Results 21 to 30 of about 4,462 (166)

The Effects of Intra-Ductal Mammary Administration of Orexin-A Antagonist (SB-334867) on the PPARγ and SREBP1c Gene Expression and Serum Adiponectin Levels in Lactating Rats [PDF]

International Journal of Basic Science in Medicine, 2022
Introduction: Orexin A and adiponectin are involved in controlling metabolism and energy distribution in the body during lactation. Lactation is a process with high demand for lipid synthesis.
Sepideh babaei garmkhani, Homayoun Khazali   +1 more
doaj   +1 more source

Gene Silencing of Toll-like Receptor 2 Gene Expression as a Tactic to Control Mycobacterium Tuberculosis and Granuloma Formation [PDF]

Archives of Razi Institute, 2022
Mycobacterium tuberculosis (MT) is the causative agent of tuberculosis (TB) in humans. Tuberculosis is one of the top 10 causes of mortality worldwide, resulting in 1.8 million deaths and 10.4 million new cases in 2016.
M. A Nama
doaj   +1 more source

WITHDRAWN: Mouse Trefoil Factor 3 (Tff3) Ameliorates Fatty Liver Phenotype via Increasing Peroxisome Proliferator-activated Receptor-α (PPARα) Expression

Oncotarget, 2017
// Xiaojie Wu 1, * , Haiyong Jin 2, * , Yueling Zhang 3 , Mingyuan Dong 3 , Xiaoting Wu 3 , Jiadi Zhou 1 , Weishan Zhuge 4 , Jianjing Yang 5 , Qichuan Zhuge 5 , Xiying Luan 1 , Dexiang Ban 6 , Wenjie Zhu 3 , Yongjun Jin 7 and Jiangnan Xue 1 1 Department of Immunology, Binzhou Medical University, Yantai, China 2 Department of ...
Xiaojie Wu, Xiaojie Wu, Haiyong Jin, Haiyong Jin, Yueling Zhang, Yueling Zhang, Mingyuan Dong, Mingyuan Dong, Xiaoting Wu, Xiaoting Wu, Jiadi Zhou, Jiadi Zhou, Weishan Zhuge, Weishan Zhuge, Jianjing Yang, Jianjing Yang, Qichuan Zhuge, Qichuan Zhuge, Xiying Luan, Xiying Luan, Dexiang Ban, Dexiang Ban, Wenjie Zhu, Wenjie Zhu, Yongjun Jin, Yongjun Jin, Jiangnan Xue, Jiangnan Xue   +27 more
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Thiazolidinediones/PPARγ agonists and fatty acid synthase inhibitors as an experimental combination therapy for prostate cancer

International Journal of Oncology, 2011
The prostate cancer (PCa) cell lines LNCaP, PC-3, and DU-145 express peroxisome proliferator-activated receptor γ (PPARγ) but its role in PCa is unclear. Thiazolidinediones (TZDs), a family of PPARγ activators and type 2 anti-diabetic drugs, exhibit anti-tumor apoptotic effects in human PCa cell lines. Likewise, pharmacological inhibitors of fatty acid
Mahmoud, Mansour, Dean, Schwartz, Robert, Judd, Benson, Akingbemi, Tim, Braden, Edward, Morrison, John, Dennis, Frank, Bartol, Amanda, Hazi, India, Napier, Asim B, Abdel-Mageed   +10 more
openaire   +3 more sources

Designing Specific Primers for Amplification and Quantitative Analysis of the GPR120 and PPARγ Genes [PDF]

Research in Molecular Medicine, 2022
Background: Designing the primer pairs is one of the most important factors in the amplification and quantitative analysis of the nucleic acid sequences of interest. Using in silico methods, the present study intends to design highly specific primers for
Ramin Lotfi, Farhad Salari
doaj  

Cynarin inhibits PDGF-BB-induced proliferation and activation in hepatic stellate cells through PPARγ

Open Chemistry, 2022
Cynarin, a caffeoylquinic acid compound that was mainly extracted from Cynara scolymus L., displays various activities such as antioxidant, antibacterial, choleretic, and hepatoprotective functions. However, the target of cynarin and the mechanism of its
Ding Yong, Tao Congcong, Chen Qian, Chen Lulu, Hu Xianwen, Li Mingyu, Wang Shicong, Jiang Fuquan   +7 more
doaj   +1 more source

Chronic activation of PPARα with fenofibrate reduces autophagic proteins in the liver of mice independent of FGF21

PLOS ONE, 2017
Autophagy is a catabolic mechanism to degrade cellular components to maintain cellular energy levels during starvation, a condition where PPARα may be activated. Here we report a reduced autophagic capacity in the liver following chronic activation of PPARα with fenofibrate (FB) in mice.
Ye, J, Li, S, Liang, Q, Zhang, X, Wang, H, Herbert, T, Guiliou, H, Jenkins, T, Xu, A, Jo, E   +9 more
openaire   +7 more sources

Low-intensity pulsed ultrasound inhibits adipogenic differentiation via HDAC1 signalling in rat visceral preadipocytes

Adipocyte, 2019
Non-drug strategy targeting adipocyte differentiation is critical for alleviating visceral obesity and its related diseases. However, whether and how low intensity pulsed ultrasound (LIPUS) could be used for inhibiting visceral adipocyte differentiation ...
Tianhua Xu, Kun Zhao, Xiasheng Guo, Juan Tu, Dong Zhang, Wei Sun, Xiangqing Kong   +6 more
doaj   +1 more source

Gene variants and haplotypes of Vitamin D biosynthesis, transport, and function in preeclampsia

Hypertension in Pregnancy, 2021
Objective: To find whether the gene variants and haplotypes of cytochrome (CYP) 27B1 (1α-hydroxylase), group-specific component (GC) that is a vitamin D binding protein, vitamin D receptor (VDR), peroxisome proliferator-activated receptor γ (PPARγ) and ...
Zahra Ghorbani, Mohammad Shakiba, Negin Rezavand, Ziba Rahimi, Asad Vaisi-Raygani, Zohreh Rahimi, Ebrahim Shakiba   +6 more
doaj   +1 more source

p21Cip1 plays a critical role in the physiological adaptation to fasting through activation of PPARα

Scientific Reports, 2016
AbstractFasting is a physiological stress that elicits well-known metabolic adaptations, however, little is known about the role of stress-responsive tumor suppressors in fasting. Here, we have examined the expression of several tumor suppressors upon fasting in mice.
Lopez-Guadamillas, Elena, Fernandez-Marcos, Pablo J., Pantoja, Cristina, Muñoz-Martin, Maribel, Martínez, Dolores, Gómez-López, Gonzalo, Campos-Olivas, Ramón, Valverde, Angela M., Serrano, Manuel   +8 more
openaire   +5 more sources