Leptin - Open Access .click

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Molecular Metabolism, 2017
Background: The hormone leptin is an important regulator of metabolic homeostasis, able to inhibit food intake and increase energy expenditure. Leptin can also independently lower blood glucose levels, particularly in hyperglycemic models of leptin or ...
Anna M. D'souza +3 more
doaj +1 more source

The leptin system and its expression at different nutritional and pregnant stages in lined seahorse (Hippocampus erectus)

Biology Open, 2016
Leptin is an essential hormone for the regulation of energy metabolism and food intake in vertebrate animals. To better understand the physiological roles of leptin in nutrient regulation in paternal ovoviviparous fish (family Syngnathidae), the present ...
Huixian Zhang +4 more
doaj +1 more source

Genetic identification of leptin neural circuits in energy and glucose homeostases

Nature, 2018
Leptin, a hormone produced in white adipose tissue, acts in the brain to communicate fuel status, suppress appetite following a meal, promote energy expenditure and maintain blood glucose stability1,2.
Jie Xu +6 more
semanticscholar +1 more source

Decreased leptin concentration in neonates is associated with enhanced postnatal growth during the first year

Kaohsiung Journal of Medical Sciences, 2012
Leptin regulates maternal metabolism and fetal growth by reducing food intake and increasing energy expenditure, particularly during the third trimester.
Ling-Jen Wang +5 more
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Leptin in inflammation and autoimmunity

Cytokine, 2017
HighlightsAs a cytokine, leptin modulates both innate and adaptive immune responses.Leptin contributes to the generation and maintenance of low‐grade inflammation.Leptin levels are elevated in multiple autoimmune diseases.Leptin blockade is beneficial in
A. La Cava
semanticscholar +1 more source

Anticontractile effect of perivascular adipose tissue and leptin are reduced in hypertension

Frontiers in Pharmacology, 2012
Leptin causes vasodilatation both by endothelium-dependent and -independent mechanisms. Leptin is synthetized by perivascular adipose tissue (PVAT). The hypothesis of this study is that a decrease of leptin production in PVAT of spontaneously rats (SHR ...
Beatriz eGálvez-Prieto +11 more
doaj +1 more source

Transcriptional Regulation of Neuronal Genes and Its Effect on Neural Functions: Transcriptional Regulation of Neuropeptide Y Gene by Leptin and Its Effect on Feeding

Journal of Pharmacological Sciences, 2005
Leptin is an adipose tissue-derived secretory hormone that suppresses appetite by inhibition of neuropepeptide Y (NPY) gene expression in arcuate nucleus (ARC) in the hypothalamus.
Hiroshi Higuchi, Ayumi Hasegawa, Tsuyoshi Yamaguchi +2 more
doaj +1 more source

Leptin and leptin resistance in obesity: current evidence, mechanisms and future directions

Endocrine Connections
Leptin, a key adipokine regulating energy homeostasis, has been extensively studied for its potential in the management of obesity. However, its therapeutic efficacy is often limited due to leptin resistance.
Wenjing Hu, Huijuan Zhu, Fengying Gong
doaj +1 more source

Leptin Promotes the Expression of Pro-inflammatory Mediator Genes but Does Not Alter Osteoclastogenesis and Early Stage Differentiation of Osteoblasts

Journal of Physiological Investigation
Leptin, a hormone secreted by adipose tissue, plays a pivotal role in maintaining energy metabolism and bone quality. Dysregulation of leptin can lead to the development of various pathological conditions.
Chien-Ning Hsu +7 more
doaj +1 more source

Insulin elevates leptin secretion and mRNA levels via cyclic AMP in 3T3-L1 adipocytes deprived of glucose

Heliyon, 2016
Aims: Leptin plays an important role in the pathogenesis of obesity and diabetes, yet the regulatory mechanisms of this hormone have not been fully elucidated.
Tomomi Tsubai +6 more
doaj +1 more source

obesity
leptin receptor
leptin resistance