Results 31 to 40 of about 80,968 (287)

In vivo and ex vivo regulation of visfatin production by leptin in human and murine adipose tissue : role of mitogen-activated protein kinase and phosphatidylinositol 3-kinase signaling pathways [PDF]

, 2009
Visfatin is an adipogenic adipokine with increased levels in obesity, properties common to leptin. Thus, leptin may modulate visfatin production in adipose tissue (AT).
Brown, James, Clifford J. Bailey, Jing Chen, Bee K. Tan, Tan, Bee K., Bailey, C. J. (Clifford J.), Adya, Raghu, Randeva, Harpal S., Vinod Menon, James Brown, Hendrik Lehnert, Menon, Vinod, Raghu Adya, Manjunath Ramanjaneya, Harpal S. Randeva, Ramanjaneya, Manjunath, Chen, Jing, Lehnert, Hendrik   +17 more
core   +1 more source

Conjugated linoleic acid fails to worsen insulin resistance but induces hepatic steatosis in the presence of leptin in ob/ob mice

Journal of Lipid Research, 2008
Conjugated linoleic acid (CLA) induces insulin resistance preceded by rapid depletion of the adipokines leptin and adiponectin, increased inflammation, and hepatic steatosis in mice.
Angela A. Wendel, Aparna Purushotham, Li-Fen Liu, Martha A. Belury   +3 more
doaj   +1 more source

Association of Leptin and Leptin receptor Gene polymorphisms with Insulin resistance in pregnant women: A cross-sectional study [version 2; peer review: 2 approved]

F1000Research, 2022
Introduction: Leptin is an adipokine hormone that regulates insulin sensitivity and lipid profile, which may contribute to complications like gestational diabetes.The goal of the study was to examine if there was a link between the leptin (LEP)/leptin ...
Usha Adiga, Tirthal Rai, Nandit Banawalikar   +2 more
doaj   +1 more source

Serum leptin and its relation to anthropometric measures of obesity in pre-diabetic Saudis [PDF]

, 2007
Background: Little information is available on leptin concentrations in individuals with IGT. This study aims to determine and correlate leptin levels to anthropometric measures of obesity in prediabetic, (IFG and IGT), type 2 diabetic and normoglycaemic
Al-Rubeaan, Khalid, Mohammad Al-Katari, Khalid Al-Rubeaan, Mohieldin, Mehad, Jones, Alan F., Kumar Sudhesh, Jones Alan F, Kumar, Sudhesh, Mehad Mohieldin, Al-Katari Mohammad, Al-Rubeaan Khalid, Mohieldin Mehad, Nasser M Al-Daghri, Sudhesh Kumar, Omar S Al-Attas, Al-Attas, Omar S., Alan F Jones, Al-Daghri, Nasser M., Al-Katari, Mohammad, Al-Attas Omar S, Al-Daghri Nasser M   +20 more
core   +1 more source

Time-resolved hypothalamic open flow micro-perfusion reveals normal leptin transport across the blood–brain barrier in leptin resistant mice

Molecular Metabolism, 2018
Objective: The inability of leptin to suppress food intake in diet-induced obesity, sometimes referred to as leptin resistance, is associated with several distinct pathological hallmarks.
Maximilian Kleinert, Petra Kotzbeck, Thomas Altendorfer-Kroath, Thomas Birngruber, Matthias H. Tschöp, Christoffer Clemmensen   +5 more
doaj   +1 more source

Pregnancy glycaemia and cord-blood levels of insulin and leptin in Pakistani and white British mother-offspring pairs:findings from a prospective pregnancy cohort [PDF]

, 2014
AIMS/HYPOTHESIS: To determine the extent to which gestational fasting and postload levels of glucose explain differences in infant fat mass between UK-born Pakistani and white British infants.METHODS: Analyses were undertaken in a prospective pregnancy ...
Bhopal, Raj S, Bhopal, RS, Tuffnell, Derek, Bhopal, Raj S., West, J, Nelson, Scott M., Freeman, Dilys J., Sattar, N, Fairley, L, Freeman, DJ, John Wright, Lawlor, Debbie A, Nelson, SM, Dilys J. Freeman, Debbie A. Lawlor, Freeman, Dilys J, Wright, John, Whitelaw, Donald C., Lesley Fairley, Whitelaw, DC, Fairley, Lesley, Sattar, Naveed, Nelson, Scott M, Jane West, Whitelaw, Donald C, Lawlor, Debbie A., Derek Tuffnell, Scott M. Nelson, Raj S. Bhopal, Donald C. Whitelaw, Naveed Sattar, Lawlor, DA, Wright, J, Tuffnell, D, West, Jane   +34 more
core   +1 more source

Do ethnic differences in cord blood leptin levels differ by birthweight category? Findings from the Born in Bradford cohort study. [PDF]

, 2014
BACKGROUND: There is evidence that South Asian individuals have higher fat mass for a given weight than Europeans. One study reported that the greater fatness for a given birthweight may increase with increasing birth weight, suggesting that any attempt ...
Wright, John, West, J, Wright, J., Lawlor, D., Sattar, N, Fairley, Lesley, Sattar, Naveed, Whincup, Petter, Sattar, N., Whincup, P., Fairley, L, Whincup, P, Lawlor, Debbie A., Lawlor, DA, West, J., Wright, J, West, Jane, Fairley, L.   +17 more
core   +1 more source

The Role of SOCS-3 in Leptin Signaling and Leptin Resistance [PDF]

Journal of Biological Chemistry, 1999
We earlier demonstrated that leptin induces expression of SOCS-3 mRNA in the hypothalamus. Furthermore, transfection data suggest that SOCS-3 is an inhibitor of leptin signaling. However, little is known about the regulation of SOCS-3 expression by leptin and the mechanism by which SOCS-3 inhibits leptin action.
C, Bjørbaek, K, El-Haschimi, J D, Frantz, J S, Flier   +3 more
openaire   +2 more sources

The role of leptin resistance in the development of thyroid neoplasia

Mìžnarodnij Endokrinologìčnij Žurnal, 2023
Background. Leptin influences energy metabolism, as it is able to inform the central nervous system about adipose tissue reserves, and is also an important neuroendocrine regulator.
O.S. Miroshnichenko
doaj   +1 more source

Phlorotannins from Ecklonia cava Attenuates Palmitate-Induced Endoplasmic Reticulum Stress and Leptin Resistance in Hypothalamic Neurons

Marine Drugs, 2019
Leptin resistance in the hypothalamus has an essential role in obesity. Saturated fatty acids such as palmitate bind to Toll-like receptor 4 (TLR4) and lead to endoplasmic reticulum (ER) stress and leptin resistance.
Seyeon Oh, Myeongjoo Son, Junwon Choi, Chang Hu Choi, Kook Yang Park, Kuk Hui Son, Kyunghee Byun   +6 more
doaj   +1 more source