Results 11 to 20 of about 4,462 (166)

Biological Rationale for the Use of PPARγ Agonists in Glioblastoma [PDF]

Frontiers in Oncology, 2014
Glioblastoma multiforme (GBM) is the most common primary intrinsic central nervous system tumor and has an extremely poor overall survival with only 10% patients being alive after 5 years. There has been interesting preliminary evidence suggesting that diabetic patients receiving peroxisome proliferator-activated receptor gamma (PPARγ) agonists, a ...
Hayley Patricia Ellis, Kathreena Mary Kurian, Kathreena Mary Kurian   +2 more
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Oleuropein Promotes Neural Plasticity and Neuroprotection via PPARα-Dependent and Independent Pathways

Biomedicines, 2023
Oleuropein (OLE), a main constituent of olive, displays a pleiotropic beneficial dynamic in health and disease, based mainly on its antioxidant and hypolipidemic properties, and its capacity to protect myocardium during ischemia. Furthermore, OLE activates peroxisome proliferator-activated receptor (PPARα) in neurons and astrocytes, providing
Foteini Malliou, Christina E. Andriopoulou, Aristeidis Kofinas, Allena Katsogridaki, George Leondaritis, Frank J. Gonzalez, Theologos M. Michaelidis, Marousa Darsinou, Leandros A. Skaltsounis, Maria Konstandi   +9 more
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PPARβ/δ and PPARγ maintain undifferentiated phenotypes of mouse adult neural precursor cells from the subventricular zone [PDF]

Frontiers in Cellular Neuroscience, 2015
The subventricular zone (SVZ) is one of the main niches of neural stem cells in the adult mammalian brain. Stem and precursor cells in this region are the source for neurogenesis and oligodendrogesis, mainly in the olfactory bulb and corpus callosum, respectively.
Carolina eBernal, Carolina eBernal, Claudia eAraya, Veronica ePalma, Miguel eBronfman   +4 more
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PPARγ signaling is required for mediating EETs protective effects in neonatal cardiomyocytes exposed to LPS [PDF]

Frontiers in Pharmacology, 2014
Lipopolysaccharide (LPS) is a bacterial wall endotoxin producing many pathophysiological conditions including myocardial inflammation leading to cardiotoxicity. Epoxyeicosatrienoic acids (EETs) are biologically active metabolites of arachidonic acids capable of activating protective cellular pathways in response to stress stimuli. EETs evoke a plethora
Victor eSamokhvalov, Jelle eVriend, Jelle eVriend, Kristi L Jamieson, Maria eAkhnokh, Rajkumar eManne, John R Falck, John M. Seubert, John M. Seubert   +8 more
openaire   +3 more sources

Sinapic acid prevents adipogenesis by regulating transcription factors and exerts an anti-ROS effect by modifying the intracellular anti-oxidant system in 3T3-L1 adipocytes [PDF]

Iranian Journal of Basic Medical Sciences, 2022
Objective(s): In this study, we tested the hypothesis that sinapic acid (SA), a naturally occurring hydroxycinnamic acid found in vegetables, cereal grains, and oilseed crops with various biological activities suppresses adipogenesis in 3T3-L1 adipocytes
Cordelia John, Sumathy Arockiasamy
doaj   +1 more source

The use of telmisartan in patients with refractory arterial hypertension and obesity

Кардиоваскулярная терапия и профилактика, 2019
Aim. To evaluate the effectiveness of telmisartan as a component of triple antihypertensive therapy in patients with obesity and refractory arterial hypertension.Material and methods.
I. Е. Deneka, A. V. Rodionov, V. V. Fomin   +2 more
doaj   +1 more source

Rice consumption and predisposition to metabolic diseases: The role of PPARγ and GLUT4 dysregulation

Journal of Nutrition & Intermediary Metabolism, 2017
Metabolic diseases of significant dietary cause have been multiplying since the climax of the Industrial Revolution and are approaching pandemic proportions. Diet has been promulgated as a cornerstone in tackling these diseases. Understanding the long-term molecular modulatory functions of a diet on key metabolic pathways associated with the ...
Bilyaminu Abubakar, Norsharina Ismail, Abdul Rahman Omar, Md Zuki Abu bakar, Maznah Ismail   +4 more
openaire   +2 more sources

Localization of peroxisome proliferator-activated receptor alpha (PPARα) and N-acyl phosphatidylethanolamine phospholipase D (NAPE-PLD) in cells expressing the Ca2+-binding proteins calbindin, calretinin, and parvalbumin in the adult rat hippocampus [PDF]

Frontiers in Neuroanatomy, 2014
The N-acylethanolamines (NAEs), oleoylethanolamide (OEA) and palmithylethanolamide (PEA) are known to be endogenous ligands of PPARα receptors, and their presence requires the activation of a specific phospholipase D (NAPE-PLD) associated with intracellular Ca(2+) fluxes.
Rivera, Patricia, Arrabal, Sergio, Vargas, Antonio, Blanco Calvo, Eduardo, Serrano, Antonia, Pavón, Francisco Javier, Rodríguez de Fonseca, Fernando, Suárez, Juan   +7 more
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PPAR γ/TLR4/TGF-β1 axis mediates the protection effect of erythropoietin on cyclosporin A-induced chronic nephropathy in rat

Renal Failure, 2020
Objective Nephrotoxicity is the main side effect of cyclosporine A and finding an effective combating method is urgent. The present study investigates the improving effect of erythropoietin (EPO) on cyclosporine A induce renal injury in rats and further ...
Bin Liu, Ping Tan
doaj   +1 more source

PENGARUH PEMBERIAN OX-LDL TERHADAP AKTIVASI NF-кB DAN PPARγ γγ γSERTA APOPTOSIS PADA KULTUR HUVEC’s

Jurnal Kedokteran Brawijaya, 2013
Oxidized LDL (ox-LDL) causes activation and dysfunction of endothelial cells through NFκB activation after binding process of ox-LDL to LOX-1. One of ox-LDL components had been known as the activator of PPARγ. This study was done to see the effect of ox-LDL on NFκB and PPARγactivation and apoptosis of HUVEC’s culture.
Wibi Riawan, Samodijanti Wibowati
openaire   +2 more sources