Results 21 to 30 of about 1,272,125 (151)

Normal leptin expression, lower adipogenic ability, decreased leptin receptor and hyposensitivity to Leptin in Adolescent Idiopathic Scoliosis. [PDF]

PLoS ONE, 2012
Leptin has been suggested to play a role in the etiology of Adolescent Idiopathic Scoliosis (AIS), however, the leptin levels in AIS girls are still a discrepancy, and no in vitro study of leptin in AIS is reported.
Guoyan Liang, Wenjie Gao, Anjing Liang, Wei Ye, Yan Peng, Liangming Zhang, Swarkar Sharma, Peiqiang Su, Dongsheng Huang   +8 more
doaj   +1 more source

Phocid seal leptin: tertiary structure and hydrophobic receptor binding site preservation during distinct leptin gene evolution [PDF]

, 2012
The cytokine hormone leptin is a key signalling molecule in many pathways that control physiological functions. Although leptin demonstrates structural conservation in mammals, there is evidence of positive selection in primates, lagomorphs and ...
John A. Hammond (170370), Hall, Ailsa Jane, Chris Hauton, Hammond John A., Hammond, John Anthony, Hammond, John A., Ailsa J. Hall (29488), Hall Ailsa J., John A Hammond, Hauton Chris, Bennett, Kimberley A., Hall, Ailsa J., Ailsa J Hall, Kimberley A Bennett, Chris Hauton (170376), Bennett Kimberley A., Hauton, Chris, Kimberley A. Bennett (170381)   +17 more
core   +2 more sources

In vivo and ex vivo regulation of visfatin production by leptin in human and murine adipose tissue : role of mitogen-activated protein kinase and phosphatidylinositol 3-kinase signaling pathways [PDF]

, 2009
Visfatin is an adipogenic adipokine with increased levels in obesity, properties common to leptin. Thus, leptin may modulate visfatin production in adipose tissue (AT).
Brown, James, Clifford J. Bailey, Jing Chen, Bee K. Tan, Tan, Bee K., Bailey, C. J. (Clifford J.), Adya, Raghu, Randeva, Harpal S., Vinod Menon, James Brown, Hendrik Lehnert, Menon, Vinod, Raghu Adya, Manjunath Ramanjaneya, Harpal S. Randeva, Ramanjaneya, Manjunath, Chen, Jing, Lehnert, Hendrik   +17 more
core   +2 more sources

Leptin and Pro-Inflammatory Stimuli Synergistically Upregulate MMP-1 and MMP-3 Secretion in Human Gingival Fibroblasts [PDF]

, 2016
Introduction Gingival fibroblast-mediated extracellular matrix remodelling is implicated in the pathogenesis of periodontitis, yet the stimuli that regulate this response are not fully understood. The immunoregulatory adipokine leptin is detectable in
Andrew J Skelton, Todryk, Stephen M., Rowan, Andrew, Skelton, Andrew J., Skelton, Andrew J, Williams, Rachel C., Preshaw, Philip M.; id_orcid, Preshaw, Philip M, Taylor, John, Rowan, Andrew D., Skelton, Andrew, Preshaw, Philip, Taylor, John J, Taylor, John J., Todryk, Stephen, Philip M Preshaw, Todryk, Stephen M, Rachel C Williams, Stephen M Todryk, Williams, Rachel C, Andrew D Rowan, Rowan, Andrew D, John J Taylor   +22 more
core   +2 more sources

Impact of single nucleotide polymorphisms in leptin, leptin receptor, growth hormone receptor, and diacylglycerol acyltransferase (DGAT1) gene loci on milk production, feed, and body energy traits of UK dairy cows [PDF]

, 2008
The impact of 9 single nucleotide polymorphisms (SNP) in the leptin (LEP), leptin receptor (LEPR), growth hormone receptor (GHR), and diacylglycerol acyltransferase (DGAT1) gene loci on daily milk production, feed intake, and feed conversion, and weekly ...
Woodward, B. W., Forbes, A. B., Coffey, M. P., Banos, G., Woolliams, J. A.   +4 more
core   +1 more source

Differences in zinc status and the leptin axis in anorexic and recovered adolescents and young adults : a pilot study [PDF]

, 2012
Background: Evidence from animal studies suggests that leptin metabolism is associated with zinc (Zn) status. However, research investigating this relationship in adolescents and young adults with anorexia nervosa (AN) is scarce; the present study aims ...
Wöckel, Lars, Hintereder, Gudrun, F. Glass, Kratzsch, J., Wöckel, L., Sungurtekin, I., I. Sungurtekin, Sungurtekin, Idil, F.D. Zepf, Biskup, Caroline, Zepf, Florian Daniel, Kratzsch, Jürgen, L. Wöckel, Peetz, D., Elstrodt, L., Biskup, Caroline Sarah, Hintereder, G., Poustka, F., D. Peetz, Peetz, Dirk, C.S. Biskup, Glass, F., J. Kratzsch, Zepf, F. D., G. Hintereder, Biskup, C. S., Elstrodt, Linda, Glass, Franziska, F. Poustka, Zepf, FD, Poustka, Fritz, L. Elstrodt   +31 more
core   +1 more source

Leptin mediates the increase in blood pressure associated with obesity [PDF]

, 2014
Obesity is associated with increased blood pressure (BP), which in turn increases the risk of cardiovascular diseases. We found that the increase in leptin levels seen in diet-induced obesity (DIO) drives an increase in BP in rodents, an effect that was ...
Cowley, Michael A., Ravussin, E., Cowley, M., Elmquist, Joel K., Myers, M., Enriori, P., Spanswick, D., O’Rahilly, S. (Stephen), Myers, Martin G., Henning, Elana, Licinio, Julio, Simonds, Stephanie E., Greenway, Frank L., Simonds, S., Farooqi, I., Brown, Russell D., Allen, A., Brown, R., Spanswick, David C., Dileone, R., Farooqi, I. Sadaf, Allen, Andrew M., Elmquist, J., Bassi, J., O’Rahilly, Stephen, Keogh, Julia M., Keogh, J., Sternson, S., Myer, Martin G., Greenway, F., Licinio, J., Enriori, Pablo J., Pryor, J., Pryor, Jack T., Dileone, Ralph, Grove, Kevin L., O’Rahilly, S., Henning, E., Ravussin, Eric, Bassi, Jaspreet, Sternson, Scott M., Grove, K.   +41 more
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Leptin Receptor Blockade Attenuates Hypertension, but Does Not Affect Ventilatory Response to Hypoxia in a Model of Polygenic Obesity

Frontiers in Physiology, 2021
BackgroundObesity can cause hypertension and exacerbates sleep-disordered breathing (SDB). Leptin is an adipocyte-produced hormone, which increases metabolic rate, suppresses appetite, modulates control of breathing, and increases blood pressure.
Lenise J. Kim, Mi-Kyung Shin, Huy Pho, Laszlo Otvos, Laszlo Otvos, Laszlo Otvos, Sergio Tufik, Monica L. Andersen, Luu V. Pham, Vsevolod Y. Polotsky   +9 more
doaj   +1 more source

Leptin and Leptin Receptor Expression in the Rat Ovary [PDF]

Endocrinology, 2003
Leptin is an important satiety hormone and reproductive regulator and is found, along with its receptors, throughout the ovary. To date, the changes in ovarian expression of both of these proteins throughout the estrous cycle has not been studied, and the examination of protein expression has not distinguished between different forms of the receptor ...
Ryan, N., Van Der Hoek, K., Robertson, S., Norman, R.   +3 more
openaire   +3 more sources

Leptin induces IL-6 expression through OBRl receptor signaling pathway in human synovial fibroblasts. [PDF]

PLoS ONE, 2013
BACKGROUND: Leptin, an adipocyte-secreted hormone that centrally regulates weight control, may exert proinflammatory effects in the joint, depending on the immune response.
Wei-Hung Yang, Shan-Chi Liu, Chun-Hao Tsai, Yi-Chin Fong, Shoou-Jyi Wang, Yung-Sen Chang, Chih-Hsin Tang   +6 more
doaj   +1 more source