Results 41 to 50 of about 2,304,681 (286)

Lipocalin‐2 activates hepatic stellate cells and promotes nonalcoholic steatohepatitis in high‐fat diet–fed Ob/Ob mice

Hepatology, EarlyView., 2022
Graphical summary of obesity‐induced NASH progression by LCN2 targeted to HSC activation. Abstract Background and Aims In obesity and type 2 diabetes mellitus, leptin promotes insulin resistance and contributes to the progression of NASH via activation of hepatic stellate cells (HSCs).
Kyung Eun Kim, Jaewoong Lee, Hyun Joo Shin, Eun Ae Jeong, Hye Min Jang, Yu Jeong Ahn, Hyeong Seok An, Jong Youl Lee, Meong Cheol Shin, Soo Kyoung Kim, Won Gi Yoo, Won Ho Kim, Gu Seob Roh   +12 more
wiley   +1 more source

An alternative neural basis underlying leptin resistance. [PDF]

Cell Rep
Overconsumption of a palatable Western diet, a condition linked to central leptin resistance, contributes extensively to the current obesity epidemic. In this context, intensive efforts have focused on detailing the molecular mechanisms underlying leptin
Li H, Su C, Xu Y, Ludwig MQ, Davis J, Tong Q.   +5 more
europepmc   +2 more sources

Pregnancy glycaemia and cord-blood levels of insulin and leptin in Pakistani and white British mother-offspring pairs:findings from a prospective pregnancy cohort [PDF]

, 2014
AIMS/HYPOTHESIS: To determine the extent to which gestational fasting and postload levels of glucose explain differences in infant fat mass between UK-born Pakistani and white British infants.METHODS: Analyses were undertaken in a prospective pregnancy ...
Bhopal, Raj S, Bhopal, RS, Tuffnell, Derek, Bhopal, Raj S., West, J, Nelson, Scott M., Freeman, Dilys J., Sattar, N, Fairley, L, Freeman, DJ, John Wright, Lawlor, Debbie A, Nelson, SM, Dilys J. Freeman, Debbie A. Lawlor, Freeman, Dilys J, Wright, John, Whitelaw, Donald C., Lesley Fairley, Whitelaw, DC, Fairley, Lesley, Sattar, Naveed, Nelson, Scott M, Jane West, Whitelaw, Donald C, Lawlor, Debbie A., Derek Tuffnell, Scott M. Nelson, Raj S. Bhopal, Donald C. Whitelaw, Naveed Sattar, Lawlor, DA, Wright, J, Tuffnell, D, West, Jane   +34 more
core   +1 more source

The role of leptin resistance in the development of thyroid neoplasia

Mìžnarodnij Endokrinologìčnij Žurnal, 2023
Background. Leptin influences energy metabolism, as it is able to inform the central nervous system about adipose tissue reserves, and is also an important neuroendocrine regulator.
O.S. Miroshnichenko
doaj   +1 more source

Do ethnic differences in cord blood leptin levels differ by birthweight category? Findings from the Born in Bradford cohort study. [PDF]

, 2014
BACKGROUND: There is evidence that South Asian individuals have higher fat mass for a given weight than Europeans. One study reported that the greater fatness for a given birthweight may increase with increasing birth weight, suggesting that any attempt ...
Wright, John, West, J, Wright, J., Lawlor, D., Sattar, N, Fairley, Lesley, Sattar, Naveed, Whincup, Petter, Sattar, N., Whincup, P., Fairley, L, Whincup, P, Lawlor, Debbie A., Lawlor, DA, West, J., Wright, J, West, Jane, Fairley, L.   +17 more
core   +1 more source

Phlorotannins from Ecklonia cava Attenuates Palmitate-Induced Endoplasmic Reticulum Stress and Leptin Resistance in Hypothalamic Neurons

Marine Drugs, 2019
Leptin resistance in the hypothalamus has an essential role in obesity. Saturated fatty acids such as palmitate bind to Toll-like receptor 4 (TLR4) and lead to endoplasmic reticulum (ER) stress and leptin resistance.
Seyeon Oh, Myeongjoo Son, Junwon Choi, Chang Hu Choi, Kook Yang Park, Kuk Hui Son, Kyunghee Byun   +6 more
doaj   +1 more source

Leptin Resistance

Journal of the American College of Cardiology, 2008
Leptin is an adipocyte-derived hormone and cytokine that regulates energy balance through a wide range of functions, including several that are important to cardiovascular health. Increased circulating leptin, a marker of leptin resistance, is common in obesity and independently associated with insulin resistance and cardiovascular disease (CVD) in ...
Martin, Seth S., Qasim, Atif, Reilly, Muredach P.   +2 more
openaire   +2 more sources

The Role of SOCS-3 in Leptin Signaling and Leptin Resistance [PDF]

Journal of Biological Chemistry, 1999
We earlier demonstrated that leptin induces expression of SOCS-3 mRNA in the hypothalamus. Furthermore, transfection data suggest that SOCS-3 is an inhibitor of leptin signaling. However, little is known about the regulation of SOCS-3 expression by leptin and the mechanism by which SOCS-3 inhibits leptin action.
C, Bjørbaek, K, El-Haschimi, J D, Frantz, J S, Flier   +3 more
openaire   +2 more sources

Identification of a non-mammalian leptin-like gene:characterization and expression in the tiger salamander (Ambystoma tigrinum) [PDF]

, 2006
Leptin is well established as a multifunctional cytokine in mammals. However, little is known about the evolution of the leptin gene in other vertebrates. A recently published set of ESTs from the tiger salamander (Ambystoma tigrinum) contains a sequence
Joseph, N, Joseph, Nerine, Sharp, PJ, Boswell, T, Sharp, Peter J, Burt, DW, Boswell, Timothy, Dunn, Ian C, Wilson, Peter W, Wilson, PW, Burt, David W, Dunn, IC   +11 more
core   +1 more source

Glucocorticoids as Counterregulatory Hormones of Leptin: Toward an Understanding of Leptin Resistance [PDF]

Diabetes, 1997
The product of the ob gene, leptin, is a hormone secreted by adipose tissue that acts in the hypothalamus to regulate the size of the body fat depot. Its central administration has been shown to decrease food intake and body weight, while favoring energy dissipation.
Zakrzewska KE, Cusin I, Sainsbury A, Rohner-Jeanrenaud F, Jeanrenaud B   +4 more
openaire   +3 more sources