Results 11 to 20 of about 80,968 (287)
Leptin receptor action and mechanisms of leptin resistance [PDF]
Cellular and Molecular Life Sciences, 2005 The adipose tissue-derived hormone leptin regulates energy balance and neuroendocrine function. Resistance to the appetite-suppressing effects of leptin is associated with common forms of obesity.
Sarah H Bates, Martin G Myers
exaly +5 more sources
A mathematical model of leptin resistance [PDF]
Mathematical Biosciences, 2015 International audienceObesity is often associated with leptin resistance, which leads to a physiological system with high leptin concentration but unable to respond to leptin signals and to regulate food intake.
Marine Jacquier, Fabien Crauste
exaly +7 more sources
Leptin resistance and obesity [PDF]
Obesity, 2006 The prevalence of obesity, and the human and economic costs of the disease, creates a need for better therapeutics and better understanding of the physiological processes that balance energy intake and energy expenditure.
Enriori, Pablo J +7 more
core +4 more sources
An alternative neural basis underlying leptin resistance. [PDF]
Cell RepOverconsumption of a palatable Western diet, a condition linked to central leptin resistance, contributes extensively to the current obesity epidemic. In this context, intensive efforts have focused on detailing the molecular mechanisms underlying leptin
Li H +5 more
europepmc +2 more sources
PATHOGENETIC MECHANISMS OF LEPTIN RESISTANCE
Российский кардиологический журнал, 2015 Leptin is a regulatory protein from adipokines family, that maintain energy homeostasis of the body and deter obesity development. Impaired transfer of leptin signals to hypothalamus leads to leptin resistance and its adverse complications. Understanding
G. A. Chumakova +4 more
doaj +3 more sources
Leptin receptor signaling: pathways to leptin resistance
Frontiers in Bioscience, 2011 The identification of spontaneous mutations in the leptin- and leptin receptor (ObR)-encoding ob and db gene, respectively, opened up a new field in obesity research. Leptin, an adipocyte-derived hormone, mirrors the body's fat stores and thereby informs
Wauman, Joris, Tavernier, Jan
core +3 more sources
Drug targeting of leptin resistance
Life Sciences, 2015 Leptin regulates glucose, lipid and energy homeostasis as well as feeding behavior, serving as a bridge between peripheral metabolically active tissues and the central nervous system (CNS). Indeed, this adipocyte-derived hormone, whose circulating levels
MELI, ROSARIA +2 more
core +4 more sources
Role of leptin resistance in the development of obesity in older patients
Clinical Interventions in Aging, 2013 Sophie Carter,1,* Alexandre Caron,2,* Denis Richard,2 Frédéric Picard1 1Faculty of Pharmacy, 2Faculty of Medicine, Dept Anatomy and Physiology, Université Laval, Québec, QC, Canada *These authors contributed equally to the ...
Carter S, Caron A, Richard D, Picard F
doaj +1 more source
MCBS (Molecular and Cellular Biomedical Sciences), 2021 Background: Leptin resistance which leads to excessive circulating leptin levels is thought to affect ovarian function. This study aimed to study the correlation between serum leptin levels with insulin resistance in patients with polycystic ovary ...
Arsyi Adliah Anwar +5 more
doaj +1 more source
Leptin, Obesity, and Leptin Resistance: Where Are We 25 Years Later? [PDF]
Nutrients, 2019 Andrea G Izquierdo +2 more
exaly +2 more sources