Results 21 to 30 of about 74,494 (249)

Leptin resensitisation: a reversion of leptin-resistant states [PDF]

Journal of Endocrinology, 2019
Leptin resistance refers to states in which leptin fails to promote its anticipated effects, frequently coexisting with hyperleptinaemia. Leptin resistance is closely associated with obesity and also observed in physiological situations such as pregnancy and in seasonal animals.
Andreoli, Maria Florencia, Donato, Jose, Cakir, Isin, Perelló, Mario Carlos   +3 more
openaire   +4 more sources

The Phlorotannin-Rich Fraction of Ecklonia cava Extract Attenuated the Expressions of the Markers Related with Inflammation and Leptin Resistance in Adipose Tissue

International Journal of Endocrinology, 2020
Obesity is associated with systemic chronic inflammation, and it induces central leptin resistance which blocks the appetite-suppressing effect of leptin and leptin resistance in adipocytes. In the present study, we evaluated the effects of Ecklonia cava
Myeongjoo Son, Seyeon Oh, Junwon Choi, Ji Tae Jang, Chang Hu Choi, Kook Yang Park, Kuk Hui Son, Kyunghee Byun   +7 more
doaj   +1 more source

Postnatal growth after intrauterine growth restriction alters central leptin signal and energy homeostasis. [PDF]

PLoS ONE, 2012
Intrauterine growth restriction (IUGR) is closely linked with metabolic diseases, appetite disorders and obesity at adulthood. Leptin, a major adipokine secreted by adipose tissue, circulates in direct proportion to body fat stores, enters the brain and ...
Bérengère Coupé, Isabelle Grit, Philippe Hulin, Gwenaëlle Randuineau, Patricia Parnet   +4 more
doaj   +1 more source

Acute leptin deficiency, leptin resistance, and the physiologic response to leptin withdrawal [PDF]

Proceedings of the National Academy of Sciences, 2005
Food restriction and weight loss result in reduced plasma leptin, which is associated with a pleiotropic biologic response. However, because weight loss itself is also associated with changes in numerous other humoral and metabolic signals, it can be difficult to determine the precise features of the biologic response to acute leptin deficiency.
Jason M, Montez, Alex, Soukas, Esra, Asilmaz, Gulnorakhon, Fayzikhodjaeva, Giamila, Fantuzzi, Jeffrey M, Friedman   +5 more
openaire   +2 more sources

Recent evidence in support of traditional chinese medicine to restore normal leptin function in simple obesity

Heliyon, 2022
Reducing the incidence of obesity is the focus of global attention, and traditional Chinese medicine (TCM) may play an important role in achieving this goal. Numerous studies have shown that most individuals with obesity have leptin resistance, exogenous
Jialin Shao, Chen Li, Litao Bai, Xiaolin Ni, Shaoqin Ge, Jinghui Zhang, Hanqing Zhao   +6 more
doaj   +1 more source

Lipocalin‐2 activates hepatic stellate cells and promotes nonalcoholic steatohepatitis in high‐fat diet–fed Ob/Ob mice

Hepatology, EarlyView., 2022
Graphical summary of obesity‐induced NASH progression by LCN2 targeted to HSC activation. Abstract Background and Aims In obesity and type 2 diabetes mellitus, leptin promotes insulin resistance and contributes to the progression of NASH via activation of hepatic stellate cells (HSCs).
Kyung Eun Kim, Jaewoong Lee, Hyun Joo Shin, Eun Ae Jeong, Hye Min Jang, Yu Jeong Ahn, Hyeong Seok An, Jong Youl Lee, Meong Cheol Shin, Soo Kyoung Kim, Won Gi Yoo, Won Ho Kim, Gu Seob Roh   +12 more
wiley   +1 more source

Time-resolved hypothalamic open flow micro-perfusion reveals normal leptin transport across the blood–brain barrier in leptin resistant mice

Molecular Metabolism, 2018
Objective: The inability of leptin to suppress food intake in diet-induced obesity, sometimes referred to as leptin resistance, is associated with several distinct pathological hallmarks.
Maximilian Kleinert, Petra Kotzbeck, Thomas Altendorfer-Kroath, Thomas Birngruber, Matthias H. Tschöp, Christoffer Clemmensen   +5 more
doaj   +1 more source

Concordance of bioactive vs. total immunoreactive serum leptin levels in children with severe early onset obesity. [PDF]

PLoS ONE, 2017
Leptin secreted from adipose tissue signals peripheral energy status to the brain. Monogenic leptin deficiency results in severe early onset obesity with hyperphagia.
Juraj Stanik, Jürgen Kratzsch, Kathrin Landgraf, Kathrin Scheuermann, Ulrike Spielau, Ruth Gausche, Daniela Gasperikova, Wieland Kiess, Antje Körner   +8 more
doaj   +1 more source

Association of Leptin and Leptin receptor Gene polymorphisms with Insulin resistance in pregnant women: A cross-sectional study [version 2; peer review: 2 approved]

F1000Research, 2022
Introduction: Leptin is an adipokine hormone that regulates insulin sensitivity and lipid profile, which may contribute to complications like gestational diabetes.The goal of the study was to examine if there was a link between the leptin (LEP)/leptin ...
Usha Adiga, Tirthal Rai, Nandit Banawalikar   +2 more
doaj   +1 more source

Conjugated linoleic acid fails to worsen insulin resistance but induces hepatic steatosis in the presence of leptin in ob/ob mice

Journal of Lipid Research, 2008
Conjugated linoleic acid (CLA) induces insulin resistance preceded by rapid depletion of the adipokines leptin and adiponectin, increased inflammation, and hepatic steatosis in mice.
Angela A. Wendel, Aparna Purushotham, Li-Fen Liu, Martha A. Belury   +3 more
doaj   +1 more source