Results 71 to 80 of about 151,999 (312)

Expression of leptin and its receptor in female breast cancer in relation with selected apoptotic markers.

Folia Histochemica et Cytobiologica, 2008
Leptin and its receptor may be engaged in pathogenesis of breast cancer among various human tumors. In vitro investigations showed leptin-mediated escalation of estrogen synthesis and boosted activity of estrogen receptor ERalpha.
Stanislaw Sulkowski, Katarzyna Jarzabek, Luiza Kanczuga-Koda, Mariola Sulkowska, Mariusz Koda   +4 more
doaj   +3 more sources

Plasma leptin levels in pigs with different leptin and leptin receptor genotypes

Journal of Animal Breeding and Genetics, 2008
SummaryA C3469T mutation at exon 3 of the pig leptin (Lep) gene has been genotyped in diverse pig breeds yielding controversial results with regard to its association with growth, fatness and carcass traits. A similar situation has been reported for a HpaII restriction fragment length polymorphism (RFLP) in the pig leptin receptor (Lepr) gene, where ...
Amills, Marcel, Villalba, D., Tor, M., Mercadé, Anna, Gallardo, David, Cabrera, Betlem, Jiménez, N., Noguera, José L., Sánchez, Armand, Estany, J.   +9 more
openaire   +3 more sources

Neurovascular coupling in bone regeneration: Mechanisms, advanced biomaterials and challenges

BMEMat, EarlyView.
This figure illustrates various material strategies for neurovascularized bone regeneration, including electroactive scaffolds, ion‐loaded materials, drug delivery systems, surface modifications, cells/cell products, growth factors, and peptides. These approaches aim to synergistically promote the regeneration of neural, vascular, and bone tissues ...
Yixin Ma, Nan Jiang, Liyuan Chen, He Zhang, Xinjia Cai, Karan Gulati, Danqing He, Zhigang Cai, Yan Liu   +8 more
wiley   +1 more source

Genomic Insights Into Risperidone Treatment Outcomes in Children and Adolescents: Experience From a Psychiatric Hospital Serving Rural Youth

Clinical Pharmacology &Therapeutics, EarlyView.
Risperidone is a commonly used antipsychotic for treating psychiatric illness in children and adolescents. There is a large variability in risperidone response and discontinuation rates remain high. Pharmacogenomics offers the opportunity to improve risperidone outcomes, yet studies in pediatric populations are limited.
Jack W. Staples, Shayna R. Killam, Karen E. Brown, Rachel Dalton, Elizabeth Sather, Qiang Chen, Joshua Loveland, Corbin Schwanke, Abdallah F. Elias, Kristin L. Bigos, Erica L. Woodahl   +10 more
wiley   +1 more source

Leptin and Exercise

Experimental Biology and Medicine, 2002
Short-term exercise (<60 min) studies suggest that leptin concentrations are not acutely affected in healthy males and females. Most reports of reductions in serum leptin may be attributed to circadian rhythms or hemoconcentration. For long-term (≥60 min) exercise, a reduction in leptin concentrations reported from 1 to 3 hr of running or cycling ...
Robert R, Kraemer, Hongnan, Chu, V Daniel, Castracane   +2 more
openaire   +2 more sources

Acute leptin deficiency, leptin resistance, and the physiologic response to leptin withdrawal [PDF]

Proceedings of the National Academy of Sciences, 2005
Food restriction and weight loss result in reduced plasma leptin, which is associated with a pleiotropic biologic response. However, because weight loss itself is also associated with changes in numerous other humoral and metabolic signals, it can be difficult to determine the precise features of the biologic response to acute leptin deficiency.
Jason M, Montez, Alex, Soukas, Esra, Asilmaz, Gulnorakhon, Fayzikhodjaeva, Giamila, Fantuzzi, Jeffrey M, Friedman   +5 more
openaire   +2 more sources

The Serotonin 2B (5‐HT2B) Receptor: A Narrative Review of Preclinical and Clinical Evidence on the Safety Considerations and Therapeutic Potential for the Treatment of Depression

Clinical Pharmacology &Therapeutics, EarlyView.
Major depressive disorder (MDD) and treatment‐resistant depression (TRD) remain leading causes of disability, providing the impetus for receptor‐level treatment strategies beyond monoamine reuptake. The serotonin 5‐HT2B receptor (5‐HT2BR) is uniquely positioned at the interface of central‐antidepressant mechanisms and peripheral cardiac risks.
Gia Han Le, Sabrina Wong, Danica E. Johnson, Diana K. Orsini, Yang Jing Zheng, Kayla M. Teopiz, Christine E. Dri, Joshua D. Rosenblat, Roger S. McIntyre   +8 more
wiley   +1 more source

Editorial: Leptin in Physiology and Disease

, 2022
Since the discovery of leptin, a product of the ob gene, in 1994, there has been a large amount of research identifying the role of this hormone in the maintenance of normal physiology and in disease states.
Hryciw, Deanne H, Singh, Harbindar Jeet, Hryciw, Deanne H.   +2 more
core   +1 more source

The glucoregulatory actions of leptin

Molecular Metabolism, 2017
Background: The hormone leptin is an important regulator of metabolic homeostasis, able to inhibit food intake and increase energy expenditure. Leptin can also independently lower blood glucose levels, particularly in hyperglycemic models of leptin or ...
Anna M. D'souza, Ursula H. Neumann, Maria M. Glavas, Timothy J. Kieffer   +3 more
doaj   +1 more source

Cannabidiol in Anorexia Nervosa: A Double‐Blind Randomized Placebo Controlled Pilot Study to Test Safety, Pharmacokinetics, and Symptom Change

International Journal of Eating Disorders, EarlyView.
ABSTRACT Objective Anorexia nervosa (AN) is a severe psychiatric disorder marked by an intense fear of gaining weight and persistent body dissatisfaction, both during periods of underweight and after weight restoration. The endocannabinoid system may offer therapeutic benefits, particularly in reducing anxiety.
Neha Sahota, David J. Grelotti, Tyler Nguyen, Walter H. Kaye, Skylar Swindle, Raymond Suhandynata, Spencer Seely, Megan E. Shott, Guido K. W. Frank   +8 more
wiley   +1 more source