Results 41 to 50 of about 4,462 (166)

Synthesis and Biological Activity of Piperine Derivatives as Potential PPARγ Agonists

Drug Design, Development and Therapy, 2020
Yanli Wang,1– 3 Yuan Yao,4,5 Jing Liu,2,6 Lili Wu,7 Tonghua Liu,7 Jian Cui,1 David Yue-Wei Lee2 1School of Pharmacy, Minzu University of China, Beijing 100081, People’s Republic of China; 2Bio-Organic and Natural Products Laboratory, McLean ...
Wang Y, Yao Y, Liu J, Wu L, Liu T, Cui J, Lee DYW   +6 more
doaj  

THEAFLAVIN MENGHAMBAT DIFERENSIASI PREADIPOSIT VISERAL MANUSIA MELALUI PPARγ γγ γSECARA IN VITRO

Jurnal Kedokteran Brawijaya, 2013
Differentiation of pre-adipocytes into adipocytes, is a complex process that involves coordination of  expression of specific genes and proteins associated with each stage of differentiation. This process is regulated by several signaling pathways. CCAAT element-binding proteins (C/EBP)  αand  βand sterol response element-binding protein 1 (ADD1/
openaire   +2 more sources

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

STK38 is a PPARγ-interacting protein promoting adipogenesis

Adipocyte, 2021
Peroxisome proliferator-activated receptor-γ (PPARγ) is the master regulator of adipogenesis, but knowledge about how PPARγ is regulated at the protein level is very limited.
Kun Qian, Daozhan Yu, Weiming Wang, Mengqi Jiang, Rongze Yang, Robert Brown, Da-Wei Gong   +6 more
doaj   +1 more source

Agnuside Stabilizes the Complex I Assembly Factor NDUFAF6 to Reinforce Mitochondrial Efficiency and Thermogenic Responsiveness

Advanced Science, EarlyView.
ABSTRACT Brown and beige adipocytes dissipate energy as heat, yet effective strategies to enhance their mitochondrial efficiency remain limited. Here, we identify Agnuside (AGN) as a selective stabilizer of the complex I assembly factor NDUFAF6. AGN directly binds cytosolic NDUFAF6, suppresses its ubiquitination, prolongs its half‐life, and facilitates
Qingwen Zhao, Li Xie, Qianzhuo Wang, Shuying Dai, Bei Li, Yingjuan Zhang, Zhe Sun, Yue Gao   +7 more
wiley   +1 more source

PENINGKATAN KADAR LEPTIN DENGAN PUFA (Polyunsaturated Fatty Acid) MELALUI AKTIVASI PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR gamma (PPARγ) PADA KULTUR PREADIPOSIT KELINCI

Jurnal Kedokteran Brawijaya, 2013
ABSTRACT For the past three decades, PUFA has been recognized as importnant energy sources and cell membrane component. PUFA also plays key roles in many cellular events such as gene regulation and leptin activation. The role of this fatty acid is still unknown especially in vitro.
openaire   +2 more sources

Bifidobacterium Pseudolongum‐Derived Inosine Mitigates Polystyrene Nanoplastics‐Induced Hepatic Injury by Inhibiting the Polarization of M1 Macrophages

Advanced Science, EarlyView.
Probiotic B.p colonization elevated gut‐derived inosine level in the liver, while elevated inosine activated A2AR and subsequently blocked NPs‐induced polarization of M1 macrophages by repressing the miR155/SOCS1/NF‐κB pathway. This reduced the release of inflammatory cytokines and thereby, mitigated NPs‐induced hepatic injury.
Kaikai Zhang, Yuchuan Chen, Jiayuan Wan, Jianzheng Yang, Lijian Chen, Qingyuan Li, Anding Zhou, Nian Zhou, Jiuyang Ding, Qi Wang, Jian Sun   +10 more
wiley   +1 more source

Effects of peroxisome proliferator activated receptor gamma (PPARγ) agonist on fasting model applied neuron cultures

Türk Biyokimya Dergisi, 2021
Peroxisome proliferator activated receptor gamma (PPARγ) agonists used for the treatment of Diabetes Mellitus (DM), has important roles on the regulation of metabolism including ketogenesis in fasting and low glucose states.
Pınarbaşı Arzu, Pak Meltem, Kolay Murat, Öz Arslan Devrim, Aksungar Fehime Benli   +4 more
doaj   +1 more source

Lilrb4a Suppression Reprograms Microglia to Mitigate APOE4‐Associated Amyloid Plaques and Cerebral Amyloid Angiopathy in Association With a PPAR‐Linked Pro‐Clearance State

Advanced Science, EarlyView.
Targeting Lilrb4a in Apolipoprotein E4 (APOE4)‐associated Alzheimer's disease (AD) reprograms microglia toward a beneficial, phagocytic state. Genetic deletion or antisense inhibition of Lilrb4a suppresses p‐SHP2/NF‐κB/STAT1 signaling, restores PPAR‐linked lipid and energy metabolism, and reduces amyloid plaque burden and cerebral amyloid angiopathy ...
Changxu Nie, Ruixi Yang, Xiaotong Wang, Ping Jia, Xueqi Zhang, Yaqi Dai, Xue Bai, Sijia Duan, Yufeng Li, Peng Zheng, Xin Tian, Li Jiang, Chao Wang   +12 more
wiley   +1 more source