Results 61 to 70 of about 242,212 (304)
Advanced Science, EarlyView.Plastin‐2 (PLS2) is identified as a dual‐function receptor on DCs that mediates both nanoparticle uptake and immunomodulation. A nanobody‐LNP platform is engineered to integrate antigen delivery with relicensing DCs. The therapeutic strategy elicits potent anti‐tumor T cell responses and leads to significant inhibition of established tumors in vivo ...
Shugang Qin +9 more
wiley +1 more source
Regulatory T cell proliferative potential as novel marker to investigate immune tolerance and clinical progression in Multiple Sclerosis [PDF]
, 2011 In autoimmune disorders such as Multiple Sclerosis (MS) one of the determining alteration is the breakdown of self-antigen immune-tolerance. Peripheral immune tolerance is maintained, at least in part, by Regulatory T cells (Treg).
Carbone, Fortunata
core +1 more source
Alzheimer's Disease Risk Factor APOE4 Exerts Dimorphic Effects on Female Bone
Advanced Science, EarlyView.In aging bone, osteocytes accumulate neurodegenerative risk factor Apolipoprotein E (APOE). A humanized version of the Alzheimer's disease risk allele APOE4 altered the mouse bone transcriptome and proteome, with effects in female bone surpassing the brain, including bone fragility due to suppressed osteocytic maintenance of bone quality, identifying ...
Charles A. Schurman +15 more
wiley +1 more source
ObesitiesLeptin is secreted by adipose tissue and expressed in several organs, including the placenta. We investigated the influence of leptin in maternal blood on leptin expression and concentration in the placenta and umbilical cord and its influence on fetal ...
Daniela G. M. Fonseca +5 more
doaj +1 more source
Serum lipid peroxidation and leptin levels in male and female type 2 diabetic patients in Gorgan (south east of Caspian Sea), Iran [PDF]
, 2009 Background: The aim of the present study was to determinate the possible relationship between serum leptin and lipid peroxidation in male and female type 2 diabetic patients in Gorgan, Iran.
Badeleh, M.T., Marjani, A., Veghari, G.
core
Annals of Gastroenterological Surgery, EarlyView.The present study aimed to investigate the relationship between changes in body weight and composition during chemoradiotherapy, such as the psoas muscle mass index, visceral fat index, and subcutaneous fat index obtained from computed tomography images, and long‐term outcomes in rectal cancer patients.
Shinya Abe +9 more
wiley +1 more source
Genomic and epigenomic mapping of leptin-responsive neuronal populations involved in body weight regulation. [PDF]
, 2019 Genome wide association studies (GWAS) in obesity have identified a large number of noncoding loci located near genes expressed in the central nervous system.
Ahituv, Nadav +6 more
core +1 more source
Animal models of NASH: getting both pathology and metabolic context right [PDF]
, 2015 Non-alcoholic fatty liver disease (NAFLD) is the most common cause of referral to liver clinics, and its progressive form, non-alcoholic steatohepatitis (NASH), can lead to cirrhosis and end-stage liver disease.
Larter, Claire Z., Yeh, Matthew M.
core +1 more source
Automating AI Discovery for Biomedicine Through Knowledge Graphs and Large Language Models Agents
Advanced Intelligent Discovery, EarlyView.This work proposes a novel framework that automates biomedical discovery by integrating knowledge graphs with multiagent large language models. A biologically aligned graph exploration strategy identifies hidden pathways between biomedical entities, and specialized agents use this pathway to iteratively design AI predictors and wet‐lab validation ...
Naafey Aamer +3 more
wiley +1 more source
Decreased leptin levels in antisocial personality disorder patients
Psychiatry and Clinical Psychopharmacology, 2021 Background: Leptin has attracted considerable interest in psychiatric disorders. It is expressed in the brain and an interaction between leptinergic and serotonergic systems has been demonstrated.
Recep Tutuncu +3 more
doaj +1 more source