Results 51 to 60 of about 101,448 (257)

The effects of pioglitazone, a PPARγ receptor agonist, on the abuse liability of oxycodone among nondependent opioid users [PDF]

, 2016
Aims: Activation of PPARγ by pioglitazone (PIO) has shown some efficacy in attenuating addictive-like responses in laboratory animals. The ability of PIO to alter the effects of opioids in humans has not been characterized in a controlled laboratory ...
Alonzo, Banks, Begelow, Beitner-Johnson, Berger, Bhargava, Bland, Bush, Bussiere, Carr, Chang, Cone, Cooper, de Guglielmo, de Guglielmo, Dhalla, Eisenstein, Eisenstein, Eisenstein, Eng, Ferguson, Fraser, Gagnon, Garrido, Gelinas, Gillies, Hopkins, Hutchinson, Hutchinson, Hutchinson, Jeanne M. Manubay, Jermaine D. Jones, Johnston, Katz, Kielian, Kreutzberg, Ledeboer, Levine, Maria A. Sullivan, Marie-Claire, Martin, Mellon, Moreno, Nakajima, Narita, Pacifici, Pelvig, Roberto Ciccocioppo, Sandra D. Comer, Sarruf, Shanthi Mogali, Song, SPSS, Stoll, Stopponi, Stopponi, Strain, Sweitzer, Tawfik, Tontonoz, Verena E. Metz, Verkhratsky, Walker, Walker, Walsh, Walsh, Watkins, Watkins, Wightman, Woods, Wybran, Zacny, Zacny, Zacny, Zhang   +74 more
core   +1 more source

The NADPH oxidase NOX4 regulates redox and metabolic homeostasis preventing HCC progression

Hepatology, EarlyView., 2022
Loss of NOX4 in HCC tumor cells induces metabolic reprogramming in a Nrf2/MYC‐dependent manner to promote HCC progression. Abstract Background and Aims The NADPH oxidase NOX4 plays a tumor‐suppressor function in HCC. Silencing NOX4 confers higher proliferative and migratory capacity to HCC cells and increases their in vivo tumorigenic potential in ...
Irene Peñuelas‐Haro, Rut Espinosa‐Sotelo, Eva Crosas‐Molist, Macarena Herranz‐Itúrbide, Daniel Caballero‐Díaz, Ania Alay, Xavier Solé, Emilio Ramos, Teresa Serrano, María L. Martínez‐Chantar, Ulla G. Knaus, José M. Cuezva, Antonio Zorzano, Esther Bertran, Isabel Fabregat   +14 more
wiley   +1 more source

The Differentiation Balance of Bone Marrow Mesenchymal Stem Cells Is Crucial to Hematopoiesis. [PDF]

, 2018
Bone marrow mesenchymal stem cells (BMSCs), the important component and regulator of bone marrow microenvironment, give rise to hematopoietic-supporting stromal cells and form hematopoietic niches for hematopoietic stem cells (HSCs).
Li, Shengwen Calvin, Li, Zhongjun, Ran, Qian, Wu, Jiang, Xiang, Yang, Zhang, Weiwei, Zhong, Jiang F   +6 more
core   +2 more sources

Effects Of PPARγ2 Pro12Ala Variant On Adipocyte Phenotype Dependent Of DHA.

Diabetes, metabolic syndrome and obesity : targets and therapy, 2019
Peroxisome proliferator-activated receptor γ2 (PPARγ2) plays a critical role in the regulation of adipocyte differentiation and adipocytokine production. The Pro12Ala variant is the most common mutation in the PPARγ2 gene. Its effect appears to be sensitive to dietary factors, such as docosahexaenoic acid (DHA) level.
Wan,Renhui, Ding,Zhengping, Xia,Sheng, Zheng,Longyi, Lu,Jin   +4 more
openaire   +4 more sources

RIPK3 dampens mitochondrial bioenergetics and lipid droplet dynamics in metabolic liver disease

Hepatology, EarlyView., 2022
RIPK3 dampens mitochondrial bioenergetics and lipid droplet dynamics in metabolic liver disease. Abstract Background and Aims Receptor‐interacting protein kinase 3 (RIPK3) mediates NAFLD progression, but its metabolic function is unclear. Here, we aimed to investigate the role of RIPK3 in modulating mitochondria function, coupled with lipid droplet (LD)
Marta B. Afonso, Tawhidul Islam, Julie Magusto, Ricardo Amorim, Véronique Lenoir, Rui F. Simões, José Teixeira, Liana C. Silva, Dominique Wendum, Isabelle Jéru, Corinne Vigouroux, Rui E. Castro, Paulo J. Oliveira, Carina Prip‐Buus, Vlad Ratziu, Jérémie Gautheron, Cecília M. P. Rodrigues   +16 more
wiley   +1 more source

VSP-2 attenuates secretion of inflammatory cytokines induced by LPS in BV2 cells by mediating the PPARγ/NF-κB signaling pathway

Open Life Sciences
Neuroinflammation, characterized by microglial activation and the subsequent secretion of inflammatory cytokines, plays a pivotal role in neurodegenerative diseases and brain injuries, often leading to neuronal damage and death.
Cui Jingxin, Xu Liwei, Sun Yimeng, Dai Lingfei, Mo Yuxiu, Yun Keli, Chen Yifei, Chen Linglin   +7 more
doaj   +1 more source

Synthesis and Biological Activity of Piperine Derivatives as Potential PPARγ Agonists

Drug Design, Development and Therapy, 2020
Yanli Wang,1– 3 Yuan Yao,4,5 Jing Liu,2,6 Lili Wu,7 Tonghua Liu,7 Jian Cui,1 David Yue-Wei Lee2 1School of Pharmacy, Minzu University of China, Beijing 100081, People’s Republic of China; 2Bio-Organic and Natural Products Laboratory, McLean ...
Wang Y, Yao Y, Liu J, Wu L, Liu T, Cui J, Lee DYW   +6 more
doaj  

Cynarin inhibits PDGF-BB-induced proliferation and activation in hepatic stellate cells through PPARγ

Open Chemistry, 2022
Cynarin, a caffeoylquinic acid compound that was mainly extracted from Cynara scolymus L., displays various activities such as antioxidant, antibacterial, choleretic, and hepatoprotective functions. However, the target of cynarin and the mechanism of its
Ding Yong, Tao Congcong, Chen Qian, Chen Lulu, Hu Xianwen, Li Mingyu, Wang Shicong, Jiang Fuquan   +7 more
doaj   +1 more source

Ciglitazone-a human PPARγ agonist-disrupts dorsoventral patterning in zebrafish. [PDF]

, 2019
Peroxisome proliferator-activated receptor γ (PPARγ) is a ligand-activated transcription factor that regulates lipid/glucose homeostasis and adipocyte differentiation.
Cheng, Vanessa, Dasgupta, Subham, Reddam, Aalekhya, Volz, David C   +3 more
core  

Pharmacologic approaches against advanced glycation end products (ages) in diabetic cardiovascular disease [PDF]

, 2015
Advanced Glycation End-Products (AGEs) are signaling proteins associated to several vascular and neurological complications in diabetic and non-diabetic patients.
Avtaar Singh, Sanjeet Singh, Chello, Massimo, DI DOMENICO, Fabio, Nappi, Francesco, Nenna, Antonio, Spadaccio, Cristiano, Sutherland, Fraser W   +6 more
core   +2 more sources