Results 1 to 10 of about 1,172 (173)

Association between Pro12Ala polymorphism and albuminuria in type 2 diabetic nephropathy [PDF]

Journal of Diabetes Investigation, 2020
Aims/Introduction Diabetic nephropathy (DN) is a complication of diabetes mellitus that is characterized by the gradual loss of kidney function, which results in increased levels of albumin in the urine.
Yung‐Nien Chen, Pei‐Wen Wang, Shih‐Chen Tung, Ming‐Chun Kuo, Shao‐Wen Weng, Chen‐Kai Chou, Chih‐Min Chang, Chia‐Jen Tsa, Cheng‐Feng Taso, Feng‐Chih Shen, Jung‐Fu Chen   +10 more
doaj   +4 more sources

Pro12Ala polymorphism of peroxisome proliferator activated receptor gamma 2 may be associated with adverse neurodevelopment in European preterm babies [PDF]

Brain and Behavior, 2021
Introduction Prematurity is the leading cause of death and disability in children under 5 years of age. Understanding the molecular mechanisms of the biological processes involved in preterm brain injury may help develop novel neuroprotective treatment ...
Suresh Victor, Andrew Chew, Shona Falconer   +2 more
doaj   +3 more sources

Molecular Dynamics Simulation and Essential Dynamics of Deleterious Proline 12 Alanine Single-Nucleotide Polymorphism in PPARγ2 Associated with Type 2 Diabetes, Cardiovascular Disease, and Nonalcoholic Fatty Liver Disease. [PDF]

PPAR Res, 2022
Background. Peroxisome proliferator‐activated receptor‐γ (PPARγ) gene is located at 3p25 position. PPARγ functions as the master regulator of glucose homeostasis and lipoprotein metabolism, and recent studies have reported that it is involved in various metabolic diseases such as diabetes mellitus, hyperlipidemia, coronary artery disease (CAD), and ...
Taghvaei S, Saremi L.
europepmc   +2 more sources

Implications of Genetic Elements on Type 2 Diabetes Mellitus Pathogenesis and Management. [PDF]

Endocrinol Diabetes Metab
Genetic variations in T2DM, including key metabolic and insulin‐related genes, influence disease risk, insulin resistance, and drug response. Understanding these polymorphisms enables precision medicine, optimising therapy and improving glycaemic control across diverse populations.
Ngcobo NN, Sibiya NH.
europepmc   +2 more sources

Polymorphism of Pro12Ala and C1431T PPARγin the pathogenesis of Graves' orbitopathy

Клиническая и экспериментальная тиреоидология, 2013
AIM: to examine the association of polymorphisms Pro12Ala and C1431T PPARγwith the development of thyroid eye disease (TEO). Materials and methods. A total of 88 people: 52 patients with TEO, 36 – healthy individuals.
D M Serkin, O V Serebryakova, M A Serkin, S V Charinzeva, N N Strambovskaya, S D Dagbaeva   +5 more
doaj   +3 more sources

The Effect of PPARγ rs1801282 Variant on Mortality Risk Among Asians With Chronic Kidney Disease: A Cohort Study and Meta-Analysis [PDF]

Frontiers in Genetics, 2022
Background: Chronic kidney disease (CKD) is a public health issue, and an independent risk factor for cardiovascular disease. The peroxisome proliferator-activated receptor gamma (PPARG) plays an important role in the cardiovascular system.
Wei-Teing Chen, Wei-Teing Chen, Chih-Chien Chiu, Dung-Jang Tsai, Dung-Jang Tsai, Pi-Shao Ko, Pi-Shao Ko, Meng-Chang Lee, Hsiao-Ting Lin, Ying-Kai Chen, Ying-Kai Chen, Wen Su, Yuh-Feng Lin, Yuh-Feng Lin, Sui-Lung Su   +14 more
doaj   +2 more sources

Pathophysiologic Mechanisms of Insulin Secretion and Signaling-Related Genes in Etiology of Polycystic Ovary Syndrome. [PDF]

Genet Res (Camb), 2021
Polycystic ovary syndrome (PCOS) is a common endocrinopathy in women. PCOS is characterized by anovulation, hyperandrogenism, polycystic ovaries, insulin resistance, and obesity. Despite the finding that the genetic origin of PCOS is well demonstrated in previous twin and familial clustering studies, genes and factors that can exactly explain the PCOS ...
Shaaban Z, Khoradmehr A, Amiri-Yekta A, Nowzari F, Jafarzadeh Shirazi MR, Tamadon A.   +5 more
europepmc   +2 more sources

Effects Of PPARγ2 Pro12Ala Variant On Adipocyte Phenotype Dependent Of DHA

Diabetes, Metabolic Syndrome and Obesity, 2019
Renhui Wan,* Zhengping Ding,* Sheng Xia, Longyi Zheng, Jin Lu Department of Endocrinology, Changhai Hospital, Second Military Medical University, Shanghai 200433, People’s Republic of China*These authors contributed equally to this ...
Wan R, Ding Z, Xia S, Zheng L, Lu J
doaj   +4 more sources

Association of PPARγ2 Pro12Ala polymorphism with gestational diabetes mellitus risk: A systematic review and meta-analysis [PDF]

Biomolecules & Biomedicine
Gestational diabetes mellitus (GDM) is a prevalent pregnancy complication that poses significant risks to both mothers and their offspring, with genetic susceptibility believed to play a role in its pathogenesis.
Yuanting Xu, Yi Du, Tengfei Shan, Qingwen Xie, Hongli Zhu   +4 more
doaj   +2 more sources

The PPAR-gamma Pro12Ala polymorphism and risk of cognitive impairment in a longitudinal study [PDF]

Neurobiology of Aging, 2010
The Pro12Ala polymorphism in the PPAR-gamma gene has been associated with reduced incidence of type 2 diabetes. Although diabetes has been implicated as a risk factor for dementia, the association of Pro12Ala with cognitive impairment is unclear. Dementia and cognitive impairment without dementia (CIND) were determined during six annual follow-up ...
Mary Haan
exaly   +3 more sources