PPARβ/δ and PPARγ maintain undifferentiated phenotypes of mouse adult neural precursor cells from the subventricular zone [PDF]
Frontiers in Cellular Neuroscience, 2015 The subventricular zone (SVZ) is one of the main niches of neural stem cells in the adult mammalian brain. Stem and precursor cells in this region are the source for neurogenesis and oligodendrogesis, mainly in the olfactory bulb and corpus callosum, respectively.
Carolina eBernal +4 more
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Astragaloside IV regulates autophagy-mediated proliferation and apoptosis in a rat model of PCOS by activating the PPARγ pathway [PDF]
Iranian Journal of Basic Medical Sciences, 2022 Objective(s): Astragaloside IV (AS-IV) is a bioactive saponin with a wide range of pharmacological effects. This study was aimed at investigating its potential effect on polycystic ovary syndrome (PCOS).
Mingxiao Wen +3 more
doaj +1 more source
Curcumin improves adipocytes browning and mitochondrial function in 3T3-L1 cells and obese rodent model [PDF]
Royal Society Open Science, 2021 Accumulating evidence suggests that mitochondrial dysfunction and adipocyte differentiation promote lipid accumulation in the development of obesity and diabetes.
Dandan Zhao +12 more
doaj +1 more source
PPARγ signaling is required for mediating EETs protective effects in neonatal cardiomyocytes exposed to LPS [PDF]
Frontiers in Pharmacology, 2014 Lipopolysaccharide (LPS) is a bacterial wall endotoxin producing many pathophysiological conditions including myocardial inflammation leading to cardiotoxicity. Epoxyeicosatrienoic acids (EETs) are biologically active metabolites of arachidonic acids capable of activating protective cellular pathways in response to stress stimuli. EETs evoke a plethora
Victor eSamokhvalov +8 more
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Exercise retards ongoing adipose tissue fibrosis in diet-induced obese mice
Endocrine Connections, 2021 Exercise has been recommended as an important strategy to impro ve glucose metabolism in obesity. Adipose tissue fibrosis is associated with inflammati on and is implicated in glucose metabolism disturbance and insulin resistance in obesit y.
Liangming Li +10 more
doaj +1 more source
Sinapic acid prevents adipogenesis by regulating transcription factors and exerts an anti-ROS effect by modifying the intracellular anti-oxidant system in 3T3-L1 adipocytes [PDF]
Iranian Journal of Basic Medical Sciences, 2022 Objective(s): In this study, we tested the hypothesis that sinapic acid (SA), a naturally occurring hydroxycinnamic acid found in vegetables, cereal grains, and oilseed crops with various biological activities suppresses adipogenesis in 3T3-L1 adipocytes
Cordelia John, Sumathy Arockiasamy
doaj +1 more source
The use of telmisartan in patients with refractory arterial hypertension and obesity
Кардиоваскулярная терапия и профилактика, 2019 Aim. To evaluate the effectiveness of telmisartan as a component of triple antihypertensive therapy in patients with obesity and refractory arterial hypertension.Material and methods.
I. Е. Deneka +2 more
doaj +1 more source
Rice consumption and predisposition to metabolic diseases: The role of PPARγ and GLUT4 dysregulation
Journal of Nutrition & Intermediary Metabolism, 2017 Metabolic diseases of significant dietary cause have been multiplying since the climax of the Industrial Revolution and are approaching pandemic proportions. Diet has been promulgated as a cornerstone in tackling these diseases. Understanding the long-term molecular modulatory functions of a diet on key metabolic pathways associated with the ...
Bilyaminu Abubakar +4 more
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Localization of peroxisome proliferator-activated receptor alpha (PPARα) and N-acyl phosphatidylethanolamine phospholipase D (NAPE-PLD) in cells expressing the Ca2+-binding proteins calbindin, calretinin, and parvalbumin in the adult rat hippocampus [PDF]
Frontiers in Neuroanatomy, 2014 The N-acylethanolamines (NAEs), oleoylethanolamide (OEA) and palmithylethanolamide (PEA) are known to be endogenous ligands of PPARα receptors, and their presence requires the activation of a specific phospholipase D (NAPE-PLD) associated with intracellular Ca(2+) fluxes.
Rivera, Patricia +7 more
openaire +7 more sources
Renal Failure, 2020 Objective Nephrotoxicity is the main side effect of cyclosporine A and finding an effective combating method is urgent. The present study investigates the improving effect of erythropoietin (EPO) on cyclosporine A induce renal injury in rats and further ...
Bin Liu, Ping Tan
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