Results 51 to 60 of about 53,696 (166)

The role of insulin receptor substrate 2 in hypothalamic and β cell function [PDF]

, 2005
Insulin receptor substrate 2 (Irs2) plays complex roles in energy homeostasis. We generated mice lacking Irs2 in β cells and a population of hypothalamic neurons (RIPCreIrs2KO), in all neurons (NesCreIrs2KO), and in proopiomelanocortin neurons ...
Hisadome, Kazunari, Choudhury, Agharul I., Smith, Mark A., Simmgen, M., Diakonov, Ivan, Allison W. Xu, Bedford, D.C., Michael L.J. Ashford, Speakman, J.R., Helen Heffron, Bedford, David C., Selman, Colin, Marc Claret, Xu, Allison W., Kazunari Hisadome, Claret, Marc, MacColl, Gavin, Bell, Jimmy D., Speakman, John R., Heffron, H., Melanie Clements, Barsh, Gregory S., Agharul I. Choudhury, Choudhury, A.I., Heffron, Helen, Hind Al-Qassab, Xu, A.W., Vazira Moosajee, Withers, D.J., Hisadome, K., Barsh, G.S., Clements, Melanie, Mark A. Smith, Ashford, Michael L.J.; id_orcid, Withers, Dominic J., Moosajee, Vazira, Dominic J. Withers, Claret, M., MacColl, G., Selman, C., Ivan Diakonov, Al-Qassab, H., Al-Qassab, Hind, Moosajee, V., Gavin MacColl, Simmgen, Marcus, Bell, J.D., Smith, M.A., Ashford, M.L.J., Gregory S. Barsh, Diakonov, I., Batterham, R.L., David C. Bedford, Batterham, Rachel L., Colin Selman, Jimmy D. Bell, Clements, M., Marcus Simmgen, Rachel L. Batterham, John R. Speakman   +59 more
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The glucoregulatory actions of leptin

Molecular Metabolism, 2017
Background: The hormone leptin is an important regulator of metabolic homeostasis, able to inhibit food intake and increase energy expenditure. Leptin can also independently lower blood glucose levels, particularly in hyperglycemic models of leptin or ...
Anna M. D'souza, Ursula H. Neumann, Maria M. Glavas, Timothy J. Kieffer   +3 more
doaj   +1 more source

The physiological and pathophysiological role of leptin in neurological and behavioral disorders [PDF]

, 2023
Many factors can impact behavioral problems, including genetic, physiological, structural, and psychological factors. The genesis of behavioral disorders is influenced by several elements as a result of this complicated relationship. Because hormones are
Kiliç, U., Soytürk, H., Yildiz, A.
core  

Leptin and leptin receptors.

, 2013
Plasma leptin levels on PND7 (A) and on PND90 (B); peripheral leptin sensitivity challenge (intake changes in grams, 4, 20 & 24 hours after peripheral leptin injection (2 mg/kg) (normalized to intake after saline injection)) (C); protein levels for the ...
Noga Kronfeld-Schor (210963), Mariana Schroeder (360122), Aron Weller (360129)   +2 more
core   +1 more source

Leptin as a critical regulator of hepatocellular carcinoma development through modulation of human telomerase reverse transcriptase

BMC Cancer, 2010
Background Numerous epidemiological studies have documented that obesity is associated with hepatocellular carcinoma (HCC). The aim of this study was to investigate the biological actions regulated by leptin, the obesity biomarker molecule, and its ...
Stefanou Nikolaos, Papanikolaou Vassilis, Furukawa Yoichi, Nakamura Yusuke, Tsezou Aspasia   +4 more
doaj   +1 more source

Leptin and its cardiovascular effects: Focus on angiogenesis

Advanced Biomedical Research, 2015
Leptin is an endocrine hormone synthesized by adipocytes. It plays a key role in the energy homeostasis in central and peripheral tissues and has additional roles are attributed to it, such as the regulation of reproduction, immune function, bone ...
Zoya Tahergorabi, Majid Khazaei
doaj   +1 more source

Effects of clozapine on adipokine secretions/productions and lipid droplets in 3T3-L1 adipocytes

Journal of Pharmacological Sciences, 2017
Clozapine, a second-generation antipsychotic (SGA), is a cause of side effects related to metabolic syndrome. The participation of serotonin 5-HT2C and histamine H1 receptors in the central nervous system has been reported as a mechanism of the weight ...
Tomomi Tsubai, Akira Yoshimi, Yoji Hamada, Makoto Nakao, Hiroshi Arima, Yutaka Oiso, Yukihiro Noda   +6 more
doaj   +1 more source

Increased Leptin/Leptin Receptor Pathway Affects Systemic and Airway Inflammation in COPD Former Smokers [Retraction]

Journal of Inflammation Research, 2021
Bruno A, Alessi M, Soresi S, et al. J Inflamm Res. 2011;4:51–59. The Editor and Publisher of Journal of Inflammation Research wish to retract the published article.
Bruno A, Alessi M, Soresi S, Bonanno A, Riccobono L, Montalbano AM, Albano GD, Gjomarkaj M, Profita M   +8 more
doaj  

The Phlorotannin-Rich Fraction of Ecklonia cava Extract Attenuated the Expressions of the Markers Related with Inflammation and Leptin Resistance in Adipose Tissue

International Journal of Endocrinology, 2020
Obesity is associated with systemic chronic inflammation, and it induces central leptin resistance which blocks the appetite-suppressing effect of leptin and leptin resistance in adipocytes. In the present study, we evaluated the effects of Ecklonia cava
Myeongjoo Son, Seyeon Oh, Junwon Choi, Ji Tae Jang, Chang Hu Choi, Kook Yang Park, Kuk Hui Son, Kyunghee Byun   +7 more
doaj   +1 more source

Leptin increases sympathetic nerve activity via induction of its own receptor in the paraventricular nucleus

eLife, 2020
Whether leptin acts in the paraventricular nucleus (PVN) to increase sympathetic nerve activity (SNA) is unclear, since PVN leptin receptors (LepR) are sparse.
Zhigang Shi, Nicole E Pelletier, Jennifer Wong, Baoxin Li, Andrei D Sdrulla, Christopher J Madden, Daniel L Marks, Virginia L Brooks   +7 more
doaj   +1 more source