Results 1 to 10 of about 186,310 (210)
Leptin and Obesity: Role and Clinical Implication
Frontiers in Endocrinology, 2021 The peptide hormone leptin regulates food intake, body mass, and reproductive function and plays a role in fetal growth, proinflammatory immune responses, angiogenesis and lipolysis. Leptin is a product of the obese (ob) gene and, following synthesis and
Takashi Gojobori +2 more
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Adiponectin, Leptin and Cardiovascular Disorders
Circulation Research, 2021 The landmark discoveries of leptin and adiponectin firmly established adipose tissue as a sophisticated and highly active endocrine organ, opening a new era of investigating adipose-mediated tissue crosstalk.
Christine Kusminski +2 more
exaly +2 more sources
Leptin, Obesity, and Leptin Resistance: Where Are We 25 Years Later?
Nutrients, 2019 Leptin, a hormone that is capable of effectively reducing food intake and body weight, was initially considered for use in the treatment of obesity.
Andrea G Izquierdo +2 more
exaly +2 more sources
Partial Leptin Reduction as an Insulin Sensitization and Weight Loss Strategy
Cell Metabolism, 2019 SUMMARY The physiological role of leptin is thought to be a driving force to reduce food intake and increase energy expenditure. However, leptin therapies in the clinic have failed to effectively treat obesity, predominantly due to a phenomenon referred ...
Angela Odle +2 more
exaly +2 more sources
Journal of Biological Chemistry, 1997 Of the many genetic obesity syndromes, none have been as intensively studied as ob/ob and db/db mice. These two mutant mice were originally identified over 30 years ago (1, 2) and shown to be a result of two distinct single gene mutations residing on ...
L. Tartaglia
semanticscholar +3 more sources
Leptin signaling and leptin resistance
Medical Review, 2022 Abstract With the prevalence of obesity and associated comorbidities, studies aimed at revealing mechanisms that regulate energy homeostasis have gained increasing interest. In 1994, the cloning of leptin was a milestone in metabolic research. As an adipocytokine, leptin governs food intake and energy homeostasis through leptin receptors
Jiarui Liu +3 more
openaire +3 more sources
BMC Genomics, 2021 Background Brown adipose tissue (BAT) is specialized to dissipate energy in the form of heat. BAT-mediated heat production in rodents and humans is critical for effective temperature adaptation of newborns to the extrauterine environment immediately ...
Sujoy Ghosh +10 more
doaj +1 more source
Leptin-Activity Modulators and Their Potential Pharmaceutical Applications
Biomolecules, 2021 Leptin, a multifunctional hormone primarily, but not exclusively, secreted in adipose tissue, is implicated in a wide range of biological functions that control different processes, such as the regulation of body weight and energy expenditure ...
Marianna Greco +6 more
doaj +1 more source
Aquaculture Reports, 2022 In mammals, leptin is an endocrine hormone involved in the regulation of feeding and energy metabolism, and glucocorticoids were previously reported to induce leptin gene expression.
Aifen Yan +7 more
doaj +1 more source
A small genomic region containing several loci required for gastrulation in Drosophila. [PDF]
PLoS ONE, 2009 Genetic screens in Drosophila designed to search for loci involved in gastrulation have identified four regions of the genome that are required zygotically for the formation of the ventral furrow.
Sam J Mathew +2 more
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