Results 31 to 40 of about 186,310 (210)
STAT3 phosphorylation in central leptin resistance
Nutrition & Metabolism, 2021 Mechanism exploitation of energy homeostasis is urgently required because of the worldwide prevailing of obesity-related metabolic disorders in human being.
Huimin Liu +3 more
doaj +1 more source
Leptin resistance: underlying mechanisms and diagnosis
Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy, 2019 Leptin and its receptors have been identified as key regulators of body weight and energy homeostasis. A decrease in tissue sensitivity to leptin leads to the development of obesity and metabolic disorders, such as insulin resistance and dyslipidemia ...
O. Gruzdeva +4 more
semanticscholar +1 more source
The Neuronal Actions of Leptin and the Implications for Treating Alzheimer’s Disease
Pharmaceuticals, 2021 It is widely accepted that the endocrine hormone leptin controls food intake and energy homeostasis via activation of leptin receptors expressed on hypothalamic arcuate neurons.
Kirsty Hamilton, Jenni Harvey
doaj +1 more source
Role of Leptin in Inflammation and Vice Versa
International Journal of Molecular Sciences, 2020 Inflammation is an essential immune response for the maintenance of tissue homeostasis. In a general sense, acute and chronic inflammation are different types of adaptive response that are called into action when other homeostatic mechanisms are ...
A. Pérez-Pérez +3 more
semanticscholar +1 more source
Leptin resensitisation: a reversion of leptin-resistant states [PDF]
Journal of Endocrinology, 2019 Leptin resistance refers to states in which leptin fails to promote its anticipated effects, frequently coexisting with hyperleptinaemia. Leptin resistance is closely associated with obesity and also observed in physiological situations such as pregnancy and in seasonal animals.
Andreoli, Maria Florencia +3 more
openaire +4 more sources
A theory that predicts behaviors of disordered cytoskeletal networks
Molecular Systems Biology, 2017 Morphogenesis in animal tissues is largely driven by actomyosin networks, through tensions generated by an active contractile process. Although the network components and their properties are known, and networks can be reconstituted in vitro, the ...
Julio M Belmonte +2 more
doaj +1 more source
Aberrant miR-874-3p/leptin/EGFR/c-Myc signaling contributes to nasopharyngeal carcinoma pathogenesis
Journal of Experimental & Clinical Cancer Research, 2022 Background Leptin is important in physiological and pathological functions in various cancers, however, the significance and mechanisms of leptin in nasopharyngeal carcinoma remain ambiguous.
Sheng-Dean Luo +7 more
doaj +1 more source
Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus
Nature, 2001 The administration of leptin to leptin-deficient humans, and the analogous Lepob/Lepob mice, effectively reduces hyperphagia and obesity. But common obesity is associated with elevated leptin, which suggests that obese humans are resistant to this ...
M. Cowley +7 more
semanticscholar +1 more source
Molecular Metabolism, 2018 Objective: The inability of leptin to suppress food intake in diet-induced obesity, sometimes referred to as leptin resistance, is associated with several distinct pathological hallmarks.
Maximilian Kleinert +5 more
doaj +1 more source
Leptin revisited: The role of leptin in starvation [PDF]
Molecular & Cellular Oncology, 2018 Starvation causes reductions in plasma leptin concentrations, but the physiologic impact of this observation had not been documented in the starved state. Here we discuss our recent work demonstrating that hypoleptinemia activates the hypothalamic-pituitary-adrenal (HPA) axis, increasing white adipose tissue (WAT) lipolysis and mediating a shift from ...
openaire +3 more sources