Results 21 to 30 of about 23,167 (255)
Cells, 2019 Autophagy is the cell self-eating mechanism to maintain cell homeostasis by removing damaged intracellular proteins or organelles. It has also been implicated in the development and differentiation of various cell types including the adipocyte.
Mahmoud Ahmed +5 more
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Nocturnin: a circadian target of Pparg‐induced adipogenesis [PDF]
Annals of the New York Academy of Sciences, 2010 Nuclear receptors (NRs) control cell fate and regulate tissue function. Some of the NRs are expressed in a circadian and tissue‐specific manner. Clock genes are part of the circadian network and fine‐tune gene expression in adipose and skeletal tissues.
Kawai, M +5 more
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PPARG Could Work as a Valid Therapeutic Strategy for the Treatment of Lung Squamous Cell Carcinoma
PPAR Research, 2020 Previous studies showed that PPAR-gamma (PPARG) ligands might serve as potential therapeutic agents for nonsmall cell lung cancer (NSCLC). However, a few studies reported the specific relationship between PPARG and lung squamous cell carcinoma (LSCC ...
Shunbin Shi +5 more
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, 2023 We provide evidence here from overexpression-based gain-of-function studies in human cells (1, 2) which demonstrate control of peroxisome proliferator-activated receptor gamma, PPARG, by the NLR (nucleotide-binding oligomerization domain-like receptor) family protein NOD2.
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A Pharmacogenetic Approach to the Treatment of Patients With PPARG Mutations [PDF]
Diabetes, 2018 Loss-of-function mutations in PPARG cause familial partial lipodystrophy type 3 (FPLD3) and severe metabolic disease in many patients. Missense mutations in PPARG are present in ∼1 in 500 people. Although mutations are often binarily classified as benign or deleterious, prospective functional classification of all missense PPARG variants suggests that ...
Agostini, Maura +17 more
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Сахарный диабет, 2015 Metabolic syndrome (MS) is extremely common (20%–25% of the world’s population), and its diagnostic criteria are defined and well known. It has been shown that patients who have MS are twice as likely to die from a cardiovascular complication and three ...
Ekaterina Leonidovna Sorkina +7 more
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PPAR Research, 2020 Previous studies showed that low PPARG expression was associated with poor prognosis of lung adenocarcinoma (LA) with limited mechanisms identified. We first conducted a large-scale literature-based data mining to identify potential molecular pathways ...
Min Zhao +5 more
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Cotranscription and intergenic splicing of the PPARG and TSEN2 genes in cattle [PDF]
BMC Genomics, 2006 Abstract Background Intergenic splicing resulting in the combination of mRNAs sequences from distinct genes is a newly identified mechanism likely to contribute to protein diversity. Few cases have been described, most of them involving neighboring genes and thus suggesting a cotranscription event presumably due to ...
Roux, Matthieu +2 more
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Journal of Experimental Pharmacology, 2023 Eko Fuji Ariyanto,1 Widad Aghnia Shalannandia,2 Uci Ary Lantika,3 Taufik Muhammad Fakih,4 Dwi Syah Fitra Ramadhan,5 Arini Nurisydayanti Gumilar,6 Farhan Khalil Permana,6 Anisa Nadia Rahmah,6 Nur Atik,2 Astrid Feinisa Khairani2 1Division of Biochemistry ...
Ariyanto EF +9 more
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Frontiers in Oncology, 2020 Introduction: The role and underlying mechanisms of miR-27b-3p in triple-negative breast cancer (TNBC) remains unclear.Methods: miR-27b-3p expression level was evaluated in 99 TNBC patients with a median follow-up time of 133 months.
Song-Jie Shen +6 more
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