Results 81 to 90 of about 94,652 (323)

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Sirt3 regulates adipogenesis and adipokine secretion via its enzymatic activity

Pharmacology Research & Perspectives, 2020
The purpose of this research was to identify if Sirt3 plays a role in marrow adipogenesis and adipokines secretion, especially adiponectin using bone marrow‐derived stroma (ST2) cell model.
Oanh Ma, Truc Le, George Talbott, Tram HoangThao Nguyen, Dorothy Ha, Linh Ho   +5 more
doaj   +1 more source

A stromal cell population that inhibits adipogenesis in mammalian fat depots

Nature, 2018
Adipocyte development and differentiation have an important role in the aetiology of obesity and its co-morbidities1,2. Although multiple studies have investigated the adipogenic stem and precursor cells that give rise to mature adipocytes3–14, our ...
P. C. Schwalie, H. Dong, M. Zachara, Julie Russeil, D. Alpern, Nassila Akchiche, Christian Caprara, Wenfei Sun, K. Schlaudraff, G. Soldati, C. Wolfrum, B. Deplancke   +11 more
semanticscholar   +1 more source

MicroRNA regulation in mammalian adipogenesis

, 2011
Adipogenesis, the complex development from preadipocytes or mesenchymal stem cells to mature adipocytes, is essential for fat formation and metabolism of adipose tissues in mammals.
Moore, Stephen S., Le Luo Guan, Josue M Romao, Jin, Weiwu, Stephen S Moore, Dodson, Michael V., Gary J Hausman, Romao, Josue M., le Guan, Luo, Weiwu Jin, Michael V Dodson, Hausman, Gary J.   +11 more
core   +2 more sources

Identification of KMU-3, a novel derivative of gallic acid, as an inhibitor of adipogenesis.

PLoS ONE, 2014
Differentiation of preadipocyte, also called adipogenesis, leads to the phenotype of mature adipocyte. Excessive adipogenesis, however, is largely linked to the development of obesity.
Yu-Kyoung Park, Jinho Lee, Victor Sukbong Hong, Jong-Soon Choi, Tae-Yoon Lee, Byeong-Churl Jang   +5 more
doaj   +1 more source

The RNA-binding protein HuR is a negative regulator in adipogenesis

Nature Communications, 2020
Human antigen R (HuR) is an essential regulator of RNA metabolism, but its function in metabolism remains unclear. This study identifies HuR as a major repressor during adipogenesis.
Diana Teh Chee Siang, Yen-Ching Lim, A. M. Kyaw, K. Win, S. Chia, Ufuk Degirmenci, Xiang Hu, Bryan C. Tan, Arcinas Camille Esther Walet, Lei Sun, Dan Xu   +10 more
semanticscholar   +1 more source

Activins in adipogenesis and obesity [PDF]

International Journal of Obesity, 2012
Activins are secreted proteins members of the transforming growth factor-β family. They are involved in many biological responses including regulation of apoptosis, proliferation and differentiation of different cell types. Activins A, B and AB are highly expressed in adipose tissue, and in this review we will illustrate that activins have a role in ...
openaire   +2 more sources

YAP1‐Driven Pathogenic Fibro‐Adipogenic Progenitors Secrete IL‐6 and FGF21 to Mediate Muscle‐Bone Crosstalk and Promote Bone Loss

Advanced Science, EarlyView.
Fibro‐adipogenic progenitors (FAPs) in atrophic muscle undergo YAP1‐driven pathogenic activation, secreting IL‐6 and FGF21 as bone‐catabolic myokines that mediate muscle‐bone crosstalk and promote bone loss. Genetic or pharmacological targeting of this YAP1‐FAP‐myokine axis rescues skeletal deterioration, identifying FAP‐derived myokines as therapeutic
Xiaoyu Cai, Tao Xu, Rui Ma, Weikun Meng, Shutao Gao, Yakefu Abulizi, Alafate Kahaer, Chuanhui Xun, Maierdan Maimaiti, Rui Cao, Weidong Liang, Polati Maimaiti, Qiang Deng, Jun Sheng, Ting Wang, Mingchong Liu, Weibin Sheng   +16 more
wiley   +1 more source

Ahcy Acts as an Effector of Hnf4a‐Driven Super‐Enhancer Activation to Alleviate MASLD During Intermittent Fasting

Advanced Science, EarlyView.
Our study identifies an Hnf4a‐driven super‐enhancer of hepatic Ahcy that mediates the protective effects of intermittent fasting against MASLD. Disruption of the Ahcy super‐enhancer reduces Ahcy expression and exacerbates lipid accumulation. This pathway prevents aberrant promoter hypermethylation by maintaining the SAM/SAH balance, as exemplified by ...
Huafeng Chen, Shilin Zhang, Xiaojie Deng, Wenqiang Xie, Fen Xu, Jie Shen, Hua Liang   +6 more
wiley   +1 more source

Long noncoding RNAs regulate adipogenesis

, 2012
The prevalence of obesity has led to a surge of interest in understanding the detailed mechanisms underlying adipocyte development. Many protein-coding genes, mRNAs, and microRNAs have been implicated in adipocyte development, but the global expression ...
Hacisuleyman, Ezgi, Sauvageau, Martin, Yuan, Bingbing B., Hendrickson, David G., Kellis, Manolis, Kelley, David R., Tazon-Vega, Barbara, Goff, Loyal, Rinn, John L., Alexander, Ryan K., Sun, Lei, Lo, Kinyui Alice, Lodish, Harvey F., Trapnell, Cole   +13 more
core   +2 more sources