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Leptin signaling and leptin resistance [PDF]
Medical Review, 2022 With the prevalence of obesity and associated comorbidities, studies aimed at revealing mechanisms that regulate energy homeostasis have gained increasing interest. In 1994, the cloning of leptin was a milestone in metabolic research. As an adipocytokine,
Liu Jiarui +3 more
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STAT3 phosphorylation in central leptin resistance [PDF]
Nutrition & Metabolism, 2021 Mechanism exploitation of energy homeostasis is urgently required because of the worldwide prevailing of obesity-related metabolic disorders in human being.
Huimin Liu +3 more
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Leptin resistance: underlying mechanisms and diagnosis [PDF]
Diabetes, Metabolic Syndrome and Obesity, 2019 Olga Gruzdeva,1,2 Daria Borodkina,3 Evgenya Uchasova,1 Yulia Dyleva,1 Olga Barbarash1,2 1Federal State Budgetary Institution, Research Institute for Complex Issues of Cardiovascular Diseases, Kemerovo, Russian Federation; 2Federal State Budget ...
Gruzdeva O +4 more
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Leptin signaling and leptin resistance [PDF]
Frontiers of Medicine, 2013 Leptin is secreted into the bloodstream by adipocytes and is required for the maintenance of energy homeostasis and body weight. Leptin deficiency or genetic defects in the components of the leptin signaling pathways cause obesity. Leptin controls energy balance and body weight mainly through leptin receptor b (LEPRb)-expressing neurons in the brain ...
Liangyou Rui +2 more
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Leptin and leptin resistance in obesity: current evidence, mechanisms and future directions [PDF]
Endocrine ConnectionsLeptin, a key adipokine regulating energy homeostasis, has been extensively studied for its potential in the management of obesity. However, its therapeutic efficacy is often limited due to leptin resistance.
Wenjing Hu, Huijuan Zhu, Fengying Gong
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Hippocampal Leptin Resistance and Cognitive Decline: Mechanisms, Therapeutic Strategies and Clinical Implications [PDF]
BiomedicinesBackground: Leptin, an adipokine essential for regulating energy balance, exerts important effects on brain function, notably within the hippocampus, a region integral to learning and memory.
Ismael Valladolid-Acebes
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The Effects of Laparoscopic Sleeve Gastrectomy on the Parameters of Leptin Resistance in Obesity [PDF]
Biomolecules, 2019 Obesity is a growing public health problem worldwide. Bariatric surgical procedures achieve the most sustainable and efficacious outcomes in the treatment of morbid obesity.
Tagleb S. Mazahreh +7 more
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The role of leptin in leptin resistance and obesity
Physiology and Behavior, 2006 Although the presence of hyperleptinemia with leptin resistance and obesity has long been recognized, a causal role of elevated leptin in these biological states remains unclear. This article summarizes some recent work from our laboratory supporting the concept that leptin, in and of itself, promotes leptin resistance and such resistance compounds the
Philip J Scarpace
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Hyperleptinemia is required for the development of leptin resistance. [PDF]
PLoS ONE, 2010 Leptin regulates body weight by signaling to the brain the availability of energy stored as fat. This negative feedback loop becomes disrupted in most obese individuals, resulting in a state known as leptin resistance.
Zachary A Knight +3 more
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Leptin receptor action and mechanisms of leptin resistance [PDF]
Cellular and Molecular Life Sciences, 2005 The adipose tissue-derived hormone leptin regulates energy balance and neuroendocrine function. Resistance to the appetite-suppressing effects of leptin is associated with common forms of obesity. Here, we review the mechanisms by which leptin activates intracellular signals and the roles that these signals play in leptin action in vivo.
Martin Myers
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