Results 21 to 30 of about 38,455 (298)
Is PPARG the key gene in diabetic retinopathy? [PDF]
British Journal of Pharmacology, 2011 Diabetic retinopathy, a microvascular complication of diabetes mellitus, is major cause of non‐inherited blindness among adults. Although diabetic retinopathy is a common complication of diabetes, we still know little about the underlying molecular mechanisms.
Costa V, Ciccodicola A
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Nocturnin: a circadian target of Pparg‐induced adipogenesis [PDF]
Annals of the New York Academy of Sciences, 2010 Nuclear receptors (NRs) control cell fate and regulate tissue function. Some of the NRs are expressed in a circadian and tissue‐specific manner. Clock genes are part of the circadian network and fine‐tune gene expression in adipose and skeletal tissues.
Kawai, M +5 more
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Frontiers in Endocrinology, 2017 The tropical freshwater zebrafish has recently emerged as a valuable model organism for the study of adipose tissue biology and obesity-related disease. The strengths of the zebrafish model system are its wealth of genetic mutants, transgenic tools, and ...
Rebecca Wafer +2 more
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PPARG: A Promising Therapeutic Target in Breast Cancer and Regulation by Natural Drugs
PPAR Research, 2023 Breast cancer (BC) is the most common type of cancer among females. Peroxisome proliferator-activated receptor gamma (PPARG) can regulate the production of adipocyte-related genes and has anti-inflammatory and anti-tumor effects.
De-Hui Li +5 more
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Seipin oligomers can interact directly with AGPAT2 and lipin 1, physically scaffolding critical regulators of adipogenesis [PDF]
, 2015 This work was supported by a Merit Scholarship from the Islamic Development Bank (to M.M.U.T.), The Agency for Science, Technology and Research, Singapore (A*STAR) (M.F.M.S), the Medical Research Council (MRC) [NIRG GO800203 and Research Grant MR/L002620/
Edwardson, J Michael +4 more
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Cells, 2019 Autophagy is the cell self-eating mechanism to maintain cell homeostasis by removing damaged intracellular proteins or organelles. It has also been implicated in the development and differentiation of various cell types including the adipocyte.
Mahmoud Ahmed +5 more
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The Genetics ofPPARGand the Skeleton
PPAR Research, 2006 Osteoporosis is a complex metabolic bone disorder. Recently it has been appreciated that the “obesity in bone” phenomenon occurs at the expense of bone formation, and that is a key component of the pathology of this disease. Mouse models with altered bone expression levels of peroxisome proliferator-activated receptor gamma (PPARG) impact bone ...
Cheryl Ackert-Bicknell, Clifford Rosen
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PPARG Could Work as a Valid Therapeutic Strategy for the Treatment of Lung Squamous Cell Carcinoma
PPAR Research, 2020 Previous studies showed that PPAR-gamma (PPARG) ligands might serve as potential therapeutic agents for nonsmall cell lung cancer (NSCLC). However, a few studies reported the specific relationship between PPARG and lung squamous cell carcinoma (LSCC ...
Shunbin Shi +5 more
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PPAR Research, 2020 Previous studies showed that low PPARG expression was associated with poor prognosis of lung adenocarcinoma (LA) with limited mechanisms identified. We first conducted a large-scale literature-based data mining to identify potential molecular pathways ...
Min Zhao +5 more
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Frontiers in Genetics, 2021 Background: Breast cancer (BRCA) is the most frequent malignancy. Identification of potential biomarkers could help to better understand and combat the disease at early stages.Methods: We selected the overlapping genes of differential expressed genes and
Jianbin Wu +4 more
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