Results 71 to 80 of about 94,652 (323)

An Epigenetic Fate Converter Based on Nuclei‐Targeting Lipid Nanoparticles Drives Neuronal Programming of Stem Cells for Spinal Cord Repair

Advanced Functional Materials, EarlyView.
Schematic illustration of LNP‐MPG nuclei‐targeting delivery of HMW‐FGF2 promoting histone acetylation to regulate the fate of DPSCs and treat spinal cord injury. LNPs components include pHMW‐FGF2 plasmid, DSPC, Dlin‐MC3‐DMA, cholesterol, and PEG2000, and are modified with MPG to form HMW‐FGF2@LNP‐MPG (HLM). HLM nuclei‐targets DPSCs to deliver HMW‐FGF2,
Heng Zhou, Qiang Qin, Xiqin Li, Hanyu Ding, Chun Xu, Yan He, Qingsong Ye   +6 more
wiley   +1 more source

The Phytochemical Rhein Mediates M6A-Independent Suppression of Adipocyte Differentiation

Frontiers in Nutrition, 2021
Adipogenesis is mediated by the complex gene expression networks involving the posttranscriptional modifications. The natural compound rhein has been linked to the regulation of adipogenesis, but the underlying regulatory mechanisms remain elusive ...
Linyuan Huang, Jun Zhang, Xinyun Zhu, Xue Mi, Qiujie Li, Jing Gao, Jianheng Zhou, Jun Zhou, Jun Zhou, Xiao-Min Liu   +9 more
doaj   +1 more source

Advances in 3D Bioprinting for Breast Cancer Modeling: Tumor Microenvironment, Metastasis, and Drug Screening

Advanced Healthcare Materials, EarlyView.
Three‐dimensional bioprinting transforms breast cancer modeling from simple constructs into spatially organized, multicellular, perfused, and patient‐derived platforms. This review shows how bioinks, cellular composition, architecture, and flow govern tumor behavior and drug response, while revealing why complexity alone is insufficient without ...
Mustafa Nakipoglu, Mahboobeh Mahmoodi, Ehsanul Hoque Apu, Fahimeh Shahabipour, Sibel Emir Diltemiz, Sanjib Saha, Halima Alem, Nureddin Ashammakhi   +7 more
wiley   +1 more source

Gene-chip studies of adipogenesis-regulated microRNAs in mouse primary adipocytes and human obesity

BMC Endocrine Disorders, 2011
Background Adipose tissue abundance relies partly on the factors that regulate adipogenesis, i.e. proliferation and differentiation of adipocytes. While components of the transcriptional program that initiates adipogenesis is well-known, the importance ...
Gallagher Iain J, Petrovic Natasa, Gburcik Valentina, Keller Pernille, Nedergaard Jan, Cannon Barbara, Timmons James A   +6 more
doaj   +1 more source

GDNF‐Enriched Small Extracellular Vesicle‐Loaded ROS‐Scavenging Hydrogel Promotes Neural Regeneration After Spinal Cord Injury

Advanced Healthcare Materials, EarlyView.
A glial cell line‐derived neurotrophic factor (GDNF)‐enriched small extracellular vesicle‐loaded reactive oxygen species (ROS)‐scavenging hydrogel integrates sustained neurotrophic delivery with local modulation of oxidative and inflammatory stress after spinal cord injury. The composite hydrogel improves local vesicle retention, protects neural tissue,
Xingyu Zhu, Zhong Liu, Kewei Li, Yuhong Fan, Kangjia Yang, Xiaopeng Sun, Hang Shi, Lixuan Sun, Yang Lou, Min Wang, Peipei Wu, Hui Qian, Qiang Fu, Hua Ding   +13 more
wiley   +1 more source

FGF6 and FGF9 regulate UCP1 expression independent of brown adipogenesis

Nature Communications, 2020
Uncoupling protein-1 (UCP1) plays a central role in energy dissipation in brown adipose tissue (BAT). Using high-throughput library screening of secreted peptides, we identify two fibroblast growth factors (FGF), FGF6 and FGF9, as potent inducers of UCP1
F. Shamsi, Rui-Dan Xue, Tian-Lian Huang, M. Lundh, Yang Liu, L. O. Leiria, M. Lynes, Elena Kempf, Chih-Hao Wang, Satoru Sugimoto, P. Nigro, Kathrin Landgraf, T. Schulz, Yiming Li, Brice Emanuelli, S. Kothakota, L. Williams, N. Jessen, S. B. Pedersen, Y. Böttcher, M. Blüher, A. Körner, Laurie J. Goodyear, M. Mohammadi, C. R. Kahn, Yu-Hua Tseng   +25 more
semanticscholar   +1 more source

Cistanche promotes the adipogenesis of 3T3-L1 preadipocytes

PLoS ONE, 2022
Cistanche deserticola Ma (cistanche) is a traditional herb with a wide range of therapeutic properties. However, no evidence of cistanche’s effect on adipogenesis has been found.
Ping Zhang, Le Su, Xiuyu Ji, Feifan Ma, Qiulin Yue, Chen Zhao, Song Zhang, Xin Sun, Kunlun Li, Lin Zhao   +9 more
doaj  

Monoalkylglycerol Ether Lipids Promote Adipogenesis

, 2016
The molecular mechanisms that lead to the generation of adipose tissue (adipogenesis) are of basic and biomedical interest. Cellular models of adipogenesis have proven extremely valuable in defining biomoleculesprimarily genes and proteinsthat regulate
Yun-Gon Kim (227765), James P. Cardia (2210503), Edwin A. Homan (1335243), Alan Saghatelian (105846)   +3 more
core   +1 more source

Rab1A Promotes Hepatic Steatosis by Suppressing Mitophagy via the Raf‐1/ERK1/2/PINK1 Signaling Axis

Advanced Science, EarlyView.
Why does fat accumulate in the liver? Our study reveals Rab1A as the molecular switch that silences the cell's mitochondrial cleanup crew. Turning Rab1A off reactivates mitophagy, clears excess fat, and reverses fatty liver disease in mice—offering a promising new therapeutic target for MASLD, a growing global health challenge.
Li Zhang, Jianhua Li, Huilu Zhang, Qi Qin, Yichen Huang, Xiaofan Tian, Chao Sun, Binbin Li, Zhengxin Wang, Xin Zhang   +9 more
wiley   +1 more source

Novel perspectives on autophagy-oxidative stress-inflammation axis in the orchestration of adipogenesis

Frontiers in Endocrinology
Adipose tissue, an indispensable organ, fulfils the pivotal role of energy storage and metabolism and is instrumental in maintaining the dynamic equilibrium of energy and health of the organism.
Chun Hong, Xinming Li, Kunli Zhang, Qiuyan Huang, Qiuyan Huang, Baohong Li, Haiyun Xin, Bin Hu, Fanming Meng, Xiangxing Zhu, Dongsheng Tang, Chuanhuo Hu, Chuanhuo Hu, Chenyu Tao, Jianhao Li, Yang Cao, Hai Wang, Bo Deng, Sutian Wang, Sutian Wang   +19 more
doaj   +1 more source