Results 11 to 20 of about 53,904 (214)

Leptin resistance: underlying mechanisms and diagnosis [PDF]

Diabetes, Metabolic Syndrome and Obesity, 2019
Olga Gruzdeva,1,2 Daria Borodkina,3 Evgenya Uchasova,1 Yulia Dyleva,1 Olga Barbarash1,2 1Federal State Budgetary Institution, Research Institute for Complex Issues of Cardiovascular Diseases, Kemerovo, Russian Federation; 2Federal State Budget ...
Gruzdeva O, Borodkina D, Uchasova E, Dyleva Y, Barbarash O   +4 more
doaj   +1 more source

Leptin mediates the increase in blood pressure associated with obesity [PDF]

, 2014
Obesity is associated with increased blood pressure (BP), which in turn increases the risk of cardiovascular diseases. We found that the increase in leptin levels seen in diet-induced obesity (DIO) drives an increase in BP in rodents, an effect that was ...
Cowley, Michael A., Ravussin, E., Cowley, M., Elmquist, Joel K., Myers, M., Enriori, P., Spanswick, D., O’Rahilly, S. (Stephen), Myers, Martin G., Henning, Elana, Licinio, Julio, Simonds, Stephanie E., Greenway, Frank L., Simonds, S., Farooqi, I., Brown, Russell D., Allen, A., Brown, R., Spanswick, David C., Dileone, R., Farooqi, I. Sadaf, Allen, Andrew M., Elmquist, J., Bassi, J., O’Rahilly, Stephen, Keogh, Julia M., Keogh, J., Sternson, S., Myer, Martin G., Greenway, F., Licinio, J., Enriori, Pablo J., Pryor, J., Pryor, Jack T., Dileone, Ralph, Grove, Kevin L., O’Rahilly, S., Henning, E., Ravussin, Eric, Bassi, Jaspreet, Sternson, Scott M., Grove, K.   +41 more
core   +1 more source

Leptin and Pro-Inflammatory Stimuli Synergistically Upregulate MMP-1 and MMP-3 Secretion in Human Gingival Fibroblasts [PDF]

, 2016
Introduction Gingival fibroblast-mediated extracellular matrix remodelling is implicated in the pathogenesis of periodontitis, yet the stimuli that regulate this response are not fully understood. The immunoregulatory adipokine leptin is detectable in
Andrew J Skelton, Todryk, Stephen M., Rowan, Andrew, Skelton, Andrew J., Skelton, Andrew J, Williams, Rachel C., Preshaw, Philip M.; id_orcid, Preshaw, Philip M, Taylor, John, Rowan, Andrew D., Skelton, Andrew, Preshaw, Philip, Taylor, John J, Taylor, John J., Todryk, Stephen, Philip M Preshaw, Todryk, Stephen M, Rachel C Williams, Stephen M Todryk, Williams, Rachel C, Andrew D Rowan, Rowan, Andrew D, John J Taylor   +22 more
core   +1 more source

Human mast cells express leptin and leptin receptors. [PDF]

, 2009
Mast cells are immune cells that produce and secrete a variety of mediators and cytokines that influence various inflammatory and immune processes. Leptin is a cytokine regulating metabolic, endocrine as well as immune functions via the leptin receptor ...
Waelput, Wim, Braet, Katleen, Cuvelier, Claude A, Bachert, Claus, Rottiers, Isabelle, Pérez-Novo, Claudina A, Waeytens, Anouk, Perez-Novo, Claudina A., Taildeman, Jasmien, Ferdinande, Liesbeth, Demetter, Pieter, De Colvenaer, Veerle, Perez Novo, Claudina, Cuvelier, Claude A., Cuvelier, Claude   +14 more
core   +3 more sources

Mutations in the Human Leptin and Leptin Receptor Genes as Models of Serum Leptin Receptor Regulation [PDF]

Diabetes, 2002
A part of serum Ob leptin, an adipocyte-secreted peptide, is bound to a soluble Ob receptor (sObR). Immunoreactive sObR was measured in 125 lean or obese control subjects (group 1), 18 individuals with a mutation in the leptin gene impairing leptin secretion (group 2), and 10 individuals with a mutation in the ObR gene, leading to production of a ...
Najiba, Lahlou, Tarik, Issad, Yves, Lebouc, Jean-Claude, Carel, Luc, Camoin, Marc, Roger, Jean, Girard   +6 more
openaire   +2 more sources

In vivo and ex vivo regulation of visfatin production by leptin in human and murine adipose tissue : role of mitogen-activated protein kinase and phosphatidylinositol 3-kinase signaling pathways [PDF]

, 2009
Visfatin is an adipogenic adipokine with increased levels in obesity, properties common to leptin. Thus, leptin may modulate visfatin production in adipose tissue (AT).
Brown, James, Clifford J. Bailey, Jing Chen, Bee K. Tan, Tan, Bee K., Bailey, C. J. (Clifford J.), Adya, Raghu, Randeva, Harpal S., Vinod Menon, James Brown, Hendrik Lehnert, Menon, Vinod, Raghu Adya, Manjunath Ramanjaneya, Harpal S. Randeva, Ramanjaneya, Manjunath, Chen, Jing, Lehnert, Hendrik   +17 more
core   +1 more source

PATHOGENETIC MECHANISMS OF LEPTIN RESISTANCE

Российский кардиологический журнал, 2015
Leptin is a regulatory protein from adipokines family, that maintain energy homeostasis of the body and deter obesity development. Impaired transfer of leptin signals to hypothalamus leads to leptin resistance and its adverse complications. Understanding
G. A. Chumakova, A. V. Ott, N. G. Veselovskaya, O. V. Gritsenko, N. N. Shenkova   +4 more
doaj   +1 more source

Gender dimorphism in skeletal muscle leptin receptors, serum leptin and insulin sensitivity. [PDF]

PLoS ONE, 2008
To determine if there is a gender dimorphism in the expression of leptin receptors (OB-R170, OB-R128 and OB-R98) and the protein suppressor of cytokine signaling 3 (SOCS3) in human skeletal muscle, the protein expression of OB-R, perilipin A, SOCS3 and ...
Borja Guerra, Teresa Fuentes, Safira Delgado-Guerra, Amelia Guadalupe-Grau, Hugo Olmedillas, Alfredo Santana, Jesus Gustavo Ponce-Gonzalez, Cecilia Dorado, José A L Calbet   +8 more
doaj   +1 more source

Identification of a non-mammalian leptin-like gene:characterization and expression in the tiger salamander (Ambystoma tigrinum) [PDF]

, 2006
Leptin is well established as a multifunctional cytokine in mammals. However, little is known about the evolution of the leptin gene in other vertebrates. A recently published set of ESTs from the tiger salamander (Ambystoma tigrinum) contains a sequence
Joseph, N, Joseph, Nerine, Sharp, PJ, Boswell, T, Sharp, Peter J, Burt, DW, Boswell, Timothy, Dunn, Ian C, Wilson, Peter W, Wilson, PW, Burt, David W, Dunn, IC   +11 more
core   +1 more source

Leptin regulates gonadotropins and steroid receptors in the rats ovary

Nutrición Hospitalaria, 2013
The leptin hormone is important to satiety and an important link between the nutritional status and reproductive processes. Owing to the contradictory effects of leptin on the ovary and the failure to clarify the precise mechanism by which leptin affects
Fernanda Silveira Cavalcante, Verónica Aiceles, Cristiane da Fonte Ramos   +2 more
doaj   +1 more source