Results 61 to 70 of about 69,441 (277)

Sirt3 regulates adipogenesis and adipokine secretion via its enzymatic activity

Pharmacology Research & Perspectives, 2020
The purpose of this research was to identify if Sirt3 plays a role in marrow adipogenesis and adipokines secretion, especially adiponectin using bone marrow‐derived stroma (ST2) cell model.
Oanh Ma, Truc Le, George Talbott, Tram HoangThao Nguyen, Dorothy Ha, Linh Ho   +5 more
doaj   +1 more source

A Circuit of Mechanically Regulated Transcription Factors Balances Regenerative and Fibrotic Memory of Mesenchymal Stromal Cells

Advanced Science, EarlyView.
Producing MSCs on rigid culture substrates induces a scar‐making phenotype, jeapordizing therapeutic success. ‘Tissue‐soft’ surfaces prevent MSC fibrogenesis and preserve regenerative traits. An epigenetic network, driven by HOXA11 and SALL1, maintains ‘soft memory’ by keeping chromatin open in relaxed MSCs, promoting anti‐fibrotic programs.
Fereshteh Sadat Younesi, Andrew E. Miller, Li Diao, Xinying Guo, Natalie Andonian, Elham Karimizadeh, Thomas H. Barker, Boris Hinz   +7 more
wiley   +1 more source

Modeling Adipogenesis: Current and Future Perspective [PDF]

, 2020
Adipose tissue is contemplated as a dynamic organ that plays key roles in the human body. Adipogenesis is the process by which adipocytes develop from adipose-derived stem cells to form the adipose tissue.
Jiranuwat Sapudom, Wassim Abou-Kheir, Joseph Azar, Reem Daouk, Jeremy C. M. Teo, Azar, Joseph, Daouk, Reem, Al-Sayegh, Mohamed Ahmed, Bahmad, Hisham F., Abou-Kheir, Wassim G., Hisham F. Bahmad, Sapudom, Jiranuwat, Teo, Jeremy C.M., Mohamed Al-Sayegh   +13 more
core   +1 more source

Epoxy Clerodane Diterpene Attenuates the Differentiated Adipocyte Hypertrophy and Enhances Mitochondrial Metabolism. [PDF]

ChemistryOpen
Epoxy Clerodane Diterpene (ECD) significantly reduces adipocyte hypertrophy and lipid accumulation in human mesenchymal stem cell (hMSC)‐derived adipocytes. ECD improves mitochondrial membrane potential (ΔΨm), increases thermogenic regulators (UCP‐1, PPARγC1α), decreases adipogenic markers (C/EBPα, PPARγ), and reduces inflammatory mediators (TNF‐α, NF ...
AlSedairy SA, Subash-Babu P, Alhussain MH, Binobead MA, Alshatwi AA.   +4 more
europepmc   +2 more sources

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Morphological and molecular characterization of GALNT2-mediated adipogenesis

, 2021
3T3L1 mouse pre-adipocytes develop into adipocytes differently in response to GALNT2 overexpression or to stimulation with rosiglitazone, a reference inducer of adipogenesis.
Antonucci A., Scarale M. G., De Bonis C., Trischitta V., Di Paola R., Marucci A., Mangiacotti D.   +6 more
core   +2 more sources

IL-17 in obesity and adipogenesis [PDF]

Cytokine & Growth Factor Reviews, 2010
The pro-inflammatory cytokine interleukin (IL)-17 (also known as IL-17) has been associated with induction of tissue inflammation. Obese individuals exhibit many symptoms of chronic low-grade inflammation, suggesting that IL-17 may impact adipose tissue. However, the role of IL-17 in obesity is largely unexplored. Emerging studies indicate that obesity
Mushtaq, Ahmed, Sarah L, Gaffen
openaire   +2 more sources

Multi‐Omics Profiling Reveals Immunomodulatory and Pro‐Regenerative Effects of a Graphene Oxide–Collagen Scaffold in Massive Rotator Cuff Tears

Advanced Science, EarlyView.
A graphene oxide/collagen scaffold is developed for chronic massive rotator cuff tear repair. The scaffold improves compressive stability, supports reparative mesenchymal differentiation, and modulates the immune microenvironment. In chronic MRCT models, it reduces muscle degeneration, enhances tendon–bone regeneration, and improves functional recovery,
Renwen Wan, Yechuan Deng, Zixin Hu, Yanwei He, Xinting Feng, Jun Ma, Yisheng Chen, Zhijie Zhao, Jie Mei, Zhiheng Lin, Wei Luo, Zhengyuan Fang, Zhufeng Hu, Kunlun Feng, Xinrong Li, Dan Wu, Bowen Han, James Hoi po Hui, Xuanyong Liu, Chen Chen, Gang Chen, Shiyi Chen, Nirong Bao, Jiajun Qiu, Zhiwen Luo   +24 more
wiley   +1 more source

Lactoferrin Deficiency During Lactation Causes Adult Obesity‐Related Metabolic Disease Through Persistent Adipose Dysfunction Driven by Impaired Adipocyte Development

Advanced Science, EarlyView.
Lactational lactoferrin deficiency exerts lasting effects on epididymal adipose tissue development from lactation into adulthood: it impairs adipocyte hyperplasia and induces pathological hypertrophy, resulting in lower body weight yet exacerbated metabolic dysfunction under a high‐fat diet in adulthood.
Qin An, Yunxia Zou, Wenli Wang, Zhimei Cheng, Zhuoxing Zhang, Ruwei Liu, Xiong Wang, Kunlun Huang, Fangrong Ding, Yunping Dai, Qingyong Meng, Yali Zhang   +11 more
wiley   +1 more source

MicroRNAs in bovine adipogenesis: Genomic context, expression and function

, 2014
Background MicroRNAs (miRNAs) are small non-coding RNAs found to regulate several biological processes including adipogenesis. Understanding adipose tissue regulation is critical for beef cattle as fat is an important determinant of beef quality and ...
Jin, Weiwu, Guan, Leluo, Romao, Josue M., McAllister, Tim, He, Maolong   +4 more
core   +1 more source