Results 91 to 100 of about 74,506 (264)

Beyond Potency: Emerging Determinants and Optimization Strategies Enhancing Therapeutic Efficacy of Adult Stem Cells

Advanced Science, EarlyView.
Adult stem cell therapy requires more than high in vitro potency. This review proposes a systems framework in which cell‐intrinsic programs, instructive microenvironmental cues, and pre‐/post‐delivery engineering are co‐designed under standardized translational rules.
Soo‐Rim Kim, Yun Jae Jung, Hwa‐Yong Lee   +2 more
wiley   +1 more source

Pparγ agonistic activity of sulphonylureas

, 2019
Background: Sulphonylureas (SU) are known to cause weight gain. Some investigators have reported increased insulin sensitivity with some sulphonylurea agents. Objective: To review available evidence of SU agents having PPARγ agonist activity. Methods: We
Banerjee, Debjani, Bharaj, Harnovdeep Singh, Banerjee, Moulinath; id_orcid   +2 more
core   +1 more source

Evasion of immunosurveillance by genomic alterations of PPARγ/RXRα in bladder cancer. [PDF]

, 2017
Muscle-invasive bladder cancer (MIBC) is an aggressive disease with limited therapeutic options. Although immunotherapies are approved for MIBC, the majority of patients fail to respond, suggesting existence of complementary immune evasion mechanisms ...
Bernhard Kiss, Victoria Rimkunas, Kumar, Namita, Kiss, Bernhard, Furman, Craig, Namita Kumar, Korpal, Manav, Hao, Ming-Hong, Henry, Ryan, Daugaard, Mads, Roland Seiler, Jaya Julie Joshi, Davide Tortora, Matijevic, Mark, Morgan Roberts, Chris K. Wang, Lihua Yu, James Douglas, Davis, Allison, Seiler, Roland, Kuznetsov, Galina, Kristjan Bloudoff, Kumar, Pavan, Bloudoff, Kristjan, Hua Yang, Ladan Fazli, Michael Seiler, Markus Warmuth, Black, Peter C, Anand Selvaraj, Vanitha Subramanian, Black, Peter C., Warmuth, Markus, et al., Larsen, Nicholas, Irwin, Sean, Jian Zou, Yu, Lihua, Rimkunas, Victoria, Peter C. Black, Puyang, Xiaoling, Jesse Chow, Manav Korpal, Smith, Peter G, Peter G. Smith, Corson, Laura, Xiaoling Puyang, Mark Matijevic, Hao, Ming Hong, Fazli, Ladan, Craig Furman, Laura Corson, Feala, Jacob, Roberts, Morgan, Sean Irwin, Julie Joshi, Jaya, Yang, Hua, Nicholas Larsen, Mads Daugaard, Smith, Peter G., Jeremy Wu, Zhenhua, Oo, Htoo Z., Douglas, James, Zou, Jian, Ping Zhu, Wang, Chris K., Jacob Feala, Peter Fekkes, Selvaraj, Anand, Wang, Chris K, Seiler, Michael, Allison Davis, Zhu, Ping, Galina Kuznetsov, Zhenhua Jeremy Wu, Pavan Kumar, Chow, Jesse, Ryan Henry, Fekkes, Peter, Tortora, Davide, Ming-Hong Hao, Htoo Zarni Oo, Subramanian, Vanitha, Oo, Htoo Z   +83 more
core   +1 more source

A Hydrogen Sulfide–Releasing Dynamic Hydrogel Modulates Coordinated Neurovascular, Immune, and Angiogenic Responses for Scar‐Suppressed Diabetic Wound Repair

Advanced Science, EarlyView.
ROS‐Responsive H2S Hydrogel (HAPPF) Coordinated Regeneration for High‐Quality Diabetic Wound Repair.A self‐regulating dynamic hydrogel is developed to deliver a fluorogenic H2S donor in response to excessive ROS. Released H2S acts as a master regulator to resolve chronic inflammation (M2 polarization), restore VEGF‐driven angiogenesis, and rebalance ...
Xuyang Ning, Ziqiang Zhou, Bangming Li, Hong Lu, Haoyang Wen, Zhoulong Huang, Gang Li, Ping Hu   +7 more
wiley   +1 more source

Identification and Isolation of Active Compounds from Astragalus membranaceus that Improve Insulin Secretion by Regulating Pancreatic Β-Cell Metabolism

Biomolecules, 2019
In type 2 diabetes (T2D), insufficient secretion of insulin from the pancreatic β-cells contributes to high blood glucose levels, associated with metabolic dysregulation.
Dahae Lee, Da Hye Lee, Sungyoul Choi, Jin Su Lee, Dae Sik Jang, Ki Sung Kang   +5 more
doaj   +1 more source

PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR γ (PPARγ) REGULATES CELL PROLIFERATION, WHICH IS AN EXPLANATION FOR THE ANTI-TUMORIGENIC PROPERTIES OF PPARγ

, 2005
核内受容体であるPPARγは消化管,特に大腸上皮に多量に存在するが,その生理的役割は明らかでない.PPARγは大腸癌にも高発現しており,PPARγの抗腫瘍効果の機序解明が進んでいる.一方,大腸癌では過剰に蓄積したβ-cateninが,転写調節因子として増殖関連遺伝子の発現を充進していると考えられている.本研究ではPPARγの活性化による大腸癌細胞及び大腸上皮細胞の増殖への影響とPPARγのβ-cateninに対する作用を検討した ...
中島, 淳, FUJISAWA, Nobutaka, フジサワ, ノブタカ, 2145, ナカジマ, アツシ, 2144, 2143, NAKAJIMA, Atsushi, 2142, 藤澤, 信隆   +9 more
core  

The Many Faces of PPARγ

, 2005
In an era marked by the increasing prevalence of obesity, diabetes, and cardiovascular disease, the nuclear receptor peroxisome proliferator-activated receptor γ (PPARγ) has emerged as a transcriptional regulator of metabolism whose activity can be ...
Lehrke, Michael, Lazar, Mitchell A.
core   +1 more source

PPARγ Regulates Triclosan Induced Placental Dysfunction

, 2021
Exposure to the antibacterial agent triclosan (TCS) is associated with abnormal placenta growth and fetal development during pregnancy. Peroxisome proliferator-activated receptor γ (PPARγ) is crucial in placenta development.
Xinxin Yang, Jing Li, Weiyi Song, Pengfei Xu, Xiaojie Quan, Zhenyao Huang, Saifei Lei, Qi Wang, Ting Yu, Yue Zhang   +9 more
core   +1 more source

Deep Learning Network‐Tailored Microenvironment Matching of 4D Bioprinting Bioactive Scaffolds for Bone Regeneration

Advanced Science, EarlyView.
A DLN dataset was built to analyze MABS composition versus in vitro/in vivo osteogenesis and angiogenesis. An MLP neural network, taking BG morphological parameters as input, extracts bioactive features from these datasets. A rabbit tibial defect model then validates 4D‐printed MABS for adaptability and bone regeneration in critical defects.
Xiongjie Liang, Yuechi Zhang, Weifeng Hu, Shiyan Lv, Fan Jia, Yan Zhang, Feng Wu, Changjiang Yang, Guanqi Zhen, Jinglong Yan, Xu Cui, Wei Zhao, Guanghua Chen   +12 more
wiley   +1 more source

Interaction between circadian gene Bmal1 and adipogenic regulator PPARγ in UVB-exposed mesenchymal stem cells

Trakya University Journal of Natural Sciences
Background: Mesenchymal stem cells (MSCs), including adipose-derived MSCs (ADMSCs) and bone marrow-derived MSCs (BMMSCs), are multipotent cells essential for tissue repair, with strong self-renewal and differentiation abilities. Bmal1 is a core component
Afra Keban, Elçin Tank, Beril Erdem, Esin Akbay Çetin   +3 more
doaj   +1 more source