Results 41 to 50 of about 80,968 (287)

Phocid seal leptin: tertiary structure and hydrophobic receptor binding site preservation during distinct leptin gene evolution

, 2012
The cytokine hormone leptin is a key signalling molecule in many pathways that control physiological functions. Although leptin demonstrates structural conservation in mammals, there is evidence of positive selection in primates, lagomorphs and ...
John A. Hammond (170370), Hall, Ailsa Jane, Chris Hauton, Hammond John A., Hammond, John Anthony, Hammond, John A., Ailsa J. Hall (29488), Hall Ailsa J., John A Hammond, Hauton Chris, Bennett, Kimberley A., Hall, Ailsa J., Ailsa J Hall, Kimberley A Bennett, Chris Hauton (170376), Bennett Kimberley A., Hauton, Chris, Kimberley A. Bennett (170381)   +17 more
core   +1 more source

Glucocorticoids as Counterregulatory Hormones of Leptin: Toward an Understanding of Leptin Resistance [PDF]

Diabetes, 1997
The product of the ob gene, leptin, is a hormone secreted by adipose tissue that acts in the hypothalamus to regulate the size of the body fat depot. Its central administration has been shown to decrease food intake and body weight, while favoring energy dissipation.
Zakrzewska KE, Cusin I, Sainsbury A, Rohner-Jeanrenaud F, Jeanrenaud B   +4 more
openaire   +3 more sources

Association of 25 (OH) Vitamin D and leptin in individuals with insulin resistance

Indian Journal of Endocrinology and Metabolism, 2022
Introduction: Asian-Indian individuals with diabetes have been shown to have low vitamin D levels. Whether this hypovitamonisis D is associated with hyperleptinaemia is unclear.
S V Madhu, M Aslam, B K Mishra, A Gupta, Rajat Jhamb   +4 more
doaj   +1 more source

Thrifty metabolic programming in rats is induced by both maternal undernutrition and postnatal leptin treatment, but masked in the presence of both: implications for models of developmental programming. [PDF]

, 2014
BACKGROUND Maternal undernutrition leads to an increased risk of metabolic disorders in offspring including obesity and insulin resistance, thought to be due to a programmed thrifty phenotype which is inappropriate for a subsequent richer nutritional ...
Stewart Gilmour, Morris, Tiffany J., Vickers, Mark H., Nabeel A Affara, Gilmour, Stewart, Benjamin M Skinner, Sargent, Carole A., Mark H Vickers, Peter D Gluckman, Affara, Nabeel A., Ellis, Peter J.I., Skinner, Benjamin M., Peter JI Ellis, Tiffany J Morris, Carole A Sargent, Gluckman, Peter D.   +15 more
core   +1 more source

Leptin Resistance and the Neuro-Adipose Connection [PDF]

Frontiers in Endocrinology, 2017
This article was submitted to Cellular Endocrinology, a section of the journal Frontiers in Endocrinology.
Barateiro, A, Mahú, I, Domingos, A
openaire   +3 more sources

Adipokines and redox signaling: impact on fatty liver disease. [PDF]

, 2011
Adipokines (adipose tissue cytokines) are polypeptide factors secreted by adipose tissue in a highly regulated manner. The 'classical' adipokines (leptin, adiponectin, and resistin) are expressed only by adipocytes, but other adipokines have been shown ...
Marra, Fabio., Parola, Maurizio, Parola, Maurizio.   +2 more
core   +1 more source

Insulin resistance, leptin and adiponectin in lean and hypothyroid children and adolescents with obesity

BMC Pediatrics, 2022
Background Obesity usually complicates hypothyroidism. Adipokines like leptin and adiponectin secreted by adipose tissue modulate insulin resistance (IR), appetite, and obesity.
Doaa El Amrousy, Dalia El-Afify, Shaimaa Salah   +2 more
doaj   +1 more source

Leptin and Pro-Inflammatory Stimuli Synergistically Upregulate MMP-1 and MMP-3 Secretion in Human Gingival Fibroblasts

, 2016
Introduction Gingival fibroblast-mediated extracellular matrix remodelling is implicated in the pathogenesis of periodontitis, yet the stimuli that regulate this response are not fully understood. The immunoregulatory adipokine leptin is detectable in
Andrew J Skelton, Todryk, Stephen M., Rowan, Andrew, Skelton, Andrew J., Skelton, Andrew J, Williams, Rachel C., Preshaw, Philip M.; id_orcid, Preshaw, Philip M, Taylor, John, Rowan, Andrew D., Skelton, Andrew, Preshaw, Philip, Taylor, John J, Taylor, John J., Todryk, Stephen, Philip M Preshaw, Todryk, Stephen M, Rachel C Williams, Stephen M Todryk, Williams, Rachel C, Andrew D Rowan, Rowan, Andrew D, John J Taylor   +22 more
core   +1 more source

Physiological Models of Leptin Resistance [PDF]

Journal of Neuroendocrinology, 2009
In common forms of obesity, animals and humans become leptin resistant associated with impaired regulation of energy homeostasis. Over the last decade, significant advances in delineating the underlying mechanisms have been achieved. As well as the obvious scientific progress obtained by novel transgenic animals, natural and physiological models of ...
openaire   +2 more sources

Adipocyte‐Derived Leptolin Enhances Energy Expenditure and Prevents Obesity

Advanced Science, EarlyView.
We identified a novel adipokine, which we named leptolin. In humans, leptolin levels in white adipose tissue were positively correlated with exercise and negatively associated with body mass index. We observed elevated leptolin in serum from athletes and lower leptolin in serum from obese individuals.
Jiarui Liu, Bingwei Wang, Zhijie Su, Xiaoxv Han, Miao He, Yun Zhao, Yujia Hou, Daotong Li, Weiguang Zhang, Lihua Qin, Ke Wang, Yanchun Li, Yi Yan, Siwang Yu, Xiaoshuai Huang, Tairan Yuwen, Jianyuan Luo, Ruimao Zheng   +17 more
wiley   +1 more source