Results 1 to 10 of about 53,696 (166)
Biomolecules, 2023 Craniopharyngioma (CP) is a benign tumor with a high rate of obesity and frequent recurrence. Moreover, the role of leptin/leptin receptors axis in obesity and the prognosis of CP is still unknown.
Youchao Xiao +9 more
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Leptin Prevents Lipopolysaccharide-Induced Depressive-Like Behaviors in Mice: Involvement of Dopamine Receptors [PDF]
Frontiers in Psychiatry, 2019 Depression is a chronic and recurrent disorder, associated with high morbidity and risk of suicide. Leptin was firstly described as an anti-obesity hormone, but several actions of leptin in CNS have been reported.
Rafaela Carneiro Cordeiro +10 more
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Leptin resistance: underlying mechanisms and diagnosis
Diabetes, Metabolic Syndrome and Obesity, 2019 Olga Gruzdeva,1,2 Daria Borodkina,3 Evgenya Uchasova,1 Yulia Dyleva,1 Olga Barbarash1,2 1Federal State Budgetary Institution, Research Institute for Complex Issues of Cardiovascular Diseases, Kemerovo, Russian Federation; 2Federal State Budget ...
Gruzdeva O +4 more
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Impact of the Central Histaminergic and Melanocortin Systems on Leptin-Induced Hypophagia in Neonatal Layer Chicken [PDF]
Archives of Razi Institute, 2021 The present study aimed to assess the probable impact of the central histaminergic and melanocortin systems on leptin-induced hypophagia in neonatal layer chickens.
M Shalikar +3 more
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Food for Thought: Leptin and Hippocampal Synaptic Function
Frontiers in Pharmacology, 2022 It is well documented that the endocrine hormone, leptin controls energy homeostasis by providing key signals to specific hypothalamic nuclei. However, our knowledge of leptin’s central actions has advanced considerably over the last 20 years, with the ...
Jenni Harvey
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Combination of Silibinin and Curcumin Reduced Leptin Receptor Expression in MCF-7 Human Breast Cancer Cell Line [PDF]
Iranian Journal of Medical Sciences, 2020 Background: Leptin and leptin receptor (Ob-R) are associated with worse prognosis, distant metastasis, and poor survival of breast cancer. We investigated the cytotoxic effect of silibinin and curcumin, individually and combined, on Ob-R expression in ...
Somaye Dalimi-Asl +2 more
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Estradiol and Estrogen Receptor Agonists Oppose Oncogenic Actions of Leptin in HepG2 Cells. [PDF]
PLoS ONE, 2016 Obesity is a significant risk factor for certain cancers, including hepatocellular carcinoma (HCC). Leptin, a hormone secreted by white adipose tissue, precipitates HCC development. Epidemiology data show that men have a much higher incidence of HCC than
Minqian Shen, Haifei Shi
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Cancer Medicine, 2020 Background Prostate cancer (PCa) is one of the most frequently diagnosed cancers worldwide. Despite the growing evidence associating obesity and adipokines, particularly leptin and its receptors, with cancer development and progression, it is still a ...
Hala Fawzy Mohamed Kamel +2 more
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Leptin suppresses development of GLP-1 inputs to the paraventricular nucleus of the hypothalamus
eLife, 2020 The nucleus of the solitary tract (NTS) is critical for the central integration of signals from visceral organs and contains preproglucagon (PPG) neurons, which express leptin receptors in the mouse and send direct projections to the paraventricular ...
Jessica E Biddinger +3 more
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Leptin mediates the increase in blood pressure associated with obesity [PDF]
, 2014 Obesity is associated with increased blood pressure (BP), which in turn increases the risk of cardiovascular diseases. We found that the increase in leptin levels seen in diet-induced obesity (DIO) drives an increase in BP in rodents, an effect that was ...
Cowley, Michael A. +41 more
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