Results 51 to 60 of about 186,310 (210)

The role of leptin in leptin resistance and obesity

Physiology & Behavior, 2006
Although the presence of hyperleptinemia with leptin resistance and obesity has long been recognized, a causal role of elevated leptin in these biological states remains unclear. This article summarizes some recent work from our laboratory supporting the concept that leptin, in and of itself, promotes leptin resistance and such resistance compounds the
Research Service, Department of Veterans Affairs Medical Center, Gainesville, FL 32608, United States ( host institution ), Zhang, Yi ( author ), Scarpace, Philip J. ( author )   +2 more
openaire   +3 more sources

Pengaruh Leptin terhadap Kadar Interleukin 6 Serum Tikus yang Diberi Pakan Tinggi Lemak

Mutiara Medika, 2014
Pada keadaan obesitas, meningkatnya jumlah sel lemak merupakan salah satu penyebab meningkatnya sitokin proinflamasi seperti IL-6. Obesitas dapat dimulai dengan terjadinya resistensi leptin.
Daniel Setiawan, Soemardini Soemardini, Rasjad M. Indra   +2 more
doaj   +1 more source

Establishment of Leptin-Responsive Cell Lines from Adult Mouse Hypothalamus. [PDF]

PLoS ONE, 2016
Leptin resistance is considered to be the primary cause of obesity. However, the cause of leptin resistance remains incompletely understood, and there is currently no cure for the leptin-resistant state.
Hiroshi Iwakura, Katsuko Dote, Mika Bando, Hiroyuki Koyama, Kiminori Hosoda, Kenji Kangawa, Kazuwa Nakao   +6 more
doaj   +1 more source

Kinetics of Leptin Binding to the Q223R Leptin Receptor

PLoS ONE, 2014
Studies in human populations and mouse models of disease have linked the common leptin receptor Q223R mutation to obesity, multiple forms of cancer, adverse drug reactions, and susceptibility to enteric and respiratory infections. Contradictory results cast doubt on the phenotypic consequences of this variant.
Verkerke, Hans, Naylor, Caitlin, Zabeau, Lennart, Tavernier, Jan, Petri, William A, Jr, Marie, Chelsea   +5 more
openaire   +4 more sources

Leptin, soluble leptin receptor, and free leptin index in patients with metabolic syndrome

Ожирение и метаболизм, 2017
Aim. To assess the levels of leptin, its soluble receptor, and index of the formation of free leptin in metabolic syndrome (MS). Materials and methods. The study included 110 individuals with obesity and overweight.
Elena N. Smirnova, Sofia G. Shulkina
doaj   +1 more source

Role of Leptin in Cardiovascular Diseases

Frontiers in Endocrinology, 2020
The adipocyte-derived adipokine leptin exerts pleiotropic effects, which are essential for the regulation of energy balance and cell metabolism, for controlling inflammatory and immune responses, and for the maintenance of homeostasis of the ...
M. Poetsch, A. Strano, K. Guan
semanticscholar   +1 more source

The Potential Role of Leptin in the Regulation of Maternal Weight during Pregnancy and Its Impact on Neonate Weight and Apgar

Obesities
Leptin is secreted by adipose tissue and expressed in several organs, including the placenta. We investigated the influence of leptin in maternal blood on leptin expression and concentration in the placenta and umbilical cord and its influence on fetal ...
Daniela G. M. Fonseca, Maria-Carmen N. Souza-Carmo, Raquel N. Ruas, Solange S. Pereira, Lílian Goncalves Teixeira, e Jacqueline I. Alvarez-Leite   +5 more
doaj   +1 more source

Acute leptin deficiency, leptin resistance, and the physiologic response to leptin withdrawal [PDF]

Proceedings of the National Academy of Sciences, 2005
Food restriction and weight loss result in reduced plasma leptin, which is associated with a pleiotropic biologic response. However, because weight loss itself is also associated with changes in numerous other humoral and metabolic signals, it can be difficult to determine the precise features of the biologic response to acute leptin deficiency.
Jason M, Montez, Alex, Soukas, Esra, Asilmaz, Gulnorakhon, Fayzikhodjaeva, Giamila, Fantuzzi, Jeffrey M, Friedman   +5 more
openaire   +2 more sources

Cardiac leptin overexpression in the context of acute MI and reperfusion potentiates myocardial remodeling and left ventricular dysfunction. [PDF]

PLoS ONE, 2018
BACKGROUND:Acute MI induces leptin expression in the heart, however the role of myocardial leptin in cardiac ischemia and reperfusion (IR) remains unknown.
David Kain, Amos J Simon, Avraham Greenberg, Danny Ben Zvi, Boris Gilburd, Jacob Schneiderman   +5 more
doaj   +1 more source

Decreased leptin levels in antisocial personality disorder patients

Psychiatry and Clinical Psychopharmacology, 2021
Background: Leptin has attracted considerable interest in psychiatric disorders. It is expressed in the brain and an interaction between leptinergic and serotonergic systems has been demonstrated.
Recep Tutuncu, Huseyin Gunay, Hakan Balibey, Dilek Abaslı   +3 more
doaj   +1 more source