Results 51 to 60 of about 74,506 (264)

PPARγ in Inflammatory Bowel Disease [PDF]

, 2012
Peroxisome proliferator-activated receptor gamma (PPARγ) is member of a family of nuclear receptors that interacts with nuclear proteins acting as coactivators and corepressors.
Francesca Rogai, Alessia Settesoldi, Vito Annese, Siro Bagnoli   +3 more
core   +1 more source

A Dual‐Bioresponsive and Programmable Microneedle Matrix as a Bioinspired Coupler for Orchestrating Diabetic Bone Regeneration

Advanced Materials, EarlyView.
This project developed a smart bandage‐like patch (a microneedle array) for repairing diabetic bone damage. It intelligently senses signals from infection and inflammation, then releases its medicines in a specific, timed sequence: first an antibacterial agent, then an anti‐inflammatory agent, and finally growth factors.
Yu Wang, Rui Chen, Yu Chen, Haowen Lu, Yuchen Qian, Zhiheng Gao, Zheming Shen, Xiaofei Zheng, Huilin Yang, Jun Zou, Yusen Qiao   +10 more
wiley   +1 more source

NF-κB Needs PPARγ

, 2010
Unliganded PPARγ is proinflammatory, whereas agonist-bound PPARγ is anti-inflammatory.
Nancy R. Gough
core   +1 more source

Therapeutic Implications of PPARγ in Cardiovascular Diseases [PDF]

, 2010
Peroxisome proliferator-activated receptor-γ (PPARγ) is the members of the nuclear receptor superfamily as a master transcriptional factor that promotes differentiation of preadipocytes by activating adipose-specific gene expression.
Hiroshi Hasegawa, Issei Komuro, Hiroyuki Takano   +2 more
core   +1 more source

PENINGKATAN KADAR LEPTIN DENGAN PUFA (Polyunsaturated Fatty Acid) MELALUI AKTIVASI PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR gamma (PPARγ) PADA KULTUR PREADIPOSIT KELINCI

Jurnal Kedokteran Brawijaya, 2013
ABSTRACT For the past three decades, PUFA has been recognized as importnant energy sources and cell membrane component. PUFA also plays key roles in many cellular events such as gene regulation and leptin activation. The role of this fatty acid is still unknown especially in vitro.
openaire   +2 more sources

Agnuside Stabilizes the Complex I Assembly Factor NDUFAF6 to Reinforce Mitochondrial Efficiency and Thermogenic Responsiveness

Advanced Science, EarlyView.
ABSTRACT Brown and beige adipocytes dissipate energy as heat, yet effective strategies to enhance their mitochondrial efficiency remain limited. Here, we identify Agnuside (AGN) as a selective stabilizer of the complex I assembly factor NDUFAF6. AGN directly binds cytosolic NDUFAF6, suppresses its ubiquitination, prolongs its half‐life, and facilitates
Qingwen Zhao, Li Xie, Qianzhuo Wang, Shuying Dai, Bei Li, Yingjuan Zhang, Zhe Sun, Yue Gao   +7 more
wiley   +1 more source

Effects of peroxisome proliferator activated receptor gamma (PPARγ) agonist on fasting model applied neuron cultures

Türk Biyokimya Dergisi, 2021
Peroxisome proliferator activated receptor gamma (PPARγ) agonists used for the treatment of Diabetes Mellitus (DM), has important roles on the regulation of metabolism including ketogenesis in fasting and low glucose states.
Pınarbaşı Arzu, Pak Meltem, Kolay Murat, Öz Arslan Devrim, Aksungar Fehime Benli   +4 more
doaj   +1 more source

PPARγ in Placental Angiogenesis

, 2010
Peroxisome proliferator-activated receptor γ (PPARγ) is a nuclear receptor involved in diverse biological processes including adipocyte differentiation, glucose homeostasis, and inflammatory responses.
Karim Nadra, Laure Quignodon, Sardella, C., Joye, E., Béatrice Desvergne, Mucciolo, A., Quignodon, L., Chiara Sardella, Antonio Mucciolo, Roman Chrast, Desvergne, B., Nadra, K., Chrast, R., Elisabeth Joye   +13 more
core   +1 more source

Self‐Assembling Hybrid Hydrogel Reprograms the Stromal Vascular Fraction to Treat Osteoarthritis

Advanced Science, EarlyView.
This study presents a bioinspired injectable hydrogel that enhances the therapeutic potential of stem cell‐rich stromal vascular fraction for treating osteoarthritis. By reprogramming cell behavior through epigenetic modulation, the hydrogel promotes cartilage regeneration and reduces joint damage in a rat model, offering a promising new approach for ...
Waifang Hou, Yongfeng Chen, Longyou Xiao, Wei Qi, Tianshu Du, Qiang Sun, Borui Xue, Qinghe Zhao, Pengfei Xie, Zi Ye, Fei Han, Lingli Guo, Yang Jiao, Ranran Zhang, Hong Jia, Xiao Huang, Jianwei Guo, Peng Wang, Huayi Wang, Yuanrui Wang, Wenjing Chen, Haining Wu, Liumin He, Dawei Zhang   +23 more
wiley   +1 more source

Recent Developments in Diabetes Management: Exploring Receptors, Pathways, and Compounds

BIO Integration
Diabetes mellitus (DM) is a widespread metabolic disorder with profound effects on vital organs. Often referred to as a “systemic” or “multi-organ” disorder due to the impact on key organs, such as the kidneys, pancreas, eyes, and heart, DM is ...
Pallavi Pandey, Vikash Jakhmola, Supriyo Saha, Anand Gaurav   +3 more
doaj   +1 more source