Results 31 to 40 of about 74,506 (264)
Gene variants and haplotypes of Vitamin D biosynthesis, transport, and function in preeclampsia
Hypertension in Pregnancy, 2021 Objective: To find whether the gene variants and haplotypes of cytochrome (CYP) 27B1 (1α-hydroxylase), group-specific component (GC) that is a vitamin D binding protein, vitamin D receptor (VDR), peroxisome proliferator-activated receptor γ (PPARγ) and ...
Zahra Ghorbani +6 more
doaj +1 more source
p21Cip1 plays a critical role in the physiological adaptation to fasting through activation of PPARα
Scientific Reports, 2016 AbstractFasting is a physiological stress that elicits well-known metabolic adaptations, however, little is known about the role of stress-responsive tumor suppressors in fasting. Here, we have examined the expression of several tumor suppressors upon fasting in mice.
Lopez-Guadamillas, Elena +8 more
openaire +5 more sources
Pharmacogenetic Aspects of Type 2 Diabetes Treatment
Acta Biomedica Scientifica, 2020 In this article, we analyze the role of different variants of the KCNJ11, TCF7L2, SLC22A1, SLC22A3, CYP2C9, CYP2C8, PPARγ genes polymorphisms in efficacy of diabetes mellitus pharmacotherapy.
N. O. Pozdnyakov +9 more
doaj +1 more source
Psychiatry and Clinical Psychopharmacology, 2019 OBJECTIVES: Bipolar disorder (BD) carries a high rate of morbidity and mortality, and the clarification of its aetiology continues to be an important field of research.
Gamze Erzin +6 more
doaj +1 more source
Environmental Health Perspectives, 2012 Triflumizole (TFZ) is an imidazole fungicide used on many food and ornamental crops. TFZ is not thought to be particularly toxic or carcinogenic, but little is known about its effect on development. TFZ is identified as a peroxisome proliferator activated receptor gamma (PPARγ) activator in ToxCast.
Li, X +3 more
openaire +5 more sources
Effects of Aerobic Interval Training and Adenosine on the Expression of AMPK, PPARγ and A2B Receptor in the Liver of Rats Fed a High-Fat Diet [PDF]
Journal of Advanced Biomedical Sciences, 2020 Background & Objective: Obesity causes steatosis in the liver. PPARγ transcription factor of glucose and fat metabolism genes and AMPK cell energy sensor are considered as therapeutic targets in non-alcoholic fatty liver (NAFLD) patients.
Abolhasan Hedayati katooli +3 more
doaj
Long noncoding RNA ACART knockdown decreases 3T3-L1 preadipocyte proliferation and differentiation
Open Life Sciences, 2023 Obesity is a main risk factor for diabetes and cardiovascular disorders and is closely linked to preadipocyte differentiation or adipogenesis. Peroxisome proliferator-activated receptor γ (PPARγ) is an indispensable transcription factor in adipogenesis ...
Huang Renyan, Shi Chenyan, Liu Guobin
doaj +1 more source
Diabetes, Metabolic Syndrome and Obesity, 2023 Yi-Kun Zhao,1 Xiang-Dong Zhu,2 Rong Liu,1 Xia Yang,1 Yong-Lin Liang,1 Yan Wang2 1Department of Basic Medical College, Gansu University of Chinese Medicine, Lanzhou City, People’s Republic of China; 2Department of Traditional Chinese Medicine College ...
Zhao YK +5 more
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Enhanced anticancer effect of cetuximab combined with ethanol extract of Volvariella volvacea in colorectal cancer targeted TOP2A and PPARγ [PDF]
Journal of Pharmacy & Pharmacognosy ResearchContext: Colorectal cancer (CRC) is a major global health concern as innovative therapeutic strategies to enhance treatment outcomes. This study investigates the therapeutic potential of the ethanol extract derived from Volvariella volvacea in ...
Sofy Permana +8 more
doaj +1 more source
Effects Of PPARγ2 Pro12Ala Variant On Adipocyte Phenotype Dependent Of DHA.
Diabetes, metabolic syndrome and obesity : targets and therapy, 2019 Peroxisome proliferator-activated receptor γ2 (PPARγ2) plays a critical role in the regulation of adipocyte differentiation and adipocytokine production. The Pro12Ala variant is the most common mutation in the PPARγ2 gene. Its effect appears to be sensitive to dietary factors, such as docosahexaenoic acid (DHA) level.
Wan,Renhui +4 more
openaire +4 more sources