Results 31 to 40 of about 101,448 (257)
Small molecule-mediated tribbles homolog 3 promotes bone formation induced by bone morphogenetic protein-2. [PDF]
, 2017 Although bone morphogenetic protein-2 (BMP2) has demonstrated extraordinary potential in bone formation, its clinical applications require supraphysiological milligram-level doses that increase postoperative inflammation and inappropriate adipogenesis ...
Aghaloo, Tara L +8 more
core +1 more source
International Journal of Oncology, 2011 The prostate cancer (PCa) cell lines LNCaP, PC-3, and DU-145 express peroxisome proliferator-activated receptor γ (PPARγ) but its role in PCa is unclear. Thiazolidinediones (TZDs), a family of PPARγ activators and type 2 anti-diabetic drugs, exhibit anti-tumor apoptotic effects in human PCa cell lines. Likewise, pharmacological inhibitors of fatty acid
Mahmoud, Mansour +10 more
openaire +3 more sources
Adipogenic Differentiation of hMSCs is Mediated by Recruitment of IGF-1r Onto the Primary Cilium Associated With Cilia Elongation [PDF]
, 2015 Funded by Marie Curie Intra European Fellowship (GENOMICDIFF) Wellcome Trust ...
Chapple, JP +4 more
core +1 more source
STK38 is a PPARγ-interacting protein promoting adipogenesis
Adipocyte, 2021 Peroxisome proliferator-activated receptor-γ (PPARγ) is the master regulator of adipogenesis, but knowledge about how PPARγ is regulated at the protein level is very limited.
Kun Qian +6 more
doaj +1 more source
Sinapic acid prevents adipogenesis by regulating transcription factors and exerts an anti-ROS effect by modifying the intracellular anti-oxidant system in 3T3-L1 adipocytes [PDF]
Iranian Journal of Basic Medical Sciences, 2022 Objective(s): In this study, we tested the hypothesis that sinapic acid (SA), a naturally occurring hydroxycinnamic acid found in vegetables, cereal grains, and oilseed crops with various biological activities suppresses adipogenesis in 3T3-L1 adipocytes
Cordelia John, Sumathy Arockiasamy
doaj +1 more source
Designing Specific Primers for Amplification and Quantitative Analysis of the GPR120 and PPARγ Genes [PDF]
Research in Molecular Medicine, 2022 Background: Designing the primer pairs is one of the most important factors in the amplification and quantitative analysis of the nucleic acid sequences of interest. Using in silico methods, the present study intends to design highly specific primers for
Ramin Lotfi, Farhad Salari
doaj
PLOS ONE, 2017 Autophagy is a catabolic mechanism to degrade cellular components to maintain cellular energy levels during starvation, a condition where PPARα may be activated. Here we report a reduced autophagic capacity in the liver following chronic activation of PPARα with fenofibrate (FB) in mice.
Ye, J +9 more
openaire +6 more sources
Adipocyte, 2019 Non-drug strategy targeting adipocyte differentiation is critical for alleviating visceral obesity and its related diseases. However, whether and how low intensity pulsed ultrasound (LIPUS) could be used for inhibiting visceral adipocyte differentiation ...
Tianhua Xu +6 more
doaj +1 more source
Türk Biyokimya Dergisi, 2021 Peroxisome proliferator activated receptor gamma (PPARγ) agonists used for the treatment of Diabetes Mellitus (DM), has important roles on the regulation of metabolism including ketogenesis in fasting and low glucose states.
Pınarbaşı Arzu +4 more
doaj +1 more source
Lesinurad, a novel, oral compound for gout, acts to decrease serum uric acid through inhibition of urate transporters in the kidney. [PDF]
, 2016 BackgroundExcess body burden of uric acid promotes gout. Diminished renal clearance of uric acid causes hyperuricemia in most patients with gout, and the renal urate transporter (URAT)1 is important for regulation of serum uric acid (sUA) levels.
Girardet, Jean-Luc +12 more
core +2 more sources