Results 31 to 40 of about 66,281 (214)
Astragaloside IV regulates autophagy-mediated proliferation and apoptosis in a rat model of PCOS by activating the PPARγ pathway [PDF]
Iranian Journal of Basic Medical Sciences, 2022 Objective(s): Astragaloside IV (AS-IV) is a bioactive saponin with a wide range of pharmacological effects. This study was aimed at investigating its potential effect on polycystic ovary syndrome (PCOS).
Mingxiao Wen +3 more
doaj +1 more source
Jurnal Kedokteran Brawijaya, 2013 Oxidized LDL (ox-LDL) causes activation and dysfunction of endothelial cells through NFκB activation after binding process of ox-LDL to LOX-1. One of ox-LDL components had been known as the activator of PPARγ. This study was done to see the effect of ox-LDL on NFκB and PPARγactivation and apoptosis of HUVEC’s culture.
Wibi Riawan, Samodijanti Wibowati
openaire +2 more sources
International Journal of Oncology, 2011 The prostate cancer (PCa) cell lines LNCaP, PC-3, and DU-145 express peroxisome proliferator-activated receptor γ (PPARγ) but its role in PCa is unclear. Thiazolidinediones (TZDs), a family of PPARγ activators and type 2 anti-diabetic drugs, exhibit anti-tumor apoptotic effects in human PCa cell lines. Likewise, pharmacological inhibitors of fatty acid
Mahmoud, Mansour +10 more
openaire +3 more sources
Curcumin improves adipocytes browning and mitochondrial function in 3T3-L1 cells and obese rodent model [PDF]
Royal Society Open Science, 2021 Accumulating evidence suggests that mitochondrial dysfunction and adipocyte differentiation promote lipid accumulation in the development of obesity and diabetes.
Dandan Zhao +12 more
doaj +1 more source
STK38 is a PPARγ-interacting protein promoting adipogenesis
Adipocyte, 2021 Peroxisome proliferator-activated receptor-γ (PPARγ) is the master regulator of adipogenesis, but knowledge about how PPARγ is regulated at the protein level is very limited.
Kun Qian +6 more
doaj +1 more source
Designing Specific Primers for Amplification and Quantitative Analysis of the GPR120 and PPARγ Genes [PDF]
Research in Molecular Medicine, 2022 Background: Designing the primer pairs is one of the most important factors in the amplification and quantitative analysis of the nucleic acid sequences of interest. Using in silico methods, the present study intends to design highly specific primers for
Ramin Lotfi, Farhad Salari
doaj
Sinapic acid prevents adipogenesis by regulating transcription factors and exerts an anti-ROS effect by modifying the intracellular anti-oxidant system in 3T3-L1 adipocytes [PDF]
Iranian Journal of Basic Medical Sciences, 2022 Objective(s): In this study, we tested the hypothesis that sinapic acid (SA), a naturally occurring hydroxycinnamic acid found in vegetables, cereal grains, and oilseed crops with various biological activities suppresses adipogenesis in 3T3-L1 adipocytes
Cordelia John, Sumathy Arockiasamy
doaj +1 more source
PLOS ONE, 2017 Autophagy is a catabolic mechanism to degrade cellular components to maintain cellular energy levels during starvation, a condition where PPARα may be activated. Here we report a reduced autophagic capacity in the liver following chronic activation of PPARα with fenofibrate (FB) in mice.
Ye, J +9 more
openaire +7 more sources
Adipocyte, 2019 Non-drug strategy targeting adipocyte differentiation is critical for alleviating visceral obesity and its related diseases. However, whether and how low intensity pulsed ultrasound (LIPUS) could be used for inhibiting visceral adipocyte differentiation ...
Tianhua Xu +6 more
doaj +1 more source
Türk Biyokimya Dergisi, 2021 Peroxisome proliferator activated receptor gamma (PPARγ) agonists used for the treatment of Diabetes Mellitus (DM), has important roles on the regulation of metabolism including ketogenesis in fasting and low glucose states.
Pınarbaşı Arzu +4 more
doaj +1 more source