Obesity Induces Hypothalamic Endoplasmic Reticulum Stress and Impairs Proopiomelanocortin (POMC) Post-translational Processing [PDF]
, 2013 It was shown previously that abnormal prohormone processing or inactive proconverting enzymes that are responsible for this processing cause profound obesity.
Cakir, Isin +6 more
core +1 more source
The Effects of Laparoscopic Sleeve Gastrectomy on the Parameters of Leptin Resistance in Obesity
Biomolecules, 2019 Obesity is a growing public health problem worldwide. Bariatric surgical procedures achieve the most sustainable and efficacious outcomes in the treatment of morbid obesity.
Tagleb S. Mazahreh +7 more
doaj +1 more source
Leptin and leptin receptor expression in asthma [PDF]
Journal of Allergy and Clinical Immunology, 2009 The adipokine leptin is a potential new mediator for bronchial epithelial homeostasis. Asthma is a chronic inflammatory disease characterized by airway remodeling that might affect disease chronicity and severity. TGF-beta is a tissue growth factor the dysregulation of which is associated with airway remodeling.We sought to determine whether a ...
Andreina, Bruno +9 more
openaire +2 more sources
Pengaruh Leptin terhadap Kadar Interleukin 6 Serum Tikus yang Diberi Pakan Tinggi Lemak
Mutiara Medika, 2014 Pada keadaan obesitas, meningkatnya jumlah sel lemak merupakan salah satu penyebab meningkatnya sitokin proinflamasi seperti IL-6. Obesitas dapat dimulai dengan terjadinya resistensi leptin.
Daniel Setiawan +2 more
doaj +1 more source
The associations of adipokines with selected markers of the renin-angiotensinogen-aldosterone system: the multi-ethnic study of atherosclerosis. [PDF]
, 2015 Among obese individuals, increased sympathetic nervous system (SNS) activity results in increased renin and aldosterone production, as well as renal tubular sodium reabsorption.
Allison, MA +4 more
core +3 more sources
Bace1-dependent amyloid processing regulates hypothalamic leptin sensitivity in obese mice [PDF]
, 2018 We thank AstraZeneca for providing AZ-4217, Mark Smith (Imperial College, London) and Yuchio Yanagawa (Gunma University, Maebashi) for VGlut2-GFP and GAD67-GFP tissue, respectively.
Allsop, David J. P. +15 more
core +5 more sources
Advanced Healthcare Materials, EarlyView.Engineered microparticle topographies direct human mesenchymal stem cell osteogenesis without biochemical additives. This osteogenic commitment is driven by canonical Hedgehog signaling and followed by temporal IGF‐II engagement. Two‐photon polymerization demonstrates spatial control, enabling the engineering of topographical gradients that pattern ...
Fatmah I. Ghuloum +5 more
wiley +1 more source
Leptin, soluble leptin receptor, and free leptin index in patients with metabolic syndrome
Ожирение и метаболизм, 2017 Aim. To assess the levels of leptin, its soluble receptor, and index of the formation of free leptin in metabolic syndrome (MS). Materials and methods. The study included 110 individuals with obesity and overweight.
Elena N. Smirnova, Sofia G. Shulkina
doaj +1 more source
Advanced Science, EarlyView.We demonstrate that Cars2, a cysteine catabolic enzyme in mouse iBAT, is critical for cold tolerance and brown adipocyte differentiation. Through its CPERS activity, Cars2 produces CysSSH/H2S to induce EBF2 persulfidation, promoting its interaction with PPARγ and BRG1 to enhance thermogenic gene expression.
Xin Peng +8 more
wiley +1 more source
Cardiac leptin overexpression in the context of acute MI and reperfusion potentiates myocardial remodeling and left ventricular dysfunction. [PDF]
PLoS ONE, 2018 BACKGROUND:Acute MI induces leptin expression in the heart, however the role of myocardial leptin in cardiac ischemia and reperfusion (IR) remains unknown.
David Kain +5 more
doaj +1 more source