Results 11 to 20 of about 186,310 (210)
Annual Review of Physiology, 2000 ▪ Abstract The discovery of the adipose-derived hormone leptin has generated enormous interest in the interaction between peripheral signals and brain targets involved in the regulation of feeding and energy balance. Plasma leptin levels correlate with fat stores and respond to changes in energy balance. It was initially proposed that leptin serves a
R S, Ahima, J S, Flier
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Human Pathology Reports, 2022 Context: Breast cancer is the most common cancer and the most common cause of death from cancer among women. Leptin is thought to play role in cell proliferation.
Irem Atalay Karacay +5 more
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Slik and the receptor tyrosine kinase Breathless mediate localized activation of Moesin in terminal tracheal cells. [PDF]
PLoS ONE, 2014 A key element in the regulation of subcellular branching and tube morphogenesis of the Drosophila tracheal system is the organization of the actin cytoskeleton by the ERM protein Moesin.
Fiona Paul Ukken +3 more
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Obesity as a Risk Factor for Dementia and Alzheimer’s Disease: The Role of Leptin
International Journal of Molecular Sciences, 2022 Obesity is a growing worldwide health problem, affecting many people due to excessive saturated fat consumption, lack of exercise, or a sedentary lifestyle.
J. A. Flores-Cordero +5 more
semanticscholar +1 more source
Current Immunology Reviews, 2008 The past few years of research on leptin have provided important information on the link between metabolism and immune homeostasis. Adipocytes influence not only the endocrine system but also the immune response through several cytokine-like mediators known as adipokines, which include leptin.
Iikuni N +4 more
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Concordance of bioactive vs. total immunoreactive serum leptin levels in children with severe early onset obesity. [PDF]
PLoS ONE, 2017 Leptin secreted from adipose tissue signals peripheral energy status to the brain. Monogenic leptin deficiency results in severe early onset obesity with hyperphagia.
Juraj Stanik +8 more
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Biomolecules, 2023 Craniopharyngioma (CP) is a benign tumor with a high rate of obesity and frequent recurrence. Moreover, the role of leptin/leptin receptors axis in obesity and the prognosis of CP is still unknown.
Youchao Xiao +9 more
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Leptin as a key regulator of the adipose organ
Reviews in Endocrine & Metabolic Disorders, 2021 Leptin is a hormone primarily produced by the adipose tissue in proportion to the size of fat stores, with a primary function in the control of lipid reserves.
C. Picó +4 more
semanticscholar +1 more source
Normal leptin expression, lower adipogenic ability, decreased leptin receptor and hyposensitivity to Leptin in Adolescent Idiopathic Scoliosis. [PDF]
PLoS ONE, 2012 Leptin has been suggested to play a role in the etiology of Adolescent Idiopathic Scoliosis (AIS), however, the leptin levels in AIS girls are still a discrepancy, and no in vitro study of leptin in AIS is reported.
Guoyan Liang +8 more
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Leptin modulates nutrient reward via inhibitory galanin action on orexin neurons
Molecular Metabolism, 2015 Objective: Leptin modulates food reward via central leptin receptor (LepRb) expressing neurons. Food reward requires stimulation of midbrain dopamine neurons and is modulated by central leptin action, but the exact central mechanisms remain unclear ...
Amanda Laque +10 more
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