Results 21 to 30 of about 53,696 (166)

Absence of functional leptin receptor isoforms in the POUND (Lepr(db/lb)) mouse is associated with muscle atrophy and altered myoblast proliferation and differentiation. [PDF]

PLoS ONE, 2013
Leptin receptors are abundant in human skeletal muscle, but the role of leptin in muscle growth, development and aging is not well understood. Here we utilized a novel mouse model lacking all functional leptin receptor isoforms (POUND mouse, Lepr(db/lb))
Phonepasong Arounleut, Matthew Bowser, Sunil Upadhyay, Xing-Ming Shi, Sadanand Fulzele, Maribeth H Johnson, Alexis M Stranahan, William D Hill, Carlos M Isales, Mark W Hamrick   +9 more
doaj   +1 more source

Leptin Suppresses Glutamate-Induced Apoptosis Through Regulation of ERK1/2 Signaling Pathways in Rat Primary Astrocytes

Cellular Physiology and Biochemistry, 2017
Background/Aims: Leptin is a hormone expressed by adipose tissue that regulates body energy homeostasis and weight loss by activating leptin receptors in the hypothalamus. Leptin receptors are also expressed in astrocytes.
Hyunju Park, So-Hee Ahn, Yieun Jung, Joo Chun Yoon, Youn-Hee Choi   +4 more
doaj   +1 more source

The Effects of Leptin on Glial Cells in Neurological Diseases

Frontiers in Neuroscience, 2019
It is known that various endocrine modulators, including leptin and ghrelin, have neuroprotective roles in neurological diseases. Leptin is a hormone produced by adipocytes and was originally identified as a gene related to obesity in mice.
Yuki Fujita, Yuki Fujita, Toshihide Yamashita, Toshihide Yamashita, Toshihide Yamashita, Toshihide Yamashita   +5 more
doaj   +1 more source

CB1 cannabinoid receptor in SF1-expressing neurons of the ventromedial hypothalamus determines metabolic responses to diet and leptin

Molecular Metabolism, 2014
Metabolic flexibility allows rapid adaptation to dietary change, however, little is known about the CNS mechanisms regulating this process. Neurons in the hypothalamic ventromedial nucleus (VMN) participate in energy balance and are the target of the ...
Pierre Cardinal, Caroline André, Carmelo Quarta, Luigi Bellocchio, Samantha Clark, Melissa Elie, Thierry Leste-Lasserre, Marlene Maitre, Delphine Gonzales, Astrid Cannich, Uberto Pagotto, Giovanni Marsicano, Daniela Cota   +12 more
doaj   +1 more source

Adipokine Leptin Co-operates With Mechanosensitive Ca2 +-Channels and Triggers Actomyosin-Mediated Motility of Breast Epithelial Cells

Frontiers in Cell and Developmental Biology, 2021
In postmenopausal women, a major risk factor for the development of breast cancer is obesity. In particular, the adipose tissue-derived adipokine leptin has been strongly linked to tumor cell proliferation, migration, and metastasis, but the underlying ...
Anna Acheva, Tytti Kärki, Niccole Schaible, Ramaswamy Krishnan, Sari Tojkander   +4 more
doaj   +1 more source

Assessment of leptin and resistin levels in non-obese multiple myeloma patients and their relation with Ig level and disease stage

Journal of the Egyptian National Cancer Institute, 2014
Introduction: Multiple myeloma (MM) accounts for approximately 0.8% of all cancer diagnoses and 0.9% of cancer deaths. Leptin receptors were expressed on CD34+ cells.
Noha E. Esheba, Abeer Shahba, Ola El Shora   +2 more
doaj   +1 more source

Leptin and Pro-Inflammatory Stimuli Synergistically Upregulate MMP-1 and MMP-3 Secretion in Human Gingival Fibroblasts

, 2016
Introduction Gingival fibroblast-mediated extracellular matrix remodelling is implicated in the pathogenesis of periodontitis, yet the stimuli that regulate this response are not fully understood. The immunoregulatory adipokine leptin is detectable in
Andrew J Skelton, Todryk, Stephen M., Rowan, Andrew, Skelton, Andrew J., Skelton, Andrew J, Williams, Rachel C., Preshaw, Philip M.; id_orcid, Preshaw, Philip M, Taylor, John, Rowan, Andrew D., Skelton, Andrew, Preshaw, Philip, Taylor, John J, Taylor, John J., Todryk, Stephen, Philip M Preshaw, Todryk, Stephen M, Rachel C Williams, Stephen M Todryk, Williams, Rachel C, Andrew D Rowan, Rowan, Andrew D, John J Taylor   +22 more
core   +1 more source

Human mast cells express leptin and leptin receptors.

, 2009
Mast cells are immune cells that produce and secrete a variety of mediators and cytokines that influence various inflammatory and immune processes. Leptin is a cytokine regulating metabolic, endocrine as well as immune functions via the leptin receptor ...
Waelput, Wim, Braet, Katleen, Cuvelier, Claude A, Bachert, Claus, Rottiers, Isabelle, Pérez-Novo, Claudina A, Waeytens, Anouk, Perez-Novo, Claudina A., Taildeman, Jasmien, Ferdinande, Liesbeth, Demetter, Pieter, De Colvenaer, Veerle, Perez Novo, Claudina, Cuvelier, Claude A., Cuvelier, Claude   +14 more
core   +2 more sources

CORRELATION OF LEPTIN AND ADIPONECTIN RECEPTOR EXPRESSION WITH CLINICOPATHOLOGICAL PARAMETERS IN COLORECTAL CARCINOMA - A CROSS-SECTIONAL PROSPECTIVE STUDY [PDF]

Arquivos de Gastroenterologia
Background: Colorectal carcinoma (CRC) is one of the common carcinomas with a rising incidence of metastasis due to its advanced stage of presentation.
Priyanka PARMESH, Udupi Shastri DINESH, Ajay S KHANDAGALE, Anil Bargale BAPU, Roshni SADASHIV, Pradnya REDDY   +5 more
doaj   +1 more source

The role of melanocortins and cytokines in human adipose tissue and adipocytes [PDF]

, 2007
During the last decades obesity has become a major health problem in developed countries, and more recently also in the developing countries it is seriously affecting parts of the populations.
Hoch, Matthias
core   +1 more source