Results 61 to 70 of about 186,310 (210)
Leptin and environmental temperature as determinants of bone marrow adiposity in female mice
Frontiers in Endocrinology, 2022 Bone marrow adipose tissue (BMAT) levels are higher in distal femur metaphysis of female mice housed at thermoneutral (32°C) than in mice housed at 22°C, as are abdominal white adipose tissue (WAT) mass, and serum leptin levels.
Russell T. Turner +8 more
doaj +1 more source
Obesity, Fat Mass and Immune System: Role for Leptin
Frontiers in Physiology, 2018 Obesity is an epidemic disease characterized by chronic low-grade inflammation associated with a dysfunctional fat mass. Adipose tissue is now considered an extremely active endocrine organ that secretes cytokine-like hormones, called adipokines, either ...
V. Francisco +7 more
semanticscholar +1 more source
Folia Histochemica et Cytobiologica, 2008 Leptin and its receptor may be engaged in pathogenesis of breast cancer among various human tumors. In vitro investigations showed leptin-mediated escalation of estrogen synthesis and boosted activity of estrogen receptor ERalpha.
Stanislaw Sulkowski +4 more
doaj +3 more sources
Adipocyte, 2018 Obesity is currently the most extended metabolic disturbance worldwide favoring the development of cardiometabolic alterations such as type 2 diabetes, hypertension, and dyslipidemia.
G. Frühbeck +3 more
semanticscholar +1 more source
European Journal of Medical Research, 2010 Leptin or obesity receptor (Ob-R) is a member of class I cytokine receptor family. Ob-R, expressed in six isoforms, is the product of alternative RNA splicing of db gene. According to its structural differences, the receptor's isoforms are divided into three classes: long, short, and secretory isoforms.
Elżbieta Hanna Górska +5 more
openaire +2 more sources
Discovery of the elusive leptin in birds: identification of several 'missing links' in the evolution of leptin and its receptor. [PDF]
PLoS ONE, 2014 Leptin is a pleiotropic protein best known for regulation of appetite and fat storage in mammals. While many leptin orthologs have been identified among vertebrates, an authentic leptin in birds has remained elusive and controversial.
Jeremy W Prokop +10 more
doaj +1 more source
Anales del Sistema Sanitario de Navarra, 2009 Obesity appears as a result of the balance between the individual's calorie consumption and energy expenditure. There are numerous neuroendocrinological factors responsible for regulating the energy metabolism; however, it was the discovery of the leptin that opened the way for numerous investigations destined to lay bare the mechanisms involved in ...
E, Simón, A S, Del Barrio
openaire +3 more sources
Cellular Physiology and Biochemistry, 2017 Background/Aims: Leptin is a hormone expressed by adipose tissue that regulates body energy homeostasis and weight loss by activating leptin receptors in the hypothalamus. Leptin receptors are also expressed in astrocytes.
Hyunju Park +4 more
doaj +1 more source
The cellular and molecular bases of leptin and ghrelin resistance in obesity
Nature Reviews Endocrinology, 2017 Obesity, a major risk factor for the development of diabetes mellitus, cardiovascular diseases and certain types of cancer, arises from a chronic positive energy balance that is often due to unlimited access to food and an increasingly sedentary ...
Huxing Cui, Miguel López, K. Rahmouni
semanticscholar +1 more source
Human Reproduction Update, 2000 Leptin, the product of the ob gene, is a small peptide molecule synthesized by white adipocytes with an important role in the regulation of body fat and food intake. Leptin and leptin receptor mRNA were first detected in the brain and hypothalamus but now their ubiquitous presence has been demonstrated.
R R, González +6 more
openaire +2 more sources