Results 61 to 70 of about 632,116 (307)

Encapsulated Leptin‐Producing Cells Facilitate Entrainment of Circadian Rhythms in Rodents and Nonhuman Primates

Advanced Science, EarlyView.
A clinically translatable cell line can be engineered to produce leptin, encapsulated in biomaterial and safely implanted to produce and deliver the metabolic regulating protein within the body. Implantation of these encapsulated cells decreases the time it takes for mice and non‐human primates to adjust to circadian disruptions similar to those ...
Samantha T. Fleury, Xuanyi Lin, Peter D. Rios, Christopher Olker, Eun Joo Song, Alejandra Cobos Perez, Cody Fell, Daisy Lopez, Ira Joshi, Hafsa Nasir, Cecelia Curtis, Danna Muringi, Kaiyuan Wang, José Oberholzer, Fred W. Turek, Isaac B. Hilton, Jonathan Rivnay, Martha Hotz Vitaterna, Omid Veiseh   +18 more
wiley   +1 more source

The Adipose‐Sympathetic Nerve Crosstalk: FSTL1 as an Adipocyte‐Derived Neurotrophic Factor for WAT Browning

Advanced Science, EarlyView.
As a novel adipose‐derived neurotrophic factor, Follistatin‐like 1 is endocytosed by sympathetic neurons primarily via tropomyosin‐related kinase B. This process promotes sympathetic innervation in adipose tissue and norepinephrine release, leading to white adipose tissue browning, enhanced thermogenesis, and anti‐obesity effects in mice.
Xiao‐Wei Jia, Jia‐Xin Liu, Rui‐Ping Wang, Xue‐Qin Wu, Yao Che, Mu‐Chen Wu, Hong‐Wei Shang, Xin Lu, Tao Lu, Lu‐Lu Wang, Chun‐Yan Jiang, Dong‐Liang Fang, Chun Yang, Yan Gao   +13 more
wiley   +1 more source

Leptin potentiates astrogenesis in the developing hypothalamus

Molecular Metabolism, 2015
Background: The proper establishment of hypothalamic feeding circuits during early development has a profound influence on energy homeostasis, and perturbing this process could predispose individuals to obesity and its associated consequences later in ...
Daniele M. Rottkamp, Ivan A. Rudenko, Matthew T. Maier, Sahar Roshanbin, Ernie Yulyaningsih, Luz Perez, Martin Valdearcos, Streamson Chua, Suneil K. Koliwad, Allison W. Xu   +9 more
doaj   +1 more source

The role of leptin in selected skin diseases

Lipids in Health and Disease, 2020
Leptin is an adipokine, adipocyte-derived compound, which acts both as a hormone and cytokine. It is mainly synthesized by adipocytes of white adipose tissue. Leptin possesses pleiotropic functions including, among others, stimulation of angiogenesis and
Klaudia Dopytalska, Agnieszka Baranowska-Bik, Marek Roszkiewicz, Wojciech Bik, Irena Walecka   +4 more
doaj   +1 more source

Sympathetic Nervous System Catecholamines and Neuropeptide Y Neurotransmitters Are Upregulated in Human NAFLD and Modulate the Fibrogenic Function of Hepatic Stellate Cells [PDF]

, 2013
Background Sympathetic nervous system (SNS) signalling regulates murine hepatic fibrogenesis through effects on hepatic stellate cells (HSC), and obesity-related hypertension with SNS activation accelerates progression of non-alcoholic fatty liver ...
Vander Borght, S, McKee, C, Vander Borght Sara, Mazzoccoli, G, Ching-I Lin, Gianluigi Mazzoccoli, Lin Ching-I, Selden, C, Maelle Morgan, Pazienza Valerio, Selden Clare, Junpei Soeda, Jude A Oben, Barbara Sigala, Manlio Vinciguerra, Oben, JA, Tania Roskams, Sara Vander Borght, Pazienza, V, Roskams, T, Clare Selden, Lin, CI, McKee Chad, Mazzoccoli Gianluigi, Vinciguerra, M, Morgan Maelle, Valerio Pazienza, Sigala Barbara, Vinciguerra Manlio, Soeda, J, Chad McKee, Soeda Junpei, Oben Jude A., Sigala, B, Roskams Tania, Morgan, M   +35 more
core   +2 more sources

Leveraging Microphysiological Systems to Facilitate Neutrophil‐Based Cancer Immunotherapy

Advanced Science, EarlyView.
Microphysiological systems are emerging as powerful human‐relevant platforms for studying neutrophil biology in cancer. Current applications of spheroids, organoids, and organ‐on‐a‐chip models are reviewed, together with future opportunities in behaviorome profiling, multi‐omics integration, personalized medicine, immune crosstalk, and multi‐organ ...
Shuai Shao, Markus Isfeld Diehl, Caroline N. Jones   +2 more
wiley   +1 more source

Regulatory T cell proliferative potential as novel marker to investigate immune tolerance and clinical progression in Multiple Sclerosis [PDF]

, 2011
In autoimmune disorders such as Multiple Sclerosis (MS) one of the determining alteration is the breakdown of self-antigen immune-tolerance. Peripheral immune tolerance is maintained, at least in part, by Regulatory T cells (Treg).
Carbone, Fortunata
core   +1 more source

Leptin receptor signaling: pathways to leptin resistance

Frontiers in Bioscience, 2011
The identification of spontaneous mutations in the leptin- and leptin receptor (ObR)-encoding ob and db gene, respectively, opened up a new field in obesity research. Leptin, an adipocyte-derived hormone, mirrors the body's fat stores and thereby informs the brain about the body's energy status.
Joris, Wauman, Jan, Tavernier
openaire   +2 more sources

Multi‐Tissue Crosstalk Regulating Meniscus Healing Under Inflammation and Physiological Loading

Advanced Science, EarlyView.
Using a novel Meniscus‐on‐a‐chip (MoC) model integrated with a meniscus‐specific bioreactor, this study investigated the roles of multi‐tissue crosstalk that regulates injury, healing, and degeneration of the meniscus injury under inflammation and pathophysiological loading.
Hun Jin Jeong, Elen Zhu, Min Seo Kang, Ming Wang, Sam Comito, Chang H. Lee   +5 more
wiley   +1 more source

Plasma Leptin Levels, Polymorphism and Mammographic Breast Density: A Cross-sectional Study

The International Journal of Biological Markers, 2013
Obesity is associated with breast cancer in postmenopausal women, and breast density is a marker of breast cancer risk. Leptin is produced by the adipose tissue, acts through receptors that are polymorphic in nature, and is considered a cancer growth ...
Cher Dallal, Seymour Garte, Camille Ragin, Jiangying Chen, Stacy Lloyd, Francesmary Modugno, Joel Weissfeld, Emanuela Taioli   +7 more
doaj   +1 more source