Results 11 to 20 of about 2,304,681 (286)
Leptin resistance: underlying mechanisms and diagnosis. [PDF]
Diabetes Metab Syndr Obes, 2019 Olga Gruzdeva,1,2 Daria Borodkina,3 Evgenya Uchasova,1 Yulia Dyleva,1 Olga Barbarash1,2 1Federal State Budgetary Institution, Research Institute for Complex Issues of Cardiovascular Diseases, Kemerovo, Russian Federation; 2Federal State Budget ...
Gruzdeva O +4 more
europepmc +6 more sources
Leptin resistance and obesity [PDF]
Obesity, 2006 The prevalence of obesity, and the human and economic costs of the disease, creates a need for better therapeutics and better understanding of the physiological processes that balance energy intake and energy expenditure.
Enriori, Pablo J +7 more
core +4 more sources
Hyperleptinemia is required for the development of leptin resistance. [PDF]
PLoS ONE, 2010 Leptin regulates body weight by signaling to the brain the availability of energy stored as fat. This negative feedback loop becomes disrupted in most obese individuals, resulting in a state known as leptin resistance.
Zachary A Knight +3 more
doaj +5 more sources
Leptin receptor action and mechanisms of leptin resistance [PDF]
Cellular and Molecular Life Sciences, 2005 The adipose tissue-derived hormone leptin regulates energy balance and neuroendocrine function. Resistance to the appetite-suppressing effects of leptin is associated with common forms of obesity.
Bates, S. H. +3 more
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PATHOGENETIC MECHANISMS OF LEPTIN RESISTANCE [PDF]
Российский кардиологический журнал, 2015 Leptin is a regulatory protein from adipokines family, that maintain energy homeostasis of the body and deter obesity development. Impaired transfer of leptin signals to hypothalamus leads to leptin resistance and its adverse complications. Understanding
G. A. Chumakova +4 more
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Leptin receptor signaling: pathways to leptin resistance
Frontiers in Bioscience, 2011 The identification of spontaneous mutations in the leptin- and leptin receptor (ObR)-encoding ob and db gene, respectively, opened up a new field in obesity research. Leptin, an adipocyte-derived hormone, mirrors the body's fat stores and thereby informs
Wauman, Joris, Tavernier, Jan
core +3 more sources
Drug targeting of leptin resistance
Life Sciences, 2015 Leptin regulates glucose, lipid and energy homeostasis as well as feeding behavior, serving as a bridge between peripheral metabolically active tissues and the central nervous system (CNS). Indeed, this adipocyte-derived hormone, whose circulating levels
MELI, ROSARIA +2 more
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Role of leptin resistance in the development of obesity in older patients
Clinical Interventions in Aging, 2013 Sophie Carter,1,* Alexandre Caron,2,* Denis Richard,2 Frédéric Picard1 1Faculty of Pharmacy, 2Faculty of Medicine, Dept Anatomy and Physiology, Université Laval, Québec, QC, Canada *These authors contributed equally to the ...
Carter S, Caron A, Picard F, Richard D
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Leptin and leptin resistance in obesity: current evidence, mechanisms and future directions. [PDF]
Endocr ConnectLeptin, a key adipokine regulating energy homeostasis, has been extensively studied for its potential in the management of obesity. However, its therapeutic efficacy is often limited due to leptin resistance.
Hu W, Zhu H, Gong F.
europepmc +2 more sources
Hippocampal Leptin Resistance and Cognitive Decline: Mechanisms, Therapeutic Strategies and Clinical Implications. [PDF]
BiomedicinesBackground: Leptin, an adipokine essential for regulating energy balance, exerts important effects on brain function, notably within the hippocampus, a region integral to learning and memory.
Valladolid-Acebes I.
europepmc +2 more sources