Results 11 to 20 of about 23,167 (255)
PLoS ONE, 2012 BackgroundGenome-wide comparisons of transcription factor binding sites in different species can be used to evaluate evolutionary constraints that shape gene regulatory circuits and to understand how the interaction between transcription factors shapes ...
Sebastian Pott +4 more
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Is PPARG the key gene in diabetic retinopathy? [PDF]
British Journal of Pharmacology, 2011 Diabetic retinopathy, a microvascular complication of diabetes mellitus, is major cause of non‐inherited blindness among adults. Although diabetic retinopathy is a common complication of diabetes, we still know little about the underlying molecular mechanisms.
Costa V, Ciccodicola A
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PPARG as therapeutic target for antifibrotic therapy
EXCLI journal, 2020 EXCLI Journal;Vol. 19.
Ghallab, Ahmed, Seddek, Abdellatief
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Effect of Black Cumin on the Expression of Genes Related to Lipid Metabolism in Adipose Tissue: A Mouse Model Study [PDF]
Journal of Genetic ResourcesObesity, as a complex multifactorial disease, can be considered as a suitable goal for treatment by traditional medicine. This study aimed to investigate the effect of black cumin on the expression of some important genes in the metabolism of lipids. For
Roya Maleki, Ali Ahadi, Hoda Ayat
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The Genetics ofPPARGand the Skeleton
PPAR Research, 2006 Osteoporosis is a complex metabolic bone disorder. Recently it has been appreciated that the “obesity in bone” phenomenon occurs at the expense of bone formation, and that is a key component of the pathology of this disease. Mouse models with altered bone expression levels of peroxisome proliferator-activated receptor gamma (PPARG) impact bone ...
Cheryl Ackert-Bicknell, Clifford Rosen
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Polymorphism of Pro12Ala and C1431T PPARγin the pathogenesis of Graves' orbitopathy
Клиническая и экспериментальная тиреоидология, 2013 AIM: to examine the association of polymorphisms Pro12Ala and C1431T PPARγwith the development of thyroid eye disease (TEO). Materials and methods. A total of 88 people: 52 patients with TEO, 36 – healthy individuals.
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Frontiers in Pharmacology, 2023 Peroxisome proliferator-activated receptor gamma (PPARG), a key transcription factor involved in lipid metabolism and glucose homeostasis, has been implicated in various types of cancer. However, its precise role in cancer remains unclear. In this study,
Yunsheng Ran +16 more
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Вопросы современной педиатрии, 2018 Background. The genetic nature of a comorbid development of obesity and arterial hypertension (AH) in children is poorly studied. In this regard, it is important to study genes, the polymorphism of which is associated with disturbances in both metabolic ...
Olga P. Kovtun +1 more
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Frontiers in Endocrinology, 2017 The tropical freshwater zebrafish has recently emerged as a valuable model organism for the study of adipose tissue biology and obesity-related disease. The strengths of the zebrafish model system are its wealth of genetic mutants, transgenic tools, and ...
Rebecca Wafer +2 more
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PPARG: A Promising Therapeutic Target in Breast Cancer and Regulation by Natural Drugs
PPAR Research, 2023 Breast cancer (BC) is the most common type of cancer among females. Peroxisome proliferator-activated receptor gamma (PPARG) can regulate the production of adipocyte-related genes and has anti-inflammatory and anti-tumor effects.
De-Hui Li +5 more
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