Results 61 to 70 of about 74,506 (264)

PPARγ binds three MCFAs.

, 2012
(A) Structure of the PPARγ LBD chain A subunit showing positions of MCFA electron densities in the LBP; NA1 (site I), NA2 (site II) and NA3 (site III).
Mário Sérgio Palma (162711), Francisco A. R. Neves (162716), Munir S. Skaf (162722), Steven D. Ayers (162670), Angela Angelica Amato (162690), Tuo Deng (162685), Leandro Martínez (79928), Igor Polikarpov (89402), Rodrigo L. Silveira (162673), Willa A. Hsueh (162700), Paulo C. T. Souza (162677), Marie Togashi (162694), Paul Webb (66473), Marcelo Vizoná Liberato (162662), Jean Z. Lin (105176), Aleksandra Cvoro (105194), Kevin Phillips (162705), Alessandro S. Nascimento (162666), Daniel Saidemberg (162681)   +18 more
core   +1 more source

Multi‐Omics Profiling Reveals Immunomodulatory and Pro‐Regenerative Effects of a Graphene Oxide–Collagen Scaffold in Massive Rotator Cuff Tears

Advanced Science, EarlyView.
A graphene oxide/collagen scaffold is developed for chronic massive rotator cuff tear repair. The scaffold improves compressive stability, supports reparative mesenchymal differentiation, and modulates the immune microenvironment. In chronic MRCT models, it reduces muscle degeneration, enhances tendon–bone regeneration, and improves functional recovery,
Renwen Wan, Yechuan Deng, Zixin Hu, Yanwei He, Xinting Feng, Jun Ma, Yisheng Chen, Zhijie Zhao, Jie Mei, Zhiheng Lin, Wei Luo, Zhengyuan Fang, Zhufeng Hu, Kunlun Feng, Xinrong Li, Dan Wu, Bowen Han, James Hoi po Hui, Xuanyong Liu, Chen Chen, Gang Chen, Shiyi Chen, Nirong Bao, Jiajun Qiu, Zhiwen Luo   +24 more
wiley   +1 more source

Structural Basis for the Regulation of PPARγ Activity by Imatinib

Molecules, 2019
Imatinib is an effective anticancer drug for the treatment of leukemia. Interestingly, when an FDA-approved drug library was tested for agents that block peroxisome proliferator-activated receptor γ (PPARγ) phosphorylation at Ser245 to evaluate
Jun Young Jang, Hyun-Jung Kim, Byung Woo Han   +2 more
doaj   +1 more source

Effects of reintroducing PPARγ into PPARγ^−/− TS cells.

, 2013
A) PPARγ overexpression in undifferentiated null TS cells further inhibits cell growth.
Mark W. Salata (368834), Vannessa Davis (368835), Aleksandar Ciric (368833), Heather Yu (368832), David S. Milstone (368836), Mana M. Parast (368831)   +5 more
core   +1 more source

PPARγ-independent induction of growth arrest and apoptosis in prostate and bladder carcinoma [PDF]

, 2006
Background Although PPARγ antagonists have shown considerable pre-clinical efficacy, recent studies suggest PPARγ ligands induce PPARγ-independent effects.
Chaffer, CL, Thompson, EW, Thompson Erik W, Thompson, Erik W., Williams, Elizabeth D., Chaffer Christine L, Thomas David M, Chaffer, Christine L., Williams, ED, Thomas, David M., Thomas, DM, Williams Elizabeth D   +11 more
core   +1 more source

Multi‐Omics Insights Into the Mechanisms of Early Muscle Fiber Difference and Transformation Between Lean‐Type and Chinese Indigenous Pigs

Advanced Science, EarlyView.
Multi‐omics analyses uncover breed‐specific cis‐regulatory landscapes and higher‐order chromatin architectural differences that underlie early postnatal muscle fiber divergence in pigs. A super‐enhancer upstream of PPP3CB recruits MEF2C to activate PPP3CB transcription, while the PPP3CB–MEF2C positive feedback loop promotes oxidative muscle fiber ...
Shuailong Zheng, Hainan Wu, Min Liu, Kunpeng Wu, Shuntao Huang, Zulfiqar Ahmed, Lenox Pius, Mengjin Zhu, Dequan Xu   +8 more
wiley   +1 more source

Inclisiran inhibits oxidized low-density lipoprotein-induced foam cell formation in Raw264.7 macrophages via activating the PPARγ pathway

Autoimmunity, 2022
Proprotein convertase subtilisin kexin type 9 (PCSK9) is a well-known proprotein convertase that influences foam cell formation and modulates atherosclerosis. Inclisiran is a novel chemosynthetic small interfering RNA that inhibits PCSK9 synthesis.
Zhaoping Wang, Xiangyu Chen, Jingxing Liu, Yingcui Wang, Suhua Zhang   +4 more
doaj   +1 more source

KLF16 inhibits PPARγ expression.

, 2016
(A) Knockdown of KLF16 led to increased PPARγ expression. Primary brown preadipocytes were transfected with KLF16 siRNA and were differentiated in differentiation medium. Expression of KLF16 and PPARγ was determined at D0 and D4 by western blot and qPCR.
Myeong Ho Jung (85206), Min-Kyung Jang (3111393), Sunwoo Lee (1447036)   +2 more
core   +1 more source

Lilrb4a Suppression Reprograms Microglia to Mitigate APOE4‐Associated Amyloid Plaques and Cerebral Amyloid Angiopathy in Association With a PPAR‐Linked Pro‐Clearance State

Advanced Science, EarlyView.
Targeting Lilrb4a in Apolipoprotein E4 (APOE4)‐associated Alzheimer's disease (AD) reprograms microglia toward a beneficial, phagocytic state. Genetic deletion or antisense inhibition of Lilrb4a suppresses p‐SHP2/NF‐κB/STAT1 signaling, restores PPAR‐linked lipid and energy metabolism, and reduces amyloid plaque burden and cerebral amyloid angiopathy ...
Changxu Nie, Ruixi Yang, Xiaotong Wang, Ping Jia, Xueqi Zhang, Yaqi Dai, Xue Bai, Sijia Duan, Yufeng Li, Peng Zheng, Xin Tian, Li Jiang, Chao Wang   +12 more
wiley   +1 more source

CircRNF111 Contributes to Adipocyte Differentiation by Elevating PPARγ Expression via miR-27a-3p

Epigenetics, 2023
The content and distribution of adipocytes is an important factor that affects meat quality. Previous studies showed that circRNAs are involved in various physiological processes.
Xuemei Shen, Jia Tang, Yongzhen Huang, Xianyong Lan, Chuzhao Lei, Hong Chen   +5 more
doaj   +1 more source