Results 1 to 10 of about 38,455 (298)

Integrated investigation and experimental validation of PPARG as an oncogenic driver: implications for prognostic assessment and therapeutic targeting in hepatocellular carcinoma

Frontiers in Pharmacology, 2023
Peroxisome proliferator-activated receptor gamma (PPARG), a key transcription factor involved in lipid metabolism and glucose homeostasis, has been implicated in various types of cancer. However, its precise role in cancer remains unclear. In this study,
Yunsheng Ran, Yunsheng Ran, Chujiao Hu, Chujiao Hu, Junzhao Wan, Junzhao Wan, Qian Kang, Ruixian Zhou, Ping Liu, Dan Ma, Dan Ma, Dan Ma, Jianta Wang, Jianta Wang, Lei Tang, Lei Tang, Lei Tang   +16 more
exaly   +3 more sources

miR-27b-3p directly targets PPARG to regulate pancreatic cancer progression [PDF]

Discover Oncology
Background miR-27b-3p is dysregulated in many cancers, but its expression, clinical role, and mechanism in pancreatic cancer are not fully understood.
Lijun Zhu, Cuiping Long, Yaxin Tang, Chenxi Wu, Linxi Wei, Tao Ye, Jun Chen   +6 more
doaj   +2 more sources

Hypermethylation of PPARG-encoding gene promoter mediates fine particulate matter-induced pulmonary fibrosis by regulating the HMGB1/NLRP3 axis

Ecotoxicology and Environmental Safety
The inflammatory response induced by fine particulate matter (PM2.5), a common class of air pollutants, is an important trigger for the development of pulmonary fibrosis.
Siyu Yang, Yaochuan Sun, Yajun Luo, Yingyi Liu, Mengyu Jiang, Jiayou Li, Qibing Zhang, Jun Bai   +7 more
exaly   +3 more sources

Association of PPARG rs3856806 C>T polymorphism with body mass index, glycaemia and lipid parameters in Serbian adolescents [PDF]

Scripta Medica, 2021
Background/Aim: Peroxisome proliferator-activated receptor gamma (PPARg) belongs to a family of nuclear hormone receptors and ligand-activated transcription factors.
Vidović Vanja, Maksimović Nela, Vidović Stojko, Damnjanović Tatjana, Novaković Ivana   +4 more
doaj   +1 more source

PPARG genindeki Pro12Ala polimorfizmi, Türk populasyonunda insülin direnci ve tip 2 diyabet ile ilişkili değildir: Bir vaka-kontrol çalışması

Genel Tıp Dergisi, 2021
Amaç: Tip 2 diyabet (T2D), diyabetin en sık görülen türüdür ve tüm dünyada olduğu gibi ülkemizde de ciddi bir halk sağlığı sorunu haline gelmiştir. İnsülin sekresyonunun azalması ve/veya insülin direnci (İR) gelişimi, T2D patogenezinde yer alan iki ana ...
Süleyman Baldane, Suleyman Ipekci, Funda İşçioğlu, Hilal Arikoglu, Dudu Erkoç Kaya   +4 more
doaj   +1 more source

The role of the rs1801282 PPARG polymorphic marker in the prediction and choice of carbohydrate metabolism disorders management: A review

Consilium Medicum, 2022
The PPARG gene has the great value in predicting of carbohydrate metabolism disorders development and the patients response to different therapy options.
Kamilya B. Khasanova, Maria S. Medvedeva, Elena V. Valeeva, Zhanna A. Rodygina, Tatiana A. Kiseleva, Farida V. Valeeva   +5 more
doaj   +1 more source

Evaluation of expression levels of NFATc2 and PPARG genes two effector elements of WNT pathway in non-small cell lung carcinoma

Advanced Biomedical Research, 2023
Background: There is an emergency need in discovering an efficient profile of molecular biomarkers for early diagnosis of Non-small cell lung cancer (NSCLC).
Kaveh Motamediyan, Venus Zafari, Soghra Bornehdeli, Ayşe Caner, Milad Asadi, Shahryar Hashemzadeh, Mohammad Reza Firozi, Mortaza Raeisi   +7 more
doaj   +1 more source

Changes in body composition depending on the rs1801282 PPARG polymorphism in patients with different variants of treatment of early carbohydrate metabolism disorders

Медицинский вестник Юга России, 2021
Objective: To study the effect of the rs1801282 PPARG polymorphism on changes in the body composition of patients with early carbohydrate metabolism disorders in groups with different variants of treatment.Materials and Methods: The study involved 64 ...
F. V. Valeeva, M. S. Medvedeva, K. B. Khasanova, T. S. Turtseva, T. S. Yilmaz   +4 more
doaj   +1 more source

Effect of Black Cumin on the Expression of Genes Related to Lipid Metabolism in Adipose Tissue: A Mouse Model Study [PDF]

Journal of Genetic Resources
Obesity, as a complex multifactorial disease, can be considered as a suitable goal for treatment by traditional medicine. This study aimed to investigate the effect of black cumin on the expression of some important genes in the metabolism of lipids. For
Roya Maleki, Ali Ahadi, Hoda Ayat
doaj   +1 more source

Sleeping Beauty screen reveals Pparg activation in metastatic prostate cancer [PDF]

, 2016
Prostate cancer (CaP) is the most common adult male cancer in the developed world. The paucity of biomarkers to predict prostate tumor biology makes it important to identify key pathways that confer poor prognosis and guide potential targeted therapy ...
Adams, David J., Ahmad, Imran, Edwards, Joanne, Galbraith, Laura, Hedley, Ann, Leung, Hing Y., Loveridge, Carolyn, Markert, Elke, Mui, Ernest, Patel, Rachana, Repiscak, Peter, Rust, Alistair G., Salji, Mark, Sansom, Owen J., Tan, Ee Hong, van der Weyden, Louise   +15 more
core   +1 more source