Results 11 to 20 of about 134,529 (291)
Olanzapine- induced metabolic syndrome pathogenesis: Hypothalamic “leptin resistance” or “pomc resistance”? [PDF]
European Psychiatry, 2021 Introduction Olanzapine (OL) represents one of the main chooses for the treatment of psychosis. However, OL increase the risk of metabolic syndrome (MS). Previous literature proposes the “Leptin resistance” as a possible hypothalamic pathogenesis of OL
F. Veneziani +3 more
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The effect of resistance training and genistein on leptin and lipid profile of streptozotocin-induced diabetic rats [PDF]
Fiyz̤, 2018 Background: Diabetes is a chronic disease which can lead to increased levels of leptin and lipid profile. The aim of this study was to examine the effect of resistance training and genistein on leptin and lipid profile of streptozotocin-induced diabetic ...
Seyyed Ali Hosseini +4 more
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Association between serum leptin concentrations and insulin resistance: a population-based study from China. [PDF]
PLoS ONE, 2013 BACKGROUND: Insulin resistance contributes to the cardio-metabolic risk. The effect of leptin in obese and overweight population on insulin resistance was seldom reported.
Hui Zuo +5 more
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PATHOGENETIC MECHANISMS OF LEPTIN RESISTANCE
Российский кардиологический журнал, 2015 Leptin is a regulatory protein from adipokines family, that maintain energy homeostasis of the body and deter obesity development. Impaired transfer of leptin signals to hypothalamus leads to leptin resistance and its adverse complications. Understanding
G. A. Chumakova +4 more
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MCBS (Molecular and Cellular Biomedical Sciences), 2021 Background: Leptin resistance which leads to excessive circulating leptin levels is thought to affect ovarian function. This study aimed to study the correlation between serum leptin levels with insulin resistance in patients with polycystic ovary ...
Arsyi Adliah Anwar +5 more
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Leptin signaling and leptin resistance [PDF]
Frontiers of Medicine, 2013 Leptin is secreted into the bloodstream by adipocytes and is required for the maintenance of energy homeostasis and body weight. Leptin deficiency or genetic defects in the components of the leptin signaling pathways cause obesity. Leptin controls energy balance and body weight mainly through leptin receptor b (LEPRb)-expressing neurons in the brain ...
Yingjiang, Zhou, Liangyou, Rui
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The Leptin System and Diet: A Mini Review of the Current Evidence
Frontiers in Endocrinology, 2021 Leptin promotes satiety and modulates energy balance and weight. Diet-induced obesity leads to leptin resistance, exacerbating overeating. We reviewed the literature on the relationship between diet and leptin, which suggests that addressing leptin ...
Kenny Mendoza-Herrera +6 more
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Hyperleptinemia is required for the development of leptin resistance. [PDF]
PLoS ONE, 2010 Leptin regulates body weight by signaling to the brain the availability of energy stored as fat. This negative feedback loop becomes disrupted in most obese individuals, resulting in a state known as leptin resistance.
Zachary A Knight +3 more
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Leptin Resistance and Obesity [PDF]
Obesity, 2006 AbstractThe prevalence of obesity, and the human and economic costs of the disease, creates a need for better therapeutics and better understanding of the physiological processes that balance energy intake and energy expenditure. Leptin is the primary signal from energy stores and exerts negative feedback effects on energy intake.
Enriori, Pablo J +3 more
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Leptin resensitisation: a reversion of leptin-resistant states [PDF]
Journal of Endocrinology, 2019 Leptin resistance refers to states in which leptin fails to promote its anticipated effects, frequently coexisting with hyperleptinaemia. Leptin resistance is closely associated with obesity and also observed in physiological situations such as pregnancy and in seasonal animals.
Andreoli, Maria Florencia +3 more
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