Glucose enhances leptin signaling through modulation of AMPK activity. [PDF]
PLoS ONE, 2012 Leptin exerts its action by binding to and activating the long form of leptin receptors (LEPRb). LEPRb activates JAK2 that subsequently phosphorylates and activates STAT3.
Haoran Su +3 more
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Leptin receptor signaling: pathways to leptin resistance
Frontiers in Bioscience, 2011 The identification of spontaneous mutations in the leptin- and leptin receptor (ObR)-encoding ob and db gene, respectively, opened up a new field in obesity research. Leptin, an adipocyte-derived hormone, mirrors the body's fat stores and thereby informs the brain about the body's energy status.
Joris, Wauman, Jan, Tavernier
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Increased circulating ANG II and TNF-α represents important risk factors in obese Saudi adults with hypertension irrespective of diabetic status and BMI [PDF]
, 2012 Central adiposity is a significant determinant of obesity-related hypertension risk, which may arise due to the pathogenic inflammatory nature of the abdominal fat depot.
Bindahman, Lotfi S. +32 more
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Altered leptin signaling and attenuated cardiac vagal activity in rats with type 2 diabetes
Frontiers in PhysiologyIntroductionThe leading cause of death in type 2 diabetes mellitus (T2DM) patients is cardiovascular-related events, including myocardial infraction-induced ventricular arrhythmia.
Anthony J. Evans +7 more
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Leptin and peroxisome proliferator activated receptor alpha: understanding their contribution towards normalising the programmed phenotype in the peripheral tissues of IUGR offspring [PDF]
, 2010 In a rat model of intrauterine growth restriction (IUGR) induced by maternal global undernutrition, adult offspring are obese with associated metabolic disturbances. These metabolic abnormalities are all augmented by feeding a high calorie postnatal diet
Garratt, Emma
core
Effects of diabetes family history and exercise training on the expression of adiponectin and leptin and their receptors [PDF]
, 2011 Daughters of diabetes patients have lower insulin sensitivity than women with no diabetes family history, but increase insulin sensitivity to a greater extent with exercise training.
Moran, Colin N. +21 more
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Insulin and Leptin Signaling Interact in the Mouse Kiss1 Neuron during the Peripubertal Period. [PDF]
PLoS ONE, 2015 Reproduction requires adequate energy stores for parents and offspring to survive. Kiss1 neurons, which are essential for fertility, have the potential to serve as the central sensors of metabolic factors that signal to the reproductive axis the presence
Xiaoliang Qiu +10 more
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Leptin potentiates astrogenesis in the developing hypothalamus
Molecular Metabolism, 2015 Background: The proper establishment of hypothalamic feeding circuits during early development has a profound influence on energy homeostasis, and perturbing this process could predispose individuals to obesity and its associated consequences later in ...
Daniele M. Rottkamp +9 more
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Role of Leptin and metabolism in survival of autoreactive CD4+ T cells [PDF]
, 2009 Recent evidence has shown that leptin, the adipose-tissue derived hormone, can influence T cell homeostasis and survival through the control of genes involved in these processes. Leptin deficient ob/ob mice and humans show reduced circulating number of T
Galgani, Mario
core
Postnatal development of hypothalamic leptin receptors. [PDF]
, 2010 The hormone, leptin, plays a key role in the regulation of energy balance and neuroendocrine function, as well as modulating a range of other physiological systems from immunity to cognition.
Cottrell, Elizabeth C.; id_orcid +5 more
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