The Effects of Laparoscopic Sleeve Gastrectomy on the Parameters of Leptin Resistance in Obesity. [PDF]
Biomolecules, 2019 Obesity is a growing public health problem worldwide. Bariatric surgical procedures achieve the most sustainable and efficacious outcomes in the treatment of morbid obesity.
Mazahreh TS +7 more
europepmc +2 more sources
Establishment of Leptin-Responsive Cell Lines from Adult Mouse Hypothalamus. [PDF]
PLoS ONE, 2016 Leptin resistance is considered to be the primary cause of obesity. However, the cause of leptin resistance remains incompletely understood, and there is currently no cure for the leptin-resistant state.
Hiroshi Iwakura +6 more
doaj +1 more source
The Leptin System and Diet: A Mini Review of the Current Evidence
Frontiers in Endocrinology, 2021 Leptin promotes satiety and modulates energy balance and weight. Diet-induced obesity leads to leptin resistance, exacerbating overeating. We reviewed the literature on the relationship between diet and leptin, which suggests that addressing leptin ...
Kenny Mendoza-Herrera +6 more
doaj +1 more source
Leptin resensitisation: a reversion of leptin-resistant states [PDF]
Journal of Endocrinology, 2019 Leptin resistance refers to states in which leptin fails to promote its anticipated effects, frequently coexisting with hyperleptinaemia. Leptin resistance is closely associated with obesity and also observed in physiological situations such as pregnancy and in seasonal animals.
Andreoli, Maria Florencia +3 more
openaire +4 more sources
Sildenafil ameliorates leptin resistance and normalizes lipid handling in the hypothalamic and adipose tissues of testosterone-exposed pregnant rats. [PDF]
Heliyon, 2021 Leptin and hypothalamic-adipose lipid handling are relevant in determining the shift of metabolic activities. There are scanty findings connecting glucose dysregulation as a result of hyperandrogenism during gestation to hypothalamic-adipose axis and ...
Areola ED +9 more
europepmc +2 more sources
International Journal of Endocrinology, 2020 Obesity is associated with systemic chronic inflammation, and it induces central leptin resistance which blocks the appetite-suppressing effect of leptin and leptin resistance in adipocytes. In the present study, we evaluated the effects of Ecklonia cava
Myeongjoo Son +7 more
doaj +1 more source
Phocid seal leptin: tertiary structure and hydrophobic receptor binding site preservation during distinct leptin gene evolution [PDF]
, 2012 The cytokine hormone leptin is a key signalling molecule in many pathways that control physiological functions. Although leptin demonstrates structural conservation in mammals, there is evidence of positive selection in primates, lagomorphs and ...
John A. Hammond (170370) +17 more
core +2 more sources
Obesity and the ageing brain : could leptin play a role in neurodegeneration? [PDF]
, 2011 Obesity and ageing are both characteristics of the human population that are on the increase across the globe. It has long been established that ageing is the major risk factor for neurodegenerative conditions such as Alzheimer’s disease, and it is ...
G. H. Doherty, Doherty, Gayle Helane
core +1 more source
Postnatal growth after intrauterine growth restriction alters central leptin signal and energy homeostasis. [PDF]
PLoS ONE, 2012 Intrauterine growth restriction (IUGR) is closely linked with metabolic diseases, appetite disorders and obesity at adulthood. Leptin, a major adipokine secreted by adipose tissue, circulates in direct proportion to body fat stores, enters the brain and ...
Bérengère Coupé +4 more
doaj +1 more source
Heliyon, 2022 Reducing the incidence of obesity is the focus of global attention, and traditional Chinese medicine (TCM) may play an important role in achieving this goal. Numerous studies have shown that most individuals with obesity have leptin resistance, exogenous
Jialin Shao +6 more
doaj +1 more source