Results 11 to 20 of about 74,494 (249)
Sildenafil ameliorates leptin resistance and normalizes lipid handling in the hypothalamic and adipose tissues of testosterone-exposed pregnant rats [PDF]
Heliyon, 2021 Leptin and hypothalamic-adipose lipid handling are relevant in determining the shift of metabolic activities. There are scanty findings connecting glucose dysregulation as a result of hyperandrogenism during gestation to hypothalamic-adipose axis and ...
Emmanuel Damilare Areola +9 more
doaj +2 more sources
A mathematical model of leptin resistance [PDF]
Mathematical Biosciences, 2015 Obesity is often associated with leptin resistance, which leads to a physiological system with high leptin concentration but unable to respond to leptin signals and to regulate food intake. We propose a mathematical model of the leptin-leptin receptors system, based on the assumption that leptin is a regulator of its own receptor activity, and ...
Fabien Crauste, Marine Jacquier
exaly +5 more sources
Systemic and Local Leptin Resistance in Patients with Cardiovascular Diseases [PDF]
DiagnosticsBackground/Objectives: The causes and mechanisms underlying the development of leptin resistance (LR) in patients with cardiovascular disease (CVD) remain unknown.
Olga Gruzdeva +8 more
doaj +2 more sources
Olanzapine- induced metabolic syndrome pathogenesis: Hypothalamic “leptin resistance” or “pomc resistance”? [PDF]
European Psychiatry, 2021 Introduction Olanzapine (OL) represents one of the main chooses for the treatment of psychosis. However, OL increase the risk of metabolic syndrome (MS). Previous literature proposes the “Leptin resistance” as a possible hypothalamic pathogenesis of OL
F. Veneziani +3 more
doaj +2 more sources
Journal of the American College of Cardiology, 2008 Muredach Reilly, , Atif Qasim
exaly +2 more sources
MCBS (Molecular and Cellular Biomedical Sciences), 2021 Background: Leptin resistance which leads to excessive circulating leptin levels is thought to affect ovarian function. This study aimed to study the correlation between serum leptin levels with insulin resistance in patients with polycystic ovary ...
Arsyi Adliah Anwar +5 more
doaj +1 more source
Leptin, Obesity, and Leptin Resistance: Where Are We 25 Years Later? [PDF]
Nutrients, 2019 Andrea G Izquierdo +2 more
exaly +2 more sources
Establishment of Leptin-Responsive Cell Lines from Adult Mouse Hypothalamus. [PDF]
PLoS ONE, 2016 Leptin resistance is considered to be the primary cause of obesity. However, the cause of leptin resistance remains incompletely understood, and there is currently no cure for the leptin-resistant state.
Hiroshi Iwakura +6 more
doaj +1 more source
The Leptin System and Diet: A Mini Review of the Current Evidence
Frontiers in Endocrinology, 2021 Leptin promotes satiety and modulates energy balance and weight. Diet-induced obesity leads to leptin resistance, exacerbating overeating. We reviewed the literature on the relationship between diet and leptin, which suggests that addressing leptin ...
Kenny Mendoza-Herrera +6 more
doaj +1 more source
Leptin Resistance and Obesity [PDF]
Obesity, 2006 AbstractThe prevalence of obesity, and the human and economic costs of the disease, creates a need for better therapeutics and better understanding of the physiological processes that balance energy intake and energy expenditure. Leptin is the primary signal from energy stores and exerts negative feedback effects on energy intake.
Enriori, Pablo J +3 more
openaire +3 more sources