Cell-free DNA methylation as liquid biopsy for the assessment of fibrosis in patients with nonalcoholic steatohepatitis: a gap between innovation and implementation [PDF]
, 2017 The presence of cfDNA in the circulating compartment was demonstrated three decades ago , leading to the emergence of liquid biopsy.However, the implementation of cfDNA methylation as a non-invasive molecular tool for the diagnosis of fibrosis imposes ...
Pirola, Carlos José +1 more
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p21Cip1 plays a critical role in the physiological adaptation to fasting through activation of PPARα
Scientific Reports, 2016 AbstractFasting is a physiological stress that elicits well-known metabolic adaptations, however, little is known about the role of stress-responsive tumor suppressors in fasting. Here, we have examined the expression of several tumor suppressors upon fasting in mice.
Lopez-Guadamillas, Elena +8 more
openaire +5 more sources
Psychiatry and Clinical Psychopharmacology, 2019 OBJECTIVES: Bipolar disorder (BD) carries a high rate of morbidity and mortality, and the clarification of its aetiology continues to be an important field of research.
Gamze Erzin +6 more
doaj +1 more source
Autoimmunity, 2022 Proprotein convertase subtilisin kexin type 9 (PCSK9) is a well-known proprotein convertase that influences foam cell formation and modulates atherosclerosis. Inclisiran is a novel chemosynthetic small interfering RNA that inhibits PCSK9 synthesis.
Zhaoping Wang +4 more
doaj +1 more source
VIP treatment prevents embryo resorption by modulating efferocytosis and activation profile of maternal macrophages in the CBAxDBA resorption prone model [PDF]
, 2016 Successful embryo implantation occurs followed by a local pro-inflammatory response subsequently shifted toward a tolerogenic one. VIP (vasoactive intestinal peptide) has embryotrofic, anti-inflammatory and tolerogenic effects.
Calo, Guillermina +7 more
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Environmental Health Perspectives, 2012 Triflumizole (TFZ) is an imidazole fungicide used on many food and ornamental crops. TFZ is not thought to be particularly toxic or carcinogenic, but little is known about its effect on development. TFZ is identified as a peroxisome proliferator activated receptor gamma (PPARγ) activator in ToxCast.
Li, X +3 more
openaire +5 more sources
CircRNF111 Contributes to Adipocyte Differentiation by Elevating PPARγ Expression via miR-27a-3p
Epigenetics, 2023 The content and distribution of adipocytes is an important factor that affects meat quality. Previous studies showed that circRNAs are involved in various physiological processes.
Xuemei Shen +5 more
doaj +1 more source
Effects of Aerobic Interval Training and Adenosine on the Expression of AMPK, PPARγ and A2B Receptor in the Liver of Rats Fed a High-Fat Diet [PDF]
Journal of Advanced Biomedical Sciences, 2020 Background & Objective: Obesity causes steatosis in the liver. PPARγ transcription factor of glucose and fat metabolism genes and AMPK cell energy sensor are considered as therapeutic targets in non-alcoholic fatty liver (NAFLD) patients.
Abolhasan Hedayati katooli +3 more
doaj
Diabetes, Metabolic Syndrome and Obesity, 2023 Yi-Kun Zhao,1 Xiang-Dong Zhu,2 Rong Liu,1 Xia Yang,1 Yong-Lin Liang,1 Yan Wang2 1Department of Basic Medical College, Gansu University of Chinese Medicine, Lanzhou City, People’s Republic of China; 2Department of Traditional Chinese Medicine College ...
Zhao YK +5 more
doaj
Enhanced anticancer effect of cetuximab combined with ethanol extract of Volvariella volvacea in colorectal cancer targeted TOP2A and PPARγ [PDF]
Journal of Pharmacy & Pharmacognosy ResearchContext: Colorectal cancer (CRC) is a major global health concern as innovative therapeutic strategies to enhance treatment outcomes. This study investigates the therapeutic potential of the ethanol extract derived from Volvariella volvacea in ...
Sofy Permana +8 more
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