Results 41 to 50 of about 74,506 (264)

Anti‐diabetic effect of andrographolide from Sambiloto herbs (Andrographis paniculata (Burm.f.) Nees) through the expression of PPARγ and GLUT‐4 in adipocytes

Indonesian Journal of Biotechnology, 2022
Andrographolide has been shown to have a pharmacological effect as an antidiabetic. Nevertheless, the comprehensive mechanism of action has yet to be determined.
Novia Tri Astuti, Putri Rachma Novitasari, Raymond Tjandrawinata, Agung Endro Nugroho, Suwijiyo Pramono   +4 more
doaj   +1 more source

The NADPH oxidase NOX4 regulates redox and metabolic homeostasis preventing HCC progression

Hepatology, EarlyView., 2022
Loss of NOX4 in HCC tumor cells induces metabolic reprogramming in a Nrf2/MYC‐dependent manner to promote HCC progression. Abstract Background and Aims The NADPH oxidase NOX4 plays a tumor‐suppressor function in HCC. Silencing NOX4 confers higher proliferative and migratory capacity to HCC cells and increases their in vivo tumorigenic potential in ...
Irene Peñuelas‐Haro, Rut Espinosa‐Sotelo, Eva Crosas‐Molist, Macarena Herranz‐Itúrbide, Daniel Caballero‐Díaz, Ania Alay, Xavier Solé, Emilio Ramos, Teresa Serrano, María L. Martínez‐Chantar, Ulla G. Knaus, José M. Cuezva, Antonio Zorzano, Esther Bertran, Isabel Fabregat   +14 more
wiley   +1 more source

VSP-2 attenuates secretion of inflammatory cytokines induced by LPS in BV2 cells by mediating the PPARγ/NF-κB signaling pathway

Open Life Sciences
Neuroinflammation, characterized by microglial activation and the subsequent secretion of inflammatory cytokines, plays a pivotal role in neurodegenerative diseases and brain injuries, often leading to neuronal damage and death.
Cui Jingxin, Xu Liwei, Sun Yimeng, Dai Lingfei, Mo Yuxiu, Yun Keli, Chen Yifei, Chen Linglin   +7 more
doaj   +1 more source

Synthesis and Biological Activity of Piperine Derivatives as Potential PPARγ Agonists

Drug Design, Development and Therapy, 2020
Yanli Wang,1– 3 Yuan Yao,4,5 Jing Liu,2,6 Lili Wu,7 Tonghua Liu,7 Jian Cui,1 David Yue-Wei Lee2 1School of Pharmacy, Minzu University of China, Beijing 100081, People’s Republic of China; 2Bio-Organic and Natural Products Laboratory, McLean ...
Wang Y, Yao Y, Liu J, Wu L, Liu T, Cui J, Lee DYW   +6 more
doaj  

Differential Regulation Of Peroxisome Proliferator Activated Receptor Gamma (Ppary) By Cytokines In Murine Macrophage J774.2 Cell Line : Elucidation Of Signal Transduction Pathways Of Tumour Necrosis Factor Alpha (Tnfa) In Regulating Macrophage Ppary Gene Expression [QH603.P47 L732 2007 f rb]. [PDF]

, 2007
Aterosklerosis merupakan punca kematian utama di negara-negara maju. Peranan PPARγ dalam makrofaj yang diaktifkan oleh sitokina adalah penting di dalam patogenesis aterosklerosis.
Lim, Chui Hun
core  

Daidzein has neuroprotective effects through ligand-binding-independent PPARγ activation

, 2012
Phytoestrogens are a group of plant-derived compounds that include mainly isoflavones like daidzein. Phytoestrogens prevent neuronal damage and improve outcome in experimental stroke; however, the mechanisms of this neuroprotective action have not been ...
Lizasoaín Hernández, Ignacio, Pradillo Justo, Jesús Miguel, Hurtado Moreno, Olivia, Ballesteros Martin, Ivan, Sánchez Prieto,, Bartolomé Martín, David, Torres Muñoz, Margarita, Cuartero Desviat, María Isabel, Ramírez Franco, Jose Jorge, Moro Sánchez, María Ángeles, Moraga Yébenes, Ana   +10 more
core   +1 more source

THEAFLAVIN MENGHAMBAT DIFERENSIASI PREADIPOSIT VISERAL MANUSIA MELALUI PPARγ γγ γSECARA IN VITRO

Jurnal Kedokteran Brawijaya, 2013
Differentiation of pre-adipocytes into adipocytes, is a complex process that involves coordination of  expression of specific genes and proteins associated with each stage of differentiation. This process is regulated by several signaling pathways. CCAAT element-binding proteins (C/EBP)  αand  βand sterol response element-binding protein 1 (ADD1/
openaire   +2 more sources

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

RIPK3 dampens mitochondrial bioenergetics and lipid droplet dynamics in metabolic liver disease

Hepatology, EarlyView., 2022
RIPK3 dampens mitochondrial bioenergetics and lipid droplet dynamics in metabolic liver disease. Abstract Background and Aims Receptor‐interacting protein kinase 3 (RIPK3) mediates NAFLD progression, but its metabolic function is unclear. Here, we aimed to investigate the role of RIPK3 in modulating mitochondria function, coupled with lipid droplet (LD)
Marta B. Afonso, Tawhidul Islam, Julie Magusto, Ricardo Amorim, Véronique Lenoir, Rui F. Simões, José Teixeira, Liana C. Silva, Dominique Wendum, Isabelle Jéru, Corinne Vigouroux, Rui E. Castro, Paulo J. Oliveira, Carina Prip‐Buus, Vlad Ratziu, Jérémie Gautheron, Cecília M. P. Rodrigues   +16 more
wiley   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source