Results 11 to 20 of about 165,445 (252)

Leptin and Pro-Inflammatory Stimuli Synergistically Upregulate MMP-1 and MMP-3 Secretion in Human Gingival Fibroblasts. [PDF]

PLoS ONE, 2016
Gingival fibroblast-mediated extracellular matrix remodelling is implicated in the pathogenesis of periodontitis, yet the stimuli that regulate this response are not fully understood.
Rachel C Williams, Andrew J Skelton, Stephen M Todryk, Andrew D Rowan, Philip M Preshaw, John J Taylor   +5 more
doaj   +3 more sources

Encapsulated Leptin-Producing Cells Facilitate Entrainment of Circadian Rhythms in Rodents and Nonhuman Primates. [PDF]

Adv Sci (Weinh)
A clinically translatable cell line can be engineered to produce leptin, encapsulated in biomaterial and safely implanted to produce and deliver the metabolic regulating protein within the body. Implantation of these encapsulated cells decreases the time it takes for mice and non‐human primates to adjust to circadian disruptions similar to those ...
Fleury ST, Lin X, Rios PD, Olker C, Song EJ, Perez AC, Fell C, Lopez D, Joshi I, Nasir H, Curtis C, Muringi D, Wang K, Oberholzer J, Turek FW, Hilton IB, Rivnay J, Vitaterna MH, Veiseh O.   +18 more
europepmc   +2 more sources

Dual-Organelle Secretome Conjugation and Organ-Uptake Tracking (DuO-SCOUT) Enables Deep and Sensitive Mapping of the Secreted Proteins. [PDF]

Adv Sci (Weinh)
A novel dual‐organelle proximity labeling platform, DuO‐SCOUT, decodes the complex landscape of systemic organ‐organ communication by capturing both classical and unconventional secretomes. Application in metabolic models maps the adipose‐to‐brain secretory relay, identifying selective extra‐hypothalamic sites for adipose‐derived factors and expanding ...
Yang F, Qian R, Song J, Meng X, Kim JY, Lai KO, Wang L, Zhang L.   +7 more
europepmc   +2 more sources

Phocid seal leptin: tertiary structure and hydrophobic receptor binding site preservation during distinct leptin gene evolution [PDF]

, 2012
The cytokine hormone leptin is a key signalling molecule in many pathways that control physiological functions. Although leptin demonstrates structural conservation in mammals, there is evidence of positive selection in primates, lagomorphs and ...
John A. Hammond (170370), Hall, Ailsa Jane, Chris Hauton, Hammond John A., Hammond, John Anthony, Hammond, John A., Ailsa J. Hall (29488), Hall Ailsa J., John A Hammond, Hauton Chris, Bennett, Kimberley A., Hall, Ailsa J., Ailsa J Hall, Kimberley A Bennett, Chris Hauton (170376), Bennett Kimberley A., Hauton, Chris, Kimberley A. Bennett (170381)   +17 more
core   +2 more sources

Glucose enhances leptin signaling through modulation of AMPK activity. [PDF]

PLoS ONE, 2012
Leptin exerts its action by binding to and activating the long form of leptin receptors (LEPRb). LEPRb activates JAK2 that subsequently phosphorylates and activates STAT3.
Haoran Su, Lin Jiang, Christin Carter-Su, Liangyou Rui   +3 more
doaj   +1 more source

Leptin receptor neurons in the dorsomedial hypothalamus are key regulators of energy expenditure and body weight, but not food intake

Molecular Metabolism, 2014
Objective: Leptin responsive neurons play an important role in energy homeostasis, controlling specific autonomic, behavioral, and neuroendocrine functions.
Kavon Rezai-Zadeh, Sanghou Yu, Yanyan Jiang, Amanda Laque, Candice Schwartzenburg, Christopher D. Morrison, Andrei V. Derbenev, Andrea Zsombok, Heike Münzberg   +8 more
doaj   +1 more source

Curcumin interrupts leptin-regulated microRNA-122 in hepatic stellate cells in vitro and in vivo

Pakistan Journal of Pharmaceutical Sciences, 2023
The purpose of this study was to evaluate the effect of curcumin, an active polyphenol, on the leptin induced lowering of miR-122 in Hepatic stellate cells (HSCs) in vivo and an animal model. Gene expression was evaluated by transfection assay, real-time
Huang Limin, Xu Feifan
doaj   +1 more source

Leptin mediates the increase in blood pressure associated with obesity [PDF]

, 2014
Obesity is associated with increased blood pressure (BP), which in turn increases the risk of cardiovascular diseases. We found that the increase in leptin levels seen in diet-induced obesity (DIO) drives an increase in BP in rodents, an effect that was ...
Cowley, Michael A., Ravussin, E., Cowley, M., Elmquist, Joel K., Myers, M., Enriori, P., Spanswick, D., O’Rahilly, S. (Stephen), Myers, Martin G., Henning, Elana, Licinio, Julio, Simonds, Stephanie E., Greenway, Frank L., Simonds, S., Farooqi, I., Brown, Russell D., Allen, A., Brown, R., Spanswick, David C., Dileone, R., Farooqi, I. Sadaf, Allen, Andrew M., Elmquist, J., Bassi, J., O’Rahilly, Stephen, Keogh, Julia M., Keogh, J., Sternson, S., Myer, Martin G., Greenway, F., Licinio, J., Enriori, Pablo J., Pryor, J., Pryor, Jack T., Dileone, Ralph, Grove, Kevin L., O’Rahilly, S., Henning, E., Ravussin, Eric, Bassi, Jaspreet, Sternson, Scott M., Grove, K.   +41 more
core   +2 more sources

The relationships between leptin levels in maternal serum and breast milk of mothers and term infants

Annals of Medicine, 2021
Background Leptin in breast milk play a significant role in metabolic programming.Objective The aim of this study to evaluate the relationship between leptin levels in maternal serum and breast milk, and certain anthropometric measurements of infants and
Feray Çağiran Yilmaz, Ayşe Özfer Özçelik   +1 more
doaj   +1 more source

Identification of a non-mammalian leptin-like gene:characterization and expression in the tiger salamander (Ambystoma tigrinum) [PDF]

, 2006
Leptin is well established as a multifunctional cytokine in mammals. However, little is known about the evolution of the leptin gene in other vertebrates. A recently published set of ESTs from the tiger salamander (Ambystoma tigrinum) contains a sequence
Joseph, N, Joseph, Nerine, Sharp, PJ, Boswell, T, Sharp, Peter J, Burt, DW, Boswell, Timothy, Dunn, Ian C, Wilson, Peter W, Wilson, PW, Burt, David W, Dunn, IC   +11 more
core   +1 more source