Results 41 to 50 of about 151,999 (312)

Leptin-dependent Phosphorylation of PTEN Mediates Actin Restructuring and Activation of ATP-sensitive K+ Channels [PDF]

, 2009
Leptin activates multiple signaling pathways in cells, including the phosphatidylinositol 3-kinase pathway, indicating a degree of cross-talk with insulin signaling. The exact mechanisms by which leptin alters this signaling pathway and how it relates to
Miller, L.C., Sutherland, C., Sutherland, Calum, Gallagher, J., Miller, Lisa C., Ashford, M.L.J., Ning, K., Laidlaw, Hilary A., Watterson, Kenneth R., Sutherland, Calum; id_orcid, Laidlaw, H.A., Ning, Ke, Ashford, Michael L. J.; id_orcid, Watterson, K.R., Gallagher, Jennifer, Ashford, Michael L.J.   +15 more
core   +1 more source

Multilevel regulation of leptin storage, turnover, and secretion by feeding and insulin in rat adipose tissue

Journal of Lipid Research, 2006
The mechanisms of the increased serum leptin in response to feeding are poorly understood. Therefore, we used metabolic labeling to directly assess leptin biosynthesis, secretion, and turnover in adipose tissue from 14 h-starved compared with fed 12–14 ...
Mi-Jeong Lee, Susan K. Fried
doaj   +1 more source

Role of leptin and leptin receptor in inflammation

American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 2003
on october 30th, 2002, the World Health Report by the World Health Organization was launched subtitled Reducing risks, promoting healthy life . Many of the health risks discussed in this report concern food consumption—either too little, in the case of the poor, or too much, in the case of ...
Halle, Martin, Persson, P. B.
openaire   +3 more sources

Phocid seal leptin: tertiary structure and hydrophobic receptor binding site preservation during distinct leptin gene evolution

, 2012
The cytokine hormone leptin is a key signalling molecule in many pathways that control physiological functions. Although leptin demonstrates structural conservation in mammals, there is evidence of positive selection in primates, lagomorphs and ...
John A. Hammond (170370), Hall, Ailsa Jane, Chris Hauton, Hammond John A., Hammond, John Anthony, Hammond, John A., Ailsa J. Hall (29488), Hall Ailsa J., John A Hammond, Hauton Chris, Bennett, Kimberley A., Hall, Ailsa J., Ailsa J Hall, Kimberley A Bennett, Chris Hauton (170376), Bennett Kimberley A., Hauton, Chris, Kimberley A. Bennett (170381)   +17 more
core   +1 more source

Thrifty metabolic programming in rats is induced by both maternal undernutrition and postnatal leptin treatment, but masked in the presence of both: implications for models of developmental programming. [PDF]

, 2014
BACKGROUND Maternal undernutrition leads to an increased risk of metabolic disorders in offspring including obesity and insulin resistance, thought to be due to a programmed thrifty phenotype which is inappropriate for a subsequent richer nutritional ...
Stewart Gilmour, Morris, Tiffany J., Vickers, Mark H., Nabeel A Affara, Gilmour, Stewart, Benjamin M Skinner, Sargent, Carole A., Mark H Vickers, Peter D Gluckman, Affara, Nabeel A., Ellis, Peter J.I., Skinner, Benjamin M., Peter JI Ellis, Tiffany J Morris, Carole A Sargent, Gluckman, Peter D.   +15 more
core   +1 more source

Impact of single nucleotide polymorphisms in leptin, leptin receptor, growth hormone receptor, and diacylglycerol acyltransferase (DGAT1) gene loci on milk production, feed, and body energy traits of UK dairy cows [PDF]

, 2008
The impact of 9 single nucleotide polymorphisms (SNP) in the leptin (LEP), leptin receptor (LEPR), growth hormone receptor (GHR), and diacylglycerol acyltransferase (DGAT1) gene loci on daily milk production, feed intake, and feed conversion, and weekly ...
Woodward, B. W., Forbes, A. B., Coffey, M. P., Banos, G., Woolliams, J. A.   +4 more
core   +1 more source

Photoperiod-Induced Increases in Bone Mineral Apposition Rate in Siberian Hamsters and the Involvement of Seasonal Leptin Changes

Frontiers in Endocrinology, 2017
The adipokine leptin regulates energy balance, appetite, and reproductive maturation. Leptin also acts on bone growth and remodeling, but both osteogenic and anti-osteogenic effects have been reported depending on experimental conditions.
Marie Kokolski, Francis J. Ebling, James R. Henstock, Susan I. Anderson   +3 more
doaj   +1 more source

The role of leptin in leptin resistance and obesity

Physiology & Behavior, 2006
Although the presence of hyperleptinemia with leptin resistance and obesity has long been recognized, a causal role of elevated leptin in these biological states remains unclear. This article summarizes some recent work from our laboratory supporting the concept that leptin, in and of itself, promotes leptin resistance and such resistance compounds the
Research Service, Department of Veterans Affairs Medical Center, Gainesville, FL 32608, United States ( host institution ), Zhang, Yi ( author ), Scarpace, Philip J. ( author )   +2 more
openaire   +3 more sources

The Effects of Laparoscopic Sleeve Gastrectomy on the Parameters of Leptin Resistance in Obesity

Biomolecules, 2019
Obesity is a growing public health problem worldwide. Bariatric surgical procedures achieve the most sustainable and efficacious outcomes in the treatment of morbid obesity.
Tagleb S. Mazahreh, Mahmoud Alfaqih, Rami Saadeh, Nabil A. Al-Zoubi, Moad Hatamleh, Ahmad Alqudah, Abdelwahab J. Aleshawi, Abdallah Alzoubi   +7 more
doaj   +1 more source

Kinetics of Leptin Binding to the Q223R Leptin Receptor

PLoS ONE, 2014
Studies in human populations and mouse models of disease have linked the common leptin receptor Q223R mutation to obesity, multiple forms of cancer, adverse drug reactions, and susceptibility to enteric and respiratory infections. Contradictory results cast doubt on the phenotypic consequences of this variant.
Verkerke, Hans, Naylor, Caitlin, Zabeau, Lennart, Tavernier, Jan, Petri, William A, Jr, Marie, Chelsea   +5 more
openaire   +4 more sources