Results 51 to 60 of about 151,999 (312)

Pregnancy glycaemia and cord-blood levels of insulin and leptin in Pakistani and white British mother-offspring pairs:findings from a prospective pregnancy cohort [PDF]

, 2014
AIMS/HYPOTHESIS: To determine the extent to which gestational fasting and postload levels of glucose explain differences in infant fat mass between UK-born Pakistani and white British infants.METHODS: Analyses were undertaken in a prospective pregnancy ...
Bhopal, Raj S, Bhopal, RS, Tuffnell, Derek, Bhopal, Raj S., West, J, Nelson, Scott M., Freeman, Dilys J., Sattar, N, Fairley, L, Freeman, DJ, John Wright, Lawlor, Debbie A, Nelson, SM, Dilys J. Freeman, Debbie A. Lawlor, Freeman, Dilys J, Wright, John, Whitelaw, Donald C., Lesley Fairley, Whitelaw, DC, Fairley, Lesley, Sattar, Naveed, Nelson, Scott M, Jane West, Whitelaw, Donald C, Lawlor, Debbie A., Derek Tuffnell, Scott M. Nelson, Raj S. Bhopal, Donald C. Whitelaw, Naveed Sattar, Lawlor, DA, Wright, J, Tuffnell, D, West, Jane   +34 more
core   +1 more source

Leptin, soluble leptin receptor, and free leptin index in patients with metabolic syndrome

Ожирение и метаболизм, 2017
Aim. To assess the levels of leptin, its soluble receptor, and index of the formation of free leptin in metabolic syndrome (MS). Materials and methods. The study included 110 individuals with obesity and overweight.
Elena N. Smirnova, Sofia G. Shulkina
doaj   +1 more source

Establishment of Leptin-Responsive Cell Lines from Adult Mouse Hypothalamus. [PDF]

PLoS ONE, 2016
Leptin resistance is considered to be the primary cause of obesity. However, the cause of leptin resistance remains incompletely understood, and there is currently no cure for the leptin-resistant state.
Hiroshi Iwakura, Katsuko Dote, Mika Bando, Hiroyuki Koyama, Kiminori Hosoda, Kenji Kangawa, Kazuwa Nakao   +6 more
doaj   +1 more source

Leptin receptors [PDF]

European Journal of Medical Research, 2010
Leptin or obesity receptor (Ob-R) is a member of class I cytokine receptor family. Ob-R, expressed in six isoforms, is the product of alternative RNA splicing of db gene. According to its structural differences, the receptor's isoforms are divided into three classes: long, short, and secretory isoforms.
Gorska, E, Popko, K, Stelmaszczyk-Emmel, A, Ciepiela, O, Kucharska, A, Wasik, M   +5 more
openaire   +2 more sources

Adipocyte‐Derived Leptolin Enhances Energy Expenditure and Prevents Obesity

Advanced Science, EarlyView.
We identified a novel adipokine, which we named leptolin. In humans, leptolin levels in white adipose tissue were positively correlated with exercise and negatively associated with body mass index. We observed elevated leptolin in serum from athletes and lower leptolin in serum from obese individuals.
Jiarui Liu, Bingwei Wang, Zhijie Su, Xiaoxv Han, Miao He, Yun Zhao, Yujia Hou, Daotong Li, Weiguang Zhang, Lihua Qin, Ke Wang, Yanchun Li, Yi Yan, Siwang Yu, Xiaoshuai Huang, Tairan Yuwen, Jianyuan Luo, Ruimao Zheng   +17 more
wiley   +1 more source

Pengaruh Leptin terhadap Kadar Interleukin 6 Serum Tikus yang Diberi Pakan Tinggi Lemak

Mutiara Medika, 2014
Pada keadaan obesitas, meningkatnya jumlah sel lemak merupakan salah satu penyebab meningkatnya sitokin proinflamasi seperti IL-6. Obesitas dapat dimulai dengan terjadinya resistensi leptin.
Daniel Setiawan, Soemardini Soemardini, Rasjad M. Indra   +2 more
doaj   +1 more source

A Nanobody‐LNP Platform for Targeting and Relicensing Dendritic Cells for Potent Cancer Immunotherapy

Advanced Science, EarlyView.
Plastin‐2 (PLS2) is identified as a dual‐function receptor on DCs that mediates both nanoparticle uptake and immunomodulation. A nanobody‐LNP platform is engineered to integrate antigen delivery with relicensing DCs. The therapeutic strategy elicits potent anti‐tumor T cell responses and leads to significant inhibition of established tumors in vivo ...
Shugang Qin, Zhiying Huang, Hai Huang, Yupei Zhang, Yuting Chen, Xi He, Zhenyi Niu, Zhongzheng Xiang, Chaoyu Zou, Xiangrong Song   +9 more
wiley   +1 more source

Do ethnic differences in cord blood leptin levels differ by birthweight category? Findings from the Born in Bradford cohort study. [PDF]

, 2014
BACKGROUND: There is evidence that South Asian individuals have higher fat mass for a given weight than Europeans. One study reported that the greater fatness for a given birthweight may increase with increasing birth weight, suggesting that any attempt ...
Wright, John, West, J, Wright, J., Lawlor, D., Sattar, N, Fairley, Lesley, Sattar, Naveed, Whincup, Petter, Sattar, N., Whincup, P., Fairley, L, Whincup, P, Lawlor, Debbie A., Lawlor, DA, West, J., Wright, J, West, Jane, Fairley, L.   +17 more
core   +1 more source

T‐Cell Exhaustion in the Tumor Microenvironment: Subcellular Dysfunction, Pan‐Cancer Characteristics, and Therapeutic Interventions

Advanced Science, EarlyView.
This study elucidates the mechanisms of subcellular multidimensional collapse in exhausted T cells. By specifically targeting the nucleus, mitochondria, and endoplasmic reticulum, strategic interventions can effectively remodel the compromised organelle network. This integrated approach drives comprehensive T cell resuscitation, ultimately establishing
Mingxing Wang, Wanhui Dong, Jian Chen, Zhangjie Zhou, Shujuan Fu, Tingting Wu, Haiyan Jiang, Zhiying Wang, Zhixian Zhong, Yi Zhong   +9 more
wiley   +1 more source

SuFEx‐Enabled Reprogramming of Flavonoids for Selective α‐Glucosidase Covalent Inhibition

Advanced Science, EarlyView.
Selective inhibition of intestinal α‐glucosidase remains limited by poor enzyme specificity and off‐target metabolic effects. Here, SuFEx click chemistry is used to reprogram natural flavonoids into covalent inhibitors with enhanced α‐glucosidase selectivity and controlled reactivity. This strategy enables effective regulation of carbohydrate digestion
Fengyu Guo, Liwei Zhang, Minlong Wang, Yanjin Du, Tianyu Zhang, Hao Chen, Jiazeng Sun, Yang Yu, Zude He, Jie An, Xiaoxu Zhang, Weilin Lin, Fazheng Ren, Pengjie Wang, Ping Liu   +14 more
wiley   +1 more source