Results 31 to 40 of about 74,494 (249)
The role of leptin resistance in the development of thyroid neoplasia
Mìžnarodnij Endokrinologìčnij Žurnal, 2023 Background. Leptin influences energy metabolism, as it is able to inform the central nervous system about adipose tissue reserves, and is also an important neuroendocrine regulator.
O.S. Miroshnichenko
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The Role of SOCS-3 in Leptin Signaling and Leptin Resistance [PDF]
Journal of Biological Chemistry, 1999 We earlier demonstrated that leptin induces expression of SOCS-3 mRNA in the hypothalamus. Furthermore, transfection data suggest that SOCS-3 is an inhibitor of leptin signaling. However, little is known about the regulation of SOCS-3 expression by leptin and the mechanism by which SOCS-3 inhibits leptin action.
C, Bjørbaek +3 more
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Leptin receptor signaling: pathways to leptin resistance
Frontiers in Bioscience, 2011 The identification of spontaneous mutations in the leptin- and leptin receptor (ObR)-encoding ob and db gene, respectively, opened up a new field in obesity research. Leptin, an adipocyte-derived hormone, mirrors the body's fat stores and thereby informs the brain about the body's energy status.
Joris, Wauman, Jan, Tavernier
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Marine Drugs, 2019 Leptin resistance in the hypothalamus has an essential role in obesity. Saturated fatty acids such as palmitate bind to Toll-like receptor 4 (TLR4) and lead to endoplasmic reticulum (ER) stress and leptin resistance.
Seyeon Oh +6 more
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Glucocorticoids as Counterregulatory Hormones of Leptin: Toward an Understanding of Leptin Resistance [PDF]
Diabetes, 1997 The product of the ob gene, leptin, is a hormone secreted by adipose tissue that acts in the hypothalamus to regulate the size of the body fat depot. Its central administration has been shown to decrease food intake and body weight, while favoring energy dissipation.
Zakrzewska KE +4 more
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Leptin Resistance and the Neuro-Adipose Connection [PDF]
Frontiers in Endocrinology, 2017 This article was submitted to Cellular Endocrinology, a section of the journal Frontiers in Endocrinology.
Barateiro, A, Mahú, I, Domingos, A
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Association of 25 (OH) Vitamin D and leptin in individuals with insulin resistance
Indian Journal of Endocrinology and Metabolism, 2022 Introduction: Asian-Indian individuals with diabetes have been shown to have low vitamin D levels. Whether this hypovitamonisis D is associated with hyperleptinaemia is unclear.
S V Madhu +4 more
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BMC Pediatrics, 2022 Background Obesity usually complicates hypothyroidism. Adipokines like leptin and adiponectin secreted by adipose tissue modulate insulin resistance (IR), appetite, and obesity.
Doaa El Amrousy +2 more
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Physiological Models of Leptin Resistance [PDF]
Journal of Neuroendocrinology, 2009 In common forms of obesity, animals and humans become leptin resistant associated with impaired regulation of energy homeostasis. Over the last decade, significant advances in delineating the underlying mechanisms have been achieved. As well as the obvious scientific progress obtained by novel transgenic animals, natural and physiological models of ...
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Adipocyte‐Derived Leptolin Enhances Energy Expenditure and Prevents Obesity
Advanced Science, EarlyView.We identified a novel adipokine, which we named leptolin. In humans, leptolin levels in white adipose tissue were positively correlated with exercise and negatively associated with body mass index. We observed elevated leptolin in serum from athletes and lower leptolin in serum from obese individuals.
Jiarui Liu +17 more
wiley +1 more source