Scientific Reports, 2022 Concentrations of the hormone leptin, which is produced by adipose tissue, increase with increasing BMI, whereas leptin sensitivity often declines with higher BMI.
Ki’ara K. R. Branham +4 more
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Clinical Endocrinology, 2002 Leptin is a 167 amino acid hormonal protein product of the obesity gene that has been widely studied since its discovery by Zang et al . (1994). Initially described as being involved with satiety and energy balance, leptin was proposed to be the anti-obesity factor involved in a feedback loop from the adipocyte to the hypothalamus (Zang et al ., 1994).
Tom, Whipple +3 more
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In vivo and ex vivo regulation of visfatin production by leptin in human and murine adipose tissue : role of mitogen-activated protein kinase and phosphatidylinositol 3-kinase signaling pathways [PDF]
, 2009 Visfatin is an adipogenic adipokine with increased levels in obesity, properties common to leptin. Thus, leptin may modulate visfatin production in adipose tissue (AT).
Brown, James +17 more
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Leptin fails to blunt the lipopolysaccharide-induced activation of the hypothalamic-pituitary-adrenal axis in rats [PDF]
, 2014 Copyright @ 2013 The authors. This work is licensed under a Creative Commons Attribution 3.0 Unported License.Obesity is a risk factor for sepsis morbidity and mortality, whereas the hypothalamic-pituitary-adrenal (HPA) axis plays a protective role in ...
Bloom, SR +5 more
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STAT3 phosphorylation in central leptin resistance
Nutrition & Metabolism, 2021 Mechanism exploitation of energy homeostasis is urgently required because of the worldwide prevailing of obesity-related metabolic disorders in human being.
Huimin Liu +3 more
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Differences in zinc status and the leptin axis in anorexic and recovered adolescents and young adults : a pilot study [PDF]
, 2012 Background: Evidence from animal studies suggests that leptin metabolism is associated with zinc (Zn) status. However, research investigating this relationship in adolescents and young adults with anorexia nervosa (AN) is scarce; the present study aims ...
Wöckel, Lars +31 more
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Leptin resensitisation: a reversion of leptin-resistant states [PDF]
Journal of Endocrinology, 2019 Leptin resistance refers to states in which leptin fails to promote its anticipated effects, frequently coexisting with hyperleptinaemia. Leptin resistance is closely associated with obesity and also observed in physiological situations such as pregnancy and in seasonal animals.
Andreoli, Maria Florencia +3 more
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Obesity and the ageing brain : could leptin play a role in neurodegeneration? [PDF]
, 2011 Obesity and ageing are both characteristics of the human population that are on the increase across the globe. It has long been established that ageing is the major risk factor for neurodegenerative conditions such as Alzheimer’s disease, and it is ...
G. H. Doherty, Doherty, Gayle Helane
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The Neuronal Actions of Leptin and the Implications for Treating Alzheimer’s Disease
Pharmaceuticals, 2021 It is widely accepted that the endocrine hormone leptin controls food intake and energy homeostasis via activation of leptin receptors expressed on hypothalamic arcuate neurons.
Kirsty Hamilton, Jenni Harvey
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A theory that predicts behaviors of disordered cytoskeletal networks
Molecular Systems Biology, 2017 Morphogenesis in animal tissues is largely driven by actomyosin networks, through tensions generated by an active contractile process. Although the network components and their properties are known, and networks can be reconstituted in vitro, the ...
Julio M Belmonte +2 more
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