Results 1 to 10 of about 1,272,125 (151)
Leptin, soluble leptin receptor, and free leptin index in patients with metabolic syndrome [PDF]
Ожирение и метаболизм, 2017 Aim. To assess the levels of leptin, its soluble receptor, and index of the formation of free leptin in metabolic syndrome (MS). Materials and methods. The study included 110 individuals with obesity and overweight.
Elena N. Smirnova, Sofia G. Shulkina
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Mutations in the Human Leptin and Leptin Receptor Genes as Models of Serum Leptin Receptor Regulation [PDF]
Diabetes, 2002 A part of serum Ob leptin, an adipocyte-secreted peptide, is bound to a soluble Ob receptor (sObR). Immunoreactive sObR was measured in 125 lean or obese control subjects (group 1), 18 individuals with a mutation in the leptin gene impairing leptin secretion (group 2), and 10 individuals with a mutation in the ObR gene, leading to production of a ...
Najiba, Lahlou +6 more
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The Effects of Laparoscopic Sleeve Gastrectomy on the Parameters of Leptin Resistance in Obesity
Biomolecules, 2019 Obesity is a growing public health problem worldwide. Bariatric surgical procedures achieve the most sustainable and efficacious outcomes in the treatment of morbid obesity.
Tagleb S. Mazahreh +7 more
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Structural insights into the mechanism of leptin receptor activation
Nature Communications, 2023 Leptin is an adipocyte-derived protein hormone that promotes satiety and energy homeostasis by activating the leptin receptor (LepR)–STAT3 signaling axis in a subset of hypothalamic neurons.
Robert A. Saxton +7 more
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Role of leptin and leptin receptor in inflammation
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 2003 on october 30th, 2002, the World Health Report by the World Health Organization was launched subtitled Reducing risks, promoting healthy life . Many of the health risks discussed in this report concern food consumption—either too little, in the case of the poor, or too much, in the case of ...
Halle, Martin, Persson, P. B.
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On the Molecular Evolution of Leptin, Leptin Receptor, and Endospanin [PDF]
Frontiers in Endocrinology, 2017 Over a decade passed between Friedman's discovery of the mammalian leptin gene (1) and its cloning in fish (2) and amphibians (3). Since 2005, the concept of gene synteny conservation (vs. gene sequence homology) was instrumental in identifying leptin genes in dozens of species, and we now have leptin genes from all major classes of vertebrates.
Londraville, Richard Lyle +4 more
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Monitoring the Expression of Leptin Receptor in Avian Model
Scientific Papers Animal Science and Biotechnologies, 2023 In this study we carried the expression of leptin receptor in organs and abdominal fat of broiler chickens. The leptin receptor is a member of the class I cytokine receptor family, also known as the gpl30 receptor family, although unlike many other ...
Ľubica Mrázová +2 more
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Discovery of the elusive leptin in birds: identification of several 'missing links' in the evolution of leptin and its receptor. [PDF]
PLoS ONE, 2014 Leptin is a pleiotropic protein best known for regulation of appetite and fat storage in mammals. While many leptin orthologs have been identified among vertebrates, an authentic leptin in birds has remained elusive and controversial.
Jeremy W Prokop +10 more
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Psychiatry and Behavioral Sciences, 2023 Objective: Data on effects of vitamins, hormones and neurotrophic factors on the etiology of attention deficit hyperactivity disorder (ADHD) and major depressive disorder (MDD) in children is limited.
Dilsad Yildiz Miniksar +1 more
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Leptin secretion and leptin receptor in the human stomach [PDF]
Gut, 2000 BACKGROUND AND AIM The circulating peptide leptin produced by fat cells acts on central receptors to control food intake and body weight homeostasis. Contrary to initial reports, leptin expression has also been detected in the human placenta, muscles, and recently, in rat gastric chief cells. Here we investigate
I, Sobhani +10 more
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