Results 1 to 10 of about 3,653 (217)

Pro12Ala polymorphism of peroxisome proliferator activated receptor gamma 2 may be associated with adverse neurodevelopment in European preterm babies [PDF]

Brain and Behavior, 2021
Introduction Prematurity is the leading cause of death and disability in children under 5 years of age. Understanding the molecular mechanisms of the biological processes involved in preterm brain injury may help develop novel neuroprotective treatment ...
Suresh Victor, Andrew Chew, Shona Falconer   +2 more
doaj   +3 more sources

The Effect of PPARγ rs1801282 Variant on Mortality Risk Among Asians With Chronic Kidney Disease: A Cohort Study and Meta-Analysis [PDF]

Frontiers in Genetics, 2022
Background: Chronic kidney disease (CKD) is a public health issue, and an independent risk factor for cardiovascular disease. The peroxisome proliferator-activated receptor gamma (PPARG) plays an important role in the cardiovascular system.
Wei-Teing Chen, Wei-Teing Chen, Chih-Chien Chiu, Dung-Jang Tsai, Dung-Jang Tsai, Pi-Shao Ko, Pi-Shao Ko, Meng-Chang Lee, Hsiao-Ting Lin, Ying-Kai Chen, Ying-Kai Chen, Wen Su, Yuh-Feng Lin, Yuh-Feng Lin, Sui-Lung Su   +14 more
doaj   +2 more sources

Peroxisome proliferator-activated receptor α and γ gene polymorphisms among South Indian patients with diabetic dyslipidaemia [PDF]

Indian Journal of Endocrinology and Metabolism, 2023
Background: Peroxisome proliferator-activated receptors (PPAR) α and γ genes play an important role in dyslipidaemia of T2DM. Aims: To estimate the frequency distribution of PPAR α and γ gene polymorphisms in South Indian T2DM patients with dyslipidaemia
Isaac J Bage, Sadishkumar Kamalanathan, Sandhiya Selvarajan, Jayaprakash Sahoo, Jayanthi Mathaiyan, Dukhabandhu Naik   +5 more
doaj   +2 more sources

Association study of rs1801282 PPARG gene polymorphism and immune cells and cytokine levels in a Spanish pregnant women cohort and their offspring [PDF]

Journal of Biomedical Science, 2020
Background Peroxisome proliferator activated receptor gamma (PPARG) belongs to the nuclear receptor superfamily functioning as transcription factors to regulate cellular differentiation, development and metabolism. Moreover, it has been implicated in the
Maria García-Ricobaraza, Mercedes García-Bermúdez, Francisco J. Torres-Espinola, M. Teresa Segura Moreno, Mathieu N. Bleyere, Ligia E. Díaz-Prieto, Esther Nova, Ascensión Marcos, Cristina Campoy   +8 more
doaj   +2 more sources

Association of PPARγ2 Pro12Ala polymorphism with gestational diabetes mellitus risk: A systematic review and meta-analysis [PDF]

Biomolecules & Biomedicine
Gestational diabetes mellitus (GDM) is a prevalent pregnancy complication that poses significant risks to both mothers and their offspring, with genetic susceptibility believed to play a role in its pathogenesis.
Yuanting Xu, Yi Du, Tengfei Shan, Qingwen Xie, Hongli Zhu   +4 more
doaj   +2 more sources

PPARγ2 Pro12Ala Polymorphism is Associated in Children With Traits Related to Susceptibility to Type 2 Diabetes [PDF]

Frontiers in Pharmacology, 2021
Peroxisome proliferator-activated receptor gamma (PPARγ) is a ligand-activated nuclear receptor that regulates glucose and lipid metabolism. Pharmacological activators of PPARγ are being used as a treatment of obesity related disorders such as ...
Claudia Vales-Villamarín, Olaya de Dios, Iris Pérez-Nadador, Teresa Gavela-Pérez, Leandro Soriano-Guillén, Carmen Garcés   +5 more
doaj   +2 more sources

PPARG genindeki Pro12Ala polimorfizmi, Türk populasyonunda insülin direnci ve tip 2 diyabet ile ilişkili değildir: Bir vaka-kontrol çalışması

Genel Tıp Dergisi, 2021
Amaç: Tip 2 diyabet (T2D), diyabetin en sık görülen türüdür ve tüm dünyada olduğu gibi ülkemizde de ciddi bir halk sağlığı sorunu haline gelmiştir. İnsülin sekresyonunun azalması ve/veya insülin direnci (İR) gelişimi, T2D patogenezinde yer alan iki ana ...
Süleyman Baldane, Suleyman Ipekci, Funda İşçioğlu, Hilal Arikoglu, Dudu Erkoç Kaya   +4 more
doaj   +1 more source

Genotype Phenotype Correlation of Genetic Polymorphism of PPAR Gamma Gene and Therapeutic Response to Pioglitazone in Type 2 Diabetes Mellitus-A Pilot Study [PDF]

Journal of Clinical and Diagnostic Research, 2016
Introduction: Pro12Ala polymorphism is a missense mutation at codon 12 in peroxisome proliferator-activated receptor γ gene (PPARG). This polymorphism is known to be associated with increased insulin sensitivity. Pioglitazone, a thiazolidinedione, is
S. Shanmuga Priya, Ramalingam Sankaran, Sudha Ramalingam, Thiagarajan Sairam, LS Somasundaram   +4 more
doaj   +1 more source

Pro12Ala substitution in the peroxisome proliferator-activated receptor gamma (PPARγ) gene and non-alcoholic fatty liver disease [PDF]

Archives of Biological Sciences, 2013
The aim of this study was to analyze the relationship between Pro12Ala substitution in the peroxisome proliferator-activated receptor gamma (PPARy) gene and non-alcoholic fatty liver disease (NAFLD).
Chen Shao-Hua, Ying Lixiong, Wu Chenjiao, Wang Qunyan, Li You-Ming   +4 more
doaj   +1 more source

PPAR gamma pro12Ala polymorphism and type 2 diabetes: a study in a spanish cohort [PDF]

, 2014
Type 2 diabetes (T2D) is a disease whose occurrence is increasing prevalent in westernized civilizations and is responsible for the proliferation in the morbidity and total mortality of patients with cardiovascular diseases, worldwide.
Cieza Borrella, C, Corral Gudino, L, González Sarmiento, R, Makena Hoghtower, C, Mayoral, R, Miramontes González, JP   +5 more
core   +1 more source