Science, EarlyView.
QRICH1 has been established as a key factor contributing to impaired osteogenic potential and accelerated apoptosis of PDLSCs in diabetic periodontitis. QRICH1 not only significantly enhances UPR‐associated apoptotic signaling but also amplifies NF‐κB‐mediated inflammatory responses. Its inhibition restores osteogenic capacity and reduces alveolar bone
Han Li, Xiaoyu Yang, He Wang, Yunchun Kuang, Yiyao Hu, Houxuan Li, Shuhong Li, Deping Zeng, Jie Li, Jinlin Song   +9 more
wiley   +1 more source