Results 21 to 30 of about 632,116 (307)

On the Molecular Evolution of Leptin, Leptin Receptor, and Endospanin [PDF]

Frontiers in Endocrinology, 2017
Over a decade passed between Friedman's discovery of the mammalian leptin gene (1) and its cloning in fish (2) and amphibians (3). Since 2005, the concept of gene synteny conservation (vs. gene sequence homology) was instrumental in identifying leptin genes in dozens of species, and we now have leptin genes from all major classes of vertebrates.
Londraville, Richard Lyle, Prokop, Jeremy W., Duff, Robert Joel, Liu, Qin, Tuttle, Matthew   +4 more
openaire   +2 more sources

Identification of a non-mammalian leptin-like gene:characterization and expression in the tiger salamander (Ambystoma tigrinum) [PDF]

, 2006
Leptin is well established as a multifunctional cytokine in mammals. However, little is known about the evolution of the leptin gene in other vertebrates. A recently published set of ESTs from the tiger salamander (Ambystoma tigrinum) contains a sequence
Joseph, N, Joseph, Nerine, Sharp, PJ, Boswell, T, Sharp, Peter J, Burt, DW, Boswell, Timothy, Dunn, Ian C, Wilson, Peter W, Wilson, PW, Burt, David W, Dunn, IC   +11 more
core   +1 more source

Leptin Elicits LTC4 Synthesis by Eosinophils Mediated by Sequential Two-Step Autocrine Activation of CCR3 and PGD2 Receptors

Frontiers in Immunology, 2018
Leptin is a cytokine, produced mainly by mature adipocytes, that regulates the central nervous system, mainly to suppress appetite and stimulate energy expenditure.
Natália R. T. Amorim, Tatiana Luna-Gomes, Tatiana Luna-Gomes, Marcos Gama-Almeida, Glaucia Souza-Almeida, Claudio Canetti, Bruno L. Diaz, Peter F. Weller, Patricia Torres Bozza, Clarissa M. Maya-Monteiro, Christianne Bandeira-Melo   +10 more
doaj   +1 more source

Absence of functional leptin receptor isoforms in the POUND (Lepr(db/lb)) mouse is associated with muscle atrophy and altered myoblast proliferation and differentiation. [PDF]

PLoS ONE, 2013
Leptin receptors are abundant in human skeletal muscle, but the role of leptin in muscle growth, development and aging is not well understood. Here we utilized a novel mouse model lacking all functional leptin receptor isoforms (POUND mouse, Lepr(db/lb))
Phonepasong Arounleut, Matthew Bowser, Sunil Upadhyay, Xing-Ming Shi, Sadanand Fulzele, Maribeth H Johnson, Alexis M Stranahan, William D Hill, Carlos M Isales, Mark W Hamrick   +9 more
doaj   +1 more source

Relationship Between Circulating Metabolic Hormones and Their Central Receptors During Ovariectomy-Induced Weight Gain in Rats

Frontiers in Physiology, 2022
Although increasing research focuses on the phenomenon of body weight gain in women after menopause, the complexity of body weight regulation and the array of models used to investigate it has proven to be challenging.
Kaitlin E. Burch, Kelly McCracken, Daniel J. Buck, Randall L. Davis, Dusti K. Sloan, Kathleen S. Curtis   +5 more
doaj   +1 more source

Leptin secretion and leptin receptor in the human stomach [PDF]

Gut, 2000
BACKGROUND AND AIM The circulating peptide leptin produced by fat cells acts on central receptors to control food intake and body weight homeostasis. Contrary to initial reports, leptin expression has also been detected in the human placenta, muscles, and recently, in rat gastric chief cells. Here we investigate
I, Sobhani, A, Bado, C, Vissuzaine, M, Buyse, S, Kermorgant, J P, Laigneau, S, Attoub, T, Lehy, D, Henin, M, Mignon, M J, Lewin   +10 more
openaire   +2 more sources

Leptin and Leptin Receptor Expression in the Rat Ovary [PDF]

Endocrinology, 2003
Leptin is an important satiety hormone and reproductive regulator and is found, along with its receptors, throughout the ovary. To date, the changes in ovarian expression of both of these proteins throughout the estrous cycle has not been studied, and the examination of protein expression has not distinguished between different forms of the receptor ...
Ryan, N., Van Der Hoek, K., Robertson, S., Norman, R.   +3 more
openaire   +3 more sources

Phocid seal leptin: tertiary structure and hydrophobic receptor binding site preservation during distinct leptin gene evolution [PDF]

, 2012
The cytokine hormone leptin is a key signalling molecule in many pathways that control physiological functions. Although leptin demonstrates structural conservation in mammals, there is evidence of positive selection in primates, lagomorphs and ...
John A. Hammond (170370), Hall, Ailsa Jane, Chris Hauton, Hammond John A., Hammond, John Anthony, Hammond, John A., Ailsa J. Hall (29488), Hall Ailsa J., John A Hammond, Hauton Chris, Bennett, Kimberley A., Hall, Ailsa J., Ailsa J Hall, Kimberley A Bennett, Chris Hauton (170376), Bennett Kimberley A., Hauton, Chris, Kimberley A. Bennett (170381)   +17 more
core   +2 more sources

Leptin fails to blunt the lipopolysaccharide-induced activation of the hypothalamic-pituitary-adrenal axis in rats [PDF]

, 2014
Copyright @ 2013 The authors. This work is licensed under a Creative Commons Attribution 3.0 Unported License.Obesity is a risk factor for sepsis morbidity and mortality, whereas the hypothalamic-pituitary-adrenal (HPA) axis plays a protective role in ...
Bloom, SR, Basharat, S, Parker, JA, Murphy, KG, John, CD, Buckingham, JC   +5 more
core   +1 more source

Leptin Suppresses Glutamate-Induced Apoptosis Through Regulation of ERK1/2 Signaling Pathways in Rat Primary Astrocytes

Cellular Physiology and Biochemistry, 2017
Background/Aims: Leptin is a hormone expressed by adipose tissue that regulates body energy homeostasis and weight loss by activating leptin receptors in the hypothalamus. Leptin receptors are also expressed in astrocytes.
Hyunju Park, So-Hee Ahn, Yieun Jung, Joo Chun Yoon, Youn-Hee Choi   +4 more
doaj   +1 more source