Results 141 to 150 of about 267,086 (349)

Modelling adipocytes size distribution

, 2013
International audienceAdipocytes are cells whose task is to store excess energy as lipid droplets in their cytoplasm. Adipocytes can adapt their size according to the lipid amount to be stored.
Soulage, Christophe, Geloen, Alain, Soula, H. A., Julienne, H.   +3 more
core   +1 more source

CEBPG‐Mediated Palmitic Acid Adaptation of Cancer‐Associated Fibroblasts Drives Metastasis of Oral Squamous Cell Carcinoma

Advanced Science, EarlyView.
This study reveals a metabolic signaling axis in the OSCC microenvironment where palmitic acid (PA) drives the activation of CAFs. PA uptake triggers CEBPG‐dependent epigenetic remodeling to upregulate ERN1 and TMBIM6, thereby mitigating ER stress. This adaptive program sustains CAF survival and the pro‐metastatic phenotype, establishing this pathway ...
Yiling Duan, Yitong Li, Yufei Wu, Xiao Yang, Rui Li, Hui Zhao, Zhengjun Shang   +6 more
wiley   +1 more source

Erianin inhibits 3T3-L1 adipocyte differentiation through downregulation of CCAAT-enhancer binding protein-α and peroxisome proliferator-activated receptor-γ, lipogenic genes and impairment of mitochondrial respiration

Adipocyte
Erianin, a natural bibenzyl compound, has recently garnered attention owing to its diverse biological activities. In the present study, we investigated the effects of Erianin on adipocyte differentiation, lipid metabolism, and mitochondrial respiration ...
Hathaichanok Yimpreeda, Chayanee Laowittawat, Siraprapa Siritutsoontorn, Pinnara Rojvirat, Sarawut Kumphune, Sarawut Jitrapakdee   +5 more
doaj   +1 more source

Adipocytes and Obesity-Related Conditions Jointly Promote Breast Cancer Cell Growth and Motility: Associations With CAP1 for Prognosis

Frontiers in Endocrinology, 2018
The global increase in overweight and obesity rates represent pressing public health concerns associated with severe comorbidities, amongst a rising incidence and impaired outcome of breast cancer.
Ann H. Rosendahl, Malin Bergqvist, Barbara Lettiero, Siker Kimbung, Signe Borgquist, Signe Borgquist   +5 more
doaj   +1 more source

Flow Cytometry of Mouse and Human Adipocytes for the Analysis of Browning and Cellular Heterogeneity

Cell Reports, 2018
Summary Adipocytes, once considered simple lipid-storing cells, are rapidly emerging as complex cells with many biologically diverse functions. A powerful high-throughput method for analyzing single cells is flow cytometry.
C. Hagberg, Qian Li, Maria Kutschke, Debajit Bhowmick, E. Kiss, I. Shabalina, Matthew J. Harms, O. Shilkova, Viviana Kozina, J. Nedergaard, J. Boucher, A. Thorell, K. Spalding   +12 more
semanticscholar   +1 more source

NMI Regulates Adipose Adaptive Thermogenesis Through TLR4/IRF3 Signaling to Promote Obesity

Advanced Science, EarlyView.
Adipose tissue‐derived NMI is secreted under metabolic stress and suppresses adaptive thermogenesis through TLR4/IRF3 signaling, repressing the PPARα/PGC‐1α/UCP1 thermogenic transcriptional program. Genetic ablation or anti ‐ NMI monoclonal antibody treatment enhances energy expenditure, protects against DIO, and ameliorates adipose tissue inflammation,
Ting‐Ting Li, Xin‐Yuan Zhao, Min Zhang, Zhuang‐Feng Weng, Xiao‐Ran Guo, Ying‐Fang Liu, Qiao‐Ping Wang, Huan‐Huan Liang   +7 more
wiley   +1 more source

Palmitic acid differently modulates extracellular vesicles and cellular fatty acid composition of SGBS adipocytes without impairing their insulin signaling

Frontiers in Endocrinology
ScopeAdipocyte-derived extracellular vesicle (EV) lipid cargo reflects the obese metabolic state. Nevertheless, it is currently unknown whether the adipocyte-derived EV lipid profile is influenced by saturated fatty acid overload. This study investigated
Domenico Sergi, Sharon Angelini, Fabiola Castaldo, Marco Beccaria, Carlo Bellinghieri, Flavio Franchina, Alice Omenetto, Gabriella Stifani, Sefora Del Mastro, Stefania Merighi, Stefania Gessi, Ravin Jugdaohsingh, Carlo Cervellati, Martin Wabitsch, Luca Maria Neri, Guillaume Bidault, Antonio Vidal-Puig, Juana Maria Sanz, Angelina Passaro   +18 more
doaj   +1 more source

Mitochondria in White, Brown, and Beige Adipocytes

Stem Cells International, 2016
Mitochondria play a key role in energy metabolism in many tissues, including cardiac and skeletal muscle, brain, liver, and adipose tissue. Three types of adipose depots can be identified in mammals, commonly classified according to their colour ...
M. Cedikova, M. Kripnerová, J. Dvořáková, P. Pitule, M. Grundmanova, V. Babuška, D. Mullerova, J. Kuncová   +7 more
semanticscholar   +1 more source

Pancreatic Atrophy: A Narrative Review and Surgical Interpretation

Annals of Gastroenterological Surgery, EarlyView.
Pancreatic parenchymal atrophy pattern and intraoperative margin assessment guide surgical strategy. ABSTRACT Despite recent advances in multimodal management, pancreatic ductal adenocarcinoma remains a fatal malignancy. Early detection of indirect findings of pancreatic ductal adenocarcinoma is essential to improve treatment outcomes, drawing ...
Rika Fujino, Ken‐ichi Okada, Yohei Masugi, Eisuke Iwasaki, Masaki Mori   +4 more
wiley   +1 more source

A high-cholesterol zebrafish diet promotes hypercholesterolemia and fasting-associated liver steatosis

Journal of Lipid Research
Zebrafish are an ideal model organism to study lipid metabolism and to elucidate the molecular underpinnings of human lipid-associated disorders. Unlike murine models, to which various standardized high lipid diets such as a high-cholesterol diet (HCD ...
Yang Jin, Darby Kozan, Eric D. Young, Monica R. Hensley, Meng-Chieh Shen, Jia Wen, Tabea Moll, Jennifer L. Anderson, Hannah Kozan, John F. Rawls, Steven A. Farber   +10 more
doaj   +1 more source