Scientific Reports, 2022 Concentrations of the hormone leptin, which is produced by adipose tissue, increase with increasing BMI, whereas leptin sensitivity often declines with higher BMI.
Ki’ara K. R. Branham +4 more
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Differences in zinc status and the leptin axis in anorexic and recovered adolescents and young adults : a pilot study [PDF]
, 2012 Background: Evidence from animal studies suggests that leptin metabolism is associated with zinc (Zn) status. However, research investigating this relationship in adolescents and young adults with anorexia nervosa (AN) is scarce; the present study aims ...
Wöckel, Lars +31 more
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Role of Leptin and metabolism in survival of autoreactive CD4+ T cells [PDF]
, 2009 Recent evidence has shown that leptin, the adipose-tissue derived hormone, can influence T cell homeostasis and survival through the control of genes involved in these processes. Leptin deficient ob/ob mice and humans show reduced circulating number of T
Galgani, Mario
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Obesity and the ageing brain : could leptin play a role in neurodegeneration? [PDF]
, 2011 Obesity and ageing are both characteristics of the human population that are on the increase across the globe. It has long been established that ageing is the major risk factor for neurodegenerative conditions such as Alzheimer’s disease, and it is ...
G. H. Doherty, Doherty, Gayle Helane
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STAT3 phosphorylation in central leptin resistance
Nutrition & Metabolism, 2021 Mechanism exploitation of energy homeostasis is urgently required because of the worldwide prevailing of obesity-related metabolic disorders in human being.
Huimin Liu +3 more
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In vivo and ex vivo regulation of visfatin production by leptin in human and murine adipose tissue : role of mitogen-activated protein kinase and phosphatidylinositol 3-kinase signaling pathways [PDF]
, 2009 Visfatin is an adipogenic adipokine with increased levels in obesity, properties common to leptin. Thus, leptin may modulate visfatin production in adipose tissue (AT).
Brown, James +17 more
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A theory that predicts behaviors of disordered cytoskeletal networks
Molecular Systems Biology, 2017 Morphogenesis in animal tissues is largely driven by actomyosin networks, through tensions generated by an active contractile process. Although the network components and their properties are known, and networks can be reconstituted in vitro, the ...
Julio M Belmonte +2 more
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Aberrant miR-874-3p/leptin/EGFR/c-Myc signaling contributes to nasopharyngeal carcinoma pathogenesis
Journal of Experimental & Clinical Cancer Research, 2022 Background Leptin is important in physiological and pathological functions in various cancers, however, the significance and mechanisms of leptin in nasopharyngeal carcinoma remain ambiguous.
Sheng-Dean Luo +7 more
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The Neuronal Actions of Leptin and the Implications for Treating Alzheimer’s Disease
Pharmaceuticals, 2021 It is widely accepted that the endocrine hormone leptin controls food intake and energy homeostasis via activation of leptin receptors expressed on hypothalamic arcuate neurons.
Kirsty Hamilton, Jenni Harvey
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Leptin fails to blunt the lipopolysaccharide-induced activation of the hypothalamic-pituitary-adrenal axis in rats [PDF]
, 2014 Copyright @ 2013 The authors. This work is licensed under a Creative Commons Attribution 3.0 Unported License.Obesity is a risk factor for sepsis morbidity and mortality, whereas the hypothalamic-pituitary-adrenal (HPA) axis plays a protective role in ...
Bloom, SR +5 more
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