Results 81 to 90 of about 632,116 (307)

Trace Elements Genetics: A Potential Role in Treatment‐Resistant Major Psychoses and Related Traits?

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, EarlyView.
ABSTRACT Trace elements are pivotal to key biological processes, with possible effects on psychopathology. We investigated the hypothesis of shared genetic factors between trace elements levels, treatment resistance and related traits. We used genome‐wide summary statistics for trace elements blood concentration, treatment‐resistant depression (TRD ...
Chiara Fabbri, Alessandro Serretti, Marco Menchetti, Benedetta Vai, Francesco Benedetti, Lidia Fortaner‐Uyà, Concetta Crisafulli   +6 more
wiley   +1 more source

Human mast cells express leptin and leptin receptors.

, 2009
Mast cells are immune cells that produce and secrete a variety of mediators and cytokines that influence various inflammatory and immune processes. Leptin is a cytokine regulating metabolic, endocrine as well as immune functions via the leptin receptor ...
Waelput, Wim, Braet, Katleen, Cuvelier, Claude A, Bachert, Claus, Rottiers, Isabelle, Pérez-Novo, Claudina A, Waeytens, Anouk, Perez-Novo, Claudina A., Taildeman, Jasmien, Ferdinande, Liesbeth, Demetter, Pieter, De Colvenaer, Veerle, Perez Novo, Claudina, Cuvelier, Claude A., Cuvelier, Claude   +14 more
core   +2 more sources

Melanocortin receptors in leptin effects [PDF]

Nature, 1997
Leptin acts on the central nervous system to cause a reduction in food intake and body weight1,2. The melanocortin system in the brain is also implicated in energy homeostasis, with agonists of the melanocortin-4 (MC4) receptor reducing food intake3 and targeted mutation of the MC4 receptor causing obesity4.
Seeley, Randy J., Yagaloff, Keith A., Fisher, Stewart L., Burn, Paul, Thiele, Todd E., Dijk, Gertjan van, Baskin, Denis G., Schwartz, Michael W.   +7 more
openaire   +3 more sources

Relationships between cord blood leptin and ghrelin levels, milk intake and weight gain in human infants [PDF]

, 2003
Leptin and ghrelin are hormones involved in the regulation of appetite and adiposity. Leptin suppresses appetite and induces weight loss; ghrelin stimulates appetite and promotes weight gain.
James, Rachel J. A., James, Rachel J A
core  

Leptin May Promote Eosinophilic CRSwNP Progression by Enhancing Eosinophil Chemotaxis and Angiogenesis Under a Type 2 Inflammatory Milieu

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Chronic rhinosinusitis with nasal polyp (CRSwNP) is a heterogeneous Type 2 inflammatory disease characterized by enhanced eosinophilic infiltration. Both innate and adaptive immunity are involved in the onset and progression of CRSwNP.
Yuki Sonoda, Yohei Sato, Yoshimasa Imoto, Mayumi Tamari, Shigeharu Fujieda   +4 more
wiley   +1 more source

Leptin as a critical regulator of hepatocellular carcinoma development through modulation of human telomerase reverse transcriptase

BMC Cancer, 2010
Background Numerous epidemiological studies have documented that obesity is associated with hepatocellular carcinoma (HCC). The aim of this study was to investigate the biological actions regulated by leptin, the obesity biomarker molecule, and its ...
Stefanou Nikolaos, Papanikolaou Vassilis, Furukawa Yoichi, Nakamura Yusuke, Tsezou Aspasia   +4 more
doaj   +1 more source

Study of Serum Leptin in Well-differentiated Thyroid Carcinoma: Correlation with Patient and Tumor Characteristics [PDF]

, 2014
Background There is a proven relationship between obesity and several cancers including breast, endometrium, colorectal, and esophagus. With the increasing incidence of both obesity and thyroid cancer, we designed the present study to investigate a ...
Elwafa, RA, Elwafa, WA, Rehem, RA, Abdel-Aziz, TE   +3 more
core  

Leptin-dependent Phosphorylation of PTEN Mediates Actin Restructuring and Activation of ATP-sensitive K+ Channels [PDF]

, 2009
Leptin activates multiple signaling pathways in cells, including the phosphatidylinositol 3-kinase pathway, indicating a degree of cross-talk with insulin signaling. The exact mechanisms by which leptin alters this signaling pathway and how it relates to
Miller, L.C., Sutherland, C., Sutherland, Calum, Gallagher, J., Miller, Lisa C., Ashford, M.L.J., Ning, K., Laidlaw, Hilary A., Watterson, Kenneth R., Sutherland, Calum; id_orcid, Laidlaw, H.A., Ning, Ke, Ashford, Michael L. J.; id_orcid, Watterson, K.R., Gallagher, Jennifer, Ashford, Michael L.J.   +15 more
core   +1 more source

The liver‐brain axis: A multidimensional regulatory network implicated in Alzheimer's disease pathogenesis and clinical implications

Animal Models and Experimental Medicine, EarlyView.
Schematic diagram of the core pathways of the liver‐brain axis in regulating AD. The liver regulates cerebral Aβ deposition, tau phosphorylation, and neuroinflammation through pathways such as metabolic detoxification (urea cycle, ketone body metabolism, glutathione antioxidant system), molecular secretion (APOE, CRP, FGF21, IGF‐1), and Aβ clearance ...
Ning Zhang, Wei Chen, Meng Wang
wiley   +1 more source

Leptin and its cardiovascular effects: Focus on angiogenesis

Advanced Biomedical Research, 2015
Leptin is an endocrine hormone synthesized by adipocytes. It plays a key role in the energy homeostasis in central and peripheral tissues and has additional roles are attributed to it, such as the regulation of reproduction, immune function, bone ...
Zoya Tahergorabi, Majid Khazaei
doaj   +1 more source