Results 41 to 50 of about 1,303 (153)

Genetic Biomarkers for Periodontal Diseases: A Systematic Review

Journal of Clinical Periodontology, Volume 52, Issue S29, Page 182-210, August 2025.
ABSTRACT Aims To identify genetic biomarkers that may be used in the diagnosis, prevention or management of different forms of periodontal disease. Materials and Methods Following protocol registration and PICOTS (patient, intervention, comparison, outcome, time, studies) questions, a systematic search of the literature was conducted (PudMed, Ovid ...
H. Dommisch, D. Hoedke, E. M.‐C. Lu, A. Schäfer, G. Richter, J. Kang, L. Nibali   +6 more
wiley   +1 more source

Peroxisome proliferator-activated receptor γ2 Pro12Ala (rs1801282) polymorphism and breast cancer susceptibility: A meta-analysis

Molecular Medicine Reports, 2013
Several studies have investigated the correlation between the peroxisome proliferator-activated receptor γ2 (PPAR‑γ2) Pro12Ala (rs1801282) polymorphism and the risk of breast cancer, with inconsistent results. For this reason, a meta-analysis was conducted to identify the potential correlation after pooling data from eligible case-control studies ...
Qunxia, Mao, Huilin, Guo, Linggen, Gao, Hongwei, Wang, Xu, Ma   +4 more
openaire   +3 more sources

Association between allele 12Pro of rs1801282 polymorphism gene PPAR and diabetes mellitus type 2

Clinical endocrinology and endocrine surgery, 2016
Мета роботи – проаналізувати розподіл поліморфних генотипів та алелей при цукровому діабеті (ЦД) 2 типу та дослідити наявність асоціативного зв’язку поліморфізму Pro12Ala (rs1801282) гена PPARG з розвитком цього захворювання в українській популяції.Матеріали та методи. Дослідження проведено за участю 88 хворих, контрольну групу склали 50 пацієнтів. Для
openaire   +6 more sources

Deciphering the complex interplay of obesity, epithelial barrier dysfunction, and tight junction remodeling: Unraveling potential therapeutic avenues

Obesity Reviews, Volume 25, Issue 8, August 2024.
Summary Obesity stands as a formidable global health challenge, predisposing individuals to a plethora of chronic illnesses such as cardiovascular disease, diabetes, and cancer. A confluence of genetic polymorphisms, suboptimal dietary choices, and sedentary lifestyles significantly contribute to the elevated incidence of obesity.
Sara K. AlMarzooqi, Fajr Almarzooqi, Hana Q. Sadida, Jayakumar Jerobin, Ikhlak Ahmed, Abdul‐Badi Abou‐Samra, Khalid A. Fakhro, Punita Dhawan, Ajaz A. Bhat, Ammira S. Al‐Shabeeb Akil   +9 more
wiley   +1 more source

Effect of thiazolidinediones on dislipidemia in patients with metabolic syndrome depending on the gene PPAR-gamma rs1801282 polymorphism

HERALD of North-Western State Medical University named after I.I. Mechnikov, 2019
Background. To evaluate the effect of thiazolidinediones on lipid spectrum of blood in patients with metabolic syndrome depending on gene polymorphism rs1801282. Materials and methods. The study included 109 patients with newly diagnosed metabolic syndrome.
Tatyana V. Eremenko, Svetlana M. Kotova, Natalya V. Vorokhobina, Nikolay A. Matsievskiy, Irina Yu. Matezius   +4 more
openaire   +2 more sources

A meta-analysis of the association of PPARγ rs1801282 polymorphism and NSAID usage with the risk of developing cancer.

Biological & pharmaceutical bulletin, 2014
Use of nonsteroidal anti-inflammatory drugs (NSAIDs) is correlated with a reduced risk of cancer through the reduction of inflammation, which is an important risk factor. Several studies have investigated polymorphisms in the peroxisome proliferator-activated receptor gamma (PPARγ) gene and NSAID use in association with cancer risk.
Nagao, Mai, Sato, Youichi, Yamauchi, Aiko   +2 more
openaire   +2 more sources

Obesity-related genetic polymorphisms and adiposity indices in a young Italian population [PDF]

, 2017
Pediatric obesity develops when a complex biological predisposition collides with an obesogenic environment. To further elucidate the role of genetics in obesity onset, we performed a candidate-gene association study in a young and sportive Italian ...
PIANGERELLI, MARCO, Marchegiani, F, Laura Bordoni, GABBIANELLI, Rosita, Francesca Marchegiani, BORDONI, LAURA, Valerio Napolioni, Rosita Gabbianelli, Napolioni, V, Marco Piangerelli   +9 more
core   +1 more source

Interaction of PPARG Pro12Ala with dietary fat influences plasma lipids in subjects at cardiometabolic risk [PDF]

, 2017
Objective: The PPARG SNP rs1801282 (Pro12Ala C>G) has shown variable association with metabolic syndrome traits in healthy subjects. We investigated genotype association with plasma lipids and the influence of dietary polyunsaturated:saturated fat ratio (
O'Dell, SD, Frost, GS, Sanders, TAB, Lovegrove, JA, AlSaleh, A, Griffin, BA, Jebb, SA   +6 more
core   +1 more source

Association between PPARγ, PPARGC1A, and PPARGC1B genetic variants and susceptibility of gastric cancer in an Eastern Chinese population

, 2022
Purpose Previous studies showed that peroxisome proliferator-activated receptor gamma (PPARγ) and PPARγ coactivator1 family (PPARGC1A and PPARGC1B) gene single nucleotide variants (SNVs)were strongly associated with cancer susceptibility.
Chao Liu, Mingqiang Kang, Yu Chen, Boyang Chen, Weifeng Tang, Yafeng Wang, Jinbiao Xie   +6 more
core   +1 more source

PPARG, TMEM163, UBE2E2, and WFS1 Gene Polymorphisms Are Not Significant Risk Factors for Gestational Diabetes in the Polish Population

, 2022
Gestational diabetes mellitus (GDM) is a common disorder that occurs in pregnant women, leading to many maternal and neonatal complications. The pathogenesis of GDM is complex and includes risk factors, such as: age, obesity, and family history of ...
Damian Malinowski, Krzysztof Safranow, Przemysław Ustianowski, Andrzej Pawlik, Violetta Dziedziejko, Maciej Tarnowski   +5 more
core   +1 more source