Results 1 to 10 of about 202,089 (261)
Sleep and the hypothalamus [PDF]
Science, 2023 Neural substrates of wakefulness, rapid eye movement sleep (REMS), and non-REMS (NREMS) in the mammalian hypothalamus overlap both anatomically and functionally with cellular networks that support physiological and behavioral homeostasis. Here, we review the roles of sleep neurons of the hypothalamus in the homeostatic control of thermoregulation or ...
Antoine R. Adamantidis, Luis de Lecea
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Current Biology, 2014 SummaryThe hypothalamus is one of the oldest and smallest parts of the brain, constituting just 4 gm of the 1400 gm of adult human brain weight. And yet this tiny area contains highly conserved neural circuitry that controls basic life functions: these include energy metabolism, from feeding through digestion, metabolic control, and energy expenditure;
Saper, Clifford B., Lowell, Bradford B.
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MicroRNAs in the Hypothalamus [PDF]
Neuroendocrinology, 2013 MicroRNAs (miRNAs) are short (∼22 nucleotides) non-coding ribonucleic acid (RNA) molecules that negatively regulate the expression of protein-coding genes. Posttranscriptional silencing of target genes by miRNA is initiated by binding to the 3′-untranslated regions of target mRNAs, resulting in specific cleavage and subsequent degradation of the mRNA ...
Meister, Björn +2 more
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Blooming in the Hypothalamus [PDF]
Journal of Neurosciences in Rural Practice, 2019 ABSTRACTCavernomas are vascular malformations which are collections of endothelium-lined sinusoids without intervening cerebral parenchyma. Hypothalamic location of cavernoma is extremely rare. We present a case of a 34-year-old male who presented with complaints of recent memory loss and vomiting.
Rai, Santosh P. V. +3 more
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Differential Changes in Expression of Stress- and Metabolic-related Neuropeptides in the Rat Hypothalamus during Morphine Dependence and Withdrawal [PDF]
, 2013 Chronic morphine treatment and naloxone precipitated morphine withdrawal activates stress-related brain circuit and results in significant changes in food intake, body weight gain and energy metabolism.
Nunez, Cristina +13 more
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Identification of sex hormone-binding globulin in the human hypothalamus [PDF]
, 2005 Gonadal steroids are known to influence hypothalamic functions through both genomic and non-genomic pathways. Sex hormone-binding globulin ( SHBG) may act by a non-genomic mechanism independent of classical steroid receptors.
Caldwell, Jack D. +7 more
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The Visually Related Posterior Pretectal Nucleus in the Non-Percomorph Teleost Osteoglossum bicirrhosum Projects to the Hypothalamus [PDF]
, 1991 This study was done to elucidate the ancestral (plesiomorphic) condition for visual pathways to the hypothalamus in teleost fishes. Three patterns of pretectal organization can be discerned morphologically and histochemically in teleosts. Their taxonomic
Wullimann, M. +8 more
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Hypersomnia associated with bilateral posterior hypothalamic lesion - A polysomnographic case study [PDF]
, 2003 We examined an obese 58-year-old patient with a bilateral posterior hypothalamic lesion of unknown etiology. A 24-hour polysomnography revealed a markedly increased total sleep time (17.6 h). During daytime, only 3 continuous wake phases occurred.
Uttner, I. +6 more
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The Hypothalamus and Obesity [PDF]
Recent Patents on CNS Drug Discovery, 2006 Obesity has reached epidemic proportions across the developed world. Even though there have been numerous scientific advances in terms of the understanding of the regulation of energy homeostasis, few novel anti-obesity drugs have emerged. Furthermore, those that are available have limited efficacy in producing and maintaining a weight loss beyond 10%.
Joanne A, Harrold, Jason C G, Halford
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The rate-limiting step for glucose transport into the hypothalamus is across the blood–hypothalamus interface [PDF]
, 2009 Specialized glucosensing neurons are present in the hypothalamus, some of which neighbor the median eminence, where the blood–brain barrier has been reported leaky.
Rolf Gruetter +11 more
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