Results 31 to 40 of about 4,462 (166)

Pharmacogenetic Aspects of Type 2 Diabetes Treatment

Acta Biomedica Scientifica, 2020
In this article, we analyze the role of different variants of the KCNJ11, TCF7L2, SLC22A1, SLC22A3, CYP2C9, CYP2C8, PPARγ genes polymorphisms in efficacy of diabetes mellitus pharmacotherapy.
N. O. Pozdnyakov, I. N. Kagarmanyan, A. E. Miroshnikov, E. S. Emelyanov, A. A. Gruzdeva, A. M. Sirotkina, I. A. Dukhanina, A. A. Milkina, A. A. Khokhlov, S. O. Pozdnyakov   +9 more
doaj   +1 more source

Serum 15-d-PGJ2 and PPARγ levels are reduced in manic episode of bipolar disorder while IL-4 levels are not affected

Psychiatry and Clinical Psychopharmacology, 2019
OBJECTIVES: Bipolar disorder (BD) carries a high rate of morbidity and mortality, and the clarification of its aetiology continues to be an important field of research.
Gamze Erzin, Makbule Çiğdem Aydemir, Rabia Nazik Yüksel, Elif Tatlıdil Yaylacı, Bağdagül Çakır, Sevilay Sezer, Erol Göka   +6 more
doaj   +1 more source

Triflumizole Is an Obesogen in Mice that Acts through Peroxisome Proliferator Activated Receptor Gamma (PPAR γ )

Environmental Health Perspectives, 2012
Triflumizole (TFZ) is an imidazole fungicide used on many food and ornamental crops. TFZ is not thought to be particularly toxic or carcinogenic, but little is known about its effect on development. TFZ is identified as a peroxisome proliferator activated receptor gamma (PPARγ) activator in ToxCast.
Li, X, Pham, HT, Janesick, AS, Blumberg, B   +3 more
openaire   +5 more sources

Effects of Aerobic Interval Training and Adenosine on the Expression of AMPK, PPARγ and A2B Receptor in the Liver of Rats Fed a High-Fat Diet [PDF]

Journal of Advanced Biomedical Sciences, 2020
Background & Objective: Obesity causes steatosis in the liver. PPARγ transcription factor of glucose and fat metabolism genes and AMPK cell energy sensor are considered as therapeutic targets in non-alcoholic fatty liver (NAFLD) patients.
Abolhasan Hedayati katooli, Mohammad Ali Azarbayjani, Abdolali Banaeifar, Sajad Arshadi   +3 more
doaj  

Long noncoding RNA ACART knockdown decreases 3T3-L1 preadipocyte proliferation and differentiation

Open Life Sciences, 2023
Obesity is a main risk factor for diabetes and cardiovascular disorders and is closely linked to preadipocyte differentiation or adipogenesis. Peroxisome proliferator-activated receptor γ (PPARγ) is an indispensable transcription factor in adipogenesis ...
Huang Renyan, Shi Chenyan, Liu Guobin
doaj   +1 more source

The Role of PPARγ Gene Polymorphisms, Gut Microbiota in Type 2 Diabetes: Current Progress and Future Prospects

Diabetes, Metabolic Syndrome and Obesity, 2023
Yi-Kun Zhao,1 Xiang-Dong Zhu,2 Rong Liu,1 Xia Yang,1 Yong-Lin Liang,1 Yan Wang2 1Department of Basic Medical College, Gansu University of Chinese Medicine, Lanzhou City, People’s Republic of China; 2Department of Traditional Chinese Medicine College ...
Zhao YK, Zhu XD, Liu R, Yang X, Liang YL, Wang Y   +5 more
doaj  

Enhanced anticancer effect of cetuximab combined with ethanol extract of Volvariella volvacea in colorectal cancer targeted TOP2A and PPARγ [PDF]

Journal of Pharmacy & Pharmacognosy Research
Context: Colorectal cancer (CRC) is a major global health concern as innovative therapeutic strategies to enhance treatment outcomes. This study investigates the therapeutic potential of the ethanol extract derived from Volvariella volvacea in ...
Sofy Permana, Elsafira A. Nabilahasna, Fairuz A. Meilany, Silvi Zakiyatul Ilmiyah, Edwin Widodo, Eviana Norahmawati, Yoshiyuki Kawamoto, Heni Endrawati, Agustina T. Endharti   +8 more
doaj   +1 more source

Effects Of PPARγ2 Pro12Ala Variant On Adipocyte Phenotype Dependent Of DHA.

Diabetes, metabolic syndrome and obesity : targets and therapy, 2019
Peroxisome proliferator-activated receptor γ2 (PPARγ2) plays a critical role in the regulation of adipocyte differentiation and adipocytokine production. The Pro12Ala variant is the most common mutation in the PPARγ2 gene. Its effect appears to be sensitive to dietary factors, such as docosahexaenoic acid (DHA) level.
Wan,Renhui, Ding,Zhengping, Xia,Sheng, Zheng,Longyi, Lu,Jin   +4 more
openaire   +4 more sources

Anti‐diabetic effect of andrographolide from Sambiloto herbs (Andrographis paniculata (Burm.f.) Nees) through the expression of PPARγ and GLUT‐4 in adipocytes

Indonesian Journal of Biotechnology, 2022
Andrographolide has been shown to have a pharmacological effect as an antidiabetic. Nevertheless, the comprehensive mechanism of action has yet to be determined.
Novia Tri Astuti, Putri Rachma Novitasari, Raymond Tjandrawinata, Agung Endro Nugroho, Suwijiyo Pramono   +4 more
doaj   +1 more source

VSP-2 attenuates secretion of inflammatory cytokines induced by LPS in BV2 cells by mediating the PPARγ/NF-κB signaling pathway

Open Life Sciences
Neuroinflammation, characterized by microglial activation and the subsequent secretion of inflammatory cytokines, plays a pivotal role in neurodegenerative diseases and brain injuries, often leading to neuronal damage and death.
Cui Jingxin, Xu Liwei, Sun Yimeng, Dai Lingfei, Mo Yuxiu, Yun Keli, Chen Yifei, Chen Linglin   +7 more
doaj   +1 more source