Results 81 to 90 of about 94,971 (311)

Plasma Leptin Levels, Polymorphism and Mammographic Breast Density: A Cross-sectional Study

The International Journal of Biological Markers, 2013
Obesity is associated with breast cancer in postmenopausal women, and breast density is a marker of breast cancer risk. Leptin is produced by the adipose tissue, acts through receptors that are polymorphic in nature, and is considered a cancer growth ...
Cher Dallal, Seymour Garte, Camille Ragin, Jiangying Chen, Stacy Lloyd, Francesmary Modugno, Joel Weissfeld, Emanuela Taioli   +7 more
doaj   +1 more source

Leptin fails to blunt the lipopolysaccharide-induced activation of the hypothalamic-pituitary-adrenal axis in rats [PDF]

, 2014
Copyright @ 2013 The authors. This work is licensed under a Creative Commons Attribution 3.0 Unported License.Obesity is a risk factor for sepsis morbidity and mortality, whereas the hypothalamic-pituitary-adrenal (HPA) axis plays a protective role in ...
Ahima, ANDREIS, Arabi, Besedovsky, Blackwell, Bone, Bornstein, Carlson, Christopher D John, Clark, Connor, Costa, Csontos, Elenkov, Elmquist, GAILLARD, Heiman, Heuer, Hu, Huang, Jennifer A Parker, John, Julia C Buckingham, Kevin G Murphy, Kurt, Maffei, Mohn, Nishiyama, Ott, Pournajafi Nazarloo, Raber, Reyes, RIVIER, Rodr  guez-Wilhelmi, Saadia Basharat, Stephen R Bloom, Takao, Takemura, Vachharajani, Yousef, Zamorano   +40 more
core   +1 more source

Metabolic and biochemical profiling reveals phenotypic heterogeneity in Zucker diabetic fatty rats

Animal Models and Experimental Medicine, EarlyView.
Genetically uniform Zucker Diabetic Fatty (ZDF) rats spontaneously develop four distinct metabolic phenotypes despite identical housing and diet conditions. Each phenotype exhibits unique biomarker signatures encompassing glucose homeostasis, insulin secretion, polyol pathway activation, oxidative stress, inflammatory cytokines, and neurotrophic ...
Marek Lepáček, Pavol Boďo, Barbora Kaločayová, Marta Šoltésová Prnová   +3 more
wiley   +1 more source

The Influence of Photoperiod on the Action of Exogenous Leptin on Gene Expression of Proinflammatory Cytokines and Their Receptors in the Thoracic Perivascular Adipose Tissue (PVAT) in Ewes

Mediators of Inflammation, 2019
Leptin resistance is either a condition induced by human obesity or a natural phenomenon associated with seasonality in ruminants. In the cardiovascular system, the leptin resistance state presence is a complex issue.
Agata Krawczyńska, Andrzej P. Herman, Hanna Antushevich, Joanna Bochenek, Karolina Wojtulewicz, Dorota A. Zięba   +5 more
doaj   +1 more source

INSULIN AND LEPTIN: DISPUTABLE AND UNSOLVED QUESTIONS OF THEIR INTERACTION

Атеросклероз, 2019
Leptin and its receptor are widely distributed mainly in white adipose tissue. Serum leptin concentration correlates with body mass index, and its levels decrease with fasting.
E. V. Belik, O. V. Gruzdeva, E. I. Palicheva   +2 more
doaj   +1 more source

Pancreatic cancer cachexia: a review of mechanisms and therapeutics. [PDF]

, 2014
Over the last decade, we have gained new insight into the pathophysiology of cachexia associated with pancreatic cancer. Unfortunately, its treatment is complex and remains a challenge.
Andrew Eugene Hendifar, Andrew Eugene Hendifar, Carlyn Rose Tan, Laith eJamil, Nick eNissen, Patrick eYaffee, Richard eTuli, Simon eLo, Stephen J Pandol   +8 more
core   +2 more sources

Mutations in the Human Leptin and Leptin Receptor Genes as Models of Serum Leptin Receptor Regulation [PDF]

Diabetes, 2002
A part of serum Ob leptin, an adipocyte-secreted peptide, is bound to a soluble Ob receptor (sObR). Immunoreactive sObR was measured in 125 lean or obese control subjects (group 1), 18 individuals with a mutation in the leptin gene impairing leptin secretion (group 2), and 10 individuals with a mutation in the ObR gene, leading to production of a ...
Najiba, Lahlou, Tarik, Issad, Yves, Lebouc, Jean-Claude, Carel, Luc, Camoin, Marc, Roger, Jean, Girard   +6 more
openaire   +2 more sources

Optimization and verification of high‐fat diet formulation for establishing a rat model of obesity‐related precocious puberty

Animal Models and Experimental Medicine, EarlyView.
We identified 45% HFD as the optimal formulation to establish a juvenile rat model of obesity‐related precocious puberty. It elicits robust phenotypic (early vaginal opening, obesity), histological (advanced ovarian development), and endocrine (elevated HPG axis hormones) alterations, with leptin‐mediated GnRH secretion as a core mechanistic driver ...
Jiayi Gong, Wei Qian, Deji Song, Kang Li, Li Zhang, Li Shi   +5 more
wiley   +1 more source

Inflammatory Response as a Mechanism of Perinatal Programming: Long-term Impact on Pulmonary and Renal Function? [PDF]

, 2012
RATIONALE: Temporal changes in the fetal environment, such as malnutrition and placental insufficiency induce intrauterine growth restriction (IUGR) and lead to a permanent changes of physiological processes later in life.
Alejandre Alcázar, Miguel Angel
core  

An ultra‐processed food‐based cafeteria diet induces obesity, metabolic dysfunction, and tissue‐specific gene dysregulation in C57BL/6 mice

Animal Models and Experimental Medicine, EarlyView.
This schematic figure illustrates the experimental design and key findings of the study. Forty male C57BL/6 mice were assigned to either a standard diet control group or a cafeteria diet (CAFD) group for 16 weeks. CAFD induces obesity, insulin resistance (HOMA‐IR), hepatic steatosis, and dysregulation of a number of genes in visceral and subcutaneous ...
Guilherme Coutinho Kullmann Duarte, Daisy Crispim, Shiva Cerutti Wittée, Joana Raquel Nunes Lemos, Natalia Emerim Lemos, Mayara Souza de Oliveira, Melissa Daniele Alves, Eloísa Toscan Massignam, Tais Silveira Assmann, Felipe Mateus Pellenz   +9 more
wiley   +1 more source