Results 11 to 20 of about 151,999 (312)

Leptin and Inflammation [PDF]

Current Immunology Reviews, 2008
The past few years of research on leptin have provided important information on the link between metabolism and immune homeostasis. Adipocytes influence not only the endocrine system but also the immune response through several cytokine-like mediators known as adipokines, which include leptin.
Iikuni N, Lam QL, Lu L, MATARESE, GIUSEPPE, La Cava A.   +4 more
openaire   +5 more sources

Clinical Significance of Plasma Leptin and Its Receptors mRNA Expression in Craniopharyngiomas: A Prospective Study

Biomolecules, 2023
Craniopharyngioma (CP) is a benign tumor with a high rate of obesity and frequent recurrence. Moreover, the role of leptin/leptin receptors axis in obesity and the prognosis of CP is still unknown.
Youchao Xiao, Wentao Wu, Kefan Cai, Lu Jin, Yanfei Jia, Ning Qiao, Fangzheng Liu, Siming Ru, Lei Cao, Songbai Gui   +9 more
doaj   +1 more source

Normal leptin expression, lower adipogenic ability, decreased leptin receptor and hyposensitivity to Leptin in Adolescent Idiopathic Scoliosis. [PDF]

PLoS ONE, 2012
Leptin has been suggested to play a role in the etiology of Adolescent Idiopathic Scoliosis (AIS), however, the leptin levels in AIS girls are still a discrepancy, and no in vitro study of leptin in AIS is reported.
Guoyan Liang, Wenjie Gao, Anjing Liang, Wei Ye, Yan Peng, Liangming Zhang, Swarkar Sharma, Peiqiang Su, Dongsheng Huang   +8 more
doaj   +1 more source

Glucose enhances leptin signaling through modulation of AMPK activity. [PDF]

PLoS ONE, 2012
Leptin exerts its action by binding to and activating the long form of leptin receptors (LEPRb). LEPRb activates JAK2 that subsequently phosphorylates and activates STAT3.
Haoran Su, Lin Jiang, Christin Carter-Su, Liangyou Rui   +3 more
doaj   +1 more source

Leptin and leptin receptor expression in asthma [PDF]

Journal of Allergy and Clinical Immunology, 2009
The adipokine leptin is a potential new mediator for bronchial epithelial homeostasis. Asthma is a chronic inflammatory disease characterized by airway remodeling that might affect disease chronicity and severity. TGF-beta is a tissue growth factor the dysregulation of which is associated with airway remodeling.We sought to determine whether a ...
Andreina, Bruno, Elisabetta, Pace, Pascal, Chanez, Delphine, Gras, Isabelle, Vachier, Giuseppina, Chiappara, Maurizio, La Guardia, Stefania, Gerbino, Mirella, Profita, Mark, Gjomarkaj   +9 more
openaire   +2 more sources

Leptin modulates nutrient reward via inhibitory galanin action on orexin neurons

Molecular Metabolism, 2015
Objective: Leptin modulates food reward via central leptin receptor (LepRb) expressing neurons. Food reward requires stimulation of midbrain dopamine neurons and is modulated by central leptin action, but the exact central mechanisms remain unclear ...
Amanda Laque, Sangho Yu, Emily Qualls-Creekmore, Sarah Gettys, Candice Schwartzenburg, Kelly Bui, Christopher Rhodes, Hans-Rudolf Berthoud, Christopher D. Morrison, Brenda K. Richards, Heike Münzberg   +10 more
doaj   +1 more source

Leptin receptor neurons in the dorsomedial hypothalamus are key regulators of energy expenditure and body weight, but not food intake

Molecular Metabolism, 2014
Objective: Leptin responsive neurons play an important role in energy homeostasis, controlling specific autonomic, behavioral, and neuroendocrine functions.
Kavon Rezai-Zadeh, Sanghou Yu, Yanyan Jiang, Amanda Laque, Candice Schwartzenburg, Christopher D. Morrison, Andrei V. Derbenev, Andrea Zsombok, Heike Münzberg   +8 more
doaj   +1 more source

Leptin mediates the increase in blood pressure associated with obesity [PDF]

, 2014
Obesity is associated with increased blood pressure (BP), which in turn increases the risk of cardiovascular diseases. We found that the increase in leptin levels seen in diet-induced obesity (DIO) drives an increase in BP in rodents, an effect that was ...
Cowley, Michael A., Ravussin, E., Cowley, M., Elmquist, Joel K., Myers, M., Enriori, P., Spanswick, D., O’Rahilly, S. (Stephen), Myers, Martin G., Henning, Elana, Licinio, Julio, Simonds, Stephanie E., Greenway, Frank L., Simonds, S., Farooqi, I., Brown, Russell D., Allen, A., Brown, R., Spanswick, David C., Dileone, R., Farooqi, I. Sadaf, Allen, Andrew M., Elmquist, J., Bassi, J., O’Rahilly, Stephen, Keogh, Julia M., Keogh, J., Sternson, S., Myer, Martin G., Greenway, F., Licinio, J., Enriori, Pablo J., Pryor, J., Pryor, Jack T., Dileone, Ralph, Grove, Kevin L., O’Rahilly, S., Henning, E., Ravussin, Eric, Bassi, Jaspreet, Sternson, Scott M., Grove, K.   +41 more
core   +1 more source

The relationships between leptin levels in maternal serum and breast milk of mothers and term infants

Annals of Medicine, 2021
Background Leptin in breast milk play a significant role in metabolic programming.Objective The aim of this study to evaluate the relationship between leptin levels in maternal serum and breast milk, and certain anthropometric measurements of infants and
Feray Çağiran Yilmaz, Ayşe Özfer Özçelik   +1 more
doaj   +1 more source

Identification of a non-mammalian leptin-like gene:characterization and expression in the tiger salamander (Ambystoma tigrinum) [PDF]

, 2006
Leptin is well established as a multifunctional cytokine in mammals. However, little is known about the evolution of the leptin gene in other vertebrates. A recently published set of ESTs from the tiger salamander (Ambystoma tigrinum) contains a sequence
Joseph, N, Joseph, Nerine, Sharp, PJ, Boswell, T, Sharp, Peter J, Burt, DW, Boswell, Timothy, Dunn, Ian C, Wilson, Peter W, Wilson, PW, Burt, David W, Dunn, IC   +11 more
core   +1 more source