Results 81 to 90 of about 69,441 (277)
ROCK inhibitors enhance the production of large lipid-enriched 3D organoids of 3T3-L1 cells
Scientific Reports, 2021 Since the recent discovery of prostaglandin-associated peri-orbitopathy, a great deal of interest has developed concerning the side effects of anti-glaucoma medications toward periocular fatty tissue, especially their adipogenesis.
Yosuke Ida +2 more
doaj +1 more source
Advanced Science, EarlyView.Adult stem cell therapy requires more than high in vitro potency. This review proposes a systems framework in which cell‐intrinsic programs, instructive microenvironmental cues, and pre‐/post‐delivery engineering are co‐designed under standardized translational rules.
Soo‐Rim Kim +2 more
wiley +1 more source
Histone methyltransferase Smyd2 drives adipogenesis via regulating STAT3 phosphorylation
Cell Death and Disease, 2022 Adipogenesis is a complex cascade involved with the preadipocytes differentiation towards mature adipocytes, accelerating the onset of obesity. Histone methyltransferase SET and MYND domain-containing protein 2 (Smyd2), is involved in a variety of ...
Haibi Su +5 more
doaj +1 more source
Advanced Science, EarlyView.An integrative single‐cell atlas across multiple metabolic diseases reveals coordinated metabolic modules and disease‐shared versus disease‐specific pathway activities. By systematically comparing scoring strategies, a robust RankAve framework is established. Coupled with network analysis and drug‐target prediction, this resource uncovers cross‐disease
Kuan Yang +10 more
wiley +1 more source
Adipocyte, 2020 Given the high and increasing prevalence of obesity and associated disorders, such as type-2 diabetes, it is important to understand the mechanisms that regulate lipid storage and the differentiation of fat cells, a process termed adipogenesis. Using the
James E. Merrett +3 more
doaj +1 more source
Regulation of adipogenesis by nucleotides
Biochemical Society TransactionsThe process by which multipotent cells commit to differentiate into distinct cell types, eventually forming functional tissues and organisms, has fascinated scientists for decades. Consequently, numerous studies have contributed to our understanding of how transcription factors and signaling molecules regulate differentiation.
Julia A. Pinette +3 more
openaire +2 more sources
Pancreatic Atrophy: A Narrative Review and Surgical Interpretation
Annals of Gastroenterological Surgery, EarlyView.Pancreatic parenchymal atrophy pattern and intraoperative margin assessment guide surgical strategy. ABSTRACT Despite recent advances in multimodal management, pancreatic ductal adenocarcinoma remains a fatal malignancy. Early detection of indirect findings of pancreatic ductal adenocarcinoma is essential to improve treatment outcomes, drawing ...
Rika Fujino +4 more
wiley +1 more source
An investigation of the early molecular regulation of adipogenesis in human mesenchymal stem cells.
, 2006 Human bone marrow-derived mesenchymal stem cells (hMSCs) can differentiate in vitro into various lineages including adipocytes, osteoblasts, and chondrocytes.
Westwood, Claire, Westwood, C.
core
Transcriptional Regulation of Adipogenesis by KLF4
, 2008 SummaryWhile adipogenesis is known to be controlled by a complex network of transcription factors, less is known about the transcriptional cascade that initiates this process.
Friedman, Jeffrey +5 more
core +1 more source
, 2016 Obesity is characterized by excess adipose tissue and is one of the leading public-health issues of the industrialized world. Gain of adipose tissue can result from accumulation of fat in existing adipocytes (fat cells), as well as increased commitment ...
Partlow, Kaia +2 more
core +1 more source