Results 11 to 20 of about 267,086 (349)

UCP1 Dependent and Independent Thermogenesis in Brown and Beige Adipocytes

Frontiers in Endocrinology, 2020
Mammals have two types of thermogenic adipocytes: brown adipocytes and beige adipocytes. Thermogenic adipocytes express high levels of uncoupling protein 1 (UCP1) to dissipates energy in the form of heat by uncoupling the mitochondrial proton gradient ...
K. Ikeda, Tetsuya Yamada
exaly   +2 more sources

The Common and Distinct Features of Brown and Beige Adipocytes

Trends in Endocrinology and Metabolism, 2018
Two distinct types of thermogenic fat cells, brown adipocytes and beige adipocytes, play a key role in the regulation of systemic energy homeostasis in mammals.
Shingo Kajimura
exaly   +2 more sources

Thermogenic Ability of Uncoupling Protein 1 in Beige Adipocytes in Mice [PDF]

PLoS ONE, 2013
Chronic adrenergic activation leads to the emergence of beige adipocytes in some depots of white adipose tissue in mice. Despite their morphological similarities to brown adipocytes and their expression of uncoupling protein 1 (UCP1), a thermogenic ...
Yuko Okamatsu-Ogura, Ayumi Tsubota, Akira Terao   +2 more
exaly   +2 more sources

Human White Adipocytes Convert Into “Rainbow” Adipocytes In Vitro [PDF]

Journal of Cellular Physiology, 2017
White adipocytes are plastic cells able to reversibly transdifferentiate into brown adipocytes and into epithelial glandular cells under physiologic stimuli in vivo.
Mattiucci, D, Rippo, MR, Maurizi, G, Spartaco Santi, Cinti, S, Saverio Cinti, Severi, I, Santi, S, Antonella Poloni, Vivarelli, M, Corvera, S, Maurizi, A, Stefania Mancini, Valerio Izzi, Leoni, P, Antonio Giordano, Poloni, A, Mancini, S, Ilenia Severi, Massimo Falconi, Izzi, V, Domenico Mattiucci, Perugini, J, Silvia Corvera, Giuliani, A, Maria Cristina Zingaretti, Angela Maurizi, Jessica Perugini, Maria Rita Rippo, Falconi, M, Giulia Maurizi, Zingaretti, MC, Pietro Leoni, Marco Vivarelli, Angelica Giuliani, Giordano, A   +35 more
core   +7 more sources

Mature Human White Adipocytes Cultured under Membranes Maintain Identity, Function, and Can Transdifferentiate into Brown-like Adipocytes

Cell Reports, 2019
Summary: White adipose tissue (WAT) is a central factor in the development of type 2 diabetes, but there is a paucity of translational models to study mature adipocytes.
Matthew J. Harms, Qian Li, Sunjae Lee, Cheng Zhang, Bengt Kull, Stefan Hallen, Anders Thorell, Ida Alexandersson, Carolina E. Hagberg, Xiao-Rong Peng, Adil Mardinoglu, Kirsty L. Spalding, Jeremie Boucher   +12 more
doaj   +2 more sources

Senolytic effects of quercetin in an in vitro model of pre-adipocytes and adipocytes induced senescence [PDF]

Scientific Reports, 2021
The dysfunction of adipose tissue with aging and the accumulation of senescent cells has been implicated in the pathophysiology of chronic diseases.
E. Zoico, Nicole Nori, E. Darra, M. Tebon, V. Rizzatti, Gabriella Policastro, Annamaria De Caro, A. Rossi, F. Fantin, M. Zamboni   +9 more
semanticscholar   +2 more sources

Mechanobiology of Adipocytes

Biology
The growing obesity epidemic necessitates increased research on adipocyte and adipose tissue function and disease mechanisms that progress obesity. Historically, adipocytes were viewed simply as storage for excess energy.
Steven J. Pagano, Sean P. Blade, Dylan J. Falkowski, Sarah N. Bachand, LiKang Chin   +4 more
core   +4 more sources

Extracellular vesicle-Based Interorgan Transport of Mitochondria from Energetically Stressed Adipocytes

Cell Metabolism, 2021
Summary: Adipocytes undergo intense energetic stress in obesity resulting in loss of mitochondrial mass and function. We have found that adipocytes respond to mitochondrial stress by rapidly and robustly releasing small extracellular vesicles (sEVs ...
C. Crewe, J. Funcke, Shujuan Li, Nolwenn Joffin, Christy M. Gliniak, Alexandra L. Ghaben, Yu A. An, Hesham A. Sadek, R. Gordillo, Yucel Akgul, Shiuhwei Chen, D. Samovski, P. Fischer-Posovszky, C. Kusminski, S. Klein, P. Scherer   +15 more
semanticscholar   +1 more source

Asc-1 regulates white versus beige adipocyte fate in a subcutaneous stromal cell population

Nature Communications, 2021
Adipose tissue is composed of a variety of cell types, including adipocyte precursor populations, that contribute to adipose tissue function upon differentiation. Here, using scRNA-sequencing of adolescent and adult mouse subcutaneous adipose tissue, the
Lisa Suwandhi, Irem Altun, Ruth Karlina, Viktorian Miok, Tobias Wiedemann, David Fischer, Thomas Walzthoeni, Christina Lindner, Anika Böttcher, Silke S. Heinzmann, Andreas Israel, Ahmed Elagamy Mohamed Mahmoud Khalil, Alexander Braun, Ines Pramme-Steinwachs, Ingo Burtscher, Philippe Schmitt-Kopplin, Matthias Heinig, Martin Elsner, Heiko Lickert, Fabian J. Theis, Siegfried Ussar   +20 more
doaj   +1 more source

Immune Cell Regulation of White Adipose Progenitor Cell Fate

Frontiers in Endocrinology, 2022
Adipose tissue is essential for energy storage and endocrine regulation of metabolism. Imbalance in energy intake and expenditure result in obesity causing adipose tissue dysfunction.
Irem Altun, Irem Altun, Xiaocheng Yan, Xiaocheng Yan, Siegfried Ussar, Siegfried Ussar, Siegfried Ussar   +6 more
doaj   +1 more source