Results 31 to 40 of about 53,904 (214)

On the Molecular Evolution of Leptin, Leptin Receptor, and Endospanin [PDF]

Frontiers in Endocrinology, 2017
Over a decade passed between Friedman's discovery of the mammalian leptin gene (1) and its cloning in fish (2) and amphibians (3). Since 2005, the concept of gene synteny conservation (vs. gene sequence homology) was instrumental in identifying leptin genes in dozens of species, and we now have leptin genes from all major classes of vertebrates.
Londraville, Richard Lyle, Prokop, Jeremy W., Duff, Robert Joel, Liu, Qin, Tuttle, Matthew   +4 more
openaire   +2 more sources

Kinetics of Leptin Binding to the Q223R Leptin Receptor

PLoS ONE, 2014
Studies in human populations and mouse models of disease have linked the common leptin receptor Q223R mutation to obesity, multiple forms of cancer, adverse drug reactions, and susceptibility to enteric and respiratory infections. Contradictory results cast doubt on the phenotypic consequences of this variant.
Verkerke, Hans, Naylor, Caitlin, Zabeau, Lennart, Tavernier, Jan, Petri, William A, Jr, Marie, Chelsea   +5 more
openaire   +4 more sources

Leptin and Leptin Receptor Expression in the Rat Ovary [PDF]

Endocrinology, 2003
Leptin is an important satiety hormone and reproductive regulator and is found, along with its receptors, throughout the ovary. To date, the changes in ovarian expression of both of these proteins throughout the estrous cycle has not been studied, and the examination of protein expression has not distinguished between different forms of the receptor ...
Ryan, N., Van Der Hoek, K., Robertson, S., Norman, R.   +3 more
openaire   +3 more sources

The Effects of Leptin on Glial Cells in Neurological Diseases

Frontiers in Neuroscience, 2019
It is known that various endocrine modulators, including leptin and ghrelin, have neuroprotective roles in neurological diseases. Leptin is a hormone produced by adipocytes and was originally identified as a gene related to obesity in mice.
Yuki Fujita, Yuki Fujita, Toshihide Yamashita, Toshihide Yamashita, Toshihide Yamashita, Toshihide Yamashita   +5 more
doaj   +1 more source

CB1 cannabinoid receptor in SF1-expressing neurons of the ventromedial hypothalamus determines metabolic responses to diet and leptin

Molecular Metabolism, 2014
Metabolic flexibility allows rapid adaptation to dietary change, however, little is known about the CNS mechanisms regulating this process. Neurons in the hypothalamic ventromedial nucleus (VMN) participate in energy balance and are the target of the ...
Pierre Cardinal, Caroline André, Carmelo Quarta, Luigi Bellocchio, Samantha Clark, Melissa Elie, Thierry Leste-Lasserre, Marlene Maitre, Delphine Gonzales, Astrid Cannich, Uberto Pagotto, Giovanni Marsicano, Daniela Cota   +12 more
doaj   +1 more source

Leptin and Soluble Leptin Receptor in Follicular Fluid [PDF]

Journal of Assisted Reproduction and Genetics, 2003
Previous studies suggest that follicular fluid leptin levels predict successful assisted reproduction. The relationship between intrafollicular leptin and the soluble leptin receptor, ovarian hormones, and oocyte quality was examined to determine potential factors contributing to this finding.Follicular fluid leptin, soluble leptin receptor, hormones ...
Corrine K, Welt, Alan L, Schneyer, Kathleen, Heist, Christos S, Mantzoros   +3 more
openaire   +2 more sources

Adipokine Leptin Co-operates With Mechanosensitive Ca2 +-Channels and Triggers Actomyosin-Mediated Motility of Breast Epithelial Cells

Frontiers in Cell and Developmental Biology, 2021
In postmenopausal women, a major risk factor for the development of breast cancer is obesity. In particular, the adipose tissue-derived adipokine leptin has been strongly linked to tumor cell proliferation, migration, and metastasis, but the underlying ...
Anna Acheva, Tytti Kärki, Niccole Schaible, Ramaswamy Krishnan, Sari Tojkander   +4 more
doaj   +1 more source

Assessment of leptin and resistin levels in non-obese multiple myeloma patients and their relation with Ig level and disease stage

Journal of the Egyptian National Cancer Institute, 2014
Introduction: Multiple myeloma (MM) accounts for approximately 0.8% of all cancer diagnoses and 0.9% of cancer deaths. Leptin receptors were expressed on CD34+ cells.
Noha E. Esheba, Abeer Shahba, Ola El Shora   +2 more
doaj   +1 more source

Leptin and leptin receptors. [PDF]

, 2013
Plasma leptin levels on PND7 (A) and on PND90 (B); peripheral leptin sensitivity challenge (intake changes in grams, 4, 20 & 24 hours after peripheral leptin injection (2 mg/kg) (normalized to intake after saline injection)) (C); protein levels for the ...
Noga Kronfeld-Schor (210963), Mariana Schroeder (360122), Aron Weller (360129)   +2 more
core   +1 more source

Leptin receptor in boar spermatozoa [PDF]

International Journal of Andrology, 2007
SummaryLeptin is active in both metabolism and reproduction. In fact, it seems to exert an inhibitory action on gonadal functions by reducing testosterone production. The presence of leptin in human and boar seminal plasma and in human spermatozoa has been demonstrated; recently, leptin receptors (Ob‐R) have been localized in human spermatozoa, thus ...
DE AMBROGI, MARCO, SPINACI, MARCELLA, GALEATI, GIOVANNA, TAMANINI, CARLO   +3 more
openaire   +2 more sources