Results 101 to 110 of about 151,999 (312)

Differential modulation of arcuate nucleus and mesolimbic gene expression levels by central leptin in rats on short-term high-fat high-sugar diet.

PLoS ONE, 2014
ObjectiveLeptin resistance is a common hallmark of obesity. Rats on a free-choice high-fat high-sugar (fcHFHS) diet are resistant to peripherally administered leptin. The aim of this study was to investigate feeding responses to central leptin as well as
José K van den Heuvel, Leslie Eggels, Eric Fliers, Andries Kalsbeek, Roger A H Adan, Susanne E la Fleur   +5 more
doaj   +1 more source

Glucose and Loss of Control Eating: Evidence From Naturalistic Assessment After Roux‐en‐Y Gastric Bypass

European Eating Disorders Review, EarlyView.
ABSTRACT Objective While loss of control (LOC) eating is associated with poor outcomes following metabolic and bariatric surgery (MBS), the mechanisms driving it are less understood. This study used momentary, naturalistic data to examine glucose as a biological correlate of LOC eating after Roux‐en‐Y gastric bypass (RYGB).
Gail A. Kerver, Kristine J. Steffen, Debra L. Safer, Glen Forester, David B. Sarwer, Stephen A. Wonderlich, Scott G. Engel   +6 more
wiley   +1 more source

The role of leptin in diabetes and its complications

, 2023
Leptin is an important adipokine that is implicated in regulating energy metabolism and appetite to control food intake. However, the serum level of leptin is influenced by various factors, such as diet, lifestyle, and health conditions.
Zhang, Cheng, Feng, Yigang, Wang, Ning, Xu, Xiaoyu, Feng, Yibin   +4 more
core  

Genomics Education Alliance - Docker materials for Leptin RNA-Seq Demonstration Lesson

, 2023
Docker materials for the Genomics Education Alliance (https://qubeshub.org/community/groups/gea) Leptin RNA-Seq demonstration lesson (https://cyverse-leptin-rna-seq-lesson-dev.readthedocs-hosted.com/en/latest/index ...
Wilson Leung, Jason Williams
core   +1 more source

Insulin elevates leptin secretion and mRNA levels via cyclic AMP in 3T3-L1 adipocytes deprived of glucose

Heliyon, 2016
Aims: Leptin plays an important role in the pathogenesis of obesity and diabetes, yet the regulatory mechanisms of this hormone have not been fully elucidated.
Tomomi Tsubai, Yukihiro Noda, Kazuma Ito, Makoto Nakao, Yusuke Seino, Yutaka Oiso, Yoji Hamada   +6 more
doaj   +1 more source

Leptin Reduces Running in a Rodent Anorexia Nervosa Model via a Distributed Neural Network

European Eating Disorders Review, EarlyView.
ABSTRACT Objective Hyperactivity is a persistent and clinically relevant symptom in anorexia nervosa (AN). Hyperactivity is inversely correlated with leptin levels. While systemic leptin administration attenuates hyperactivity in rodent models, the specific brain regions mediating this effect remain unclear.
Nick J. M. Papavoine, Melissa N. Veendijk, Jessie Nijman, Mieneke C. M. Luijendijk, Inge G. Wolterink‐Donselaar, Frank J. Meye, Roger A. H. Adan   +6 more
wiley   +1 more source

Long-duration leptin transgene expression in dorsal vagal complex does not alter bone parameters in female Sprague Dawley rats

Bone Reports
The hypothalamus and dorsal vagal complex (DVC) are both important for integration of signals that regulate energy balance. Increased leptin transgene expression in either the hypothalamus or DVC of female rats was shown to decrease white adipose tissue ...
Russell T. Turner, Adam J. Branscum, Urszula T. Iwaniec   +2 more
doaj   +1 more source

Dietary and biomarker‐guided strategies as supportive measures in the fragile X syndrome

Food Biomacromolecules, EarlyView.
Abstract The fragile X syndrome (FXS) is an inherited neurodevelopmental disorder that primarily affects males, often resulting in an IQ below 55, while about two‐thirds of females also experience intellectual disability. Physical features may include an elongated face, prominent ears, finger joint laxity, and enlarged testes in males.
Jailan E. El Halawani, Reem R. AlOlaby
wiley   +1 more source

Leptin serum and disease activity in spondyloarthritis [PDF]

, 2020
Background: Spondyloarthritis (SpA) is an active chronic inflammatory disease involving pro-inflammatory cytokines; one of which is leptin. This study aimed to determine correlation between leptin serum level and disease activity in SpA patients. Method:
Luluch Mulyani, Yuliasih
core  

Leptin Promotes the Expression of Pro-inflammatory Mediator Genes but Does Not Alter Osteoclastogenesis and Early Stage Differentiation of Osteoblasts

Journal of Physiological Investigation
Leptin, a hormone secreted by adipose tissue, plays a pivotal role in maintaining energy metabolism and bone quality. Dysregulation of leptin can lead to the development of various pathological conditions.
Chien-Ning Hsu, Chih-Hong Kao, Chin-Hua Yang, Ming-Te Cheng, Yu-Pao Hsu, Shinn-Gwo Hong, Chao-Ling Yao, Yu-Hsu Chen   +7 more
doaj   +1 more source