Results 41 to 50 of about 1,103 (148)

The single nucleotide polymorphism rs11643718 in SLC12A3 is associated with the development of diabetic kidney disease in Chinese people with type 2 diabetes

Diabetic Medicine, Volume 37, Issue 11, Page 1879-1889, November 2020., 2020
Abstract Aims To examine the association between 24 literature‐based single nucleotide polymorphisms and diabetic kidney disease in Chinese people with type 2 diabetes. Methods and results Twenty‐four candidate diabetic kidney disease‐susceptible single nucleotide polymorphisms were genotyped in 208 participants with type 2 diabetes and diabetic kidney
J.‐F. Yang, X.‐F. Xiong, Y. Xiao, L. Wei, L. Li, M. Yang, Y.‐C. Han, H. Zhao, C.‐R. Li, N. Jiang, S. Xiong, L.‐F. Zeng, Z.‐G. Zhou, S.‐P. Liu, N.‐S. Wang, Y. Fan, L. Sun   +16 more
wiley   +1 more source

Association study of rs1801282 PPARG gene polymorphism and immune cells and cytokine levels in a Spanish pregnant women cohort and their offspring [PDF]

Journal of Biomedical Science, 2020
AbstractBackgroundPeroxisome proliferator activated receptor gamma (PPARG) belongs to the nuclear receptor superfamily functioning as transcription factors to regulate cellular differentiation, development and metabolism. Moreover, it has been implicated in the regulation of lipid metabolism, as well as the maturation of monocytes/macrophages and the ...
Maria García-Ricobaraza, Mercedes García-Bermúdez, Francisco J. Torres-Espinola, M. Teresa Segura Moreno, Mathieu N. Bleyere, Ligia E. Díaz-Prieto, Esther Nova, Ascensión Marcos, Cristina Campoy   +8 more
openaire   +6 more sources

PPARγ Gene Polymorphisms, Metabolic Disorders, and Coronary Artery Disease

Frontiers in Cardiovascular Medicine, 2022
Being activated by endogenous and exogenous ligands, nuclear receptor peroxisome proliferator-activated receptor gamma (PPARγ) enhances insulin sensitivity, promotes adipocyte differentiation, stimulates adipogenesis, and has the properties of anti ...
Yongyan Song, Shujin Li, Chuan He
doaj   +1 more source

Ethnic differences in adiposity and diabetes risk – insights from genetic studies

Journal of Internal Medicine, Volume 288, Issue 3, Page 271-283, September 2020., 2020
Content List ‐ Read more articles from the symposium: “Obesity and Type 2 Diabetes: Understanding the Role of Ethnicity”. Abstract Type 2 diabetes is more common in non‐Europeans and starts at a younger age and at lower BMI cut‐offs. This review discusses the insights from genetic studies about pathophysiological mechanisms which determine risk of ...
H. Yaghootkar, B. Whitcher, J. D. Bell, E. L. Thomas   +3 more
wiley   +1 more source

THE RS1801282 PPARG POLYMORPHISM DEPENDENT METABOLIC EFFECTS OF PIOGLITAZONE IN PATIENTS WITH OBESITY AND CONCOMITANT NAFLD

EUREKA: Health Sciences, 2020
The aim: to investigate the metabolic effects of different treatment options in patients with obesity and concomitant non-alcoholic fatty liver disease (NAFLD) based on the presence of CG and GG genotypes PPARG rs1801282 (Pro12Ala) polymorphism in Ukrainians.
Vadym Shypulin, Nikolai Rudenko, Oleksandr Martynchuk, Aleksandr Koliada, Vitaly Guryanov, Nataliia Melnyk   +5 more
openaire   +3 more sources

UEG Week 2023 Moderated Posters

, 2023
United European Gastroenterology Journal, Volume 11, Issue S8, Page 201-534, October 2023.
wiley   +1 more source

Two SNPs (rs1801282 and -1279G/A) of PPARγ are associated with Parkinson's disease in a northern Chinese population

, 2020
Abstract Background: This study aimed to assess the association between PPARγ gene polymorphism and susceptibility to Parkinson’s disease (PD) in a northern Chinese population. Methods : We conducted a case-control study which including 391 outpatients with PD and 391 healthy matched individuals. All subject genotypes on PPARγ gene in rs3856806,
shanshan li, Li Xue, Huimin Wang, Qingwu Tian, Anmu Xie   +4 more
openaire   +1 more source

Peroxisome proliferator-activated receptor γ2 Pro12Ala (rs1801282) polymorphism and breast cancer susceptibility: A meta-analysis

Molecular Medicine Reports, 2013
Several studies have investigated the correlation between the peroxisome proliferator-activated receptor γ2 (PPAR‑γ2) Pro12Ala (rs1801282) polymorphism and the risk of breast cancer, with inconsistent results. For this reason, a meta-analysis was conducted to identify the potential correlation after pooling data from eligible case-control studies ...
Qunxia, Mao, Huilin, Guo, Linggen, Gao, Hongwei, Wang, Xu, Ma   +4 more
openaire   +3 more sources

POLYMORPHISM PRO12ALA OF THE PPARG-2 GENE (rs1801282) IN CHILDREN WITH OBESITY

Medical science of Uzbekistan
Resume:  This article presents data from a study of the Pro12Ala polymorphism of the PPARG-2 gene in obese children. The study results are recommended for widespread implementation in the practice of pediatric hospital physicians. The aim of the work: to study the frequency of the Pro12Ala polymorphism of the PPARG 2 gene in children with different ...
Lilia Garifullina, Uktam Rustamov
openaire   +1 more source

Is the rs1801282 (G/C) Polymorphism of PPAR - Gamma Gene Associated with T2DM in Iraqi People?

Open Access Macedonian Journal of Medical Sciences, 2018
BACKGROUND: Pro12Ala (rs1801282) is a common polymorphism of the human PPAR-γ gene. Studies have demonstrated conflicting results about its association with T2DM worldwide. There are no reports about such possible association among Iraqi people. OBJECTIVES:  This study aims at finding out whether having the mutant allele (Ala12) might be associated ...
Al-Naemi, Amjad Hazim, Ahmad, Akram Jarjees   +1 more
openaire   +3 more sources