Results 31 to 40 of about 53,696 (166)

Leptin and leptin receptor evaluation in atherosclerotic plaques in patients with type 2 diabetes mellitus

Терапевтический архив, 2021
Background. Diabetes mellitus (DM) is a significant predictor of atherosclerosis, cardiovascular disease, and cardiovascular mortality. It is known that atherosclerosis occurs earlier in patients with diabetes, reducing the duration of their life. Leptin
Diana A. Dimitrova, Ilya A. Mikhailov, Konstantin Yu. Tokarev, Marina S. Michurova, Anna M. Gorbacheva, Natalia V. Danilova, Pavel G. Malkov, Viktor Yu. Kalashnikov   +7 more
doaj   +1 more source

The melanocortin receptors and their accessory proteins. [PDF]

, 2013
The five melanocortin receptors (MCRs) named MC1R-MC5R have diverse physiological roles encompassing pigmentation, steroidogenesis, energy homeostasis and feeding behavior as well as exocrine function.
Adrian J. L. Clark, Li eChan, Clark, AJ, Rebecca J. Gorrigan, Shwetha Ramachandrappa, Rebecca eGorrigan, Adrian eClark, Shwetha eRamachandrappa, Ramachandrappa, S, Gorrigan, RJ, Li F. Chan, Chan, LF, Clark, AJL   +12 more
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Leptin and Notch Signaling Cooperate in Sustaining Glioblastoma Multiforme Progression

Biomolecules, 2020
Glioblastoma multiforme (GBM) is the most malignant form of glioma, which represents one of the commonly occurring tumors of the central nervous system.
Salvatore Panza, Umberto Russo, Francesca Giordano, Antonella Leggio, Ines Barone, Daniela Bonofiglio, Luca Gelsomino, Rocco Malivindi, Francesca Luisa Conforti, Giuseppina Daniela Naimo, Cinzia Giordano, Stefania Catalano, Sebastiano Andò   +12 more
doaj   +1 more source

Sympathetic Nervous System Catecholamines and Neuropeptide Y Neurotransmitters Are Upregulated in Human NAFLD and Modulate the Fibrogenic Function of Hepatic Stellate Cells [PDF]

, 2013
Background Sympathetic nervous system (SNS) signalling regulates murine hepatic fibrogenesis through effects on hepatic stellate cells (HSC), and obesity-related hypertension with SNS activation accelerates progression of non-alcoholic fatty liver ...
Vander Borght, S, McKee, C, Vander Borght Sara, Mazzoccoli, G, Ching-I Lin, Gianluigi Mazzoccoli, Lin Ching-I, Selden, C, Maelle Morgan, Pazienza Valerio, Selden Clare, Junpei Soeda, Lin, C, Jude A Oben, Barbara Sigala, Manlio Vinciguerra, Oben, JA, Tania Roskams, Sara Vander Borght, Pazienza, V, Roskams, T, Clare Selden, Lin, CI, McKee Chad, Mazzoccoli Gianluigi, Vinciguerra, M, Morgan Maelle, Valerio Pazienza, Sigala Barbara, Vinciguerra Manlio, Soeda, J, Chad McKee, Soeda Junpei, Oben Jude A., Sigala, B, Roskams Tania, Morgan, M   +36 more
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Leptin into the rostral ventral lateral medulla (RVLM) augments renal sympathetic nerve activity and blood pressure

Frontiers in Neuroscience, 2014
Leptin is a hormone released from adipose tissue. While this hormone normally acts to reduce feeding behavior and increase energy expenditure, in obesity, resistance to these effects occurs even though the hormone is released in large amounts. Although
Maria J Barnes, David Harry McDougal
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Leptin in the Commissural Nucleus of the Tractus Solitarius (cNTS) and Anoxic Stimulus in the Carotid Body Chemoreceptors Increases cNTS Leptin Signaling Receptor and Brain Glucose Retention in Rats

Medicina, 2022
Background and Objectives: The commissural nucleus of the tractus solitarius (cNTS) not only responds to glucose levels directly, but also receives afferent signals from the liver, and from the carotid chemoreceptors (CChR).
Mónica Lemus, Cynthia Mojarro, Sergio Montero, Mario Ramírez-Flores, José Torres-Magallanes, Adrián Maturano-Melgoza, Elena Roces de Álvarez-Buylla   +6 more
doaj   +1 more source

Limited impact on glucose homeostasis of leptin receptor deletion from insulin- or proglucagon-expressing cells

Molecular Metabolism, 2015
Aims/hypothesis: The adipose tissue-derived hormone leptin plays an important role in the maintenance of body weight and glucose homeostasis. Leptin mediates its effects by interaction with leptin receptors (LepRb), which are highly expressed in the ...
Helen Soedling, David J. Hodson, Alice E. Adrianssens, Fiona M. Gribble, Frank Reimann, Stefan Trapp, Guy A. Rutter   +6 more
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Glucose enhances leptin signaling through modulation of AMPK activity. [PDF]

PLoS ONE, 2012
Leptin exerts its action by binding to and activating the long form of leptin receptors (LEPRb). LEPRb activates JAK2 that subsequently phosphorylates and activates STAT3.
Haoran Su, Lin Jiang, Christin Carter-Su, Liangyou Rui   +3 more
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Increased circulating ANG II and TNF-α represents important risk factors in obese Saudi adults with hypertension irrespective of diabetic status and BMI [PDF]

, 2012
Central adiposity is a significant determinant of obesity-related hypertension risk, which may arise due to the pathogenic inflammatory nature of the abdominal fat depot.
Bindahman, Lotfi S., Mohamed, Amany O., Draz Hossam M., Saleem, Tahia H., Alkharfy Khalid M., Lotfi S Bindahman, Mohamed Amany O., Omar S Al-Attas, Alokail, Majed S., Al-Attas, Omar S., Al-Attas Omar S., Philip G McTernan, Al-Daghri, Nasser M., Tahia H Saleem, Amany O Mohamed, Hossam M Draz, Harte Alison L., Majed S Alokail, Alison L Harte, Saleem Tahia H., Yakout Sobhy, Harte, Alison L., Al-Daghri Nasser M., Alokail Majed S., Nasser M Al-Daghri, McTernan Philip G., Bindahman Lotfi S., Yakout, Sobhy M., Draz, Hossam M., Alkharfy, Khalid M., McTernan, P. G. (Philip G.), Sobhy Yakout, Khalid M Alkharfy   +32 more
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Altered leptin signaling and attenuated cardiac vagal activity in rats with type 2 diabetes

Frontiers in Physiology
IntroductionThe leading cause of death in type 2 diabetes mellitus (T2DM) patients is cardiovascular-related events, including myocardial infraction-induced ventricular arrhythmia.
Anthony J. Evans, Huiyin Tu, Yu Li, Boris Shabaltiy, Lauren Whitney, Kassidy Carpenter, Yu-long Li, Yu-long Li   +7 more
doaj   +1 more source