Results 81 to 90 of about 74,506 (264)

PPARγ activators down-regulate the expression of PPARγ in 3T3-L1 adipocytes

, 1999
Transcriptional activation of PPARγ by the anti-diabetic compound troglitazone enhances the rate of 3T3-L1 adipocyte differentiation. In this study, we examined the effects of troglitazone, a specific PPARγ ligand, on the expression of PPARγ during and ...
Sherrie R Tafuri, Amy L Whitton, Camp, Heidi S, Tafuri, Sherrie R, Heidi S Camp, Whitton, Amy L   +5 more
core   +1 more source

An obesogenic feedforward loop involving hepatic PPARγ, Acyl-CoA Binding Protein and GABAA Receptor

, 2022
Acyl-coenzyme-A-binding protein (ACBP), also known as a diazepam-binding inhibitor (DBI), is a potent stimulator of appetite and lipogenesis. Bioinformatic analyses combined with systematic screens revealed that peroxisome proliferator-activated receptor
Anagnostopoulos, Gerasimos, Bravo San Pedro, José Manuel, Kroemer, Guido   +2 more
core   +1 more source

Engineered Exosomal miR‐146a‐5p Reprograms BMSC Fate and Restores Mitochondrial Homeostasis in Glucocorticoid‐Induced Osteonecrosis of Femoral Head

Advanced Science, EarlyView.
Exosomal miR‐146a‐5p is identified as a pivotal regulator in steroid‐induced osteonecrosis. Its reduction activates NF‐κB signaling, compromises mitophagy, and disrupts mitochondrial bioenergetics, resulting in autophagic disequilibrium. Engineered exosomes delivering miR‐146a‐5p reinstate mitochondrial function, augment oxidative phosphorylation and ...
Zehui Lv, Xuejie Cai, Yiming Xu, Xingdong Yang, Ruoying Wang, Han Wang, Yixin Bian, Jiawei Xu, Jiao Lu, Lulu Liu, Yingjie Wang, Jibin Song, Bin Feng, Xisheng Weng   +13 more
wiley   +1 more source

Lipin1 regulates PPARγ transcriptional activity

, 2013
PPARγ (peroxisome-proliferator-activated receptor γ) is a master transcription factor involved in adipogenesis through regulating adipocyte-specific gene expression.
김경섭, 고은진, 김희은, 박상욱   +3 more
core   +1 more source

NMI Regulates Adipose Adaptive Thermogenesis Through TLR4/IRF3 Signaling to Promote Obesity

Advanced Science, EarlyView.
Adipose tissue‐derived NMI is secreted under metabolic stress and suppresses adaptive thermogenesis through TLR4/IRF3 signaling, repressing the PPARα/PGC‐1α/UCP1 thermogenic transcriptional program. Genetic ablation or anti ‐ NMI monoclonal antibody treatment enhances energy expenditure, protects against DIO, and ameliorates adipose tissue inflammation,
Ting‐Ting Li, Xin‐Yuan Zhao, Min Zhang, Zhuang‐Feng Weng, Xiao‐Ran Guo, Ying‐Fang Liu, Qiao‐Ping Wang, Huan‐Huan Liang   +7 more
wiley   +1 more source

Flavonoid-enriched extract from Hippophae rhamnoides seed reduces high fat diet induced obesity, hypertriglyceridemia, and hepatic triglyceride accumulation in C57BL/6 mice

Pharmaceutical Biology, 2017
Context: Flavonoid-enriched extract from Hippophae rhamnoides L. (Elaeagnaceae) seed (FSH) has shown beneficial effects in anti-hypertension and lowering cholesterol level. However, evidence for its efficacy in treating obesity is limited.
Xin Yang, Qian Wang, Zeng-run Pang, Meng-ran Pan, Wen Zhang   +4 more
doaj   +1 more source

Diagnostic and prognostic implications of the PAX8-PPARγ translocation in thyroid carcinomas-a TMA-based study of 226 cases

, 2013
AIMS: Follicular thyroid carcinoma (FTC) has been a diagnostic challenge for decades. The PAX8-PPARγ rearrangement has been detected in FTC and classic papillary thyroid carcinomas (PTCs).
Komminoth, Paul, Thomas Rudolph, Boos, Laura, Paul Komminoth, Hans Steinert, Anja Schmitt, Sobrinho-Simões, Manuel, Rudolph, Thomas, Matthias Dettmer, Dettmer, Matthias, Boos, Laura A, Schmitt, Anja, Laura A Boos, Manuel Sobrinho‐Simões, Moch, Holger, Aurel Perren, Steinert, Hans, Schmitt Kurrer, Anja, Perren, Aurel, Holger Moch   +19 more
core   +1 more source

An Implantable Phototriggered Prodrug Depot Patch Enables Actively Programmable Drug Release for Post‐Myocardial Infarction Therapy

Advanced Science, EarlyView.
An implantable phototriggered prodrug depot patch (iPDP) is presented that enables actively programmable drug release post‐implantation. Covalently conjugated prodrug ensures minimal leakage; illumination parameters serve as a code to precisely control dose per release.
Haipeng Lu, Kaicheng Deng, Zhang Zhang, Qirui Wang, Weijing Gao, Liyin Shen, Lei Zhang, Wenting Hu, Yang Zhu, Zhengwei Mao, Tanchen Ren   +10 more
wiley   +1 more source

Abdominal Massage Ameliorates Inguinal Fat Accumulation via Augmentation of PPARγ Signaling in High-Fat Diet-Induced Obese Mice

Diabetes, Metabolic Syndrome and Obesity, 2023
Jie Zhang,1 Tieshan Wang,2 Yinghui Shi,1 Yansong Liu,1 Tao Lu1 1School of Life Science, Beijing University of Chinese Medicine, Beijing, People’s Republic of China; 2Beijing Research Institute of Chinese Medicine, Beijing University of Chinese Medicine ...
Zhang J, Wang T, Shi Y, Liu Y, Lu T
doaj  

Epitope analysis of PPARγ monoclonal antibody Pγ48.34A and its application for screening PPARγ ligands

, 2005
Peroxisome proliferator-activated receptors (PPARs) are transcription factors that directly modulate gene expression by binding to specific ligands. It has been established that PPARγ ligands play an essential role in obesity, diabetes, and inflammation.
Hae Sook Lee, S G Paik, J W Kim, P K Myung, Tae Woong Baek, Min Chul Cho, Yong Kyung Choe, Do Young Yoon, J T Hong   +8 more
core   +1 more source