Results 61 to 70 of about 94,971 (311)
Molecular Pain, 2013 Background Leptin, an adipocytokine produced mainly by white adipose tissue, has a broad role in the regulation of neuronal functions. Accumulating evidence has revealed that leptin plays an important role in influencing neuropathic pain, shown recently ...
Xin Li +8 more
doaj +1 more source
Glucose enhances leptin signaling through modulation of AMPK activity. [PDF]
PLoS ONE, 2012 Leptin exerts its action by binding to and activating the long form of leptin receptors (LEPRb). LEPRb activates JAK2 that subsequently phosphorylates and activates STAT3.
Haoran Su +3 more
doaj +1 more source
Thyroid Autoimmunity as a Window to Autoimmunity: An Explanation for Sex Differences in the Prevalence of Thyroid Autoimmunity [PDF]
, 2015 Autoimmune thyroid diseases (AITDs), predominately Graves׳ disease and Hashimoto׳s thyroiditis, comprise the most common autoimmune diseases in humans.
Merrill, Stephen, Mu, Ying
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Hypothalamic gene expression during voluntary hypophagia in the Sprague-Dawley rat on withdrawal of the palatable liquid diet, Ensure [PDF]
, 2014 Copyright © 2014 Elsevier Inc.
Archer, Zoe A +2 more
core +1 more source
Advanced Science, EarlyView.Plastin‐2 (PLS2) is identified as a dual‐function receptor on DCs that mediates both nanoparticle uptake and immunomodulation. A nanobody‐LNP platform is engineered to integrate antigen delivery with relicensing DCs. The therapeutic strategy elicits potent anti‐tumor T cell responses and leads to significant inhibition of established tumors in vivo ...
Shugang Qin +9 more
wiley +1 more source
Altered leptin signaling and attenuated cardiac vagal activity in rats with type 2 diabetes
Frontiers in PhysiologyIntroductionThe leading cause of death in type 2 diabetes mellitus (T2DM) patients is cardiovascular-related events, including myocardial infraction-induced ventricular arrhythmia.
Anthony J. Evans +7 more
doaj +1 more source
Role of leptin and leptin receptor in inflammation
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 2003 on october 30th, 2002, the World Health Report by the World Health Organization was launched subtitled Reducing risks, promoting healthy life . Many of the health risks discussed in this report concern food consumption—either too little, in the case of the poor, or too much, in the case of ...
Halle, Martin, Persson, P. B.
openaire +3 more sources
Alzheimer's Disease Risk Factor APOE4 Exerts Dimorphic Effects on Female Bone
Advanced Science, EarlyView.In aging bone, osteocytes accumulate neurodegenerative risk factor Apolipoprotein E (APOE). A humanized version of the Alzheimer's disease risk allele APOE4 altered the mouse bone transcriptome and proteome, with effects in female bone surpassing the brain, including bone fragility due to suppressed osteocytic maintenance of bone quality, identifying ...
Charles A. Schurman +15 more
wiley +1 more source
Insulin and Leptin Signaling Interact in the Mouse Kiss1 Neuron during the Peripubertal Period. [PDF]
PLoS ONE, 2015 Reproduction requires adequate energy stores for parents and offspring to survive. Kiss1 neurons, which are essential for fertility, have the potential to serve as the central sensors of metabolic factors that signal to the reproductive axis the presence
Xiaoliang Qiu +10 more
doaj +1 more source
CNS Control of Glucose Metabolism: Response to Environmental Challenges [PDF]
, 2013 Over the last 15 years, considerable work has accumulated to support the role of the CNS in regulating postprandial glucose levels. As discussed in the first section of this review, the CNS receives and integrates information from afferent neurons ...
Arble, Deanna M., Sandoval, Darleen A.
core +1 more source