Results 1 to 10 of about 151,999 (312)
Leptin and Pro-Inflammatory Stimuli Synergistically Upregulate MMP-1 and MMP-3 Secretion in Human Gingival Fibroblasts. [PDF]
PLoS ONE, 2016 Gingival fibroblast-mediated extracellular matrix remodelling is implicated in the pathogenesis of periodontitis, yet the stimuli that regulate this response are not fully understood.
Rachel C Williams +5 more
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Leptin signaling and leptin resistance
Medical Review, 2022 Abstract With the prevalence of obesity and associated comorbidities, studies aimed at revealing mechanisms that regulate energy homeostasis have gained increasing interest. In 1994, the cloning of leptin was a milestone in metabolic research. As an adipocytokine, leptin governs food intake and energy homeostasis through leptin receptors
Jiarui Liu +3 more
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BMC Genomics, 2021 Background Brown adipose tissue (BAT) is specialized to dissipate energy in the form of heat. BAT-mediated heat production in rodents and humans is critical for effective temperature adaptation of newborns to the extrauterine environment immediately ...
Sujoy Ghosh +10 more
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Leptin-Activity Modulators and Their Potential Pharmaceutical Applications
Biomolecules, 2021 Leptin, a multifunctional hormone primarily, but not exclusively, secreted in adipose tissue, is implicated in a wide range of biological functions that control different processes, such as the regulation of body weight and energy expenditure ...
Marianna Greco +6 more
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Aquaculture Reports, 2022 In mammals, leptin is an endocrine hormone involved in the regulation of feeding and energy metabolism, and glucocorticoids were previously reported to induce leptin gene expression.
Aifen Yan +7 more
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A small genomic region containing several loci required for gastrulation in Drosophila. [PDF]
PLoS ONE, 2009 Genetic screens in Drosophila designed to search for loci involved in gastrulation have identified four regions of the genome that are required zygotically for the formation of the ventral furrow.
Sam J Mathew +2 more
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Annual Review of Physiology, 2000 ▪ Abstract The discovery of the adipose-derived hormone leptin has generated enormous interest in the interaction between peripheral signals and brain targets involved in the regulation of feeding and energy balance. Plasma leptin levels correlate with fat stores and respond to changes in energy balance. It was initially proposed that leptin serves a
R S, Ahima, J S, Flier
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Slik and the receptor tyrosine kinase Breathless mediate localized activation of Moesin in terminal tracheal cells. [PDF]
PLoS ONE, 2014 A key element in the regulation of subcellular branching and tube morphogenesis of the Drosophila tracheal system is the organization of the actin cytoskeleton by the ERM protein Moesin.
Fiona Paul Ukken +3 more
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Human Pathology Reports, 2022 Context: Breast cancer is the most common cancer and the most common cause of death from cancer among women. Leptin is thought to play role in cell proliferation.
Irem Atalay Karacay +5 more
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Concordance of bioactive vs. total immunoreactive serum leptin levels in children with severe early onset obesity. [PDF]
PLoS ONE, 2017 Leptin secreted from adipose tissue signals peripheral energy status to the brain. Monogenic leptin deficiency results in severe early onset obesity with hyperphagia.
Juraj Stanik +8 more
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