Results 91 to 100 of about 94,971 (311)

The glucoregulatory actions of leptin

Molecular Metabolism, 2017
Background: The hormone leptin is an important regulator of metabolic homeostasis, able to inhibit food intake and increase energy expenditure. Leptin can also independently lower blood glucose levels, particularly in hyperglycemic models of leptin or ...
Anna M. D'souza, Ursula H. Neumann, Maria M. Glavas, Timothy J. Kieffer   +3 more
doaj   +1 more source

Performance of the Predicting Risk of Cardiovascular Disease Events Calculator in Rheumatoid Arthritis

Arthritis &Rheumatology, EarlyView.
Objective Evaluate performance of the Predicting Risk of Cardiovascular Disease Events (PREVENT) calculator in rheumatoid arthritis (RA). Methods Patients with RA were matched up to 10 controls on age, sex, and enrollment year using National Veterans Health Administration, Medicare, and National Death Index data (2006–2020).
Tate M. Johnson, Halie Frideres, Punyasha Roul, Joshua F. Baker, Brian C. Sauer, Grant W. Cannon, Isaac D. Smith, Gary A. Kunkel, Beth I. Wallace, Thomas R. Porter, Kaveh R. Bookani, Amarnath R. Annapureddy, Ted R. Mikuls, Bryant R. England   +13 more
wiley   +1 more source

Anti‐Obesity Pharmacotherapy and Emerging Multimodal Interventions for Obstructive Sleep Apnea

Chronic Diseases and Translational Medicine, EarlyView.
Cellular and molecular mechanisms of obesity‐related obstructive sleep apnea (OSA). ADMA: asymmetric dimethyrarginine, NLRP3: nucleotide‐binding domain, leucine‐rich repeat family, Pyrin domain containing 3, TLR: toll‐like receptors, IL‐1β: interleukin‐1β, IL‐6: interleukin‐6; LPS: lipopolysacharide, ROS: reactive oxygen species, TNF‐α.
Anish Preshy, Cornelius J. Fernandez, Mohammad Hamid Nedai, Joseph M. Pappachan   +3 more
wiley   +1 more source

Leptin as a critical regulator of hepatocellular carcinoma development through modulation of human telomerase reverse transcriptase

BMC Cancer, 2010
Background Numerous epidemiological studies have documented that obesity is associated with hepatocellular carcinoma (HCC). The aim of this study was to investigate the biological actions regulated by leptin, the obesity biomarker molecule, and its ...
Stefanou Nikolaos, Papanikolaou Vassilis, Furukawa Yoichi, Nakamura Yusuke, Tsezou Aspasia   +4 more
doaj   +1 more source

Influence of leptin on arterial distensibility - A novel link between obesity and cardiovascular disease? [PDF]

, 2002
Background-The mechanisms by which obesity increases the risk of atherosclerotic cardiovascular disease (CVD) are poorly understood. In experimental models, leptin, a hormone produced by adipose tissue, has been shown adversely to affect vascular health.
Cole, TJ, Deanfield, J, Farooqi, IS, Fewtrell, M, Kattenhorn, M, Lucas, A, O'Rahilly, S, Singhal, A   +7 more
core   +1 more source

Leptin and leptin receptor polymorphisms and recurrent pregnancy loss [PDF]

Journal of Perinatology, 2013
Leptin signaling is important in the establishment of pregnancy. We sought to determine if single nucleotide polymorphisms (SNPs) in the leptin and leptin receptor genes are associated with idiopathic recurrent pregnancy loss (RPL).We conducted a case-control study with cases defined as women with idiopathic RPL and controls as parous women without ...
J R, Chin, C C, Heuser, A G, Eller, D W, Branch, L T, Nelson, R M, Silver   +5 more
openaire   +2 more sources

Genomic Insights Into Risperidone Treatment Outcomes in Children and Adolescents: Experience From a Psychiatric Hospital Serving Rural Youth

Clinical Pharmacology &Therapeutics, EarlyView.
Risperidone is a commonly used antipsychotic for treating psychiatric illness in children and adolescents. There is a large variability in risperidone response and discontinuation rates remain high. Pharmacogenomics offers the opportunity to improve risperidone outcomes, yet studies in pediatric populations are limited.
Jack W. Staples, Shayna R. Killam, Karen E. Brown, Rachel Dalton, Elizabeth Sather, Qiang Chen, Joshua Loveland, Corbin Schwanke, Abdallah F. Elias, Kristin L. Bigos, Erica L. Woodahl   +10 more
wiley   +1 more source

Leptin and its cardiovascular effects: Focus on angiogenesis

Advanced Biomedical Research, 2015
Leptin is an endocrine hormone synthesized by adipocytes. It plays a key role in the energy homeostasis in central and peripheral tissues and has additional roles are attributed to it, such as the regulation of reproduction, immune function, bone ...
Zoya Tahergorabi, Majid Khazaei
doaj   +1 more source

Neuromedin U partially mediates leptin-induced hypothalamo-pituitary adrenal (HPA) stimulation and has a physiological role in the regulation of the HPA axis in the rat.

, 2006
Intracerebroventricular (ICV) administration of the hypothalamic neuropeptide neuromedin U (NMU) or the adipostat hormone leptin increases plasma ACTH and corticosterone.
Abbott, CR, Bloom, SR, Darch, SJ, Ghatei, MA, Jethwa, PH, Murphy, KG, Patel, SR, Semjonous, NM, Seth, A, Small, CJ, Smith, KL, Todd, JF   +11 more
core   +1 more source

Circulating leptin, soluble leptin receptor, free leptin index, visfatin and selected leptin and leptin receptor gene polymorphisms in sporadic breast cancer

Endocrine Journal, 2017
Leptin and visfatin are implicated in breast cancer risk but studies accounting for bioavailability of leptin are sparse. Reports on the association of leptin gene (LEP) and leptin receptor gene (LEPR) polymorphisms with breast cancer are also inconsistent.
Chrishani, Rodrigo, Kamani Hemamala, Tennekoon, Eric Hamilton, Karunanayake, Kanishka, De Silva, Indrani, Amarasinghe, Ananda, Wijayasiri   +5 more
openaire   +3 more sources