Results 91 to 100 of about 151,999 (312)
Role of Leptin and metabolism in survival of autoreactive CD4+ T cells
, 2009 Recent evidence has shown that leptin, the adipose-tissue derived hormone, can influence T cell homeostasis and survival through the control of genes involved in these processes. Leptin deficient ob/ob mice and humans show reduced circulating number of T
Galgani, Mario
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Kaohsiung Journal of Medical Sciences, 2012 Leptin regulates maternal metabolism and fetal growth by reducing food intake and increasing energy expenditure, particularly during the third trimester.
Ling-Jen Wang +5 more
doaj +1 more source
ESC Heart Failure, Volume 12, Issue 2, Page 1386-1397, April 2025.Sequeira et al. reveal how the glucagon‐like peptide‐1 receptor agonist (GLP‐1‐RA) semaglutide restores cardiomyocyte function in rats subjected to a high‐fat/high‐fructose diet (HFD). Employing fluorescence‐ and patch‐clamp technology in isolated cardiac myocytes, they demonstrate that semaglutide reverses HFD‐induced activation of L‐type calcium ...
Vasco Sequeira +12 more
wiley +1 more source
Anticontractile effect of perivascular adipose tissue and leptin are reduced in hypertension
Frontiers in Pharmacology, 2012 Leptin causes vasodilatation both by endothelium-dependent and -independent mechanisms. Leptin is synthetized by perivascular adipose tissue (PVAT). The hypothesis of this study is that a decrease of leptin production in PVAT of spontaneously rats (SHR ...
Beatriz eGálvez-Prieto +11 more
doaj +1 more source
Anales del Sistema Sanitario de Navarra, 2009 Obesity appears as a result of the balance between the individual's calorie consumption and energy expenditure. There are numerous neuroendocrinological factors responsible for regulating the energy metabolism; however, it was the discovery of the leptin that opened the way for numerous investigations destined to lay bare the mechanisms involved in ...
E, Simón, A S, Del Barrio
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Epilepsia, EarlyView.Abstract Objective Epilepsy affects ~1% of the global population and often requires lifelong antiseizure medication (ASM) therapy. Valproic acid (VPA) is a commonly prescribed first‐line ASM, yet only approximately half of patients achieve sustained seizure freedom. Treatment selection remains largely empirical.
Simeon Platte +15 more
wiley +1 more source
Leptin and leptin resistance in obesity: current evidence, mechanisms and future directions
Endocrine ConnectionsLeptin, a key adipokine regulating energy homeostasis, has been extensively studied for its potential in the management of obesity. However, its therapeutic efficacy is often limited due to leptin resistance.
Wenjing Hu, Huijuan Zhu, Fengying Gong
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Journal of Pharmacological Sciences, 2005 Leptin is an adipose tissue-derived secretory hormone that suppresses appetite by inhibition of neuropepeptide Y (NPY) gene expression in arcuate nucleus (ARC) in the hypothalamus.
Hiroshi Higuchi +2 more
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Ketogenic diet for infantile epileptic spasms
Epilepsia Open, EarlyView.Abstract Approximately half of all cases of Infantile Epileptic Spasms Syndrome (IESS) do not respond to vigabatrin and hormonal therapies. There is no clear consensus as to the second‐line therapy for IESS. Ketogenic diet (KD) has emerged as an effective treatment for certain drug‐resistant epilepsies and in many cases of IESS.
Morris H. Scantlebury +3 more
wiley +1 more source
, 2014 Background There is a proven relationship between obesity and several cancers including breast, endometrium, colorectal, and esophagus. With the increasing incidence of both obesity and thyroid cancer, we designed the present study to investigate a ...
Elwafa, RA +3 more
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