Results 51 to 60 of about 69,441 (277)
Activins in adipogenesis and obesity [PDF]
International Journal of Obesity, 2012 Activins are secreted proteins members of the transforming growth factor-β family. They are involved in many biological responses including regulation of apoptosis, proliferation and differentiation of different cell types. Activins A, B and AB are highly expressed in adipose tissue, and in this review we will illustrate that activins have a role in ...
openaire +2 more sources
ERK‐Mediated Phosphorylation of YAP Defines a Noncanonical FGF Signaling Mechanism in Stem Cells
Advanced Science, EarlyView.With a powerful combination of in vivo, ex vivo, and in vitro models, the authors highlight a novel FGF‐ERK signaling regulation of YAP at the S128 site in neural crest‐derived stem cells. This study opens exciting new directions in stem cell biology and craniofacial biology, paving the way for potential innovations in the treatment of craniofacial ...
Xiaolei Zhao +16 more
wiley +1 more source
Adipogenesis-related microRNAs in obesity
, 2022 © ExRNA. All rights reserved.In the last four decades, studies have shown that the significant increase in the prevalence of obesity has become a pandemic. While obesity decreases life expectancy, it largely increases healthcare expenditures. However, up
ENGİN, AYŞE BAŞAK +3 more
core +1 more source
Cistanche promotes the adipogenesis of 3T3-L1 preadipocytes
PLoS ONE, 2022 Cistanche deserticola Ma (cistanche) is a traditional herb with a wide range of therapeutic properties. However, no evidence of cistanche’s effect on adipogenesis has been found.
Ping Zhang +9 more
doaj
Advanced Science, EarlyView.ABSTRACT Brown and beige adipocytes dissipate energy as heat, yet effective strategies to enhance their mitochondrial efficiency remain limited. Here, we identify Agnuside (AGN) as a selective stabilizer of the complex I assembly factor NDUFAF6. AGN directly binds cytosolic NDUFAF6, suppresses its ubiquitination, prolongs its half‐life, and facilitates
Qingwen Zhao +7 more
wiley +1 more source
Monoalkylglycerol Ether Lipids Promote Adipogenesis
, 2016 The molecular mechanisms that lead to the generation of adipose tissue (adipogenesis) are of basic and biomedical interest. Cellular models of adipogenesis have proven extremely valuable in defining biomoleculesprimarily genes and proteinsthat regulate
Yun-Gon Kim (227765) +3 more
core +1 more source
Self‐Assembling Hybrid Hydrogel Reprograms the Stromal Vascular Fraction to Treat Osteoarthritis
Advanced Science, EarlyView.This study presents a bioinspired injectable hydrogel that enhances the therapeutic potential of stem cell‐rich stromal vascular fraction for treating osteoarthritis. By reprogramming cell behavior through epigenetic modulation, the hydrogel promotes cartilage regeneration and reduces joint damage in a rat model, offering a promising new approach for ...
Waifang Hou +23 more
wiley +1 more source
The Effects of Coffee Extract on Adipogenesis
, 2021 The prevalence of obesity in the United States has increased from 30.5% in 1999 to 42.4% in 2018. Fat cells are created through a process called adipogenesis; in adipogenesis, a preadipocyte, which is an undifferentiated fibroblast, is differentiated ...
Carper, Jaden
core
Frontiers in EndocrinologyAdipose tissue, an indispensable organ, fulfils the pivotal role of energy storage and metabolism and is instrumental in maintaining the dynamic equilibrium of energy and health of the organism.
Chun Hong +19 more
doaj +1 more source
Identification of KMU-3, a novel derivative of gallic acid, as an inhibitor of adipogenesis.
PLoS ONE, 2014 Differentiation of preadipocyte, also called adipogenesis, leads to the phenotype of mature adipocyte. Excessive adipogenesis, however, is largely linked to the development of obesity.
Yu-Kyoung Park +5 more
doaj +1 more source