Results 41 to 50 of about 66,281 (214)

p21Cip1 plays a critical role in the physiological adaptation to fasting through activation of PPARα

Scientific Reports, 2016
AbstractFasting is a physiological stress that elicits well-known metabolic adaptations, however, little is known about the role of stress-responsive tumor suppressors in fasting. Here, we have examined the expression of several tumor suppressors upon fasting in mice.
Lopez-Guadamillas, Elena, Fernandez-Marcos, Pablo J., Pantoja, Cristina, Muñoz-Martin, Maribel, Martínez, Dolores, Gómez-López, Gonzalo, Campos-Olivas, Ramón, Valverde, Angela M., Serrano, Manuel   +8 more
openaire   +5 more sources

Triflumizole Is an Obesogen in Mice that Acts through Peroxisome Proliferator Activated Receptor Gamma (PPAR γ )

Environmental Health Perspectives, 2012
Triflumizole (TFZ) is an imidazole fungicide used on many food and ornamental crops. TFZ is not thought to be particularly toxic or carcinogenic, but little is known about its effect on development. TFZ is identified as a peroxisome proliferator activated receptor gamma (PPARγ) activator in ToxCast.
Li, X, Pham, HT, Janesick, AS, Blumberg, B   +3 more
openaire   +5 more sources

Effects Of PPARγ2 Pro12Ala Variant On Adipocyte Phenotype Dependent Of DHA.

Diabetes, metabolic syndrome and obesity : targets and therapy, 2019
Peroxisome proliferator-activated receptor γ2 (PPARγ2) plays a critical role in the regulation of adipocyte differentiation and adipocytokine production. The Pro12Ala variant is the most common mutation in the PPARγ2 gene. Its effect appears to be sensitive to dietary factors, such as docosahexaenoic acid (DHA) level.
Wan,Renhui, Ding,Zhengping, Xia,Sheng, Zheng,Longyi, Lu,Jin   +4 more
openaire   +4 more sources

THEAFLAVIN MENGHAMBAT DIFERENSIASI PREADIPOSIT VISERAL MANUSIA MELALUI PPARγ γγ γSECARA IN VITRO

Jurnal Kedokteran Brawijaya, 2013
Differentiation of pre-adipocytes into adipocytes, is a complex process that involves coordination of  expression of specific genes and proteins associated with each stage of differentiation. This process is regulated by several signaling pathways. CCAAT element-binding proteins (C/EBP)  αand  βand sterol response element-binding protein 1 (ADD1/
openaire   +2 more sources

Rab1A Promotes Hepatic Steatosis by Suppressing Mitophagy via the Raf‐1/ERK1/2/PINK1 Signaling Axis

Advanced Science, EarlyView.
Why does fat accumulate in the liver? Our study reveals Rab1A as the molecular switch that silences the cell's mitochondrial cleanup crew. Turning Rab1A off reactivates mitophagy, clears excess fat, and reverses fatty liver disease in mice—offering a promising new therapeutic target for MASLD, a growing global health challenge.
Li Zhang, Jianhua Li, Huilu Zhang, Qi Qin, Yichen Huang, Xiaofan Tian, Chao Sun, Binbin Li, Zhengxin Wang, Xin Zhang   +9 more
wiley   +1 more source

Bioengineered Exosome‐Loaded Immunomodulatory Bioadhesive Spray Reverses Liver Fibrosis and Metabolic Dysfunction That Triggers Beneficial Gut‐Liver Crosstalk in Chronic Fatty Liver Disease

Advanced Science, EarlyView.
Umbilical cord stem cell‐derived exosomes encapsulated in an immunomodulatory bioadhesive hydrogel spray enable localized therapy, sustained vesicle delivery, macrophage polarization, suppress systemic inflammation, and mitigate glucose and insulin homeostasis impairments in MAFLD.
Triya Saha, Ayushi Mairal, Shreya Mehrotra, Shiv K. Sarin, Ashok Kumar   +4 more
wiley   +1 more source

HD‐tDCS Restores Perivascular AQP4 Polarization via PPARγ Modulation to Enhance Glymphatic Clearance After Intracerebral Hemorrhage in Mice

Advanced Science, EarlyView.
HD‐tDCS promotes recovery after intracerebral hemorrhage by enhancing PPARγ‐dependent astrocyte remodeling in a mouse model of ICH. This process suppresses proinflammatory astrocytic activation, restores perivascular AQP4 repolarization, and improves glymphatic influx and efflux, thereby facilitating hematoma and perihematomal edema clearance and ...
Zhiming Li, Yingmei Zhang, Qianqian Tong, Zhitao Gong, Shanyu Zhang, Zhen Qian, Hui Zhang, Qian Yao, Qi Li   +8 more
wiley   +1 more source

SPSB1 Promotes Subcutaneous Adipose Hyperplasia in Facial Port‐Wine Stains by Controlling HDAC1 Degradation and Stability Through Two Distinct Proteolytic Pathways

Advanced Science, EarlyView.
In PWS‐ASPCs, FOSL1 drives the expression of SPSB1. SPSB1, as part of the ESC complex, further binds to HDAC1 and promotes K29‐linked and K48‐linked polyubiquitination of HDAC1. These modifications facilitate the degradation of HDAC1 through the ALP and UPS pathways, respectively.
Hongrui Chen, Bin Sun, Yajing Qiu, Chen Hua, Xiaoxi Lin, Wei Gao   +5 more
wiley   +1 more source

Gene variants and haplotypes of Vitamin D biosynthesis, transport, and function in preeclampsia

Hypertension in Pregnancy, 2021
Objective: To find whether the gene variants and haplotypes of cytochrome (CYP) 27B1 (1α-hydroxylase), group-specific component (GC) that is a vitamin D binding protein, vitamin D receptor (VDR), peroxisome proliferator-activated receptor γ (PPARγ) and ...
Zahra Ghorbani, Mohammad Shakiba, Negin Rezavand, Ziba Rahimi, Asad Vaisi-Raygani, Zohreh Rahimi, Ebrahim Shakiba   +6 more
doaj   +1 more source

Pharmacogenetic Aspects of Type 2 Diabetes Treatment

Acta Biomedica Scientifica, 2020
In this article, we analyze the role of different variants of the KCNJ11, TCF7L2, SLC22A1, SLC22A3, CYP2C9, CYP2C8, PPARγ genes polymorphisms in efficacy of diabetes mellitus pharmacotherapy.
N. O. Pozdnyakov, I. N. Kagarmanyan, A. E. Miroshnikov, E. S. Emelyanov, A. A. Gruzdeva, A. M. Sirotkina, I. A. Dukhanina, A. A. Milkina, A. A. Khokhlov, S. O. Pozdnyakov   +9 more
doaj   +1 more source