Results 1 to 10 of about 23,167 (255)
Targeted activation of PPARG or AKT1 alleviates liver injury in mice with type 2 diabetes and sepsis by modulating inflammatory and metabolic pathways [PDF]
Annals of MedicineBackground The simultaneous presence of sepsis and type 2 diabetic mellitus (T2DM) has a synergistic effect on hepatic damage. Although the activation of peroxisome proliferator-activate receptor gamma (PPARG) and AKT serine/threonine kinase 1 (AKT1 ...
Jie Ma +16 more
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TRIM28 orchestrates SUMO-ubiquitin crosstalk to stabilize PPARG and drive bladder cancer progression [PDF]
Cell Death and DiseaseBladder cancer (BLCA) is a growing health burden with rising incidence and limited therapeutic options. To define the role of the Tripartite Motif (TRIM) family in BLCA, we integrated multi-cohort transcriptomic analyses with functional and mechanistic ...
Xuefeng Fan +10 more
doaj +2 more sources
miR-27b-3p directly targets PPARG to regulate pancreatic cancer progression [PDF]
Discover OncologyBackground miR-27b-3p is dysregulated in many cancers, but its expression, clinical role, and mechanism in pancreatic cancer are not fully understood.
Lijun Zhu +6 more
doaj +2 more sources
Development of a clinical nomogram for predicting hemorrhagic rupture in renal angiomyolipoma and analysis of molecular correlates (CD34, PPARG, and PTEN) [PDF]
Open MedicineHemorrhagic rupture is a severe and potentially life-threatening complication of renal angiomyolipoma (AML). However, current clinical tools for accurately predicting hemorrhage risk remain limited.
Li Xiaobing +4 more
doaj +2 more sources
Ecotoxicology and Environmental SafetyThe inflammatory response induced by fine particulate matter (PM2.5), a common class of air pollutants, is an important trigger for the development of pulmonary fibrosis.
Siyu Yang +7 more
exaly +3 more sources
Association of PPARG rs3856806 C>T polymorphism with body mass index, glycaemia and lipid parameters in Serbian adolescents [PDF]
Scripta Medica, 2021 Background/Aim: Peroxisome proliferator-activated receptor gamma (PPARg) belongs to a family of nuclear hormone receptors and ligand-activated transcription factors.
Vidović Vanja +4 more
doaj +1 more source
Genel Tıp Dergisi, 2021 Amaç: Tip 2 diyabet (T2D), diyabetin en sık görülen türüdür ve tüm dünyada olduğu gibi ülkemizde de ciddi bir halk sağlığı sorunu haline gelmiştir. İnsülin sekresyonunun azalması ve/veya insülin direnci (İR) gelişimi, T2D patogenezinde yer alan iki ana ...
Süleyman Baldane +4 more
doaj +1 more source
Consilium Medicum, 2022 The PPARG gene has the great value in predicting of carbohydrate metabolism disorders development and the patients response to different therapy options.
Kamilya B. Khasanova +5 more
doaj +1 more source
Advanced Biomedical Research, 2023 Background: There is an emergency need in discovering an efficient profile of molecular biomarkers for early diagnosis of Non-small cell lung cancer (NSCLC).
Kaveh Motamediyan +7 more
doaj +1 more source
Медицинский вестник Юга России, 2021 Objective: To study the effect of the rs1801282 PPARG polymorphism on changes in the body composition of patients with early carbohydrate metabolism disorders in groups with different variants of treatment.Materials and Methods: The study involved 64 ...
F. V. Valeeva +4 more
doaj +1 more source