Results 71 to 80 of about 74,506 (264)

PPARγ, neuroinflammation, and disease

, 2004
Background Peroxisome proliferator-activated receptors (PPARs) are a class of nuclear transcription factors that are activated by fatty acids and their derivatives.
Mrak Robert E, Landreth Gary E
core   +1 more source

Pparγ Is Involved in the Transcriptional Regulation of Liver LC-PUFA Biosynthesis by Targeting the Δ6Δ5 Fatty Acyl Desaturase Gene in the Marine Teleost Siganus canaliculatus [PDF]

, 2019
As the first marine teleost demonstrated to have the ability of long-chain polyunsaturated fatty acids (LC-PUFA) biosynthesis from C18 PUFA precursors, the rabbitfish Siganus canaliculatus provides us a unique model for clarifying the regulatory ...
You, Cuihong, Tocher, Douglas R, Yin, Ziyan, Li, Yuanyou, Dong, Yewei, Wang, Shuqi, Monroig, Óscar   +6 more
core   +1 more source

Integrated Single‐Cell and Spatial Analysis Reveals a Metabolic‐Immune Axis Driving Aortic Dissection

Advanced Science, EarlyView.
Single‐cell and spatial profiling of 110 human thoracic aortic samples reveals a stromal–immune circuit driving aortic dissection. An elastin‐rich fibroblast subset is depleted with age and markedly reduced in disease, weakening aortic wall integrity.
Jing Tao, Huanjie Yang, Jiahui Yong, Xueting Chen, Qiang Zhao, Xueli Wu, Lei Yan, Li Pang, Fan Luo, Mengjun Yu, Shanshan Pan, Deyang Li, Rouxi Chen, Juan Wang, Zhensheng Dong, Fan Yang, Yue Wang, Yang Chen, Hongjian Zheng, Zhimin Yang, Zijie Wang, Karsten Kristiansen, Hui Peng, Xiaodong Fang, Juan Shen, Yining Yang   +25 more
wiley   +1 more source

Two Types of PPARγ Ligands Identified in the Extract of Artemisia campestris

Chemistry, 2021
The 70% ethanol extract of Artemisia campestris was screened to find PPARγ ligands using the PPARγ ligand-responsive chimera luciferase reporter system. Capillartemisin B was identified as a PPARγ ligand that stimulated lipid accumulation in 3T3-L1 cells.
Tokio Hasegawa, Mayo Osaka, Yusaku Miyamae, Katsutoshi Nishino, Hiroko Isoda, Kiyokazu Kawada, Mohamed Neffati, Kazuhiro Irie, Masaya Nagao   +8 more
doaj   +1 more source

Curcumin reduced TGF-β1-induced PPARγ phosphorylation and reversed the reduction of PPARγ.

, 2013
HK-2 cells were incubated with curcumin at the indicated dose for 12 hours or rosiglitazone for 1 hour followed by treatment with TGF-β1 for 36 hours. (A) Western blotting analyses for PPARγ and p-PPARγ expression in HK-2 cells.
Yujun Liu (395065), Xuemei Zhang (89768), Yunman Wang (395064), Rui Li (4631), Wen Peng (372305), Wencheng Fu (395067), Hui Cai (241921), Qijing Chen (395066), Hao Wang (39217)   +8 more
core   +1 more source

Clinical Use of PPARγ Ligands in Cancer [PDF]

, 2008
The role of PPARγ in adipocyte differentiation has fueled intense interest in the function of this steroid nuclear receptor for regulation of malignant cell growth and differentiation.
Lisa D. Yee, Jennifer L. Hatton
core   +1 more source

Lactoferrin Deficiency During Lactation Causes Adult Obesity‐Related Metabolic Disease Through Persistent Adipose Dysfunction Driven by Impaired Adipocyte Development

Advanced Science, EarlyView.
Lactational lactoferrin deficiency exerts lasting effects on epididymal adipose tissue development from lactation into adulthood: it impairs adipocyte hyperplasia and induces pathological hypertrophy, resulting in lower body weight yet exacerbated metabolic dysfunction under a high‐fat diet in adulthood.
Qin An, Yunxia Zou, Wenli Wang, Zhimei Cheng, Zhuoxing Zhang, Ruwei Liu, Xiong Wang, Kunlun Huang, Fangrong Ding, Yunping Dai, Qingyong Meng, Yali Zhang   +11 more
wiley   +1 more source

PPARγ and Cognitive Performance [PDF]

, 2019
Recent findings have led to the discovery of many signaling pathways that link nuclear receptors with human conditions, including mental decline and neurodegenerative diseases.
Elisabetta Benedetti, Reyes Dominguez-Benot, Mariano Catanesi, Rodolfo Ippoliti, Annamaria Cimini, Vanessa Castelli, Michele d’Angelo, Andrea Antonosante   +7 more
core   +2 more sources

Phosphorylation of PPARγ Affects the Collective Motions of the PPARγ-RXRα-DNA Complex.

, 2015
Peroxisome-proliferator activated receptor-γ (PPARγ) is a nuclear hormone receptor that forms a heterodimeric complex with retinoid X receptor-α (RXRα) to regulate transcription of genes involved in fatty acid storage and glucose metabolism.
Josep Bassaganya-Riera (120051), Stephanie N Lewis, Lewis, Stephanie N., David R Bevan, Bassaganya-Riera, Josep, Justin A. Lemkul (1372401), David R. Bevan (172879), Josep Bassaganya-Riera, Justin A Lemkul, Stephanie N. Lewis (172882), Bevan, David R., Lemkul, Justin A.   +11 more
core   +1 more source

Oxygen Vacancy‐Enriched Platinum Single‐Atom Nanozyme Wrapped in Nanoislands: Unlocking Catalytic Activity and Reprogramming Redox Microenvironment for Osteonecrosis Repair

Advanced Science, EarlyView.
CeO2‐x/Pt single‐atom nano‐island is constructed via low‐temperature reduction, featuring abundant oxygen vacancies and an island–sea structure. It delivers outstanding multi‐enzyme‐mimetic activity and ROS‐scavenging efficiency. Density functional theory reveals optimized electronic structures and reaction pathways.
Yang Zhu, Zehui Lv, Xuejie Cai, Penghui Wei, Dengliang Wang, Zhao Wang, Ruoying Wang, Yingjie Wang, Xingdong Yang, Yixin Bian, Jiawei Xu, Xisheng Weng, Liangfeng Wei   +12 more
wiley   +1 more source