Results 31 to 40 of about 134,529 (291)
Molecular Metabolism, 2018 Objective: The inability of leptin to suppress food intake in diet-induced obesity, sometimes referred to as leptin resistance, is associated with several distinct pathological hallmarks.
Maximilian Kleinert +5 more
doaj +1 more source
Obesity Induces Hypothalamic Endoplasmic Reticulum Stress and Impairs Proopiomelanocortin (POMC) Post-translational Processing [PDF]
, 2013 It was shown previously that abnormal prohormone processing or inactive proconverting enzymes that are responsible for this processing cause profound obesity.
Cakir, Isin +6 more
core +1 more source
F1000Research, 2022 Introduction: Leptin is an adipokine hormone that regulates insulin sensitivity and lipid profile, which may contribute to complications like gestational diabetes.The goal of the study was to examine if there was a link between the leptin (LEP)/leptin ...
Usha Adiga +2 more
doaj +1 more source
Journal of Lipid Research, 2008 Conjugated linoleic acid (CLA) induces insulin resistance preceded by rapid depletion of the adipokines leptin and adiponectin, increased inflammation, and hepatic steatosis in mice.
Angela A. Wendel +3 more
doaj +1 more source
Leptin, Obesity, and Leptin Resistance: Where Are We 25 Years Later? [PDF]
Nutrients, 2019 Izquierdo AG +3 more
europepmc +2 more sources
Animal models of NASH: getting both pathology and metabolic context right [PDF]
, 2015 Non-alcoholic fatty liver disease (NAFLD) is the most common cause of referral to liver clinics, and its progressive form, non-alcoholic steatohepatitis (NASH), can lead to cirrhosis and end-stage liver disease.
Larter, Claire Z., Yeh, Matthew M.
core +1 more source
Leptin resistance after heart transplantation [PDF]
European Journal of Heart Failure, 2010 Cardiac cachexia occurs in severe heart failure (HF).1,2 Heart transplantation (HTx) is associated with weight gain and the frequent development of obesity. Although this weight gain has been attributed to glucocorticoid therapy, it is more dramatic than after other solid organ transplants, despite similar steroid regimens, and also unrelated to ...
Lars H, Lund +5 more
openaire +2 more sources
Fatty acid nitroalkenes ameliorate glucose intolerance and pulmonary hypertension in high-fat diet-induced obesity [PDF]
, 2014 Aims Obesity is a risk factor for diabetes and cardiovascular diseases, with the incidence of these disorders becoming epidemic. Pathogenic responses to obesity have been ascribed to adipose tissue (AT) dysfunction that promotes bioactive mediator ...
Baust, Jeff +14 more
core +1 more source
Leptin receptor signaling: pathways to leptin resistance
Frontiers in Bioscience, 2011 The identification of spontaneous mutations in the leptin- and leptin receptor (ObR)-encoding ob and db gene, respectively, opened up a new field in obesity research. Leptin, an adipocyte-derived hormone, mirrors the body's fat stores and thereby informs the brain about the body's energy status.
Joris, Wauman, Jan, Tavernier
openaire +2 more sources
Digested wheat gluten inhibits binding between leptin and its receptor [PDF]
, 2015 BACKGROUND: Leptin resistance is considered a primary risk factor for obesity. It has been hypothesized that dietary cereal grain protein could cause leptin resistance by preventing leptin from binding to its receptor.
Amarnadh Nalla +7 more
core +2 more sources