Results 21 to 30 of about 186,310 (210)
Glucose enhances leptin signaling through modulation of AMPK activity. [PDF]
PLoS ONE, 2012 Leptin exerts its action by binding to and activating the long form of leptin receptors (LEPRb). LEPRb activates JAK2 that subsequently phosphorylates and activates STAT3.
Haoran Su +3 more
doaj +1 more source
Molecular Metabolism, 2014 Objective: Leptin responsive neurons play an important role in energy homeostasis, controlling specific autonomic, behavioral, and neuroendocrine functions.
Kavon Rezai-Zadeh +8 more
doaj +1 more source
Leptin and leptin receptor expression in asthma [PDF]
Journal of Allergy and Clinical Immunology, 2009 The adipokine leptin is a potential new mediator for bronchial epithelial homeostasis. Asthma is a chronic inflammatory disease characterized by airway remodeling that might affect disease chronicity and severity. TGF-beta is a tissue growth factor the dysregulation of which is associated with airway remodeling.We sought to determine whether a ...
Andreina, Bruno +9 more
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Leptin in Leanness and Obesity
Journal of the American College of Cardiology, 2021 Leptin has emerged over the past 2 decades as a key hormone secreted by adipose tissue that conveys information on energy stores. Leptin is considered an important regulator of both neuroendocrine function and energy homeostasis. Numerous studies (mainly
Nikolaos Perakakis +2 more
semanticscholar +1 more source
Curcumin interrupts leptin-regulated microRNA-122 in hepatic stellate cells in vitro and in vivo
Pakistan Journal of Pharmaceutical Sciences, 2023 The purpose of this study was to evaluate the effect of curcumin, an active polyphenol, on the leptin induced lowering of miR-122 in Hepatic stellate cells (HSCs) in vivo and an animal model. Gene expression was evaluated by transfection assay, real-time
Huang Limin, Xu Feifan
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Annals of Medicine, 2021 Background Leptin in breast milk play a significant role in metabolic programming.Objective The aim of this study to evaluate the relationship between leptin levels in maternal serum and breast milk, and certain anthropometric measurements of infants and
Feray Çağiran Yilmaz +1 more
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Identification and expression cloning of a leptin receptor, OB-R.
Cell, 1995 The ob gene product, leptin, is an important circulating signal for the regulation of body weight. To identify high affinity leptin-binding sites, we generated a series of leptin-alkaline phosphatase (AP) fusion proteins as well as [125I]leptin.
L. Tartaglia +18 more
semanticscholar +1 more source
Scientific Reports, 2022 Concentrations of the hormone leptin, which is produced by adipose tissue, increase with increasing BMI, whereas leptin sensitivity often declines with higher BMI.
Ki’ara K. R. Branham +4 more
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The Role of the Adipokine Leptin in Immune Cell Function in Health and Disease
Frontiers in Immunology, 2021 Leptin is a critical mediator of the immune response to changes in overall nutrition. Leptin is produced by adipocytes in proportion to adipose tissue mass and is therefore increased in obesity. Despite having a well-described role in regulating systemic
K. Kiernan, Nancie J. MacIver
semanticscholar +1 more source
Clinical Endocrinology, 2002 Leptin is a 167 amino acid hormonal protein product of the obesity gene that has been widely studied since its discovery by Zang et al . (1994). Initially described as being involved with satiety and energy balance, leptin was proposed to be the anti-obesity factor involved in a feedback loop from the adipocyte to the hypothalamus (Zang et al ., 1994).
Tom, Whipple +3 more
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