Results 131 to 140 of about 267,086 (349)

Perilipin-2 deletion promotes carbohydrate-mediated browning of white adipose tissue at ambient temperature

Journal of Lipid Research, 2018
Mice lacking perilipin-2 (Plin2-null) are resistant to obesity, insulin resistance, and fatty liver induced by Western or high-fat diets. In the current study, we found that, compared with WT mice on Western diet, Plin2-null adipose tissue was more ...
Andrew E. Libby, Elise S. Bales, Jenifer Monks, David J. Orlicky, James L. McManaman   +4 more
doaj   +1 more source

Periprostatic adipocytes act as a driving force for prostate cancer progression in obesity

Nature Communications, 2016
Obesity favours the occurrence of locally disseminated prostate cancer in the periprostatic adipose tissue (PPAT) surrounding the prostate gland. Here we show that adipocytes from PPAT support the directed migration of prostate cancer cells and that this
Victor Laurent, Adrien Guérard, C. Mazerolles, S. Le Gonidec, A. Toulet, Laurence Nieto, Falek Zaidi, B. Majed, D. Garandeau, Y. Socrier, M. Golzio, T. Cadoudal, Karima Chaoui, C. Dray, B. Monsarrat, O. Schiltz, Y. Wang, B. Couderc, P. Valet, B. Malavaud, C. Muller   +20 more
semanticscholar   +1 more source

T‐Cell Exhaustion in the Tumor Microenvironment: Subcellular Dysfunction, Pan‐Cancer Characteristics, and Therapeutic Interventions

Advanced Science, EarlyView.
This study elucidates the mechanisms of subcellular multidimensional collapse in exhausted T cells. By specifically targeting the nucleus, mitochondria, and endoplasmic reticulum, strategic interventions can effectively remodel the compromised organelle network. This integrated approach drives comprehensive T cell resuscitation, ultimately establishing
Mingxing Wang, Wanhui Dong, Jian Chen, Zhangjie Zhou, Shujuan Fu, Tingting Wu, Haiyan Jiang, Zhiying Wang, Zhixian Zhong, Yi Zhong   +9 more
wiley   +1 more source

Emergence of highly profibrotic and proinflammatory Lrat+Fbln2+ HSC subpopulation in alcoholic hepatitis

Hepatology, EarlyView., 2022
Lrat+ quiescent hepatic stellate cells (qHSC) give rise to Lrat+Fbln2+ activated HSC (aHSC) in alcohol‐associated hepatitis and this subpopulation is highly profibrotic, inflammatory, and immunoregulatory based on their single cell transcriptomic profile. Abstract Background and Aims Relative roles of HSCs and portal fibroblasts in alcoholic hepatitis (
Steven Balog, Reika Fujiwara, Stephanie Q. Pan, Khairat B. El‐Baradie, Hye Yeon Choi, Sonal Sinha, Qihong Yang, Kinji Asahina, Yibu Chen, Meng Li, Matthew Salomon, Stanley W.‐K. Ng, Hidekazu Tsukamoto   +12 more
wiley   +1 more source

Xenotransplantation of human fetal adipose tissue: a model of in vivo adipose tissue expansion and adipogenesis

Journal of Lipid Research, 2014
Obesity during childhood and beyond may have its origins during fetal or early postnatal life. At present, there are no suitable in vivo experimental models to study factors that modulate or perturb human fetal white adipose tissue (WAT) expansion ...
Briana Garcia, Heather Francois-Vaughan, Omobola Onikoyi, Stefan Kostadinov, Monique E. De Paepe, Philip A. Gruppuso, Jennifer A. Sanders   +6 more
doaj   +1 more source

Adipocytes Sequester and Metabolize the Chemotherapeutic Daunorubicin

Molecular Cancer Research, 2017
Obesity is associated with poorer outcome for many cancers. Previously, we observed that adipocytes protect acute lymphoblastic leukemia (ALL) cells from the anthracycline, daunorubicin.
Xia Sheng, J. Parmentier, Jonathan Tucci, Hua Pei, Omar Cortez-Toledo, C. Dieli-Conwright, M. Oberley, M. Neely, E. Orgel, S. Louie, S. Mittelman   +10 more
semanticscholar   +1 more source

Rôle des adipocytes péri-tumoraux dans la progression tumorale mammaire

, 2011
De nombreux arguments suggèrent que la progression tumorale est non seulement dépendante des cellules cancéreuses mais aussi des cellules normales qui entourent la tumeur.
Bochet, Ludivine
core  

Lactoferrin Deficiency During Lactation Causes Adult Obesity‐Related Metabolic Disease Through Persistent Adipose Dysfunction Driven by Impaired Adipocyte Development

Advanced Science, EarlyView.
Lactational lactoferrin deficiency exerts lasting effects on epididymal adipose tissue development from lactation into adulthood: it impairs adipocyte hyperplasia and induces pathological hypertrophy, resulting in lower body weight yet exacerbated metabolic dysfunction under a high‐fat diet in adulthood.
Qin An, Yunxia Zou, Wenli Wang, Zhimei Cheng, Zhuoxing Zhang, Ruwei Liu, Xiong Wang, Kunlun Huang, Fangrong Ding, Yunping Dai, Qingyong Meng, Yali Zhang   +11 more
wiley   +1 more source

Is oxidative stress of adipocytes a cause or a consequence of the metabolic syndrome?

Journal of Clinical & Translational Endocrinology, 2018
Metabolic syndrome is accompanied by oxidative stress in animals and humans. The main source of ROS in experimental metabolic syndrome is NADPH oxidase and possibly adipocyte mitochondria.
L. Maslov, N. V. Naryzhnaya, A. Boshchenko, S. Popov, V. V. Ivanov, P. Oeltgen   +5 more
semanticscholar   +1 more source

Oxygen Vacancy‐Enriched Platinum Single‐Atom Nanozyme Wrapped in Nanoislands: Unlocking Catalytic Activity and Reprogramming Redox Microenvironment for Osteonecrosis Repair

Advanced Science, EarlyView.
CeO2‐x/Pt single‐atom nano‐island is constructed via low‐temperature reduction, featuring abundant oxygen vacancies and an island–sea structure. It delivers outstanding multi‐enzyme‐mimetic activity and ROS‐scavenging efficiency. Density functional theory reveals optimized electronic structures and reaction pathways.
Yang Zhu, Zehui Lv, Xuejie Cai, Penghui Wei, Dengliang Wang, Zhao Wang, Ruoying Wang, Yingjie Wang, Xingdong Yang, Yixin Bian, Jiawei Xu, Xisheng Weng, Liangfeng Wei   +12 more
wiley   +1 more source